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Caffeic acid
- Family: Plantae - Lamiaceae
- Kingdom: Plantae, Animalia
-
Class: Phenolic
- Subclass: Hydroxycinnamic Acid
| Canonical Smiles | OC(=O)/C=C/c1ccc(c(c1)O)O |
|---|---|
| InChI | InChI=1S/C9H8O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1-5,10-11H,(H,12,13)/b4-2+ |
| InChIKey | QAIPRVGONGVQAS-DUXPYHPUSA-N |
| Formula | C9H8O4 |
| HBA | 3 |
| HBD | 3 |
| MW | 180.16 |
| Rotatable Bonds | 2 |
| TPSA | 77.76 |
| LogP | 1.2 |
| Number Rings | 1 |
| Number Aromatic Rings | 1 |
| Heavy Atom Count | 13 |
| Formal Charge | 0 |
| Fraction CSP3 | 0.0 |
| Exact Mass | 180.04 |
| Number of Lipinski Rule Violations | 0 |
| # | Species | Family | Kingdom | NCBI Taxonomy ID |
|---|---|---|---|---|
| 1 | Thalassia hemprichii | Hydrocharitaceae | Plantae | 55496 |
| 2 | Apis mellifica | Apidae | Animalia | 7460 |
| 3 | Cotoneaster orbicularis | Rosaceae | Plantae | 1851000 |
| 4 | Ferula lutea | Apiaceae | Plantae | 52470 |
| 5 | Coriandrum sativum | Apiaceae | Plantae | 4047 |
| 6 | Cynara scolymus | Asteraceae | Plantae | 59895 |
| 7 | Sphaeranthus bullatus | Asteraceae | Plantae | 1548657 |
| 8 | Vepris glomerata | Rutaceae | Plantae | 2695416 |
| 9 | Vepris glomerata | Rutaceae | Plantae | 2695416 |
| 10 | Achyranthes aspera | Amaranthaceae | Plantae | 240005 |
| 11 | Rosmarinuseriocalyx | Lamiaceae | Plantae | — |
Showing of synonyms
Caffeic acid
Trans-caffeic acid
501-16-6
3,4-Dihydroxybenzeneacrylic acid
(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
3-(3,4-Dihydroxyphenyl)-2-propenoic acid
2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-
4-(2-Carboxyethenyl)-1,2-dihydroxybenzene
CCRIS 847
NSC 57197
HSDB 7088
UNII-U2S3A33KVM
2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, (E)-
EINECS 206-361-2
U2S3A33KVM
NSC-57197
NSC-623438
CHEBI:16433
AI3-63211
Trans-3,4-Dihydroxycinnamic Acid
NSC57197
3-(3,4-dihydroxyphenyl)prop-2-enoic acid
CHEBI:36281
NSC623438
2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, (2E)-
CAFFEIC ACID (IARC)
CAFFEIC ACID [IARC]
Caffeic acid, (E)-isomer
Caffeic Acid1507
Trans 3,4-Dihydroxycinnamic acid
4-(2'Carboxyvinyl)-1,2-dihydroxybenzene
2-Propenoic acid, 3-(3,4-dihdroxyphenyl)-
CAFFEIC ACID (CONSTITUENT OF BLACK COHOSH)
3,4-Dihydroxycinnamic acid
331-39-5
3-(3,4-dihydroxyphenyl)acrylic acid
(E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
Caffeicacid
Cinnamic acid, 3,4-dihydroxy-
(E)-3-(3,4-dihydroxyphenyl)acrylic acid
Trans-Caffeate
3,4-Dihydroxy-trans-cinnamate
3-(3,4-Dihydroxyphenyl)propenoic acid
4-(2'-Carboxyvinyl)-1,2-dihydroxybenzene
71693-97-5
Caffeate
(E)-3,4-dihydroxycinnamic acid
3-(3,4-Dihydroxy phenyl)-2-propenoic acid
MFCD00004392
CHEMBL145
MLS000069738
331-89-5
SMR000058214
(2E)-3-(3,4-dihydroxyphenyl)acrylic acid
Caffeic acid - Natural
SR-01000000203
DTXSID5020231
Caffeic-acid
Caffeic acid pure
Caffeic acid, 1
Caffeic acid 1000 microg/mL in Acetone
3,4-dihydroxycinnamic acid (caffeic acid)
Caffeic acid, trans-
3,4-dihydroxycinnamate
CAFFEIC ACID natural
Opera_ID_1700
CAFFEIC ACID [MI]
CAFFEIC ACID [DSC]
Cinnamic acid,4-dihydroxy-
3,4-Dihydroxycinnamic acid, predominantly trans
CAFFEIC ACID [HSDB]
3,4-Dihydroxybenzeneacrylate
SCHEMBL23358
MLS001076493
MLS002207132
MLS002222302
MLS006011849
BIDD:ER0456
DTXCID10231
SPECTRUM1503987
CAFFEIC ACID [WHO-DD]
2-Propenoic acid,3-(3,4-dihydroxyphenyl)-, (2E)-
3,4-Dihydroxycinnamate, XVII
BDBM4375
Cid_689043
GTPL5155
DTXSID901316055
HMS2235G09
HMS3260J17
HMS3649O17
BCP28271
HY-N0172
Tox21_200648
Tox21_500208
BBL012113
Caffeic Acid - CAS 331-39-5
CCG-38895
S2277
STK397812
Caffeic acid, >=98.0% (HPLC)
2-Propenoic acid,4-dihydroxyphenyl)-
AKOS000144463
AC-8006
CS-8205
DB01880
FC19625
LP00208
SDCCGMLS-0002982.P003
SDCCGSBI-0050196.P004
NCGC00017364-04
NCGC00017364-05
NCGC00017364-06
NCGC00017364-07
NCGC00017364-08
NCGC00017364-09
NCGC00017364-10
NCGC00017364-11
NCGC00017364-12
NCGC00017364-13
NCGC00017364-22
NCGC00022654-03
NCGC00022654-04
NCGC00022654-05
NCGC00022654-06
NCGC00022654-07
NCGC00022654-08
NCGC00022654-09
NCGC00258202-01
NCGC00260893-01
NCGC00263641-01
(E)-3-(3,4-dihydroxyphenyl)acrylicacid
AS-10895
BP-30112
CAS-331-39-5
SMR004703501
XC164210
Caffeic acid, purum, >=95.0% (HPLC)
DB-318886
DB-321780
HY-121231
AB00490047
CS-0081280
EU-0100208
NS00010313
SW197202-3
(E)-3-(3,4-dihydroxyphenyl)prop-2-enoicacid
C 0625
C01197
C01481
EN300-1067793
(2E)-3-(3,4-Dihydroxyphenyl)-2-propenoic acid
AR-360/40806927
Q414116
SR-01000000203-2
SR-01000000203-6
SR-01000000203-7
SR-01000000203-8
BRD-K09900591-001-06-9
BRD-K09900591-001-25-9
BRD-K09900591-001-26-7
SR-01000000203-13
CAFFEIC ACID (CONSTITUENT OF BLACK COHOSH) [DSC]
F3096-1708
Z240113804
2',3-DIHYDROXY-4,4',6'-TRIMETHOXYCHALCONE_met021
2',4-DIHYDROXY-3,4',6'-TRIMETHOXYCHALCONE_met023
8B3E4DA7-F3B0-4972-A315-2E387071737F
Trans-Caffeic acid, certified reference material, TraceCERT(R)
Caffeic acid, matrix substance for MALDI-MS, >=99.0% (HPLC)
Caffeic acid, United States Pharmacopeia (USP) Reference Standard
Caffeic acid, matrix substance for MALDI-MS, >=99.0% (HPLC), powder, light beige
InChI=1/C9H8O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1-5,10-11H,(H,12,13)/b4-2
- Hawas UW (2014). A new 8-hydroxy flavone o-xyloside sulfate and antibacterial activity from the Egyptian seagrass Thalassia hemprichii. Chemistry of Natural Compounds,2014,50(4),546-548. [View]
- Kiplimo JJ, Koorbanally NA. (2012). Antibacterial activity of an epoxidised prenylated cinnamaldehdye derivative from Vepris glomerata. Phytochemistry Letters,2012,5(3),438-442. [View] [PubMed]
- Ndhlala AR, Ghebrehiwot HM, et al. (2015). Antimicrobial, anthelmintic activities and characterisation of functional phenolic acids of Achyranthes aspera linn.: a medicinal plant used for the treatment of wounds and Ringworm in East Africa.. Frontiers in pharmacology,2015,6,274. [View] [PubMed]
- Msaada K, Ben Jemia M, et al. (2014). Antioxidant activity of methanolic extracts from three coriander (Coriandrum sativum L.) fruit varieties. Arabian Journal of Chemistry,2014, in press. [View]
- Machumi F, Yenesew A, et al. (2012). Antiparasitic and anticancer carvotacetone derivatives of Sphaeranthus bullatus. Natural Product Communications,2012,7(9),1123-1126. [View] [PubMed]
- Boufadi YM, Soubhye J, et al. (2014). Characterization and antioxidant properties of six Algerian propolis extracts: ethyl acetate extracts inhibit myeloperoxidase activity. International Journal of Molecular Sciences,2014,15(2),2327-2345. [View] [PubMed]
- Hammouda FM, Seif El-Nesr MM, et al. (1991). HPLC evaluation of the active constituents in the newly introduced romanian strain of Cynara scolymus cultivated in Egypt. Planta Medica,1991,57(2),A119-A120. [View]
- Ben Salem S, Jabrane A, et al. (2013). New bioactive dihydrofuranocoumarins from the roots of the Tunisian Ferula lutea (Poir.) Maire.. Bioorganic and Medicinal Chemistry Letters,2013,23(14),4248-4252. [View] [PubMed]
- Boudiar T, Lozano-Sánchez J, et al. (2019). Phytochemical characterization of bioactive compounds composition of Rosmarinus eriocalyx by RP–HPLC–ESI–QTOF–MS. Natural product research, 2019, 33(15), 2208-2214. [View] [PubMed]
- Kiplimo JJ, Koorbanally NA. (2012). The phytochemistry and biological activity of secondary metabolites from Kenyan Vernonia and Vepris species. PhD Thesis, University of Kwazulu-Natal, South Africa,2012. [View] [PubMed]
- El-Mousallamy AM, Hussein SA, et al. (2000). Unusual phenolic glycosides from Cotoneaster orbicularis. Phytochemistry,2000,53(6),699-704. [View] [PubMed]
Pubchem:
689043
Cas:
501-16-6
Gnps:
CCMSLIB00005759142
Zinc:
ZINC000000058172
Kegg Ligand:
C01197
Chebi:
16433
Nmrshiftdb2:
20039649
Metabolights:
MTBLC16433
Chembl:
CHEMBL145
Drugbank:
DB01880
Pdb Ligand:
DHC
Bindingdb:
4375
Selleck:
Caffeic-acid
CPRiL:
6346
SMILES: c1ccccc1
Level: 0
Mol. Weight: 180.16 g/mol
Antimicrobial
Antioxidant
Cytotoxic
Absorption
- Caco-2 (logPapp)
- -4.95
- Human Oral Bioavailability 20%
- Bioavailable
- Human Intestinal Absorption
- Absorbed
- Madin-Darby Canine Kidney
- -4.39
- Human Oral Bioavailability 50%
- Bioavailable
- P-Glycoprotein Inhibitor
- Non-Inhibitor
- P-Glycoprotein Substrate
- Non-Substrate
- Skin Permeability
- -2.34
Distribution
- Blood-Brain Barrier (CNS)
- -
- Blood-Brain Barrier
- Non-Penetrable
- Fraction Unbound (Human)
- 0.7
- Plasma Protein Binding
- 31.07
- Steady State Volume of Distribution
- -
Metabolism
- Breast Cancer Resistance Protein
- Non-Inhibitor
- CYP 1A2 Inhibitor
- Non-Inhibitor
- CYP 1A2 Substrate
- Non-Substrate
- CYP 2C19 Inhibitor
- Non-Inhibitor
- CYP 2C19 Substrate
- Non-Substrate
- CYP 2C9 Inhibitor
- Non-Inhibitor
- CYP 2C9 Substrate
- Substrate
- CYP 2D6 Inhibitor
- Non-Inhibitor
- CYP 2D6 Substrate
- Non-Substrate
- CYP 3A4 Inhibitor
- Non-Inhibitor
- CYP 3A4 Substrate
- Non-Substrate
- OATP1B1
- Non-Inhibitor
- OATP1B3
- Non-Inhibitor
Excretion
- Clearance
- 9.38
- Organic Cation Transporter 2
- Non-Inhibitor
- Half-Life of Drug
- -
Toxicity
- AMES Mutagenesis
- Safe
- Avian
- Safe
- Bee
- Safe
- Bioconcentration Factor
- -0.15
- Biodegradation
- Toxic
- Carcinogenesis
- Safe
- Crustacean
- Safe
- Liver Injury I (DILI)
- Toxic
- Eye Corrosion
- Safe
- Eye Irritation
- Toxic
- Maximum Tolerated Dose
- 0.27
- Liver Injury II
- Safe
- hERG Blockers
- Safe
- Daphnia Maga
- 4.47
- Micronucleos
- Toxic
- NR-AhR
- Safe
- NR-AR
- Safe
- NR-AR-LBD
- Safe
- NR-Aromatase
- Safe
- NR-ER
- Safe
- NR-ER-LBD
- Safe
- NR-GR
- Safe
- NR-PPAR-gamma
- Safe
- NR-TR
- Safe
- T. Pyriformis
- 3.11
- Rat (Acute)
- 1.78
- Rat (Chronic Oral)
- 2.91
- Fathead Minnow
- 4.01
- Respiratory Disease
- Safe
- Skin Sensitisation
- Toxic
- SR-ARE
- Safe
- SR-ATAD5
- Safe
- SR-HSE
- Safe
- SR-MMP
- Safe
- SR-p53
- Safe
General Properties
- Boiling Point
- 356.62
- Hydration Free Energy
- -11.66
- Log(D) at pH=7.4
- -1.56
- Log(P)
- 1.46
- Log S
- -1.63
- Log(Vapor Pressure)
- -6.19
- Melting Point
- 228.17
- pKa Acid
- 5.49
- pKa Basic
- 4.68
| Protein Name | UniProt ID | Entry Name | Species | #Pharmacophore Points | Probability (0.7 ≤ Tversky Score ≤ 1.0) |
|---|---|---|---|---|---|
| HTH-type transcriptional repressor PurR | P0ACP7 | PURR_ECOLI | Escherichia coli | 3 | 0.9321 |
| HTH-type transcriptional repressor PurR | P0ACP7 | PURR_ECOLI | Escherichia coli | 3 | 0.9321 |
| Feruloyl esterase A | O42807 | FAEA_ASPNG | Aspergillus niger | 3 | 0.9138 |
| Feruloyl esterase A | O42807 | FAEA_ASPNG | Aspergillus niger | 3 | 0.9138 |
| Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | P12995 | BIOA_ECOLI | Escherichia coli | 3 | 0.9112 |
| Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | P12995 | BIOA_ECOLI | Escherichia coli | 3 | 0.9112 |
| rRNA N-glycosylase | D9J2T9 | D9J2T9_MOMBA | Momordica balsamina | 3 | 0.9106 |
| rRNA N-glycosylase | D9J2T9 | D9J2T9_MOMBA | Momordica balsamina | 3 | 0.9106 |
| MAP kinase-activated protein kinase 2 | P49137 | MAPK2_HUMAN | Homo sapiens | 3 | 0.9029 |
| MAP kinase-activated protein kinase 2 | P49137 | MAPK2_HUMAN | Homo sapiens | 3 | 0.9029 |
| Mitogen-activated protein kinase 8 | P45983 | MK08_HUMAN | Homo sapiens | 4 | 0.9002 |
| Mitogen-activated protein kinase 8 | P45983 | MK08_HUMAN | Homo sapiens | 4 | 0.9002 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | P48736 | PK3CG_HUMAN | Homo sapiens | 3 | 0.8992 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | P48736 | PK3CG_HUMAN | Homo sapiens | 3 | 0.8992 |
| Beta-1 adrenergic receptor | P07700 | ADRB1_MELGA | Meleagris gallopavo | 3 | 0.8973 |
| Beta-1 adrenergic receptor | P07700 | ADRB1_MELGA | Meleagris gallopavo | 3 | 0.8973 |
| Polymerase acidic protein | C3W5S0 | C3W5S0_I09A0 | Influenza A virus | 3 | 0.8639 |
| Polymerase acidic protein | C3W5S0 | C3W5S0_I09A0 | Influenza A virus | 3 | 0.8639 |
| Caffeic acid O-methyltransferase | Q9ZTU2 | Q9ZTU2_LOLPR | Lolium perenne | 4 | 0.8499 |
| Caffeic acid O-methyltransferase | Q9ZTU2 | Q9ZTU2_LOLPR | Lolium perenne | 4 | 0.8499 |
| Caffeic acid 3-O-methyltransferase | P28002 | COMT1_MEDSA | Medicago sativa | 3 | 0.8449 |
| Caffeic acid 3-O-methyltransferase | P28002 | COMT1_MEDSA | Medicago sativa | 3 | 0.8449 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Q9Y233 | PDE10_HUMAN | Homo sapiens | 3 | 0.8431 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Q9Y233 | PDE10_HUMAN | Homo sapiens | 3 | 0.8431 |
| Uracil phosphoribosyltransferase | Q26998 | UPP_TOXGO | Toxoplasma gondii | 3 | 0.8360 |
| Uracil phosphoribosyltransferase | Q26998 | UPP_TOXGO | Toxoplasma gondii | 3 | 0.8360 |
| Dual specificity mitogen-activated protein kinase kinase 1 | Q02750 | MP2K1_HUMAN | Homo sapiens | 3 | 0.8258 |
| Dual specificity mitogen-activated protein kinase kinase 1 | Q02750 | MP2K1_HUMAN | Homo sapiens | 3 | 0.8258 |
| Phenylalanine-4-hydroxylase | P00439 | PH4H_HUMAN | Homo sapiens | 3 | 0.8248 |
| Phenylalanine-4-hydroxylase | P00439 | PH4H_HUMAN | Homo sapiens | 3 | 0.8248 |
| Uracil phosphoribosyltransferase | Q26998 | UPP_TOXGO | Toxoplasma gondii | 3 | 0.8190 |
| Uracil phosphoribosyltransferase | Q26998 | UPP_TOXGO | Toxoplasma gondii | 3 | 0.8190 |
| 3',5'-cyclic-AMP phosphodiesterase 4B | Q07343 | PDE4B_HUMAN | Homo sapiens | 4 | 0.8128 |
| 3',5'-cyclic-AMP phosphodiesterase 4B | Q07343 | PDE4B_HUMAN | Homo sapiens | 4 | 0.8128 |
| Glycogen phosphorylase, liver form | P06737 | PYGL_HUMAN | Homo sapiens | 3 | 0.8122 |
| Glycogen phosphorylase, liver form | P06737 | PYGL_HUMAN | Homo sapiens | 3 | 0.8122 |
| Glycogen synthase kinase-3 beta | P49841 | GSK3B_HUMAN | Homo sapiens | 3 | 0.8055 |
| Glycogen synthase kinase-3 beta | P49841 | GSK3B_HUMAN | Homo sapiens | 3 | 0.8055 |
| DNA polymerase III subunit epsilon | P03007 | DPO3E_ECOLI | Escherichia coli | 3 | 0.8051 |
| DNA polymerase III subunit epsilon | P03007 | DPO3E_ECOLI | Escherichia coli | 3 | 0.8051 |
| NADPH-dependent oxidoreductase 2-alkenal reductase | Q39172 | AER_ARATH | Arabidopsis thaliana | 3 | 0.7980 |
| NADPH-dependent oxidoreductase 2-alkenal reductase | Q39172 | AER_ARATH | Arabidopsis thaliana | 3 | 0.7980 |
| CalS13 | Q8KND8 | Q8KND8_MICEC | Micromonospora echinospora | 4 | 0.7961 |
| CalS13 | Q8KND8 | Q8KND8_MICEC | Micromonospora echinospora | 4 | 0.7961 |
| HTH-type transcriptional repressor PurR | P0ACP7 | PURR_ECOLI | Escherichia coli | 3 | 0.7909 |
| HTH-type transcriptional repressor PurR | P0ACP7 | PURR_ECOLI | Escherichia coli | 3 | 0.7909 |
| Purine nucleoside phosphorylase | P00491 | PNPH_HUMAN | Homo sapiens | 3 | 0.7844 |
| Purine nucleoside phosphorylase | P00491 | PNPH_HUMAN | Homo sapiens | 3 | 0.7844 |
| Ribonuclease J | H9CZL7 | H9CZL7_DEIRD | Deinococcus radiodurans | 3 | 0.7778 |
| Ribonuclease J | H9CZL7 | H9CZL7_DEIRD | Deinococcus radiodurans | 3 | 0.7778 |
| Heat shock protein HSP 90-alpha | P07900 | HS90A_HUMAN | Homo sapiens | 3 | 0.7751 |
| Heat shock protein HSP 90-alpha | P07900 | HS90A_HUMAN | Homo sapiens | 3 | 0.7751 |
| Mitogen-activated protein kinase 1 | P28482 | MK01_HUMAN | Homo sapiens | 3 | 0.7653 |
| Mitogen-activated protein kinase 1 | P28482 | MK01_HUMAN | Homo sapiens | 3 | 0.7653 |
| Ras-related protein Ral-B | P11234 | RALB_HUMAN | Homo sapiens | 3 | 0.7576 |
| Ras-related protein Ral-B | P11234 | RALB_HUMAN | Homo sapiens | 3 | 0.7576 |
| Nucleoside diphosphate kinase A 2 | P52175 | NDKA2_BOVIN | Bos taurus | 3 | 0.7487 |
| Nucleoside diphosphate kinase A 2 | P52175 | NDKA2_BOVIN | Bos taurus | 3 | 0.7487 |
| N-alpha-acetyltransferase 50 | Q9GZZ1 | NAA50_HUMAN | Homo sapiens | 3 | 0.7454 |
| N-alpha-acetyltransferase 50 | Q9GZZ1 | NAA50_HUMAN | Homo sapiens | 3 | 0.7454 |
| Malate synthase G | P9WK17 | MASZ_MYCTU | Mycobacterium tuberculosis | 3 | 0.7442 |
| Malate synthase G | P9WK17 | MASZ_MYCTU | Mycobacterium tuberculosis | 3 | 0.7442 |
| CCA-adding enzyme | O28126 | CCA_ARCFU | Archaeoglobus fulgidus | 2 | 0.7438 |
| CCA-adding enzyme | O28126 | CCA_ARCFU | Archaeoglobus fulgidus | 2 | 0.7438 |
| Pantothenate synthetase | P9WIL5 | PANC_MYCTU | Mycobacterium tuberculosis | 4 | 0.7436 |
| Pantothenate synthetase | P9WIL5 | PANC_MYCTU | Mycobacterium tuberculosis | 4 | 0.7436 |
| Tetracycline repressor protein class D | P0ACT4 | TETR4_ECOLX | Escherichia coli | 2 | 0.7422 |
| Tetracycline repressor protein class D | P0ACT4 | TETR4_ECOLX | Escherichia coli | 2 | 0.7422 |
| HTH-type transcriptional repressor PurR | P0ACP7 | PURR_ECOLI | Escherichia coli | 3 | 0.7368 |
| HTH-type transcriptional repressor PurR | P0ACP7 | PURR_ECOLI | Escherichia coli | 3 | 0.7368 |
| Aspartate aminotransferase | P00509 | AAT_ECOLI | Escherichia coli | 3 | 0.7350 |
| Aspartate aminotransferase | P00509 | AAT_ECOLI | Escherichia coli | 3 | 0.7350 |
| Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic | Q43088 | RBCMT_PEA | Pisum sativum | 3 | 0.7295 |
| Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic | Q43088 | RBCMT_PEA | Pisum sativum | 3 | 0.7295 |
| Ribosomal RNA small subunit methyltransferase Nep1 | Q57977 | NEP1_METJA | Methanocaldococcus jannaschii | 3 | 0.7291 |
| Ribosomal RNA small subunit methyltransferase Nep1 | Q57977 | NEP1_METJA | Methanocaldococcus jannaschii | 3 | 0.7291 |
| Glycogen synthase kinase-3 beta | P49841 | GSK3B_HUMAN | Homo sapiens | 2 | 0.7277 |
| Glycogen synthase kinase-3 beta | P49841 | GSK3B_HUMAN | Homo sapiens | 2 | 0.7277 |
| Polymerase acidic protein | C3W5S0 | C3W5S0_I09A0 | Influenza A virus | 3 | 0.7276 |
| Polymerase acidic protein | C3W5S0 | C3W5S0_I09A0 | Influenza A virus | 3 | 0.7276 |
| Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | P78356 | PI42B_HUMAN | Homo sapiens | 3 | 0.7249 |
| Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | P78356 | PI42B_HUMAN | Homo sapiens | 3 | 0.7249 |
| 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | P19992 | HSD_STREX | Streptomyces exfoliatus | 2 | 0.7247 |
| Threonine--tRNA ligase | P0A8M3 | SYT_ECOLI | Escherichia coli | 3 | 0.7247 |
| Threonine--tRNA ligase | P0A8M3 | SYT_ECOLI | Escherichia coli | 3 | 0.7247 |
| 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | P19992 | HSD_STREX | Streptomyces exfoliatus | 2 | 0.7247 |
| Albumin | P02768 | ALBU_HUMAN | Homo sapiens | 3 | 0.7225 |
| Albumin | P02768 | ALBU_HUMAN | Homo sapiens | 3 | 0.7225 |
| BMP-2-inducible protein kinase | Q9NSY1 | BMP2K_HUMAN | Homo sapiens | 2 | 0.7215 |
| BMP-2-inducible protein kinase | Q9NSY1 | BMP2K_HUMAN | Homo sapiens | 2 | 0.7215 |
| Capsid protein | Q9WBP8 | Q9WBP8_9VIRU | Adeno-associated virus - 1 | 2 | 0.7200 |
| Capsid protein | Q9WBP8 | Q9WBP8_9VIRU | Adeno-associated virus - 1 | 2 | 0.7200 |
| Nitric oxide synthase, inducible | P29477 | NOS2_MOUSE | Mus musculus | 3 | 0.7109 |
| Nitric oxide synthase, inducible | P29477 | NOS2_MOUSE | Mus musculus | 3 | 0.7109 |
| APH(2'')-Id | O68183 | O68183_ENTCA | Enterococcus casseliflavus | 3 | 0.7108 |
| APH(2'')-Id | O68183 | O68183_ENTCA | Enterococcus casseliflavus | 3 | 0.7108 |
| Nucleoside 2-deoxyribosyltransferase | Q8RLY5 | Q8RLY5_LACHE | Lactobacillus helveticus | 2 | 0.7106 |
| Nucleoside 2-deoxyribosyltransferase | Q8RLY5 | Q8RLY5_LACHE | Lactobacillus helveticus | 2 | 0.7106 |
| Aspartate aminotransferase, mitochondrial | P00508 | AATM_CHICK | Gallus gallus | 3 | 0.7089 |
| Aspartate aminotransferase, mitochondrial | P00508 | AATM_CHICK | Gallus gallus | 3 | 0.7089 |
| Thymidine phosphorylase | Q7CP66 | TYPH_SALTY | Salmonella typhimurium | 3 | 0.7080 |
| Thymidine phosphorylase | Q7CP66 | TYPH_SALTY | Salmonella typhimurium | 3 | 0.7080 |
| Ribonuclease TTHA0252 | Q5SLP1 | RNSE_THET8 | Thermus thermophilus | 3 | 0.7057 |
| Ribonuclease TTHA0252 | Q5SLP1 | RNSE_THET8 | Thermus thermophilus | 3 | 0.7057 |
| Polyribonucleotide nucleotidyltransferase | A7ZS61 | PNP_ECO24 | Escherichia coli O139:H28 | 3 | 0.7047 |
| Polyribonucleotide nucleotidyltransferase | A7ZS61 | PNP_ECO24 | Escherichia coli O139:H28 | 3 | 0.7047 |
| Tryptophan--tRNA ligase | Q9PIB4 | SYW_CAMJE | Campylobacter jejuni subsp. jejuni serotype O:2 | 4 | 0.7046 |
| Tryptophan--tRNA ligase | Q9PIB4 | SYW_CAMJE | Campylobacter jejuni subsp. jejuni serotype O:2 | 4 | 0.7046 |
| Purine nucleoside phosphorylase | P00491 | PNPH_HUMAN | Homo sapiens | 3 | 0.7045 |
| Histone-lysine N-methyltransferase EHMT1 | Q9H9B1 | EHMT1_HUMAN | Homo sapiens | 3 | 0.7045 |
| Purine nucleoside phosphorylase | P00491 | PNPH_HUMAN | Homo sapiens | 3 | 0.7045 |
| Histone-lysine N-methyltransferase EHMT1 | Q9H9B1 | EHMT1_HUMAN | Homo sapiens | 3 | 0.7045 |
| Serine/threonine-protein kinase RIO1 | Q9BRS2 | RIOK1_HUMAN | Homo sapiens | 3 | 0.7026 |
| Serine/threonine-protein kinase RIO1 | Q9BRS2 | RIOK1_HUMAN | Homo sapiens | 3 | 0.7026 |
| Queuine tRNA-ribosyltransferase | P28720 | TGT_ZYMMO | Zymomonas mobilis subsp. mobilis | 2 | 0.7017 |
| Queuine tRNA-ribosyltransferase | P28720 | TGT_ZYMMO | Zymomonas mobilis subsp. mobilis | 2 | 0.7017 |