6-hydroxymethyl-1-methyl-5- vinyl-9,10-dihydrophenanthrene-2-ol - Compound Card

6-hydroxymethyl-1-methyl-5- vinyl-9,10-dihydrophenanthrene-2-ol

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6-hydroxymethyl-1-methyl-5- vinyl-9,10-dihydrophenanthrene-2-ol

Structure
Zoomed Structure
  • Family: Juncaceae
  • Kingdom: Plantae
  • Class: Phenanthrenoid
Canonical Smiles C=Cc1c(CO)ccc2c1c1ccc(c(c1CC2)C)O
InChI InChI=1S/C18H18O2/c1-3-14-13(10-19)5-4-12-6-7-15-11(2)17(20)9-8-16(15)18(12)14/h3-5,8-9,19-20H,1,6-7,10H2,2H3
InChIKey KVXYZWAGVOSLQZ-UHFFFAOYSA-N
Formula C18H18O2
HBA 2
HBD 2
MW 266.34
Rotatable Bonds 2
TPSA 40.46
LogP 3.6
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.22
Exact Mass 266.13
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Juncus acutus Juncaceae Plantae 308385

Showing of synonyms

  • Behery FAA, Naeem ZEM, et al. (2007). Phenanthrenoids from Juncus acutus L., new natural lipopolysaccharide-inducible nitric oxide synthase inhibitors.. Chemical and Pharmaceutical Bulletin,2007,55(8),1264-1266. [View] [PubMed]
Pubchem: 5323704
Nmrshiftdb2: 75015

No compound-protein relationship available.

Structure

SMILES: c1cccc(c1c23)CCc2cccc3

Level: 0

Mol. Weight: 180.25 g/mol

Anti-inflammatory

Absorption

Caco-2 (logPapp)
-4.99
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.46
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.44

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.81
Plasma Protein Binding
54.5
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.49
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.6
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.58
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.19
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Toxic
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.28
Rat (Acute)
2.09
Rat (Chronic Oral)
2.81
Fathead Minnow
4.47
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
385.3
Hydration Free Energy
-8.62
Log(D) at pH=7.4
3.19
Log(P)
4.01
Log S
-3.67
Log(Vapor Pressure)
-7.57
Melting Point
133.03
pKa Acid
10.91
pKa Basic
6.66
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9637
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9637
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.9515
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.9515
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9504
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9504
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.9186
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.9186
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9153
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9153
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9117
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9117
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9103
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9103
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9095
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9095
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9066
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9066
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.9058
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.9058
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8998
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8998
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8963
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8963
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8943
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8943
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8943
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8943
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8884
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8884
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8868
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8868
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8857
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8857
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.8810
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.8810
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8771
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8771
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8705
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8705
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8649
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8649
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8627
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8627
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8615
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8615
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.8611
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.8611
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8595
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8595
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8568
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8568
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.8558
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.8558
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8548
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8548
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.8528
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.8528
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8508
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8508
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8503
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8503
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.8496
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.8496
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8483
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8483
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8477
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8477
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 4 0.8473
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 4 0.8473
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8458
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8458
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8452
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8452
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8449
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8449
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8415
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8415
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8408
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8408
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.8393
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.8393
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8382
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8382
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.8310
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.8310
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8301
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8301
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8295
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8295
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8293
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8293
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8234
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8234
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8214
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8214
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8208
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8208
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.8179
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.8179
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8175
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8175
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8166
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8166
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8139
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8139
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8128
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8128
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8115
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8115
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8100
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8100
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8093
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8093
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8081
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8081
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8048
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8048
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.8045
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.8045
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8007
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8007
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7984
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7984
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7943
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7943
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7938
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7938
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7937
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7937
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7867
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7867
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7852
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7852
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 4 0.7842
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 4 0.7842
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 3 0.7835
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7835
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 3 0.7835
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7835
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7799
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7799
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7782
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7782
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7781
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7781
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.7778
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.7778
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.7770
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.7770
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7767
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7767
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7761
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7761
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7747
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7747
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7745
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7745
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7741
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7741
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7734
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7734
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7722
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7722
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7709
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7709
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7693
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7693
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7685
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7685
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7685
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7685
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7682
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7682
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7677
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7677
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7672
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7672
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7672
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7672
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7666
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7666
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7664
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7664
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7659
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7659
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7659
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7659
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7652
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7652
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7639
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7639
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7633
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7633
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7633
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7633
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7628
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7628
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7624
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7624
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7612
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7612
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7595
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7595
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7574
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7574
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7572
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7572
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7571
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7571
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7567
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7567
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7567
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7567
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7565
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7565
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7558
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7558
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7558
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7558
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7548
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7548
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7542
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7542
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7542
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7542
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7530
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7530
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7530
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7530
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7518
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7518
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7511
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7511
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7510
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7510
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7509
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7509
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 3 0.7507
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 3 0.7507
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7505
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7505
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7504
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7504
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7499
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7499
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7495
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7495
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7491
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7491
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7488
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7488
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7488
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7488
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7487
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7487
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7486
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7486
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7484
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7484
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7482
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7482
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7478
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7478
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7478
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7478
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 3 0.7475
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 3 0.7475
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7470
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7470
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7467
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7467
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7465
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7465
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.7463
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7463
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7463
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7463
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7463
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.7463
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7446
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7446
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7437
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7437
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7432
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7432
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7428
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7428
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7428
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7428
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7422
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7422
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7415
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7415
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7413
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7413
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7410
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7410
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7410
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7410
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 2 0.7404
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 2 0.7404
Bifunctional dihydrofolate reductase-thymidylate synthase Q27552 Q27552_CRYPV Cryptosporidium parvum 3 0.7399
Bifunctional dihydrofolate reductase-thymidylate synthase Q27552 Q27552_CRYPV Cryptosporidium parvum 3 0.7399
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7392
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7392
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7391
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7391
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 4 0.7390
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7390
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7390
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 4 0.7390
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7387
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7387
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7386
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7386
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7384
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7384
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7382
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7382
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7378
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7378
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7376
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7376
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7372
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7372
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7367
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7367
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7361
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7361
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7355
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7355
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7351
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7351
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7331
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7331
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.7311
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.7311
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.7308
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.7308
Vitamin D3 receptor A Q9PTN2 VDRA_DANRE Danio rerio 3 0.7307
Vitamin D3 receptor A Q9PTN2 VDRA_DANRE Danio rerio 3 0.7307
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7304
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7304
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7302
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7302
Dihydroorotate dehydrogenase (quinone), mitochondrial Q02127 PYRD_HUMAN Homo sapiens 3 0.7290
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7290
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7290
Dihydroorotate dehydrogenase (quinone), mitochondrial Q02127 PYRD_HUMAN Homo sapiens 3 0.7290
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7285
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7285
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7283
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7283
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7282
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7282
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7277
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7277
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7277
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7277
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7267
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7267
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7246
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7246
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7245
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7245
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7243
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7243
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7232
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7232
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7223
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7223
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7223
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7223
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7222
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7222
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7219
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7219
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7214
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7214
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.7201
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.7201
Abscisic acid receptor PYL1 Q8VZS8 PYL1_ARATH Arabidopsis thaliana 3 0.7193
Abscisic acid receptor PYL1 Q8VZS8 PYL1_ARATH Arabidopsis thaliana 3 0.7193
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7190
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7190
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7184
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7184
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7183
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7183
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7182
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7182
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7173
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7173
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7173
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7173
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7170
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7170
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7170
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7170
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7168
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7168
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 2 0.7167
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 2 0.7167
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7162
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7162
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7162
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7162
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7161
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7161
Serine/threonine-protein kinase VRK1 Q99986 VRK1_HUMAN Homo sapiens 3 0.7159
Serine/threonine-protein kinase VRK1 Q99986 VRK1_HUMAN Homo sapiens 3 0.7159
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7156
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7156
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7146
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7146
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7142
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7142
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7138
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7138
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7134
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7134
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7133
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7133
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7126
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7126
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7117
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7117
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7116
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7116
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7116
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7116
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7113
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7113
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7108
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7108
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7103
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7103
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7094
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7094
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7093
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7093
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7089
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7089
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7089
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7089
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7087
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7087
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7085
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7085
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7085
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7085
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7083
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7083
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7080
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7080
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7080
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7080
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7062
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7062
Metallophosphoesterase MPPED2 B1WBP0 MPPD2_RAT Rattus norvegicus 3 0.7030
Metallophosphoesterase MPPED2 B1WBP0 MPPD2_RAT Rattus norvegicus 3 0.7030
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7029
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7029
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7025
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7025
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7025
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7025
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7010
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7010
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7010
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7010
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7007
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7007
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7007
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7007
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7006
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7006
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7005
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7005

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