Aikupikoxide A - Compound Card

Aikupikoxide A

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Aikupikoxide A

Structure
Zoomed Structure
  • Family: Animalia - Podospongiidae
  • Kingdom: Animalia
  • Class: Terpenoid
    • Subclass: Norsesterterpene Cyclic Peroxide
Canonical Smiles CC(=CCCC1(C)CCC(OO1)C(C(=O)O)C)CCC(=O)C(CCCC(=O)C)(C)C
InChI InChI=1S/C24H40O6/c1-17(11-12-21(26)23(4,5)14-8-10-18(2)25)9-7-15-24(6)16-13-20(29-30-24)19(3)22(27)28/h9,19-20H,7-8,10-16H2,1-6H3,(H,27,28)
InChIKey UCWHHFGTUDDROG-UHFFFAOYSA-N
Formula C24H40O6
HBA 5
HBD 1
MW 424.58
Rotatable Bonds 13
TPSA 89.9
LogP 5.44
Number Rings 1
Number Aromatic Rings 0
Heavy Atom Count 30
Formal Charge 0
Fraction CSP3 0.79
Exact Mass 424.28
Number of Lipinski Rule Violations 1
# Species Family Kingdom NCBI Taxonomy ID
1 Diacarnus erythraenus Podospongiidae Animalia 283431

Showing of synonyms

  • Youssef DT, Yoshida WY, et al. (2001). Cytotoxic cyclic norterpene peroxides from a Red Sea sponge Diacarnus erythraenus. Journal of Natural Products,2001,64(10),1332-1335. [View] [PubMed]
Pubchem: 73196956

No compound-protein relationship available.

Structure

SMILES: C1CCOOC1

Level: 0

Mol. Weight: 424.58 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp)
-5.05
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.83
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.74

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.74
Plasma Protein Binding
45.75
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
1.62
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.01
Biodegradation
Toxic
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.62
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.12
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-6.9
Rat (Acute)
2.09
Rat (Chronic Oral)
2.2
Fathead Minnow
4.29
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
424.01
Hydration Free Energy
-5.38
Log(D) at pH=7.4
1.21
Log(P)
4.63
Log S
-4.3
Log(Vapor Pressure)
-7.5
Melting Point
62.58
pKa Acid
6.07
pKa Basic
5.05
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.9736
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.9736
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9715
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9715
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.9708
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.9708
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.9570
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.9570
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.9548
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.9548
Fatty acid-binding protein 10-A, liver basic Q9I8L5 FA10A_DANRE Danio rerio 3 0.9479
Fatty acid-binding protein 10-A, liver basic Q9I8L5 FA10A_DANRE Danio rerio 3 0.9479
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9385
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9385
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.9300
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.9300
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9294
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9294
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.9266
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.9266
Branched-chain-amino-acid aminotransferase, mitochondrial O15382 BCAT2_HUMAN Homo sapiens 3 0.9236
Branched-chain-amino-acid aminotransferase, mitochondrial O15382 BCAT2_HUMAN Homo sapiens 3 0.9236
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.9101
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.9101
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.9040
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.9040
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.9019
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9019
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.9019
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9019
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9016
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9016
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8979
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8979
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.8941
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.8941
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.8932
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.8932
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8863
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8863
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.8855
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.8855
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.8836
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.8836
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8801
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8801
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8797
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8797
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8796
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8796
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 4 0.8763
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 4 0.8763
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8761
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8761
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8722
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8722
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.8708
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.8708
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8703
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8703
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8696
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8696
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8635
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8635
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8582
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8582
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 3 0.8546
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 3 0.8546
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8545
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8545
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.8515
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.8515
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 3 0.8480
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 3 0.8480
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.8479
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.8479
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.8464
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.8464
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8438
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8438
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8431
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8431
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8430
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8430
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.8396
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.8396
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8391
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8391
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 3 0.8377
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 3 0.8377
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8376
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8376
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 4 0.8339
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 4 0.8339
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8325
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8325
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8255
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8255
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 4 0.8238
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 4 0.8238
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.8236
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.8236
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.8232
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.8232
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8231
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8231
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 4 0.8215
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 4 0.8215
Muconolactone Delta-isomerase Q8G9L0 Q8G9L0_RHOOP Rhodococcus opacus 3 0.8206
Muconolactone Delta-isomerase Q8G9L0 Q8G9L0_RHOOP Rhodococcus opacus 3 0.8206
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.8184
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.8184
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 3 0.8167
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 3 0.8167
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 3 0.8113
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 3 0.8113
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8110
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8110
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8103
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8103
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.8054
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.8054
Lanosterol 14-alpha-demethylase Q385E8 Q385E8_TRYB2 Trypanosoma brucei brucei 3 0.8045
Lanosterol 14-alpha-demethylase Q385E8 Q385E8_TRYB2 Trypanosoma brucei brucei 3 0.8045
Cellular retinoic acid-binding protein 2 P29373 RABP2_HUMAN Homo sapiens 3 0.8039
Cellular retinoic acid-binding protein 2 P29373 RABP2_HUMAN Homo sapiens 3 0.8039
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.8033
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.8033
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.8030
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.8030
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8016
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8016
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7944
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7944
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7941
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7941
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7938
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7938
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7925
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7925
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.7917
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.7917
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.7917
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.7917
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7908
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7908
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7871
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7871
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7871
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7871
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.7846
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.7846
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7824
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7824
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7821
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7821
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 3 0.7812
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 3 0.7812
Phospholipase A2 P00593 PA21B_BOVIN Bos taurus 3 0.7807
Phospholipase A2 P00593 PA21B_BOVIN Bos taurus 3 0.7807
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7803
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7803
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7777
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7777
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7770
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7770
Vitamin D(3) 25-hydroxylase C4B644 CPVDH_PSEAH Pseudonocardia autotrophica 3 0.7768
Vitamin D(3) 25-hydroxylase C4B644 CPVDH_PSEAH Pseudonocardia autotrophica 3 0.7768
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7764
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7764
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.7750
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.7750
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7744
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7744
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7742
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7742
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 4 0.7733
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 4 0.7733
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7725
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7725
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7676
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7676
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7673
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7673
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7656
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7656
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7644
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7644
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7627
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7627
Nuclear receptor ROR-alpha P35398 RORA_HUMAN Homo sapiens 3 0.7620
Nuclear receptor ROR-alpha P35398 RORA_HUMAN Homo sapiens 3 0.7620
Avidin P02701 AVID_CHICK Gallus gallus 3 0.7600
Avidin P02701 AVID_CHICK Gallus gallus 3 0.7600
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 4 0.7587
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 4 0.7587
12-oxophytodienoate reductase 1 Q9XG54 OPR1_SOLLC Solanum lycopersicum 3 0.7583
12-oxophytodienoate reductase 1 Q9XG54 OPR1_SOLLC Solanum lycopersicum 3 0.7583
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 3 0.7574
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 3 0.7574
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7549
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7549
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7524
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7524
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7499
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7499
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7496
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7496
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 4 0.7486
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 4 0.7486
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7479
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7479
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7475
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7475
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7437
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7437
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 4 0.7433
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 4 0.7433
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7429
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7429
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7421
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7421
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7407
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7407
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 4 0.7388
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 4 0.7388
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 3 0.7379
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 3 0.7379
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7375
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7375
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7338
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7338
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7330
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7330
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase P9WNH5 HSAD_MYCTU Mycobacterium tuberculosis 2 0.7326
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase P9WNH5 HSAD_MYCTU Mycobacterium tuberculosis 2 0.7326
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7322
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7322
Jasmonoyl--L-amino acid synthetase JAR1 Q9SKE2 JAR1_ARATH Arabidopsis thaliana 3 0.7321
Jasmonoyl--L-amino acid synthetase JAR1 Q9SKE2 JAR1_ARATH Arabidopsis thaliana 3 0.7321
Abscisic acid receptor PYL10 Q8H1R0 PYL10_ARATH Arabidopsis thaliana 3 0.7308
Abscisic acid receptor PYL10 Q8H1R0 PYL10_ARATH Arabidopsis thaliana 3 0.7308
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7299
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7299
Lanosterol synthase P48449 ERG7_HUMAN Homo sapiens 3 0.7298
Lanosterol synthase P48449 ERG7_HUMAN Homo sapiens 3 0.7298
Ferric enterobactin-binding periplasmic protein FepB P0AEL6 FEPB_ECOLI Escherichia coli 3 0.7287
Ferric enterobactin-binding periplasmic protein FepB P0AEL6 FEPB_ECOLI Escherichia coli 3 0.7287
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.7284
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.7284
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7283
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7283
Deacetoxycephalosporin C synthase P18548 CEFE_STRCL Streptomyces clavuligerus 3 0.7278
Deacetoxycephalosporin C synthase P18548 CEFE_STRCL Streptomyces clavuligerus 3 0.7278
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7264
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7264
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7251
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7251
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7247
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7247
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7237
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7237
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7235
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7235
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.7222
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.7222
Alpha/beta hydrolase fold protein D2J2T6 D2J2T6_9RHIZ Ochrobactrum sp. T63 2 0.7214
Alpha/beta hydrolase fold protein D2J2T6 D2J2T6_9RHIZ Ochrobactrum sp. T63 2 0.7214
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7212
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7212
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7209
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7209
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7199
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7199
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 2 0.7190
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 2 0.7190
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7187
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7187
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7180
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7180
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7178
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7178
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 3 0.7124
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 3 0.7124
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7120
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7120
Bile acid receptor Q62735 NR1H4_RAT Rattus norvegicus 4 0.7100
Bile acid receptor Q62735 NR1H4_RAT Rattus norvegicus 4 0.7100
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7092
Trichodiene synthase P13513 TRI5_FUSSP Fusarium sporotrichioides 2 0.7092
Trichodiene synthase P13513 TRI5_FUSSP Fusarium sporotrichioides 2 0.7092
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7092
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 3 0.7091
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 3 0.7091
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7073
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7073
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7068
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7068
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7056
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7056
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.7048
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.7048
Carboxyethyl-arginine beta-lactam-synthase P0DJQ7 BLS_STRCL Streptomyces clavuligerus 2 0.7046
Carboxyethyl-arginine beta-lactam-synthase P0DJQ7 BLS_STRCL Streptomyces clavuligerus 2 0.7046
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7041
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7041
Beta-elicitin cryptogein P15570 ELIB_PHYCR Phytophthora cryptogea 3 0.7037
Beta-elicitin cryptogein P15570 ELIB_PHYCR Phytophthora cryptogea 3 0.7037
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7029
Fatty acid-binding protein 10-A, liver basic Q9I8L5 FA10A_DANRE Danio rerio 3 0.7029
Fatty acid-binding protein 10-A, liver basic Q9I8L5 FA10A_DANRE Danio rerio 3 0.7029
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7029
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7024
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7024
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7005
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7005

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