1-hydroxy-3,5,6,7,8-pentamethoxyxanthone - Compound Card

1-hydroxy-3,5,6,7,8-pentamethoxyxanthone

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1-hydroxy-3,5,6,7,8-pentamethoxyxanthone

Structure
Zoomed Structure
  • Family: Plantae - Gentianaceae
  • Kingdom: Plantae
  • Class: Xanthone
Canonical Smiles COc1cc(O)c2c(c1)oc1c(c2=O)c(OC)c(c(c1OC)OC)OC
InChI InChI=1S/C18H18O8/c1-21-8-6-9(19)11-10(7-8)26-15-12(13(11)20)14(22-2)16(23-3)18(25-5)17(15)24-4/h6-7,19H,1-5H3
InChIKey SVEPSJMWTARFFE-UHFFFAOYSA-N
Formula C18H18O8
HBA 8
HBD 1
MW 362.33
Rotatable Bonds 5
TPSA 96.59
LogP 2.69
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 26
Formal Charge 0
Fraction CSP3 0.28
Exact Mass 362.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Centaurium spicatum Gentianaceae Plantae 172074

Showing of synonyms

  • El-Shanawany MA, Mohamed GA, et al. (2011). A new xanthone from the roots of Centaurium spicatum. Phytochemistry Letters,2011,4,126-128. [View]
Pubchem: 5490842
Nmrshiftdb2: 70088945

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc3c(c2=O)cccc3

Level: 0

Mol. Weight: 362.33 g/mol

Antimicrobial
Antiprotozoal
Cytotoxicity

Absorption

Caco-2 (logPapp)
-4.78
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.790
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.82

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.420
Plasma Protein Binding
53.57
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.620
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.670
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.600
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
7.190
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
0.080
Rat (Acute)
2.390
Rat (Chronic Oral)
3.080
Fathead Minnow
5.410
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
444.040
Hydration Free Energy
-9.380
Log(D) at pH=7.4
3.100
Log(P)
2.97
Log S
-4.46
Log(Vapor Pressure)
-7.53
Melting Point
171.34
pKa Acid
7.83
pKa Basic
1.48
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9506
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9506
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9413
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9413
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9381
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9381
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9367
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9367
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.9344
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.9344
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9314
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9314
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9292
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9292
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9180
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9180
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9081
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9081
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8916
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8916
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8899
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8899
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8862
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8862
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8800
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8800
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8777
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8777
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8755
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8755
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8750
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8750
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8685
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8685
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8637
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8637
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.8591
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.8591
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8561
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8561
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8553
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8553
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8544
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8544
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8539
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8539
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8521
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8521
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8520
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8520
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8473
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8473
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8370
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8370
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8309
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8309
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8270
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8270
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8262
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8262
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8236
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8236
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8182
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8182
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8177
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8177
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.8061
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.8061
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8025
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8025
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7976
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7976
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7976
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7976
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7957
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7957
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7945
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7945
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7870
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7870
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7860
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7860
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7848
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7848
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7834
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7834
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7783
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7783
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7712
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7712
Dodecin Q5SIE3 DODEC_THET8 Thermus thermophilus 4 0.7703
Dodecin Q5SIE3 DODEC_THET8 Thermus thermophilus 4 0.7703
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7648
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7648
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7642
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7642
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7632
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7632
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7630
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7630
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7611
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7611
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7588
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7588
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7546
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7546
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7546
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7546
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7530
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7530
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7527
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7527
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7515
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7515
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7514
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7514
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7510
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7510
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7495
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7495
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7493
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7493
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7491
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7491
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7486
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7486
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7474
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7474
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7457
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7457
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7442
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7442
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7437
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7437
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7428
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7428
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7428
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7428
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7421
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7421
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7414
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7414
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7412
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7412
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7408
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7408
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7383
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7383
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7380
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7380
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7378
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7378
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7360
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7360
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7357
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7357
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7335
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7335
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7334
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7334
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7322
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7322
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7317
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7317
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7314
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7314
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7312
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7312
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7290
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7290
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7289
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7289
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7289
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7289
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7285
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7285
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7276
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7276
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7273
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7273
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7250
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7250
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7247
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7247
IAG-nucleoside hydrolase Q9GPQ4 Q9GPQ4_TRYVI Trypanosoma vivax 3 0.7246
IAG-nucleoside hydrolase Q9GPQ4 Q9GPQ4_TRYVI Trypanosoma vivax 3 0.7246
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7224
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7224
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 2 0.7215
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 2 0.7215
D-mycarose 3-C-methyltransferase Q194Q4 Q194Q4_STRAA Streptomyces argillaceus 4 0.7213
D-mycarose 3-C-methyltransferase Q194Q4 Q194Q4_STRAA Streptomyces argillaceus 4 0.7213
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7212
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7212
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.7208
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.7208
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7188
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7188
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7184
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7184
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7184
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7184
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7181
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7181
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7172
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7172
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7170
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7170
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7167
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7167
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7164
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7164
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7140
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7140
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7139
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7139
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7139
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7139
Orotidine 5'-phosphate decarboxylase Q9KQT7 PYRF_VIBCH Vibrio cholerae serotype O1 4 0.7136
Orotidine 5'-phosphate decarboxylase Q9KQT7 PYRF_VIBCH Vibrio cholerae serotype O1 4 0.7136
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7132
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7132
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7126
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7126
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7123
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7123
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7115
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7115
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7103
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7103
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7102
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7102
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 5 0.7093
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 5 0.7093
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7087
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7087
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7066
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7066
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7060
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7060
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7056
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7056
Ras-related protein M-Ras O08989 RASM_MOUSE Mus musculus 4 0.7055
Ras-related protein M-Ras O08989 RASM_MOUSE Mus musculus 4 0.7055
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7053
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7053
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7051
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7051
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7050
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7050
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7040
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7040
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 2 0.7033
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 2 0.7033
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7032
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7032
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7027
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7027
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7027
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7027
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7009
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7009
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7003
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7003
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7003
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7003

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