1,6-dimethyl-5-vinyl-9,10-dihydrophenanthrene-2,7-diol - Compound Card

1,6-dimethyl-5-vinyl-9,10-dihydrophenanthrene-2,7-diol

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1,6-dimethyl-5-vinyl-9,10-dihydrophenanthrene-2,7-diol

Structure
Zoomed Structure
  • Family: Plantae - Juncaceae
  • Kingdom: Plantae
  • Class: Phenanthrenoid
Canonical Smiles C=Cc1c(C)c(O)cc2c1c1ccc(c(c1CC2)C)O
InChI InChI=1S/C18H18O2/c1-4-13-10(2)17(20)9-12-5-6-14-11(3)16(19)8-7-15(14)18(12)13/h4,7-9,19-20H,1,5-6H2,2-3H3
InChIKey XNVMKPYDOHZJLR-UHFFFAOYSA-N
Formula C18H18O2
HBA 2
HBD 2
MW 266.34
Rotatable Bonds 1
TPSA 40.46
LogP 4.12
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.22
Exact Mass 266.13
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Juncus acutus Juncaceae Plantae 308385

Showing of synonyms

  • Behery FAA, Naeem ZEM, et al. (2007). Phenanthrenoids from Juncus acutus L., new natural lipopolysaccharide-inducible nitric oxide synthase inhibitors.. Chemical and Pharmaceutical Bulletin,2007,55(8),1264-1266. [View] [PubMed]
Pubchem: 72740
Nmrshiftdb2: 60045102
Bindingdb: 50537502

No compound-protein relationship available.

Structure

SMILES: c1cccc(c1c23)CCc2cccc3

Level: 0

Mol. Weight: 266.34 g/mol

Anti-inflammatory

Absorption

Caco-2 (logPapp)
-4.97
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.61
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.08

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.76
Plasma Protein Binding
53.82
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.62
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.78
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.74
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.27
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
5.39
Rat (Acute)
2.09
Rat (Chronic Oral)
2.63
Fathead Minnow
4.52
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
391.55
Hydration Free Energy
-7.97
Log(D) at pH=7.4
3.81
Log(P)
4.94
Log S
-4.26
Log(Vapor Pressure)
-7.32
Melting Point
180.31
pKa Acid
10.22
pKa Basic
8.82
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9616
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9616
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9144
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9144
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.9142
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.9142
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 4 0.9088
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 4 0.9088
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.9040
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.9040
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8931
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8931
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.8823
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.8823
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.8802
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.8802
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.8791
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.8791
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8715
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8715
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 4 0.8705
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 4 0.8705
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8685
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8685
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8665
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8665
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8636
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8636
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8575
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8575
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8560
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8560
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.8544
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.8544
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8527
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8527
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8501
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8501
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8494
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8494
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8366
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8366
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 4 0.8361
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 4 0.8361
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8309
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8309
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 3 0.8220
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 3 0.8220
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8178
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8178
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.8170
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.8170
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8125
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8125
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8122
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8122
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8097
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8097
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 3 0.8089
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 3 0.8089
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8089
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8089
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.8084
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.8084
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 3 0.8079
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 3 0.8079
Lanosterol synthase P48449 ERG7_HUMAN Homo sapiens 3 0.8053
Lanosterol synthase P48449 ERG7_HUMAN Homo sapiens 3 0.8053
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8045
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8045
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7970
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7970
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7949
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7949
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7948
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7948
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7928
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7928
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7899
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7899
Dicamba O-demethylase, oxygenase component Q5S3I3 DDMC_STEMA Stenotrophomonas maltophilia 3 0.7876
Dicamba O-demethylase, oxygenase component Q5S3I3 DDMC_STEMA Stenotrophomonas maltophilia 3 0.7876
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7861
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7861
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7851
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7851
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7845
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7845
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7828
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7828
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7791
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7791
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7789
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7789
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7782
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7782
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7777
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7777
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7773
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7773
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7771
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7771
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7770
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7770
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7753
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7753
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7747
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7747
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7744
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7744
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 4 0.7737
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 4 0.7737
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7709
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7709
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 3 0.7692
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 3 0.7692
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7677
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7677
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7666
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7666
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7648
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7648
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7636
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7636
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 3 0.7594
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 3 0.7594
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7583
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7583
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7581
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7581
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7581
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7581
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7574
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7574
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7570
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7570
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7551
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7551
Sulfotransferase 1E1 P49891 ST1E1_MOUSE Mus musculus 4 0.7538
Sulfotransferase 1E1 P49891 ST1E1_MOUSE Mus musculus 4 0.7538
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.7536
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.7536
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7520
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7520
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7514
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7514
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7511
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7511
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7496
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7496
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7494
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7494
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7489
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7489
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7480
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7480
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7468
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7468
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7466
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7466
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7460
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7460
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7458
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7458
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7425
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7425
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7399
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7399
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7394
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7394
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7385
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7385
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7384
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7384
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7376
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7376
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7365
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7365
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7359
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7359
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7355
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7355
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7348
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7348
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.7347
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.7347
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7341
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7341
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7327
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7327
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7308
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7308
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7299
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7299
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7297
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7297
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7293
Nuclear receptor coactivator 2 Q15596 NCOA2_HUMAN Homo sapiens 3 0.7293
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7293
Nuclear receptor coactivator 2 Q15596 NCOA2_HUMAN Homo sapiens 3 0.7293
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.7289
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.7289
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7275
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7275
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7267
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7267
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7262
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7262
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7255
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7255
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7244
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7244
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7236
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7236
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7224
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7224
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7212
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7212
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7210
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7210
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7210
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7210
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7206
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7206
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7190
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7190
Deoxynucleoside kinase Q9XZT6 DNK_DROME Drosophila melanogaster 4 0.7178
Deoxynucleoside kinase Q9XZT6 DNK_DROME Drosophila melanogaster 4 0.7178
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.7175
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.7175
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7174
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7174
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7173
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7173
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7168
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7168
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7150
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7150
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7149
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7149
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7147
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7147
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7144
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7144
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 4 0.7138
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 4 0.7138
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7116
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7116
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7113
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7113
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7110
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7110
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7109
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7109
Vitamin D3 receptor A Q9PTN2 VDRA_DANRE Danio rerio 3 0.7105
Vitamin D3 receptor A Q9PTN2 VDRA_DANRE Danio rerio 3 0.7105
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7100
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7100
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7086
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7086
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7066
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7066
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7058
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7058
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7053
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7053
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7048
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7048
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7040
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7040
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.7019
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.7019

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