Macrosporin - Compound Card

Macrosporin

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Macrosporin

Structure
Zoomed Structure
  • Family: Fungi - Phaeosphaeriaceae
  • Kingdom: Fungi
  • Class: Quinone
    • Subclass: Anthraquinone
Canonical Smiles COc1cc(O)c2c(c1)C(=O)c1c(C2=O)cc(c(c1)C)O
InChI InChI=1S/C16H12O5/c1-7-3-9-10(6-12(7)17)16(20)14-11(15(9)19)4-8(21-2)5-13(14)18/h3-6,17-18H,1-2H3
InChIKey FKTPLNFTYJEAAB-UHFFFAOYSA-N
Formula C16H12O5
HBA 5
HBD 2
MW 284.27
Rotatable Bonds 1
TPSA 83.83
LogP 2.19
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 284.07
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Ampelomyces species Phaeosphaeriaceae Fungi 50729

Showing of synonyms

  • Aly AH, Edrada-Ebel R, et al. (2008). Bioactive metabolites from the endophytic fungus Ampelomyces sp. isolated from the medicinal plant Urospermum picroides. Phytochemistry,2008,69(8),1716-1725. [View] [PubMed]
Pubchem: 159926
Nmrshiftdb2: 70000558
Bindingdb: 50480484

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)C(=O)c3c(C2=O)cccc3

Level: 0

Mol. Weight: 284.27 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.49
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.600
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.12

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.930
Plasma Protein Binding
58.02
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.790
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.250
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.020
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.240
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
5.020
Rat (Acute)
2.330
Rat (Chronic Oral)
2.770
Fathead Minnow
4.440
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
431.930
Hydration Free Energy
-8.490
Log(D) at pH=7.4
2.490
Log(P)
3.34
Log S
-6.72
Log(Vapor Pressure)
-7.27
Melting Point
245.07
pKa Acid
7.24
pKa Basic
4.28
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.9638
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.9638
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9375
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9375
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9334
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9334
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9170
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9170
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9110
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9110
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9101
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9101
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9082
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9082
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9076
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9076
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9071
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9071
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9021
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9021
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8982
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8982
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8848
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8848
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8820
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8820
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8723
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8723
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8634
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8634
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8557
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8557
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8516
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8516
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8410
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8410
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8395
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8395
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8373
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8373
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8361
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8361
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8307
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8307
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.8234
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.8234
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8205
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8205
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8134
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8134
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8114
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8114
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8028
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8028
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8022
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8022
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7929
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7929
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.7917
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.7917
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7855
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7855
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7835
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7835
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7788
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7788
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7768
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7768
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7761
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7761
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7729
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7729
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7703
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7703
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7701
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7701
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7686
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7686
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7674
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7674
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7674
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7674
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7646
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7646
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7641
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7641
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7628
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7628
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7623
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7623
Enoyl-[acyl-carrier-protein] reductase [NADH] Q5NGQ3 Q5NGQ3_FRATT Francisella tularensis subsp. tularensis 3 0.7620
Enoyl-[acyl-carrier-protein] reductase [NADH] Q5NGQ3 Q5NGQ3_FRATT Francisella tularensis subsp. tularensis 3 0.7620
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7610
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7610
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7595
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7595
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7563
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7563
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7563
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7563
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7555
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7555
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Q9R1E6 ENPP2_MOUSE Mus musculus 4 0.7553
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Q9R1E6 ENPP2_MOUSE Mus musculus 4 0.7553
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7553
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7553
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7526
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7526
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7519
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7519
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7507
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7507
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7502
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7502
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7496
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7496
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7480
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7480
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7458
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7458
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7449
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7449
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7440
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7440
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7430
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7430
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7426
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7426
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7424
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7424
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7378
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7378
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7377
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7377
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7347
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7347
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7335
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7335
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7332
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7332
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7325
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7325
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7315
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7315
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7311
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7311
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7270
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7270
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 4 0.7253
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 4 0.7253
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.7250
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.7250
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7243
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7243
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7228
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7228
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7227
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7227
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7226
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7226
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7226
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7226
Bifunctional F420 biosynthesis protein FbiB P9WP79 FBIB_MYCTU Mycobacterium tuberculosis 5 0.7218
Bifunctional F420 biosynthesis protein FbiB P9WP79 FBIB_MYCTU Mycobacterium tuberculosis 5 0.7218
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7216
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7216
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7182
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7182
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7174
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7174
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7173
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7173
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7160
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7160
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7154
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7154
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7141
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7141
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7134
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7134
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7128
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7128
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7121
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7121
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7112
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7112
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7108
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7108
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7106
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7106
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7076
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7076
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7064
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7064
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7048
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7048
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7024
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7024
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7020
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7020
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7017
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7017
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7011
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7011
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7002
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7002

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