Isoscutellarein - Compound Card

Isoscutellarein

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Isoscutellarein

Structure
Zoomed Structure
  • Family: Plantae - Hydrocharitaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavone
Canonical Smiles Oc1ccc(cc1)c1cc(=O)c2c(o1)c(O)c(cc2O)O
InChI InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)12-6-10(18)13-9(17)5-11(19)14(20)15(13)21-12/h1-6,16-17,19-20H
InChIKey NXHQVROAKYDSNW-UHFFFAOYSA-N
Formula C15H10O6
HBA 6
HBD 4
MW 286.24
Rotatable Bonds 1
TPSA 111.13
LogP 2.28
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.0
Exact Mass 286.05
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Thalassia hemprichii Hydrocharitaceae Plantae 55496

Showing of synonyms

  • Hawas UW (2014). A new 8-hydroxy flavone o-xyloside sulfate and antibacterial activity from the Egyptian seagrass Thalassia hemprichii. Chemistry of Natural Compounds,2014,50(4),546-548. [View]
Pubchem: 5281665
Kegg Ligand: C10097
Chebi: 6059
Nmrshiftdb2: 60022906
Metabolights: MTBLC6059
CPRiL: 29320
Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 286.24 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 286.24 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 286.24 g/mol

Antimicrobial

Absorption

Caco-2 (logPapp)
-5.26
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.180
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.15

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.810
Plasma Protein Binding
91.81
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.550
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.890
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.390
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.340
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.660
Rat (Acute)
2.430
Rat (Chronic Oral)
3.230
Fathead Minnow
4.190
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
488.710
Hydration Free Energy
-12.700
Log(D) at pH=7.4
2.490
Log(P)
2.89
Log S
-3.66
Log(Vapor Pressure)
-8.67
Melting Point
329.34
pKa Acid
5.88
pKa Basic
6.99
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9769
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9769
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9730
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9730
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9634
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9634
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9498
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9498
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9415
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9415
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9230
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9230
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9214
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9214
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9178
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9178
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.9122
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.9122
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.9107
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.9107
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9061
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9061
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9027
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9027
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.9010
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.9010
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8991
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8991
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8988
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8988
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8968
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8968
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8901
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8901
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8889
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8889
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8849
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8849
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8837
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8837
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8831
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8831
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8825
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8825
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8822
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8822
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8807
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8807
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8801
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8801
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8786
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8786
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8764
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8764
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8681
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8681
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.8670
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.8670
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.8649
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.8649
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8648
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8648
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8612
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8612
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8596
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8596
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8515
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8515
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8513
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8513
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8509
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8509
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8487
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8487
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8487
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8487
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8457
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8457
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8449
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8449
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 4 0.8439
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 4 0.8439
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8418
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8418
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8412
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8412
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8401
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8401
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8399
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8399
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8366
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8366
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8364
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8364
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.8358
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.8358
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8353
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8353
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8328
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8328
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8324
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8324
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8304
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8304
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8294
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8294
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8283
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8283
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8278
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8278
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.8277
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.8277
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8269
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8269
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8268
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8268
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8266
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8266
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8204
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8204
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8204
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8204
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8194
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8194
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8194
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8194
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8120
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8120
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8118
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8118
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8079
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8079
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8075
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8075
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8074
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8074
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8069
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8069
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8068
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8068
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8060
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8060
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8048
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8048
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8042
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8042
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8033
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8033
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8030
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8030
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8010
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8010
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7987
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7987
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7976
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7976
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7961
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7961
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7946
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7946
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7929
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7929
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7921
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7921
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 4 0.7917
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 4 0.7917
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7913
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7913
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7912
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7912
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7911
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7911
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7907
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7907
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7904
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7904
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7898
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7898
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7868
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7868
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7856
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7856
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7852
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7852
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7849
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7849
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7841
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7841
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7799
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7799
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7798
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7798
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7797
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7797
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7790
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7790
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7779
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7779
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7761
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7761
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.7754
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.7754
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7749
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7749
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 5 0.7737
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 5 0.7737
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7715
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7715
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7714
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7714
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7708
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7708
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7692
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7692
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7668
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7668
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7658
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7658
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7655
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7655
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7634
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7634
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7631
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7631
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7628
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7628
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7604
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7604
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7604
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7604
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7578
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7578
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7554
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7554
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7531
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7531
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7499
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7499
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7491
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7491
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7483
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7483
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7483
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7483
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7480
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7480
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7464
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7464
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7463
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7463
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7436
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7436
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7419
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7419
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7412
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7412
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7401
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7401
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7393
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7393
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7392
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7392
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 5 0.7384
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 5 0.7384
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7383
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7383
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7377
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7377
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7371
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7371
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7371
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7371
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7367
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7367
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7366
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7366
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7363
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7363
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7360
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7360
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7351
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7351
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7340
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7340
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7327
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7327
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7320
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7320
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7300
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7300
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7292
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7292
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7289
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7289
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7284
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7284
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7278
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7278
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7274
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7274
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7265
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7265
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7251
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7251
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7250
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7250
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7229
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7229
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7224
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7224
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7220
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7220
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7206
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7206
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7201
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7201
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7198
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7198
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7186
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7186
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7181
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7181
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7177
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7177
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7168
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7168
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7164
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7164
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7156
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7156
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7133
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7133
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7130
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7130
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7128
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7128
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7128
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7128
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7110
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7110
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 5 0.7108
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 5 0.7108
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7095
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7095
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7074
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7074
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7074
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7074
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7065
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7065
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7064
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7064
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.7056
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.7056
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7048
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7048
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7042
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7042
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7039
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7039
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7035
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7035
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7034
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7034
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7009
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7009
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7008
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7008

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