6,8-di-C-methylkaempferol 3-methyl ether - Compound Card

6,8-di-C-methylkaempferol 3-methyl ether

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6,8-di-C-methylkaempferol 3-methyl ether

Structure
Zoomed Structure
  • Family: Plantae - Myrtaceae
  • Kingdom: Plantae
  • Class: Terpenoid
    • Subclass: Triterpene
Canonical Smiles COc1c(oc2c(c1=O)c(O)c(c(c2C)O)C)c1ccc(cc1)O
InChI InChI=1S/C18H16O6/c1-8-13(20)9(2)16-12(14(8)21)15(22)18(23-3)17(24-16)10-4-6-11(19)7-5-10/h4-7,19-21H,1-3H3
InChIKey ZJWUNKIZXJVIDL-UHFFFAOYSA-N
Formula C18H16O6
HBA 6
HBD 3
MW 328.32
Rotatable Bonds 2
TPSA 100.13
LogP 3.2
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 24
Formal Charge 0
Fraction CSP3 0.17
Exact Mass 328.09
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Eucalyptus occidentalis Myrtaceae Plantae 229548

Showing of synonyms

  • Benyahia S, Benayache S, et al. (2004). Isolation from Eucalyptus occidentalis and identification of a new kaempferol derivative that induces apoptosis in human myeloid leukemia cells. Journal of Natural Products,2004,67(4),527-531. [View] [PubMed]
Pubchem: 44259654
Nmrshiftdb2: 60114536

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 328.32 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 328.32 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 328.32 g/mol

Antileukemia

Absorption

Caco-2 (logPapp)
-4.89
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.970
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.25

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.200
Plasma Protein Binding
88.76
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.950
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.050
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.340
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.390
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.810
Rat (Acute)
2.370
Rat (Chronic Oral)
2.430
Fathead Minnow
4.750
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
478.260
Hydration Free Energy
-11.720
Log(D) at pH=7.4
3.050
Log(P)
4.44
Log S
-5.41
Log(Vapor Pressure)
-8.06
Melting Point
248.54
pKa Acid
7.14
pKa Basic
5.84
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9761
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9761
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9645
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9645
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9301
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9301
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9262
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9262
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9212
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9212
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9126
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9126
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8814
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8814
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8772
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8772
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8753
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8753
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8672
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8672
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8646
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8646
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 4 0.8645
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 4 0.8645
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8579
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8579
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8482
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8482
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8479
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8479
Caspase-7 P55210 CASP7_HUMAN Homo sapiens 3 0.8478
Caspase-7 P55210 CASP7_HUMAN Homo sapiens 3 0.8478
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8461
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8461
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8362
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8362
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8356
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8356
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8336
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8336
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8321
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8321
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.8319
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.8319
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8307
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8307
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8268
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8268
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8253
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8253
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8240
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8240
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8234
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8234
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8167
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8167
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8162
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8162
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8160
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8160
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8159
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8159
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8159
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8159
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8122
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8122
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8112
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8112
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8110
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8110
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8106
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8106
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8086
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8086
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8079
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8079
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8065
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8065
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8062
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8062
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8059
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8059
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8027
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8027
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8020
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8020
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8014
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8014
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7981
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7981
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7977
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7977
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7946
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7946
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7945
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7945
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7940
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7940
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.7932
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.7932
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7929
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7929
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7925
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7925
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7921
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7921
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7904
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7904
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7902
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7902
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7902
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7902
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7898
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7898
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7883
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7883
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7867
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7867
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7863
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7863
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7854
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7854
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7850
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7850
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7824
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7824
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7801
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7801
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7786
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7786
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7778
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7778
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7777
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7777
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7773
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7773
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7727
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7727
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7695
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7695
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7688
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7688
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 4 0.7665
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 4 0.7665
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7627
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7627
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7626
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7626
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7621
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7621
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7618
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7618
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7614
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7614
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.7580
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.7580
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7551
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7551
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.7545
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.7545
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7518
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7518
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7510
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7510
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7509
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7509
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 4 0.7486
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 4 0.7486
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7481
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7481
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7448
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7448
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 3 0.7448
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 3 0.7448
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7447
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7447
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7439
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7439
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7431
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7431
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7429
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7429
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7424
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7424
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7419
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7419
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7416
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7416
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7410
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7410
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7401
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7401
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7374
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7374
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7370
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7370
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7359
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7359
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7342
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7342
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7321
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7321
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7320
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7320
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7298
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7298
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7296
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7296
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7295
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7295
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7294
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7294
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7293
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7293
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7288
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7288
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7273
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7273
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7248
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7248
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7236
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7236
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7223
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7223
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7194
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7194
Reductase homolog Q9ZGC1 Q9ZGC1_STRCY Streptomyces cyanogenus 3 0.7157
Reductase homolog Q9ZGC1 Q9ZGC1_STRCY Streptomyces cyanogenus 3 0.7157
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7156
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7156
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7106
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7106
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7073
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7073
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7066
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7066
Beta-2-microglobulin P61769 B2MG_HUMAN Homo sapiens 3 0.7058
Beta-2-microglobulin P61769 B2MG_HUMAN Homo sapiens 3 0.7058
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7054
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7054
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7047
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7047
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7041
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7041
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7034
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7034
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.7025
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.7025
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7023
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7023

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