4-[2',4'-dihydroxy-6'-(hydroxymethyl)benzyl]benzene-1,2-diol - Compound Card

4-[2',4'-dihydroxy-6'-(hydroxymethyl)benzyl]benzene-1,2-diol

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4-[2',4'-dihydroxy-6'-(hydroxymethyl)benzyl]benzene-1,2-diol

Structure
Zoomed Structure
  • Family: Fungi - Incertae sedis
  • Kingdom: Fungi
  • Class: Phenolic
Canonical Smiles OCc1cc(O)cc(c1Cc1ccc(c(c1)O)O)O
InChI InChI=1S/C14H14O5/c15-7-9-5-10(16)6-13(18)11(9)3-8-1-2-12(17)14(19)4-8/h1-2,4-6,15-19H,3,7H2
InChIKey DEEJTWOVRVKJGM-UHFFFAOYSA-N
Formula C14H14O5
HBA 5
HBD 5
MW 262.26
Rotatable Bonds 3
TPSA 101.15
LogP 1.59
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 19
Formal Charge 0
Fraction CSP3 0.14
Exact Mass 262.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Geosmithia langdonii Incertae sedis Fungi 240214

Showing of synonyms

  • Malak LG, Ibrahim MA, et al. (2014). Antileishmanial metabolites from geosmithia langdonii. Journal of Natural Products,2014,77(9),1987-1991. [View] [PubMed]
Pubchem: 118714758
Nmrshiftdb2: 60033063

No compound-protein relationship available.

Structure

SMILES: c1ccccc1Cc2ccccc2

Level: 1

Mol. Weight: 262.26 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 262.26 g/mol

Anti-leishmanial

Absorption

Caco-2 (logPapp)
-5.4
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.03
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.68

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.5
Plasma Protein Binding
55.63
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
10.95
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.47
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.62
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
4.42
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.69
Rat (Acute)
2.15
Rat (Chronic Oral)
3.36
Fathead Minnow
3.98
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
434.13
Hydration Free Energy
-11.66
Log(D) at pH=7.4
0.83
Log(P)
0.56
Log S
-1.16
Log(Vapor Pressure)
-7.7
Melting Point
216.25
pKa Acid
7.6
pKa Basic
8.33
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.9398
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.9398
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9339
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9339
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9225
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9225
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9191
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9191
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9171
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9171
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.9111
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.9111
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.9099
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.9099
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9024
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9024
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9011
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9011
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8989
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8989
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8910
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8910
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8842
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8842
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8747
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8747
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8727
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8727
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.8726
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.8726
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8683
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8683
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.8677
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.8677
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8669
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8669
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8656
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8656
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.8636
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.8636
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8627
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8627
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8624
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8624
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.8619
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.8619
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8612
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8612
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.8609
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.8609
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8603
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8603
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8597
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8597
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8587
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8587
Renin P00797 RENI_HUMAN Homo sapiens 3 0.8573
Renin P00797 RENI_HUMAN Homo sapiens 3 0.8573
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8560
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8560
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8546
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8546
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.8503
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.8503
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8487
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8487
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8466
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8466
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.8443
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.8443
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.8441
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.8441
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8429
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8429
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8422
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8422
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8420
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8420
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.8401
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.8401
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8379
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8379
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8358
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8358
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 4 0.8356
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 4 0.8356
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8331
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8331
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8328
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8328
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8315
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8315
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8305
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8305
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8297
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8297
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.8292
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.8292
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 4 0.8275
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 4 0.8275
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 4 0.8260
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 4 0.8260
Bifunctional dihydrofolate reductase-thymidylate synthase D9N170 D9N170_PLAFA Plasmodium falciparum 4 0.8246
Bifunctional dihydrofolate reductase-thymidylate synthase D9N170 D9N170_PLAFA Plasmodium falciparum 4 0.8246
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 4 0.8223
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 4 0.8223
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8216
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8216
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.8215
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.8215
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8207
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8207
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8201
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8201
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8195
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8195
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8177
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8177
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8159
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8159
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8149
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8149
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 4 0.8129
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 4 0.8129
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.8113
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.8113
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8113
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8113
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8108
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8108
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8101
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8101
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.8096
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.8096
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 3 0.8080
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 3 0.8080
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 4 0.8064
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 4 0.8064
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8034
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8034
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.8027
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.8027
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8026
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8026
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8011
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8011
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8007
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8007
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 4 0.7989
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 4 0.7989
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7980
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7980
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 3 0.7979
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 3 0.7979
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7955
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7955
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7948
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7948
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 4 0.7944
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 4 0.7944
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 4 0.7940
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 4 0.7940
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.7931
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.7931
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 3 0.7923
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 3 0.7923
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7916
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7916
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7915
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7915
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7915
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7915
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 4 0.7898
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 4 0.7898
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7878
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7878
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.7849
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.7849
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 4 0.7845
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 4 0.7845
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7825
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7825
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7788
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7788
Uncharacterized protein C7YVL8 C7YVL8_NECH7 Nectria haematococca 3 0.7743
Uncharacterized protein C7YVL8 C7YVL8_NECH7 Nectria haematococca 3 0.7743
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7701
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7701
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 4 0.7695
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 4 0.7695
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7695
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7695
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 4 0.7689
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 4 0.7689
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7685
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7685
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 4 0.7681
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 4 0.7681
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 4 0.7678
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 4 0.7678
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7674
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7674
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7646
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7646
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7636
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7636
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7633
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7633
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7621
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7621
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7616
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7616
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7611
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7611
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7605
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7605
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7591
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7591
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7591
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7591
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7564
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7564
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7556
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7556
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7551
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7551
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7536
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7536
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7532
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7532
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7528
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7528
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7524
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7524
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7520
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7520
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7508
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7508
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7505
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7505
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7500
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7500
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7500
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7500
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7497
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7497
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7486
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7486
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7476
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7476
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7474
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7474
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7471
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7471
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7467
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7467
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7454
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7454
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7454
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7454
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7450
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7450
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7450
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7450
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7449
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7449
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7444
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7444
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7424
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7424
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7406
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7406
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7403
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7403
Tryptophan--tRNA ligase Q9PIB4 SYW_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 4 0.7399
Tryptophan--tRNA ligase Q9PIB4 SYW_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 4 0.7399
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7393
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7393
7-methylguanosine phosphate-specific 5'-nucleotidase Q9W197 5NT3B_DROME Drosophila melanogaster 4 0.7369
7-methylguanosine phosphate-specific 5'-nucleotidase Q9W197 5NT3B_DROME Drosophila melanogaster 4 0.7369
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7367
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7367
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7350
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7350
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7344
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7344
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7342
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7342
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7341
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7341
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7336
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7336
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7334
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7334
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 3 0.7330
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 3 0.7330
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 4 0.7317
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 4 0.7317
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7314
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7314
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7304
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7304
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7302
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7302
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7301
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7301
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.7299
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.7299
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7298
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7298
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7294
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7294
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7289
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7289
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7288
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7288
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7286
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7286
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7282
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7282
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7276
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7276
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7275
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7275
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7269
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7269
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7262
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7262
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7261
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7261
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7260
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7260
N(2)-(2-carboxyethyl)arginine synthase Q9LCV9 CEAS_STRCL Streptomyces clavuligerus 3 0.7259
N(2)-(2-carboxyethyl)arginine synthase Q9LCV9 CEAS_STRCL Streptomyces clavuligerus 3 0.7259
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7256
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7256
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7245
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7245
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7240
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7240
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 4 0.7233
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 4 0.7233
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7231
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 4 0.7231
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 4 0.7231
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7231
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7223
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7223
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7217
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7217
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7214
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7214
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7210
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7210
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7209
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7209
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7200
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7200
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7199
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7199
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7195
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7195
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7195
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7195
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7195
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7195
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 4 0.7194
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 4 0.7194
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7191
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7191
Pyruvate dehydrogenase [ubiquinone] P07003 POXB_ECOLI Escherichia coli 3 0.7191
Pyruvate dehydrogenase [ubiquinone] P07003 POXB_ECOLI Escherichia coli 3 0.7191
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7190
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7190
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7188
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7188
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7183
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7183
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7183
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7183
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7180
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7180
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7176
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7176
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7167
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7167
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7167
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7167
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7163
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7163
L-lactate dehydrogenase Q5SJA1 LDH_THET8 Thermus thermophilus 3 0.7161
L-lactate dehydrogenase Q5SJA1 LDH_THET8 Thermus thermophilus 3 0.7161
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7159
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7159
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7157
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7157
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7156
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7156
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.7149
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7149
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7149
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.7149
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7144
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7144
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7143
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7143
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7133
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7133
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.7126
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.7126
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7122
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7122
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7110
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7110
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial P08559 ODPA_HUMAN Homo sapiens 3 0.7108
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial P08559 ODPA_HUMAN Homo sapiens 3 0.7108
beta-glucosidase Q92AS9 Q92AS9_LISIN Listeria innocua serovar 6a 3 0.7084
beta-glucosidase Q92AS9 Q92AS9_LISIN Listeria innocua serovar 6a 3 0.7084
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7081
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7081
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7078
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7078
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 5 0.7072
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 5 0.7072
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7067
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7067
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7065
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7065
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7064
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7064
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7062
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7062
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7061
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7061
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7061
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7061
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7056
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7056
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7054
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7054
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7050
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7050
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 4 0.7041
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 4 0.7041
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.7040
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.7040
Adenosine 5'-monophosphoramidase HINT1 P80912 HINT1_RABIT Oryctolagus cuniculus 3 0.7029
Adenosine 5'-monophosphoramidase HINT1 P80912 HINT1_RABIT Oryctolagus cuniculus 3 0.7029
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7023
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7023
Tyrosine 3-monooxygenase P04177 TY3H_RAT Rattus norvegicus 4 0.7005
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7005
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7005
Tyrosine 3-monooxygenase P04177 TY3H_RAT Rattus norvegicus 4 0.7005
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7004
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7004

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