Alternariol 5-O-methyl ether - Compound Card

Alternariol 5-O-methyl ether

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Alternariol 5-O-methyl ether

Structure
Zoomed Structure
  • Family: Fungi - Pleosporaceae
  • Kingdom: Fungi
  • Class: Flavonoid
Canonical Smiles COc1cc(O)cc2c1c1cc(O)cc(c1c(=O)o2)O
InChI InChI=1S/C14H10O6/c1-19-10-4-7(16)5-11-13(10)8-2-6(15)3-9(17)12(8)14(18)20-11/h2-5,15-17H,1H3
InChIKey ZFRDCJRKYHNWDE-UHFFFAOYSA-N
Formula C14H10O6
HBA 6
HBD 3
MW 274.23
Rotatable Bonds 1
TPSA 100.13
LogP 2.07
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.07
Exact Mass 274.05
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Alternaria species Pleosporaceae Fungi 5598

Showing of synonyms

  • Aly AH, Ebel R, et al. (2009). Protein kinase inhibitors from the endophytic fungus Alternaria sp. isolated from Polygonum senegalense Growing in Egypt. Planta Medica,2009,75-PE55. [View]
Pubchem: 135022001
Nmrshiftdb2: 80005791

No compound-protein relationship available.

Structure

SMILES: c1cccc(c1c23)oc(=O)c2cccc3

Level: 0

Mol. Weight: 274.23 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp)
-5.1
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.900
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.21

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.450
Plasma Protein Binding
74.71
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.660
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.400
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.920
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.450
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.500
Rat (Acute)
2.360
Rat (Chronic Oral)
3.050
Fathead Minnow
4.270
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
461.410
Hydration Free Energy
-10.480
Log(D) at pH=7.4
1.610
Log(P)
2.32
Log S
-5.15
Log(Vapor Pressure)
-6.92
Melting Point
294.69
pKa Acid
8.9
pKa Basic
5.08
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9468
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9468
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9206
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9206
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.9122
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.9122
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9072
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9072
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9039
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9039
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8924
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8924
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8829
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8829
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8756
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8756
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.8746
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.8746
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8734
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8734
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8711
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8711
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8688
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8688
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8632
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8632
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8612
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8612
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8594
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8594
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8585
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8585
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8576
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8576
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 4 0.8542
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 4 0.8542
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8539
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8539
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8515
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8515
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8443
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8443
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8414
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8414
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8405
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8405
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8355
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8355
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8330
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8330
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8301
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8301
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8177
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8177
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8153
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8153
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8148
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8148
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8060
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8060
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.8055
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.8055
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8051
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8051
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8022
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8022
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.8020
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.8020
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7972
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7972
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7965
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7965
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7943
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7943
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7926
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7926
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7904
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7904
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7890
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7890
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7862
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7862
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7826
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7826
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.7804
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.7804
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7803
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7803
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7775
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7775
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7756
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7756
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 4 0.7754
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 4 0.7754
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7718
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7718
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7695
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7695
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7694
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7694
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7674
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7674
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7653
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7653
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7647
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7647
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.7639
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.7639
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7633
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7633
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7597
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7597
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7596
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7596
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7591
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7591
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7586
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7586
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7584
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7584
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7576
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7576
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7554
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7554
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7548
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7548
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7534
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7534
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7521
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7521
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7512
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7512
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7512
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7512
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7506
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7506
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7504
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7504
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7490
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7490
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7482
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7482
Glycoside Hydrolase Family 13 Q65MI2 Q65MI2_BACLD Bacillus licheniformis 3 0.7481
Glycoside Hydrolase Family 13 Q65MI2 Q65MI2_BACLD Bacillus licheniformis 3 0.7481
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7477
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7477
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7471
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7471
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7454
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7454
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7444
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7444
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.7436
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.7436
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7434
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7434
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7432
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7432
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7421
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7421
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7399
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7399
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7394
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7394
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7385
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7385
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7381
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7381
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7353
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7353
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7352
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7352
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7343
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7343
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7325
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7325
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7324
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7324
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7324
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7324
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7306
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7306
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7288
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7288
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7280
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7280
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7279
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7279
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7278
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7278
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7277
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7277
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 4 0.7251
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 4 0.7251
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7241
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7241
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7233
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7233
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7232
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7232
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7221
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7221
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 4 0.7218
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 4 0.7218
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7214
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7214
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7213
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7213
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7209
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7209
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7204
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7204
Orotidine 5'-phosphate decarboxylase O58462 PYRF_PYRHO Pyrococcus horikoshii 3 0.7202
Orotidine 5'-phosphate decarboxylase O58462 PYRF_PYRHO Pyrococcus horikoshii 3 0.7202
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7197
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7197
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7181
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7181
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7177
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7177
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7154
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7154
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7149
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7149
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7148
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7148
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7144
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7144
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7142
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7142
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7139
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7139
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7134
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7134
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7132
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7132
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 4 0.7127
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 4 0.7127
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7122
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7122
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7122
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7122
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 3 0.7112
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 3 0.7112
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7110
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7110
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7109
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7109
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7089
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7089
Ribosomal protein L11 methyltransferase, putative C3MWA1 C3MWA1_SULIM Sulfolobus islandicus 4 0.7088
Ribosomal protein L11 methyltransferase, putative C3MWA1 C3MWA1_SULIM Sulfolobus islandicus 4 0.7088
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7076
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.7076
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.7076
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7076
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.7064
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.7064
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7062
Putative N-acetyl glucosaminyl transferase Q6U8B0 Q6U8B0_RAOTE Raoultella terrigena 3 0.7062
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7062
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7062
Putative N-acetyl glucosaminyl transferase Q6U8B0 Q6U8B0_RAOTE Raoultella terrigena 3 0.7062
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7062
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7053
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7053
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7047
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7047
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7045
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7045
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7045
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7045
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7041
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7041
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7037
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7037
Septum site-determining protein MinD P0AEZ3 MIND_ECOLI Escherichia coli 3 0.7031
Septum site-determining protein MinD P0AEZ3 MIND_ECOLI Escherichia coli 3 0.7031
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7006
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7006
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7001
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7001

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