6,8-di-C-methylkaempferol 3,4'-dimethyl ether - Compound Card

6,8-di-C-methylkaempferol 3,4'-dimethyl ether

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6,8-di-C-methylkaempferol 3,4'-dimethyl ether

Structure
Zoomed Structure
  • Family: Plantae - Myrtaceae
  • Kingdom: Plantae
  • Class: Terpenoid
    • Subclass: Triterpene
Canonical Smiles COc1ccc(cc1)c1oc2c(C)c(O)c(c(c2c(=O)c1OC)O)C
InChI InChI=1S/C19H18O6/c1-9-14(20)10(2)17-13(15(9)21)16(22)19(24-4)18(25-17)11-5-7-12(23-3)8-6-11/h5-8,20-21H,1-4H3
InChIKey JMMZJPBSEVDXHQ-UHFFFAOYSA-N
Formula C19H18O6
HBA 6
HBD 2
MW 342.35
Rotatable Bonds 3
TPSA 89.13
LogP 3.51
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 25
Formal Charge 0
Fraction CSP3 0.21
Exact Mass 342.11
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Eucalyptus occidentalis Myrtaceae Plantae 229548

Showing of synonyms

  • Benyahia S, Benayache S, et al. (2004). Isolation from Eucalyptus occidentalis and identification of a new kaempferol derivative that induces apoptosis in human myeloid leukemia cells. Journal of Natural Products,2004,67(4),527-531. [View] [PubMed]
Pubchem: 10450033
Nmrshiftdb2: 60114535

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 342.35 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 342.35 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 342.35 g/mol

Antileukemia

Absorption

Caco-2 (logPapp)
-4.53
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.820
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.51

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.370
Plasma Protein Binding
88.23
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.410
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.120
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.120
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.220
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.650
Rat (Acute)
2.380
Rat (Chronic Oral)
2.310
Fathead Minnow
4.950
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
458.550
Hydration Free Energy
-10.400
Log(D) at pH=7.4
3.210
Log(P)
4.72
Log S
-5.3
Log(Vapor Pressure)
-7.93
Melting Point
187.93
pKa Acid
7.5
pKa Basic
4.8
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9751
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9751
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9647
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9647
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9189
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9189
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8884
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8884
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8884
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8884
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8878
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8878
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8802
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8802
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8781
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8781
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8737
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8737
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8684
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8684
Caspase-7 P55210 CASP7_HUMAN Homo sapiens 3 0.8635
Caspase-7 P55210 CASP7_HUMAN Homo sapiens 3 0.8635
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 4 0.8612
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 4 0.8612
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8591
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8591
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8504
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8504
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8464
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8464
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8448
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8448
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8448
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8448
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8423
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8423
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8411
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8411
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8408
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8408
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.8392
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.8392
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8380
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8380
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8368
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8368
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8283
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8283
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8271
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8271
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8255
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8255
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 4 0.8218
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 4 0.8218
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8199
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8199
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8174
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8174
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8162
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8162
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8138
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8138
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8134
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8134
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8132
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8132
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8130
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8130
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8121
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8121
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8110
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8110
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8097
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8097
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8077
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8077
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8075
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8075
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8068
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8068
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8065
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8065
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8062
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8062
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.8060
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.8060
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8032
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8032
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8026
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8026
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8024
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8024
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8015
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8015
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8007
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8007
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7948
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7948
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7924
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7924
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7921
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7921
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7920
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7920
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7919
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7919
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7913
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7913
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7912
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7912
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7912
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7912
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7903
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7903
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7876
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7876
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7874
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7874
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.7844
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.7844
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7842
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7842
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7837
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7837
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7829
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7829
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7802
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7802
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 4 0.7789
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 4 0.7789
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7787
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7787
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7786
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7786
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7780
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7780
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7775
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7775
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7774
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7774
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7767
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7767
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7749
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7749
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7730
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7730
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7724
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7724
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7721
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7721
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7707
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7707
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7676
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7676
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7664
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7664
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7625
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7625
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7609
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7609
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7609
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7609
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7591
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7591
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7584
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7584
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7582
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7582
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7576
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7576
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.7545
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.7545
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7536
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7536
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7528
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7528
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7518
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7518
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7453
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7453
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 3 0.7448
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 3 0.7448
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7447
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7447
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7436
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7436
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7432
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7432
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7430
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7430
Reductase homolog Q9ZGC1 Q9ZGC1_STRCY Streptomyces cyanogenus 3 0.7419
Reductase homolog Q9ZGC1 Q9ZGC1_STRCY Streptomyces cyanogenus 3 0.7419
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7403
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7403
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7400
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7400
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7394
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7394
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7392
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7392
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7387
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7387
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7378
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7378
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7362
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7362
Beta-2-microglobulin P61769 B2MG_HUMAN Homo sapiens 3 0.7325
Beta-2-microglobulin P61769 B2MG_HUMAN Homo sapiens 3 0.7325
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7318
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7318
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7313
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7313
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7308
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7308
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7307
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7307
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7294
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7294
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7265
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7265
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7241
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7241
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7233
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7233
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7223
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7223
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7212
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7212
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7201
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7201
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7189
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7189
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7181
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7181
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7177
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7177
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7172
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7172
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 5 0.7144
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 5 0.7144
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7140
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7140
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7138
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7138
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7113
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7113
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7110
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7110
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7092
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7092
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7084
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7084
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7066
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7066
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7051
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7051
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7043
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7043
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7028
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7028
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7025
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7025
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7021
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7021
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7012
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7012
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7008
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7008

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