Ottelione A - Compound Card

Ottelione A

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Ottelione A

Structure
Zoomed Structure
  • Family: Plantae - Hydrocharitaceae
  • Kingdom: Plantae
  • Class: Cyclohexenone
Canonical Smiles C=C[C@@H]1C[C@H]([C@@H]2[C@H]1C(=C)C=CC2=O)Cc1ccc(c(c1)O)OC
InChI InChI=1S/C20H22O3/c1-4-14-11-15(20-16(21)7-5-12(2)19(14)20)9-13-6-8-18(23-3)17(22)10-13/h4-8,10,14-15,19-20,22H,1-2,9,11H2,3H3/t14-,15-,19+,20+/m1/s1
InChIKey ODHHTIYRUDURPW-IPZZXCBHSA-N
Formula C20H22O3
HBA 3
HBD 1
MW 310.39
Rotatable Bonds 4
TPSA 46.53
LogP 3.69
Number Rings 3
Number Aromatic Rings 1
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.35
Exact Mass 310.16
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Ottelia alismoides Hydrocharitaceae Plantae 55483

Showing of synonyms

  • Ayyad SEN, Judd AS, et al. (1998). Otteliones A and B: Potently cytotoxic 4-methylene-2-cyclohexenones from Ottelia alismoides. The Journal of Organic Chemistry,1998,63,8102-8106. [View]
Pubchem: 10946837
Nmrshiftdb2: 70088583
CPRiL: 229988
Structure

SMILES: O=C1C=CC(=C)C(C12)CCC2Cc3ccccc3

Level: 1

Mol. Weight: 310.39 g/mol

Structure

SMILES: C=C1C=CC(=O)C(C12)CCC2

Level: 0

Mol. Weight: 310.39 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 310.39 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp)
-4.83
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.47
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.51

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.13
Plasma Protein Binding
91.14
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.92
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.46
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-0.09
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
7.08
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.58
Rat (Acute)
2.84
Rat (Chronic Oral)
2.3
Fathead Minnow
4.13
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
396.6
Hydration Free Energy
-6.27
Log(D) at pH=7.4
3.62
Log(P)
3.63
Log S
-4.74
Log(Vapor Pressure)
-7.21
Melting Point
134.97
pKa Acid
9.23
pKa Basic
4.37
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9707
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9707
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.9602
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.9602
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9595
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9595
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9571
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9571
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.9540
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.9540
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9503
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9503
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9500
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9500
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9499
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9499
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9452
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9452
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.9449
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.9449
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.9433
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.9433
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9414
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9414
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 4 0.9395
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 4 0.9395
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9341
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9341
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.9317
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.9317
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9297
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9297
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.9194
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.9194
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9193
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9193
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9191
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9191
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.9164
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.9164
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.9138
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.9138
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.9054
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.9054
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.9004
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.9004
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.8949
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.8949
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8940
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8940
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8937
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8937
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8921
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8921
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8877
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8877
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8866
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8866
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8861
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8861
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8855
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8855
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8855
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8855
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8849
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8849
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8848
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8848
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8840
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8840
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8837
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8837
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8825
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8825
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8804
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8804
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8778
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8778
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8743
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8743
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8736
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8736
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8702
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8702
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8684
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8684
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.8683
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.8683
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8676
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8676
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.8659
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.8659
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8648
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8648
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8643
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8643
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8641
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8641
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8634
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8634
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8620
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8620
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8613
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8613
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8588
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8588
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8530
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8530
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.8526
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.8526
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8518
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8518
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8509
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8509
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8490
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8490
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8452
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8452
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8361
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8361
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8351
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8351
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8347
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8347
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8297
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8297
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8294
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8294
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8289
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8289
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8265
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8265
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8247
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8247
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8220
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8220
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 3 0.8207
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 3 0.8207
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8198
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8198
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8197
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8197
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8197
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8197
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8178
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8178
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8175
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8175
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.8118
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.8118
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8115
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8115
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8100
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8100
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8097
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8097
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8067
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8067
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8047
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8047
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8045
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8045
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8043
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8043
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.8024
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.8024
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7980
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7980
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7969
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7969
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7960
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7960
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7956
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7956
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7906
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7906
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7892
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7892
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7887
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7887
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7874
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7874
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 3 0.7862
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 3 0.7862
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7838
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7838
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7837
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7837
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7835
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7835
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7804
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7804
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 3 0.7796
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 3 0.7796
Raucaffricine-O-beta-D-glucosidase Q9SPP9 RG1_RAUSE Rauvolfia serpentina 3 0.7781
Raucaffricine-O-beta-D-glucosidase Q9SPP9 RG1_RAUSE Rauvolfia serpentina 3 0.7781
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7769
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7769
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 3 0.7768
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 3 0.7768
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7767
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7767
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7766
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7766
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7761
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7761
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 4 0.7760
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 4 0.7760
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7756
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7756
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7751
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7751
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7733
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7733
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7721
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7721
Glycogenin-1 P46976 GLYG_HUMAN Homo sapiens 3 0.7712
Glycogenin-1 P46976 GLYG_HUMAN Homo sapiens 3 0.7712
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7707
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 4 0.7707
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 4 0.7707
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7707
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7697
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7697
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7695
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7695
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7691
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7691
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 3 0.7687
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 3 0.7687
Thymidylate synthase Q4JQW2 TYSY_VZVO Varicella-zoster virus 3 0.7677
Thymidylate synthase Q4JQW2 TYSY_VZVO Varicella-zoster virus 3 0.7677
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7674
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7674
LL-diaminopimelate aminotransferase, chloroplastic Q93ZN9 DAPAT_ARATH Arabidopsis thaliana 2 0.7673
LL-diaminopimelate aminotransferase, chloroplastic Q93ZN9 DAPAT_ARATH Arabidopsis thaliana 2 0.7673
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7673
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7673
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7668
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7668
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7667
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7667
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7654
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7654
Purine nucleoside phosphorylase 2 P45563 XAPA_ECOLI Escherichia coli 3 0.7651
Purine nucleoside phosphorylase 2 P45563 XAPA_ECOLI Escherichia coli 3 0.7651
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7650
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7650
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7649
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7649
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7649
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7649
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7648
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7648
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7646
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7646
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7644
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7644
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.7643
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.7643
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7642
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7642
Ribosomal RNA small subunit methyltransferase Nep1 Q57977 NEP1_METJA Methanocaldococcus jannaschii 3 0.7639
Ribosomal RNA small subunit methyltransferase Nep1 Q57977 NEP1_METJA Methanocaldococcus jannaschii 3 0.7639
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7636
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7636
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7629
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7629
Fatty acid-binding protein 10-A, liver basic Q9I8L5 FA10A_DANRE Danio rerio 2 0.7622
Fatty acid-binding protein 10-A, liver basic Q9I8L5 FA10A_DANRE Danio rerio 2 0.7622
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7621
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7621
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7618
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7618
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7613
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7613
Cyclic nucleotide-binding domain-containing protein E0RR11 E0RR11_SPITD Spirochaeta thermophila 2 0.7612
Cyclic nucleotide-binding domain-containing protein E0RR11 E0RR11_SPITD Spirochaeta thermophila 2 0.7612
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7611
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7611
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7611
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7611
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7607
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7607
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7603
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7603
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7601
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7601
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7600
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7600
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7599
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7599
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7596
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7596
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7594
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7594
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7585
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7585
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7582
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7582
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7573
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7573
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7562
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7562
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7538
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7538
Tryptophan--tRNA ligase Q9PIB4 SYW_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 4 0.7537
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7537
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7537
Tryptophan--tRNA ligase Q9PIB4 SYW_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 4 0.7537
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7536
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7536
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7530
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7530
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7529
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7529
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7526
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7526
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7518
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7518
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7518
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7518
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7518
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7518
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7517
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7517
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7515
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7515
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7512
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7512
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Q9UL51 HCN2_HUMAN Homo sapiens 3 0.7509
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Q9UL51 HCN2_HUMAN Homo sapiens 3 0.7509
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7500
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7500
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7499
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7499
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7498
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7498
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7494
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7494
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7490
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7490
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7484
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7484
HD domain protein Q836G9 Q836G9_ENTFA Enterococcus faecalis 3 0.7477
HD domain protein Q836G9 Q836G9_ENTFA Enterococcus faecalis 3 0.7477
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7475
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7475
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7469
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7469
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7468
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7468
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7459
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7459
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7458
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7458
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7458
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7458
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7453
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7453
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 2 0.7451
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 2 0.7451
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7448
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7448
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7448
Adenylosuccinate synthetase isozyme 1 P28650 PURA1_MOUSE Mus musculus 4 0.7448
Adenylosuccinate synthetase isozyme 1 P28650 PURA1_MOUSE Mus musculus 4 0.7448
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7448
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7446
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7446
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7445
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7445
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7444
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7444
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7444
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7444
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7438
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7438
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7437
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7437
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7437
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7437
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7436
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7436
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 2 0.7433
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 2 0.7433
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7429
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7429
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7419
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7419
Mevalonate kinase P17256 KIME_RAT Rattus norvegicus 3 0.7413
Mevalonate kinase P17256 KIME_RAT Rattus norvegicus 3 0.7413
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7412
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7412
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 2 0.7408
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 2 0.7408
tRNA (guanine-N(1)-)-methyltransferase Q2GIL5 TRMD_ANAPZ Anaplasma phagocytophilum 3 0.7402
tRNA (guanine-N(1)-)-methyltransferase Q2GIL5 TRMD_ANAPZ Anaplasma phagocytophilum 3 0.7402
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7393
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7393
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7391
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7391
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7390
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7390
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7388
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7388
CalS8 Q8KNF6 Q8KNF6_MICEC Micromonospora echinospora 4 0.7387
CalS8 Q8KNF6 Q8KNF6_MICEC Micromonospora echinospora 4 0.7387
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7376
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7376
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7371
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7371
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7369
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7369
16S rRNA (adenine(1408)-N(1))-methyltransferase A8C927 NPMA_ECOLX Escherichia coli 3 0.7368
16S rRNA (adenine(1408)-N(1))-methyltransferase A8C927 NPMA_ECOLX Escherichia coli 3 0.7368
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7360
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7360
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7360
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7360
SKP1-like protein 1A Q39255 SKP1A_ARATH Arabidopsis thaliana 3 0.7359
SKP1-like protein 1A Q39255 SKP1A_ARATH Arabidopsis thaliana 3 0.7359
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7358
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7358
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7357
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7357
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7355
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7355
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7351
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7351
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 Q8GZB6 SUVH4_ARATH Arabidopsis thaliana 3 0.7350
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 Q8GZB6 SUVH4_ARATH Arabidopsis thaliana 3 0.7350
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7347
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7347
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7343
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7343
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 2 0.7341
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 2 0.7341
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7341
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 2 0.7341
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 2 0.7341
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7341
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7338
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7338
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7335
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7335
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7335
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7335
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7335
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7335
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7334
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7334
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7334
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7334
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7332
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7332
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7328
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7328
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7326
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7326
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7324
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7324
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7324
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7324
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7324
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7324
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7323
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7323
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7322
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7322
N-glycosylase/DNA lyase O15527 OGG1_HUMAN Homo sapiens 3 0.7319
N-glycosylase/DNA lyase O15527 OGG1_HUMAN Homo sapiens 3 0.7319
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7318
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7318
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7317
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7317
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 2 0.7316
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 2 0.7316
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7314
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7314
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7313
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7313
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7311
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7311
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7310
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7310
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7310
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7310
Guanylate kinase P15454 KGUA_YEAST Saccharomyces cerevisiae 3 0.7303
Guanylate kinase P15454 KGUA_YEAST Saccharomyces cerevisiae 3 0.7303
Rhodopsin P02699 OPSD_BOVIN Bos taurus 2 0.7302
Rhodopsin P02699 OPSD_BOVIN Bos taurus 2 0.7302
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7297
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7297
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7296
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7296
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7295
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7295
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7294
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7294
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7289
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7289
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7286
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7286
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7285
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7285
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7283
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7283
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7282
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7282
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7282
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7282
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7279
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7279
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7279
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7279
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7277
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7277
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7277
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7277
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7272
Histone-lysine N-methyltransferase 2C Q8NEZ4 KMT2C_HUMAN Homo sapiens 3 0.7272
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7272
Histone-lysine N-methyltransferase 2C Q8NEZ4 KMT2C_HUMAN Homo sapiens 3 0.7272
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7271
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7271
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 2 0.7270
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 2 0.7270
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7266
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7266
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7265
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7265
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7265
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7265
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7265
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7265
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7259
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7259
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7259
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7259
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7258
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7258
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7257
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7257
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7256
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7256
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7255
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7255
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7250
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7250
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7249
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7249
Thiazole tautomerase P25053 TENI_BACSU Bacillus subtilis 2 0.7247
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7247
Thiazole tautomerase P25053 TENI_BACSU Bacillus subtilis 2 0.7247
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7247
TamL D3Y1I2 D3Y1I2_9ACTN Streptomyces sp. 307-9 2 0.7246
TamL D3Y1I2 D3Y1I2_9ACTN Streptomyces sp. 307-9 2 0.7246
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 3 0.7245
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 3 0.7245
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7242
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7242
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7241
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7241
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7241
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7241
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7240
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7240
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7239
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7239
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7239
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7239
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7237
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7237
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7232
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7232
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7232
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7232
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7223
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7223
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7223
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7223
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.7222
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7222
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.7222
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7222
L-seryl-tRNA(Sec) kinase Q58933 PSTK_METJA Methanocaldococcus jannaschii 2 0.7214
L-seryl-tRNA(Sec) kinase Q58933 PSTK_METJA Methanocaldococcus jannaschii 2 0.7214
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7213
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7213
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7213
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7213
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7213
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7213
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7212
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7212
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 2 0.7210
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 2 0.7210
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7209
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7209
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7207
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7207
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7207
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7207
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7205
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7205
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7204
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7204
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7204
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7204
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7203
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7203
Rho family GTPase C4M4W4 C4M4W4_ENTHI Entamoeba histolytica 4 0.7202
Rho family GTPase C4M4W4 C4M4W4_ENTHI Entamoeba histolytica 4 0.7202
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7198
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7198
Catabolite activator protein C3SQJ7 C3SQJ7_ECOLX Escherichia coli 3 0.7195
Catabolite activator protein C3SQJ7 C3SQJ7_ECOLX Escherichia coli 3 0.7195
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7194
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7194
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7191
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7191
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7190
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7190
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7190
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7190
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7188
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7188
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 2 0.7185
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 2 0.7185
Lactose operon repressor P03023 LACI_ECOLI Escherichia coli 3 0.7183
Lactose operon repressor P03023 LACI_ECOLI Escherichia coli 3 0.7183
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.7180
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.7180
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7175
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7175
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7170
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7170
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7170
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7170
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7170
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7170
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 2 0.7169
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 2 0.7169
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7168
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7168
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7166
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7166
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 O88704 HCN1_MOUSE Mus musculus 3 0.7165
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 O88704 HCN1_MOUSE Mus musculus 3 0.7165
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 2 0.7164
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 2 0.7164
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7163
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7163
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7162
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7162
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7159
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7159
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7158
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7158
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7153
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7153
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7152
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7152
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 2 0.7151
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 2 0.7151
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7146
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7146
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7146
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7146
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7141
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7141
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7132
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7132
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7131
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7131
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7131
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7131
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7131
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7131
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7128
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7128
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7127
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7127
Ribosomal RNA small subunit methyltransferase E Q5SKI6 Q5SKI6_THET8 Thermus thermophilus 3 0.7125
Ribosomal RNA small subunit methyltransferase E Q5SKI6 Q5SKI6_THET8 Thermus thermophilus 3 0.7125
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 2 0.7124
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7124
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7124
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 2 0.7124
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7124
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7124
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7123
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7123
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7123
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7123
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7121
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7121
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 3 0.7119
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 3 0.7119
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7115
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7115
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7114
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7114
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7112
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7112
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7111
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7111
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7111
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7111
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7107
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7107
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7104
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7104
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7103
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7103
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7103
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7103
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 2 0.7102
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 2 0.7102
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7101
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7101
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7100
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7100
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7098
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7098
DNA (cytosine-5)-methyltransferase 3A O88508 DNM3A_MOUSE Mus musculus 3 0.7095
DNA (cytosine-5)-methyltransferase 3A O88508 DNM3A_MOUSE Mus musculus 3 0.7095
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7090
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7090
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7090
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7090
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7090
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7090
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7090
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7090
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7089
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7089
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 2 0.7085
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7085
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 2 0.7085
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7085
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7082
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7082
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7081
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7081
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 4 0.7078
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 4 0.7078
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7075
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7075
Uracil-DNA glycosylase P13051 UNG_HUMAN Homo sapiens 3 0.7070
Uracil-DNA glycosylase P13051 UNG_HUMAN Homo sapiens 3 0.7070
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7070
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7070
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7069
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7069
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7065
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7065
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7064
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7064
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7061
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7061
Ras-related protein Rap-1b P61224 RAP1B_HUMAN Homo sapiens 3 0.7060
Ras-related protein Rap-1b P61224 RAP1B_HUMAN Homo sapiens 3 0.7060
Uracil-DNA glycosylase P20536 UNG_VACCC Vaccinia virus 3 0.7058
Uracil-DNA glycosylase P20536 UNG_VACCC Vaccinia virus 3 0.7058
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7056
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7056
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7055
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7055
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7054
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7054
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 2 0.7053
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 4 0.7053
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7053
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 4 0.7053
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7053
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 2 0.7053
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7051
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7051
Transitional endoplasmic reticulum ATPase Q01853 TERA_MOUSE Mus musculus 3 0.7048
Transitional endoplasmic reticulum ATPase Q01853 TERA_MOUSE Mus musculus 3 0.7048
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7047
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7047
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7047
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7047
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7043
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7043
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7041
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7041
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7040
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7040
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7039
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 2 0.7039
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7039
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 2 0.7039
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7038
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7038
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7036
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7036
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7036
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7036
HLA class I histocompatibility antigen, B alpha chain P01889 HLAB_HUMAN Homo sapiens 3 0.7030
HLA class I histocompatibility antigen, B alpha chain P01889 HLAB_HUMAN Homo sapiens 3 0.7030
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 2 0.7028
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 2 0.7028
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 2 0.7027
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 2 0.7027
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7026
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7026
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7023
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7023
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7023
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7023
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7022
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7022
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7022
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7022
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7017
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7017
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 2 0.7014
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 2 0.7014
chitinase B0Y2Y2 B0Y2Y2_ASPFC Aspergillus fumigatus 3 0.7014
chitinase B0Y2Y2 B0Y2Y2_ASPFC Aspergillus fumigatus 3 0.7014
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7012
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7012
Holliday junction branch migration complex subunit RuvB Q9PMT7 RUVB_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 2 0.7009
Holliday junction branch migration complex subunit RuvB Q9PMT7 RUVB_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 2 0.7009
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7004
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7004
Polymerase acidic protein Q5EP34 Q5EP34_9INFA Influenza A virus 2 0.7003
Polymerase acidic protein Q5EP34 Q5EP34_9INFA Influenza A virus 2 0.7003
Nucleoside diphosphate kinase A5J299 A5J299_PENVA Penaeus vannamei 2 0.7001
dTDP-4-dehydro-6-deoxyglucose 3-epimerase Q5SFD1 CHMJ_STRBI Streptomyces bikiniensis 3 0.7001
Nucleoside diphosphate kinase A5J299 A5J299_PENVA Penaeus vannamei 2 0.7001
dTDP-4-dehydro-6-deoxyglucose 3-epimerase Q5SFD1 CHMJ_STRBI Streptomyces bikiniensis 3 0.7001

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