ANPDB

Select a section from the left sidebar

Nuzhenide

Family: Plantae - Oleaceae
Kingdom: Plantae
Class: Terpenoid
- Subclass: Secoiridoid Glucoside

Canonical Smiles	OC[C@H]1O[C@@H](O[C@@H]2OC=C(C(/C/2=C\C)CC(=O)OC[C@H]2O[C@@H](OCCc3ccc(cc3)O)[C@@H]([C@H]([C@@H]2O)O)O)C(=O)OC)[C@@H]([C@H]([C@@H]1O)O)O
InChI	InChI=1S/C31H42O17/c1-3-16-17(18(28(41)42-2)12-45-29(16)48-31-27(40)24(37)22(35)19(11-32)46-31)10-21(34)44-13-20-23(36)25(38)26(39)30(47-20)43-9-8-14-4-6-15(33)7-5-14/h3-7,12,17,19-20,22-27,29-33,35-40H,8-11,13H2,1-2H3/b16-3+/t17?,19-,20-,22-,23-,24+,25+,26-,27-,29+,30-,31+/m1/s1
InChIKey	STKUCSFEBXPTAY-YTECAPLWSA-N
Formula	C₃₁H₄₂O₁₇
HBA	17
HBD	8
MW	686.66
Rotatable Bonds	12
TPSA	260.59
LogP	-2.52
Number Rings	4
Number Aromatic Rings	1
Heavy Atom Count	48
Formal Charge	0
Fraction CSP3	0.61
Exact Mass	686.24
Number of Lipinski Rule Violations	3

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Fraxinus excelsior	Oleaceae	Plantae	38873
2	Fraxinus excelsior	Oleaceae	Plantae	38873
3	Fraxinus angustifolia	Oleaceae	Plantae	166594
4	Fraxinus angustifolia	Oleaceae	Plantae	166594
5	Olea europaea	Oleaceae	Plantae	4146

Showing of synonyms

Calis I, Hosny M, et al. (1996). A secoiridoid glucoside from Fraxinus angustifolia. Phytochemistry,1996,41(6),1557-1562. [View]
Ibarra A, Bai N, et al. (2011). Fraxinus excelsior seed extract FraxiPureTM limits weight gains and hyperglycemia in high-fat diet-induced obese mice. Phytomedicine,2011,18(6),479-485. [View]
Bai N, He K, et al. (2010). Iridoids from Fraxinus excelsior with adipocyte differentiation-inhibitory and PPARalpha activation activity. Journal of Natural Products,2010,73(1),2-6. [View] [PubMed]
Ben Mansour A, Porter EA, et al. (2015). Phenolic profile characterization of Chemlali olive stones by liquid chromatography-ion trap mass spectrometry. Journal of Agricultural and Food Chemistry,2015,63(7),1990-1995. [View]
García-Villalba R, Tomás-Barberán FA, et al. (2015). Targeted and untargeted metabolomics to explore the bioavailability of the secoiridoids from a seed/fruit extract (Fraxinus angustifolia Vahl) in human healthy volunteers: a preliminary study. Molecules,2015,20(12),22202-22219. [View] [PubMed]

Pubchem: 6440999

Cas: 39011-92-2

Gnps: CCMSLIB00006475845

Chebi: 197418

Nmrshiftdb2: 60061061

Chembl: CHEMBL1076818

CPRiL: 74230

SMILES: O1CCCCC1OC2OC=CC(C2=C)CC(=O)OCC3CCCC(O3)OCCc4ccccc4

Level: 3

Mol. Weight: 686.66 g/mol

SMILES: C1OC=CC(C1=C)CC(=O)OCC2CCCC(O2)OCCc3ccccc3

Level: 2

Mol. Weight: 686.66 g/mol

SMILES: O1CCCCC1COC(=O)CC(C2=C)C=COC2OC3CCCCO3

Level: 2

Mol. Weight: 686.66 g/mol

SMILES: C1OC=CC(C1=C)CC(=O)OCC2CCCCO2

Level: 1

Mol. Weight: 686.66 g/mol

SMILES: c1ccccc1CCOC2CCCCO2

Level: 1

Mol. Weight: 686.66 g/mol

SMILES: C1C=COC(C1=C)OC2CCCCO2

Level: 1

Mol. Weight: 686.66 g/mol

SMILES: C=C1CC=COC1

Level: 0

Mol. Weight: 686.66 g/mol

SMILES: C1CCOCC1

Level: 0

Mol. Weight: 686.66 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 686.66 g/mol

Adipocyte differentiation-inhibitory

Antidiabetic

Antiobesity property

Absorption

Caco-2 (logPapp): -6.56
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Non-Absorbed
Madin-Darby Canine Kidney: -4.780
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: 76.2

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.810
Plasma Protein Binding: 57.95
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 5.700
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: -3.600
Biodegradation: Toxic
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.750
Liver Injury II: Safe
hERG Blockers: Safe
Daphnia Maga: 6.170
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -140276.880
Rat (Acute): 2.620
Rat (Chronic Oral): 4.790
Fathead Minnow: 191.660
Respiratory Disease: Safe
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 9796.970
Hydration Free Energy: -2.920
Log(D) at pH=7.4: 0.130
Log(P): -1.63
Log S: -2.34
Log(Vapor Pressure): -333.82
Melting Point: 175.21
pKa Acid: 3.71
pKa Basic: 2.42

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.9224
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.9224
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8966
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8966
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8912
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8912
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.8911
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.8911
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.8679
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.8679
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8632
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8632
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8420
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8420
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8389
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8389
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8325
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8325
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8230
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8230
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8188
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8188
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8147
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8147
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8125
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8125
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.8024
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.8024
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7949
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7949
beta-glucosidase	Q92AS9	Q92AS9_LISIN	Listeria innocua serovar 6a	3	0.7836
beta-glucosidase	Q92AS9	Q92AS9_LISIN	Listeria innocua serovar 6a	3	0.7836
Prolyl tripeptidyl peptidase	Q7MUW6	PTP_PORGI	Porphyromonas gingivalis	3	0.7798
Prolyl tripeptidyl peptidase	Q7MUW6	PTP_PORGI	Porphyromonas gingivalis	3	0.7798
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7788
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7788
Disks large homolog 1	Q12959	DLG1_HUMAN	Homo sapiens	3	0.7658
Disks large homolog 1	Q12959	DLG1_HUMAN	Homo sapiens	3	0.7658
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.7577
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.7577
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7512
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7512
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.7507
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.7507
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7494
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7494
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7434
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7434
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7423
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7423
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7419
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7419
Chaperone protein ClpB	Q9RA63	CLPB_THET8	Thermus thermophilus	4	0.7413
Chaperone protein ClpB	Q9RA63	CLPB_THET8	Thermus thermophilus	4	0.7413
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7407
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7407
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7402
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7402
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7381
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7381
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7365
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7365
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7307
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7307
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7291
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7291
2-aminohexano-6-lactam racemase	Q7M181	ACLR_ACHOB	Achromobacter obae	2	0.7274
2-aminohexano-6-lactam racemase	Q7M181	ACLR_ACHOB	Achromobacter obae	2	0.7274
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	2	0.7258
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	2	0.7258
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	2	0.7258
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	2	0.7258
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7257
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7257
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7241
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7241
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	3	0.7233
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	3	0.7233
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7225
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7225
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7212
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7212
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7212
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7212
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	2	0.7197
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	2	0.7197
Guanylate kinase	P15454	KGUA_YEAST	Saccharomyces cerevisiae	3	0.7197
Guanylate kinase	P15454	KGUA_YEAST	Saccharomyces cerevisiae	3	0.7197
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7196
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7196
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7190
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7190
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	2	0.7186
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	2	0.7186
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7181
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7181
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7177
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7177
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7169
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7169
Uncharacterized protein	Q3F0V8	Q3F0V8_BACTI	Bacillus thuringiensis serovar israelensis ATCC 35646	3	0.7169
Uncharacterized protein	Q3F0V8	Q3F0V8_BACTI	Bacillus thuringiensis serovar israelensis ATCC 35646	3	0.7169
Purine nucleoside phosphorylase	Q8I3X4	Q8I3X4_PLAF7	Plasmodium falciparum	3	0.7154
Purine nucleoside phosphorylase	Q8I3X4	Q8I3X4_PLAF7	Plasmodium falciparum	3	0.7154
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7153
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7153
Cyclic GMP-AMP phosphodiesterase SMPDL3A	Q92484	ASM3A_HUMAN	Homo sapiens	2	0.7151
Cyclic GMP-AMP phosphodiesterase SMPDL3A	Q92484	ASM3A_HUMAN	Homo sapiens	2	0.7151
Purine nucleoside phosphorylase DeoD-type	B1JL34	DEOD_YERPY	Yersinia pseudotuberculosis serotype O:3	2	0.7118
Purine nucleoside phosphorylase DeoD-type	B1JL34	DEOD_YERPY	Yersinia pseudotuberculosis serotype O:3	2	0.7118
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7118
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7118
adenine phosphoribosyltransferase	Q967M2	Q967M2_GIAIN	Giardia intestinalis	2	0.7112
adenine phosphoribosyltransferase	Q967M2	Q967M2_GIAIN	Giardia intestinalis	2	0.7112
Serine/threonine-protein kinase toxin HipA	P23874	HIPA_ECOLI	Escherichia coli	2	0.7101
Serine/threonine-protein kinase toxin HipA	P23874	HIPA_ECOLI	Escherichia coli	2	0.7101
CCR4-NOT transcription complex subunit 6-like	Q96LI5	CNO6L_HUMAN	Homo sapiens	4	0.7095
CCR4-NOT transcription complex subunit 6-like	Q96LI5	CNO6L_HUMAN	Homo sapiens	4	0.7095
Anthranilate phosphoribosyltransferase	P00500	TRPD_ACIAD	Acinetobacter baylyi	2	0.7091
Anthranilate phosphoribosyltransferase	P00500	TRPD_ACIAD	Acinetobacter baylyi	2	0.7091
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7089
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7089
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7086
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7086
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7065
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7065
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	2	0.7059
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	2	0.7059
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7058
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7058
Acidic phospholipase A2 3	P60045	PA2A3_NAJSG	Naja sagittifera	2	0.7052
Acidic phospholipase A2 3	P60045	PA2A3_NAJSG	Naja sagittifera	2	0.7052
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7051
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7051
Holliday junction branch migration complex subunit RuvB	Q9PMT7	RUVB_CAMJE	Campylobacter jejuni subsp. jejuni serotype O:2	2	0.7049
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7049
Holliday junction branch migration complex subunit RuvB	Q9PMT7	RUVB_CAMJE	Campylobacter jejuni subsp. jejuni serotype O:2	2	0.7049
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7049
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	2	0.7043
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	2	0.7043
Myosin heavy chain kinase A	P42527	MHCKA_DICDI	Dictyostelium discoideum	2	0.7035
Myosin heavy chain kinase A	P42527	MHCKA_DICDI	Dictyostelium discoideum	2	0.7035
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7033
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7033
Kynurenine--oxoglutarate transaminase 1	Q16773	KAT1_HUMAN	Homo sapiens	2	0.7023
Kynurenine--oxoglutarate transaminase 1	Q16773	KAT1_HUMAN	Homo sapiens	2	0.7023
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	2	0.7020
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	2	0.7020
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7017
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7017
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	2	0.7015
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	2	0.7015
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.7012
Protein kinase C iota type	Q62074	KPCI_MOUSE	Mus musculus	2	0.7012
Protein kinase C iota type	Q62074	KPCI_MOUSE	Mus musculus	2	0.7012
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.7012
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	2	0.7010
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	2	0.7010
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7006
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7006
Formate--tetrahydrofolate ligase	P21164	FTHS_MOOTH	Moorella thermoacetica	2	0.7005
Formate--tetrahydrofolate ligase	P21164	FTHS_MOOTH	Moorella thermoacetica	2	0.7005
Malate dehydrogenase	P10584	MDH_THETH	Thermus thermophilus	3	0.7001
Malate dehydrogenase	P10584	MDH_THETH	Thermus thermophilus	3	0.7001

Download SDF