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Tasnemoxide C

Family: Animalia - Podospongiidae
Kingdom: Animalia
Class: Terpenoid
- Subclass: Cyclic Norsesterterpene Peroxide

Canonical Smiles	COC(=O)[C@H]([C@H]1CC[C@](OO1)(C)CCCC(=C)CCC1(O)C(=C)CCCC1(C)C)C
InChI	InChI=1S/C25H42O5/c1-18(12-17-25(27)19(2)11-9-14-23(25,4)5)10-8-15-24(6)16-13-21(29-30-24)20(3)22(26)28-7/h20-21,27H,1-2,8-17H2,3-7H3/t20-,21+,24-,25?/m0/s1
InChIKey	XFDMAFNMQSQGGI-ZBYPAWQJSA-N
Formula	C₂₅H₄₂O₅
HBA	5
HBD	1
MW	422.61
Rotatable Bonds	9
TPSA	64.99
LogP	5.67
Number Rings	2
Number Aromatic Rings	0
Heavy Atom Count	30
Formal Charge	0
Fraction CSP3	0.8
Exact Mass	422.3
Number of Lipinski Rule Violations	1

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Diacarnus erythraenus	Podospongiidae	Animalia	283431

Showing of synonyms

Youssef DT (2004). Tasnemoxides A-C, new cytotoxic cyclic norsesterterpene peroxides from the Red Sea sponge Diacarnus erythraenus. Journal of Natural Products,2004,67(1),112-114. [View] [PubMed]

Pubchem: 11304758

Cas: 655228-42-5

Chembl: CHEMBL514840

No compound-protein relationship available.

SMILES: C1CCCC(C1=C)CCC(=C)CCCC2CCCOO2

Level: 1

Mol. Weight: 422.61 g/mol

SMILES: C=C1CCCCC1

Level: 0

Mol. Weight: 422.61 g/mol

SMILES: C1CCOOC1

Level: 0

Mol. Weight: 422.61 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp): -4.62
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.660
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.94

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.690
Plasma Protein Binding: 71.99
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 5.890
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 0.480
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -0.630
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.220
Micronucleos: Safe
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -13.120
Rat (Acute): 2.770
Rat (Chronic Oral): 1.860
Fathead Minnow: 4.200
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 398.650
Hydration Free Energy: -4.890
Log(D) at pH=7.4: 4.010
Log(P): 6.07
Log S: -5.68
Log(Vapor Pressure): -6.61
Melting Point: 48.06
pKa Acid: 9.59
pKa Basic: 5.65

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Trichothecene 15-O-acetyltransferase TRI3	Q9C1B7	TRI3_FUSSP	Fusarium sporotrichioides	3	0.9830
Trichothecene 15-O-acetyltransferase TRI3	Q9C1B7	TRI3_FUSSP	Fusarium sporotrichioides	3	0.9830
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.9044
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.9044
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.9034
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.9034
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.9014
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.9014
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8857
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8857
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8506
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8506
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8386
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8386
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.8353
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.8353
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.8332
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.8332
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.8326
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.8326
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.8320
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.8320
Epoxide hydrolase	Q41415	Q41415_SOLTU	Solanum tuberosum	3	0.7997
Epoxide hydrolase	Q41415	Q41415_SOLTU	Solanum tuberosum	3	0.7997
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7986
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7986
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	4	0.7921
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	4	0.7921
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7874
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7874
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7866
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7866
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7758
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7758
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7752
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7752
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7750
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7750
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7738
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7738
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	2	0.7671
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	2	0.7671
Gastrotropin	Q6IMW5	Q6IMW5_DANRE	Danio rerio	2	0.7667
Gastrotropin	Q6IMW5	Q6IMW5_DANRE	Danio rerio	2	0.7667
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7652
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7652
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7650
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7650
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7641
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7641
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7623
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7623
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	2	0.7609
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	2	0.7609
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7605
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7605
Nuclear receptor ROR-gamma	P51449	RORG_HUMAN	Homo sapiens	2	0.7602
Nuclear receptor ROR-gamma	P51449	RORG_HUMAN	Homo sapiens	2	0.7602
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7601
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7601
Fatty acid-binding protein, liver	P80226	FABPL_CHICK	Gallus gallus	2	0.7598
Fatty acid-binding protein, liver	P80226	FABPL_CHICK	Gallus gallus	2	0.7598
NPC intracellular cholesterol transporter 1	O15118	NPC1_HUMAN	Homo sapiens	2	0.7597
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.7597
NPC intracellular cholesterol transporter 1	O15118	NPC1_HUMAN	Homo sapiens	2	0.7597
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.7597
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7575
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7575
Steroid 21-hydroxylase	P08686	CP21A_HUMAN	Homo sapiens	2	0.7561
Steroid 21-hydroxylase	P08686	CP21A_HUMAN	Homo sapiens	2	0.7561
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	2	0.7558
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	2	0.7558
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	2	0.7557
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	2	0.7557
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7548
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7548
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7546
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7546
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7540
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7540
Nuclear receptor subfamily 1 group I member 3	O35627	NR1I3_MOUSE	Mus musculus	2	0.7535
Nuclear receptor subfamily 1 group I member 3	O35627	NR1I3_MOUSE	Mus musculus	2	0.7535
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7521
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7521
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7489
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7489
Retinol-binding protein 4	P18902	RET4_BOVIN	Bos taurus	2	0.7483
Retinol-binding protein 4	P18902	RET4_BOVIN	Bos taurus	2	0.7483
Abscisic acid receptor PYL3	Q9SSM7	PYL3_ARATH	Arabidopsis thaliana	2	0.7480
Abscisic acid receptor PYL3	Q9SSM7	PYL3_ARATH	Arabidopsis thaliana	2	0.7480
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	2	0.7466
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	2	0.7466
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7462
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7462
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	2	0.7460
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	2	0.7460
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7455
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7455
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7451
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7451
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	2	0.7435
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	2	0.7435
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	2	0.7429
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	2	0.7429
Aldo-keto reductase family 1 member C1	Q04828	AK1C1_HUMAN	Homo sapiens	2	0.7423
Aldo-keto reductase family 1 member C1	Q04828	AK1C1_HUMAN	Homo sapiens	2	0.7423
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7419
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7419
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7415
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7415
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7413
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7413
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7386
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7386
Vitamin D-binding protein	P02774	VTDB_HUMAN	Homo sapiens	2	0.7379
Vitamin D-binding protein	P02774	VTDB_HUMAN	Homo sapiens	2	0.7379
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7374
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7374
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7372
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7372
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	2	0.7362
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	2	0.7362
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7352
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7352
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	2	0.7325
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	2	0.7325
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.7312
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.7312
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	2	0.7310
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7310
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	2	0.7310
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7310
Prostaglandin reductase 2	Q8N8N7	PTGR2_HUMAN	Homo sapiens	2	0.7302
Prostaglandin reductase 2	Q8N8N7	PTGR2_HUMAN	Homo sapiens	2	0.7302
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7299
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7299
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7278
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7278
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	2	0.7276
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	2	0.7276
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7243
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7243
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	2	0.7232
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	2	0.7232
Ferrichrome outer membrane transporter/phage receptor	P06971	FHUA_ECOLI	Escherichia coli	3	0.7222
Ferrichrome outer membrane transporter/phage receptor	P06971	FHUA_ECOLI	Escherichia coli	3	0.7222
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7216
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7216
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	2	0.7214
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	2	0.7214
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	3	0.7212
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	3	0.7212
11-beta-hydroxysteroid dehydrogenase 1	P50172	DHI1_MOUSE	Mus musculus	2	0.7207
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	2	0.7207
11-beta-hydroxysteroid dehydrogenase 1	P50172	DHI1_MOUSE	Mus musculus	2	0.7207
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	2	0.7207
Trichodiene synthase	P13513	TRI5_FUSSP	Fusarium sporotrichioides	2	0.7201
Trichodiene synthase	P13513	TRI5_FUSSP	Fusarium sporotrichioides	2	0.7201
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	2	0.7194
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	2	0.7194
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.7186
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.7186
Alcohol dehydrogenase 1C	P00326	ADH1G_HUMAN	Homo sapiens	2	0.7184
Alcohol dehydrogenase 1C	P00326	ADH1G_HUMAN	Homo sapiens	2	0.7184
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	2	0.7178
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	2	0.7178
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7174
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7174
Nuclear receptor ROR-beta	P45446	RORB_RAT	Rattus norvegicus	2	0.7170
Nuclear receptor ROR-beta	P45446	RORB_RAT	Rattus norvegicus	2	0.7170
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	2	0.7156
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	2	0.7156
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	2	0.7149
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	2	0.7149
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	2	0.7144
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	2	0.7144
Quorum-sensing transcriptional activator	Q8XBD0	Q8XBD0_ECO57	Escherichia coli O157:H7	2	0.7132
Quorum-sensing transcriptional activator	Q8XBD0	Q8XBD0_ECO57	Escherichia coli O157:H7	2	0.7132
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7119
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7119
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	2	0.7115
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	2	0.7115
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	2	0.7064
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	2	0.7064
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7062
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7062
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	2	0.7027
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	2	0.7027
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	3	0.7016
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	3	0.7016

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