Desmethyldiaportinol - Compound Card

Desmethyldiaportinol

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Desmethyldiaportinol

Structure
Zoomed Structure
  • Family: Fungi - Phaeosphaeriaceae
  • Kingdom: Fungi
  • Class: Coumarin
    • Subclass: Isocoumarin
Canonical Smiles OC[C@@H](Cc1oc(=O)c2c(c1)cc(cc2O)O)O
InChI InChI=1S/C12H12O6/c13-5-8(15)3-9-2-6-1-7(14)4-10(16)11(6)12(17)18-9/h1-2,4,8,13-16H,3,5H2/t8-/m1/s1
InChIKey VILYFHCPBMAWFN-MRVPVSSYSA-N
Formula C12H12O6
HBA 6
HBD 4
MW 252.22
Rotatable Bonds 3
TPSA 111.13
LogP 0.1
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 18
Formal Charge 0
Fraction CSP3 0.25
Exact Mass 252.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Ampelomyces species Phaeosphaeriaceae Fungi 50729

Showing of synonyms

  • Aly AH, Edrada-Ebel R, et al. (2008). Bioactive metabolites from the endophytic fungus Ampelomyces sp. isolated from the medicinal plant Urospermum picroides. Phytochemistry,2008,69(8),1716-1725. [View] [PubMed]
Pubchem: 24882464
Nmrshiftdb2: 80009287

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)ccoc2=O

Level: 0

Mol. Weight: 252.22 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp)
-5.1
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.74
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.51

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.59
Plasma Protein Binding
50.89
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
10.83
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
-0.12
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.67
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
3.91
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
0.06
Rat (Acute)
2.03
Rat (Chronic Oral)
2.89
Fathead Minnow
4.01
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
425.04
Hydration Free Energy
-14.81
Log(D) at pH=7.4
0.11
Log(P)
0.53
Log S
-2.01
Log(Vapor Pressure)
-8.31
Melting Point
202.79
pKa Acid
5.78
pKa Basic
6.83
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9393
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9393
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9283
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9283
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9201
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9201
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.9193
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.9193
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9174
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9174
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 3 0.9130
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 3 0.9130
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9082
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9082
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.9073
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.9073
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.9054
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.9054
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9052
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9052
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 4 0.9030
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 4 0.9030
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8966
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8966
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8966
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8966
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8952
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8952
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8946
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8946
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.8935
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.8935
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.8893
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.8893
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8849
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8849
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8837
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8837
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8775
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8775
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8754
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8754
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8752
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8752
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8752
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8752
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8744
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8744
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8742
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8742
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8724
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8724
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8722
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8722
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8709
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8709
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8704
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8704
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8703
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8703
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8703
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8703
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8690
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8690
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8623
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8623
Spermidine synthase P19623 SPEE_HUMAN Homo sapiens 5 0.8603
Spermidine synthase P19623 SPEE_HUMAN Homo sapiens 5 0.8603
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8588
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8588
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8568
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8568
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8535
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8535
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8505
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8505
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8488
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8488
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 4 0.8484
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 4 0.8484
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8471
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8471
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8431
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8431
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8393
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8393
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8378
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8378
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8370
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8370
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8330
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8330
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8296
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8296
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8290
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8290
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8268
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8268
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8264
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8264
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8262
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8262
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8215
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8215
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8179
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8179
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8164
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8164
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8153
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8153
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 4 0.8117
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 4 0.8117
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8077
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8077
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8042
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8042
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8022
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8022
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7989
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7989
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7989
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7989
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7958
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7958
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7939
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7939
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7935
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7935
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 4 0.7933
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 4 0.7933
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7885
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7885
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7883
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7883
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7874
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7874
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7869
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7869
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7854
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7854
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7847
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7847
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7840
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7840
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7835
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7835
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7821
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7821
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7792
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7792
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.7780
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.7780
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7779
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7779
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7772
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7772
Polyamine aminopropyltransferase Q5SK28 SPEE_THET8 Thermus thermophilus 4 0.7766
Polyamine aminopropyltransferase Q5SK28 SPEE_THET8 Thermus thermophilus 4 0.7766
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 3 0.7751
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 3 0.7751
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.7738
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.7738
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7735
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7735
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7727
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7727
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.7713
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.7713
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7704
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7704
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 4 0.7692
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 4 0.7692
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.7689
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.7689
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7666
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7666
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.7634
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.7634
Ribosomal RNA small subunit methyltransferase E Q5SKI6 Q5SKI6_THET8 Thermus thermophilus 4 0.7629
Ribosomal RNA small subunit methyltransferase E Q5SKI6 Q5SKI6_THET8 Thermus thermophilus 4 0.7629
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7626
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7626
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7624
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7624
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 3 0.7615
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 3 0.7615
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7606
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7606
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.7594
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.7594
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.7540
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.7540
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7531
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7531
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7521
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7521
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7508
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7508
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7490
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7490
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7465
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7465
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7429
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7429
Probable ribosomal RNA small subunit methyltransferase A Q58435 RSMA_METJA Methanocaldococcus jannaschii 5 0.7419
Probable ribosomal RNA small subunit methyltransferase A Q58435 RSMA_METJA Methanocaldococcus jannaschii 5 0.7419
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7397
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7397
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7379
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7379
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7355
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7355
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7354
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7354
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7353
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7353
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7353
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7353
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 5 0.7350
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 5 0.7350
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7334
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7334
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7334
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7334
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 3 0.7334
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 3 0.7334
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7329
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7329
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7328
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7328
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7322
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7322
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7302
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7302
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7288
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7288
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7287
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7287
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7280
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7280
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7279
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7279
Ribosomal RNA small subunit methyltransferase Nep1 Q57977 NEP1_METJA Methanocaldococcus jannaschii 4 0.7275
Ribosomal RNA small subunit methyltransferase Nep1 Q57977 NEP1_METJA Methanocaldococcus jannaschii 4 0.7275
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7270
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7270
Beta-glucosidase Q8T0W7 Q8T0W7_9NEOP Neotermes koshunensis 3 0.7268
Beta-glucosidase Q8T0W7 Q8T0W7_9NEOP Neotermes koshunensis 3 0.7268
Ribosomal protein L11 methyltransferase, putative C3MWA1 C3MWA1_SULIM Sulfolobus islandicus 4 0.7267
Ribosomal protein L11 methyltransferase, putative C3MWA1 C3MWA1_SULIM Sulfolobus islandicus 4 0.7267
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7244
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7244
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7241
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7241
Putative cysteine ligase BshC P55342 BSHC_BACSU Bacillus subtilis 3 0.7238
Putative cysteine ligase BshC P55342 BSHC_BACSU Bacillus subtilis 3 0.7238
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7237
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7237
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7229
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7229
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7225
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 4 0.7225
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7225
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 4 0.7225
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7218
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7218
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7205
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7205
Methionine--tRNA ligase P00959 SYM_ECOLI Escherichia coli 3 0.7196
Histone-arginine methyltransferase CARM1 Q4AE70 CARM1_RAT Rattus norvegicus 4 0.7196
Histone-arginine methyltransferase CARM1 Q4AE70 CARM1_RAT Rattus norvegicus 4 0.7196
Methionine--tRNA ligase P00959 SYM_ECOLI Escherichia coli 3 0.7196
Ribosomal RNA large subunit methyltransferase H P0C1V0 RLMH_STAAU Staphylococcus aureus 4 0.7195
Ribosomal RNA large subunit methyltransferase H P0C1V0 RLMH_STAAU Staphylococcus aureus 4 0.7195
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7183
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7183
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7175
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7175
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7173
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7173
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 3 0.7172
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 3 0.7172
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7166
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7166
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7151
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7151
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 3 0.7147
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 3 0.7147
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7122
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7122
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7118
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7118
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7117
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7117
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7099
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7099
Methyltransferase-like protein 5 O59611 O59611_PYRHO Pyrococcus horikoshii 5 0.7096
Methyltransferase-like protein 5 O59611 O59611_PYRHO Pyrococcus horikoshii 5 0.7096
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.7094
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.7094
Oxygenase Q194P4 Q194P4_STRAA Streptomyces argillaceus 3 0.7093
Oxygenase Q194P4 Q194P4_STRAA Streptomyces argillaceus 3 0.7093
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7092
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7092
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7092
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7092
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7085
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7085
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7080
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7080
Activated CDC42 kinase 1 Q07912 ACK1_HUMAN Homo sapiens 3 0.7066
Activated CDC42 kinase 1 Q07912 ACK1_HUMAN Homo sapiens 3 0.7066
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7050
Aspartate carbamoyltransferase catalytic subunit P0A786 PYRB_ECOLI Escherichia coli 3 0.7050
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7050
Aspartate carbamoyltransferase catalytic subunit P0A786 PYRB_ECOLI Escherichia coli 3 0.7050
Trimethylamine dehydrogenase P16099 DHTM_METME Methylophilus methylotrophus 4 0.7049
Trimethylamine dehydrogenase P16099 DHTM_METME Methylophilus methylotrophus 4 0.7049
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7042
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7042
Tyrosine-protein kinase ITK/TSK Q08881 ITK_HUMAN Homo sapiens 4 0.7034
Tyrosine-protein kinase ITK/TSK Q08881 ITK_HUMAN Homo sapiens 4 0.7034
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7032
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7032
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7028
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7028
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7020
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 4 0.7020
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 4 0.7020
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7020
Granule-bound starch synthase 1, chloroplastic/amyloplastic Q0DEV5 SSG1_ORYSJ Oryza sativa subsp. japonica 3 0.7018
Granule-bound starch synthase 1, chloroplastic/amyloplastic Q0DEV5 SSG1_ORYSJ Oryza sativa subsp. japonica 3 0.7018
Small heat shock protein StHsp14.0 Q970D9 Q970D9_SULTO Sulfurisphaera tokodaii 3 0.7016
Small heat shock protein StHsp14.0 Q970D9 Q970D9_SULTO Sulfurisphaera tokodaii 3 0.7016
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 4 0.7015
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 4 0.7015
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 4 0.7013
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 4 0.7013
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7011
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7011
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7010
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7010

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