5,6,8,4'-tetrahydroxy isoflavone - Compound Card

5,6,8,4'-tetrahydroxy isoflavone

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5,6,8,4'-tetrahydroxy isoflavone

Structure
Zoomed Structure
  • Family: Plantae - Phyllanthaceae-Euphorbiaceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles Oc1ccc(cc1)c1coc2c(c1=O)c(O)c(cc2O)O
InChI InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)9-6-21-15-11(18)5-10(17)14(20)12(15)13(9)19/h1-6,16-18,20H
InChIKey BNMUTGOMEWQLBJ-UHFFFAOYSA-N
Formula C15H10O6
HBA 6
HBD 4
MW 286.24
Rotatable Bonds 1
TPSA 111.13
LogP 2.28
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.0
Exact Mass 286.05
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Phyllanthus atropurpureus Phyllanthaceae-Euphorbiaceae Plantae 634324
2 Phyllanthus atropurpureus Phyllanthaceae-Euphorbiaceae Plantae 634324

Showing of synonyms

  • Sarg T, Abdel- Ghani A, et al. (2012). Bioactive compounds from Phyllanthus atropurpureus. Journal of Natural Products,2012,5,10-20. [View]
  • Sarg T, El Sayed A, et al. (2011). Bioactive compounds from Phyllanthus atropurpureus Bojer cultivated in Egypt. Planta Medica,2011,77-PL56. [View]
Pubchem: 156695537
Nmrshiftdb2: 70070123

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 286.24 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 286.24 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 286.24 g/mol

Antimicrobial

Absorption

Caco-2 (logPapp)
-5.21
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.160
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.26

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.840
Plasma Protein Binding
91.73
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.290
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.880
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.500
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.450
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.850
Rat (Acute)
2.460
Rat (Chronic Oral)
3.260
Fathead Minnow
4.210
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
481.790
Hydration Free Energy
-12.750
Log(D) at pH=7.4
1.950
Log(P)
2.24
Log S
-3.68
Log(Vapor Pressure)
-8.66
Melting Point
301.08
pKa Acid
5.39
pKa Basic
6.85
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9795
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9795
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9703
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9703
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9500
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9500
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.9235
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.9235
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 5 0.9193
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 5 0.9193
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.9116
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.9116
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.9013
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.9013
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9005
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9005
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8965
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8965
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8943
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8943
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8921
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8921
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8909
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8909
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8813
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8813
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8805
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8805
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8786
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8786
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8696
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8696
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8685
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8685
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8672
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8672
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8644
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8644
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8563
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8563
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8549
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8549
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8533
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8533
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8531
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8531
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8516
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8516
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.8499
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.8499
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.8473
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.8473
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.8440
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.8440
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8433
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8433
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8411
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8411
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8405
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8405
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8397
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8397
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8389
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8389
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8376
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8376
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8375
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8375
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8367
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8367
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8335
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8335
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8291
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8291
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8253
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8253
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8208
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8208
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8157
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8157
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8149
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8149
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8147
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8147
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8138
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8138
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8116
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8116
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8104
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8104
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8086
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8086
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8064
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8064
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8059
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8059
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8046
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8046
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8028
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8028
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8010
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8010
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8001
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8001
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7993
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7993
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.7990
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.7990
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7986
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7986
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7980
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7980
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7972
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7972
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7964
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7964
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7962
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7962
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7953
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7953
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7941
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7941
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7920
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7920
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7918
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7918
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7916
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7916
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7858
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7858
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7853
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7853
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7827
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7827
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7808
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7808
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 4 0.7790
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 4 0.7790
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7786
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7786
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7776
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7776
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7742
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7742
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7727
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7727
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7725
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7725
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7721
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7721
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7693
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7693
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7689
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7689
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7685
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7685
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7667
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7667
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7663
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7663
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7656
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7656
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 5 0.7604
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 5 0.7604
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7587
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7587
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7573
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7573
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7566
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7566
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7566
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7566
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7565
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7565
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7562
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7562
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7561
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7561
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7539
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7539
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7537
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7537
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7531
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7531
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7530
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7530
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7509
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7509
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7504
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7504
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7501
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7501
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7495
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7495
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7474
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7474
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7471
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7471
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7461
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7461
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 4 0.7460
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 4 0.7460
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7450
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7450
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7449
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7449
Uridine phosphorylase P12758 UDP_ECOLI Escherichia coli 4 0.7445
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7445
Uridine phosphorylase P12758 UDP_ECOLI Escherichia coli 4 0.7445
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7445
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7434
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7434
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7433
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7433
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7427
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7427
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7423
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7423
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7419
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7419
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7405
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7405
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7402
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7402
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7370
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7370
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7369
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7369
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7365
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7365
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7357
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7357
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7330
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7330
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7310
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7310
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7301
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7301
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7300
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7300
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7291
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7291
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7289
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7289
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7282
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7282
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7281
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7281
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7280
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7280
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7278
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7278
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7272
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7272
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7271
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7271
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7269
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7269
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7256
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7256
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7241
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7241
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7232
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7232
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7215
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7215
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7215
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7215
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7214
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7214
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7206
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7206
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 4 0.7205
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 4 0.7205
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7203
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7203
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7202
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7202
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7195
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7195
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7180
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7180
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7178
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7178
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7178
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7178
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7169
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7169
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 5 0.7168
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 5 0.7168
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7148
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7148
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7147
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7147
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7111
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7111
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7109
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7109
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7108
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7108
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7081
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7081
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7080
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7080
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7080
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7080
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7080
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7080
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7063
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7063
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7060
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7060
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7053
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7053
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7040
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7040
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7039
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7039
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7024
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7024
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7021
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7021
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7020
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7020
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 4 0.7012
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 4 0.7012
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7011
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7011
Ribonuclease TTHA0252 Q5SLP1 RNSE_THET8 Thermus thermophilus 3 0.7006
Ribonuclease TTHA0252 Q5SLP1 RNSE_THET8 Thermus thermophilus 3 0.7006
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7002
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7002
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7000
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7000

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