Macrocarpon C - Compound Card

Macrocarpon C

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Macrocarpon C

Structure
Zoomed Structure
  • Family: Nectriaceae
  • Kingdom: Fungi
  • Class: Pyrone Derivative
Canonical Smiles Oc1cc(cc(c1)O)Cc1cc(=O)cc(o1)C
InChI InChI=1S/C13H12O4/c1-8-2-10(14)7-13(17-8)5-9-3-11(15)6-12(16)4-9/h2-4,6-7,15-16H,5H2,1H3
InChIKey NRHPLXVYFGEACJ-UHFFFAOYSA-N
Formula C13H12O4
HBA 4
HBD 2
MW 232.23
Rotatable Bonds 2
TPSA 70.67
LogP 1.95
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 17
Formal Charge 0
Fraction CSP3 0.15
Exact Mass 232.07
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Fusarium tricinctum Nectriaceae Fungi 61284

Showing of synonyms

  • Ola AR, Thomy D, et al. (2013). Inducing secondary metabolite production by the endophytic fungus Fusarium tricinctum through coculture with Bacillus subtilis. Journal of Natural Products,2013,76(11),2094-2099. [View] [PubMed]
Pubchem: 72947236
Nmrshiftdb2: 70012335

No compound-protein relationship available.

Structure

SMILES: o1ccc(=O)cc1Cc2ccccc2

Level: 1

Mol. Weight: 186.21 g/mol

Structure

SMILES: O=c1ccocc1

Level: 0

Mol. Weight: 96.08 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.79
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.580
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.85

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.910
Plasma Protein Binding
65.62
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.500
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.230
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.050
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.430
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.730
Rat (Acute)
1.870
Rat (Chronic Oral)
2.240
Fathead Minnow
4.070
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
379.610
Hydration Free Energy
-12.190
Log(D) at pH=7.4
1.430
Log(P)
0.7
Log S
-2.64
Log(Vapor Pressure)
-6.53
Melting Point
221.92
pKa Acid
9.42
pKa Basic
5.58
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9716
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9716
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9510
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9510
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9504
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9504
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9485
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9485
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.9378
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.9378
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.9359
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.9359
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.9255
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.9255
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9242
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9242
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.9225
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.9225
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9221
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9221
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.9162
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.9162
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9154
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9154
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9068
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9068
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9003
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9003
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8996
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8996
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8932
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8932
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8903
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8903
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8851
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8851
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8821
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8821
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8820
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8820
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8816
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8816
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8780
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8780
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8762
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8762
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8745
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8745
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8665
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8665
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8630
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8630
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8574
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8574
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8542
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8542
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8541
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8541
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8530
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8530
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.8524
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.8524
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8510
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8510
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.8484
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.8484
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8442
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8442
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8393
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8393
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8380
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8380
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8367
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8367
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.8352
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.8352
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8339
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8339
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 3 0.8332
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 3 0.8332
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8324
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8324
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8300
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8300
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8295
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8295
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8292
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8292
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8246
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8246
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8227
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8227
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.8157
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.8157
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8142
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8142
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8135
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8135
11-beta-hydroxysteroid dehydrogenase 1 Q6QLL4 DHI1_CAVPO Cavia porcellus 3 0.8131
11-beta-hydroxysteroid dehydrogenase 1 Q6QLL4 DHI1_CAVPO Cavia porcellus 3 0.8131
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8115
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8115
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.8082
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.8082
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8072
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8072
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8055
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8055
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.8024
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.8024
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8006
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8006
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 5 0.7981
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 5 0.7981
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7954
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7954
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7953
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7953
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 4 0.7937
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 4 0.7937
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7922
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7922
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7916
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7916
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7902
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7902
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7898
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7898
Abscisic acid receptor PYL1 Q8VZS8 PYL1_ARATH Arabidopsis thaliana 3 0.7891
Abscisic acid receptor PYL1 Q8VZS8 PYL1_ARATH Arabidopsis thaliana 3 0.7891
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7890
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7890
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7882
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7882
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7850
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7850
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7829
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7829
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7812
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7812
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7807
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7807
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7804
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7804
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7796
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7796
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7781
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7781
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7727
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7727
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7725
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7725
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7709
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7709
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7703
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7703
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7699
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7699
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 3 0.7687
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 3 0.7687
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7673
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7673
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7627
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7627
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7624
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7624
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7603
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7603
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7588
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7588
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7576
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7576
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7570
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7570
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7569
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7569
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7557
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7557
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7532
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7532
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7528
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7528
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7524
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7524
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7513
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7513
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7503
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7503
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7489
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7489
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7488
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7488
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7483
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7483
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7471
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7471
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7459
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7459
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7443
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7443
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7433
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7433
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7420
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7420
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7416
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7416
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7407
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7407
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7389
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7389
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7387
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7387
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7386
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7386
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 2 0.7378
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 2 0.7378
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7369
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7369
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7368
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7368
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7354
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7354
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7350
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7350
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7348
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7348
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7344
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7344
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7341
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7341
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7340
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7340
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7338
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7338
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7335
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7335
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7334
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7334
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7332
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7332
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.7327
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.7327
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7323
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7323
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 4 0.7320
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 4 0.7320
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7315
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7315
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7311
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7311
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7304
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7304
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7298
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7298
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7290
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7290
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7288
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7288
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7277
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7277
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7272
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7272
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7270
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7270
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7251
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7251
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7246
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7246
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7227
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7227
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 4 0.7222
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 4 0.7222
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7219
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7219
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7196
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7196
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7193
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7193
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7192
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7192
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7186
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7186
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7185
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7185
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7184
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7184
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7182
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7182
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7180
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7180
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7179
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7179
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.7174
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.7174
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7154
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7154
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7154
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7154
Peptidoglycan recognition protein 1 Q9GK12 PGRP1_CAMDR Camelus dromedarius 3 0.7151
Peptidoglycan recognition protein 1 Q9GK12 PGRP1_CAMDR Camelus dromedarius 3 0.7151
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 3 0.7146
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 3 0.7146
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7144
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7144
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7136
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7136
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7136
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7136
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7128
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7128
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7100
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7100
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7094
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7094
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7092
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7092
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7077
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7077
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7072
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7072
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7070
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7070
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7066
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7066
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7066
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7066
D-amino-acid oxidase P14920 OXDA_HUMAN Homo sapiens 4 0.7055
D-amino-acid oxidase P14920 OXDA_HUMAN Homo sapiens 4 0.7055
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7054
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7054
Malate dehydrogenase P10584 MDH_THETH Thermus thermophilus 3 0.7049
Malate dehydrogenase P10584 MDH_THETH Thermus thermophilus 3 0.7049
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7048
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7048
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7046
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7046
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.7039
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.7039
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7030
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7030
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7026
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7026
Serine/threonine-protein kinase VRK1 Q99986 VRK1_HUMAN Homo sapiens 3 0.7018
Serine/threonine-protein kinase VRK1 Q99986 VRK1_HUMAN Homo sapiens 3 0.7018
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7005
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7005
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7001
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7001

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