Alternariol 5-O-methyl ether-4'-O-sulphate - Compound Card

Alternariol 5-O-methyl ether-4'-O-sulphate

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Alternariol 5-O-methyl ether-4'-O-sulphate

Structure
Zoomed Structure
  • Family: Fungi - Pleosporineae
  • Kingdom: Fungi
  • Class: Heterocyclic
    • Subclass: Coumestan
Canonical Smiles COc1cc(O)c2c(c1)c1c(C)cc(cc1oc2=O)OS(=O)(=O)O
InChI InChI=1S/C15H12O8S/c1-7-3-9(23-24(18,19)20)6-12-13(7)10-4-8(21-2)5-11(16)14(10)15(17)22-12/h3-6,16H,1-2H3,(H,18,19,20)
InChIKey MHJGYDSKCRKBQS-UHFFFAOYSA-N
Formula C15H12O8S
HBA 7
HBD 2
MW 352.32
Rotatable Bonds 3
TPSA 123.27
LogP 2.15
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 24
Formal Charge 0
Fraction CSP3 0.13
Exact Mass 352.03
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Alternaria species Pleosporineae Fungi 5598

Showing of synonyms

  • Aly AH, Edrada-Ebel R, et al. (2008). Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense. Journal of Natural Products,2008,71(6),972-980. [View] [PubMed]
Pubchem: 24899918
Nmrshiftdb2: 80005814

No compound-protein relationship available.

Structure

SMILES: c1cccc(c1c23)oc(=O)c2cccc3

Level: 0

Mol. Weight: 352.32 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.32
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.090
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-3.13

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.430
Plasma Protein Binding
67.38
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.960
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.230
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.590
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.900
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
7.800
Rat (Acute)
2.250
Rat (Chronic Oral)
2.850
Fathead Minnow
3.920
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
492.420
Hydration Free Energy
-7.800
Log(D) at pH=7.4
1.480
Log(P)
-0.01
Log S
-2.59
Log(Vapor Pressure)
-9.39
Melting Point
190.62
pKa Acid
8.04
pKa Basic
3.08
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.9284
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.9284
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.9227
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.9227
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9048
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9048
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.9013
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.9013
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8993
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8993
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8919
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8919
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8875
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8875
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.8853
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.8853
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8790
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8790
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8728
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8728
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8710
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8710
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.8706
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.8706
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8666
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8666
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8627
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8627
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 4 0.8625
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 4 0.8625
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.8606
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.8606
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8596
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8596
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8582
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8582
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8577
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8577
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8576
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8576
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8528
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8528
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8507
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8507
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8491
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8491
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8471
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8471
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8469
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8469
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8299
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8299
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 4 0.8272
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 4 0.8272
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8251
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8251
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8183
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8183
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8147
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8147
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 3 0.8136
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 3 0.8136
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8124
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8124
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8120
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8120
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8096
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8096
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8068
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8068
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 4 0.8065
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 4 0.8065
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 3 0.8052
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 3 0.8052
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 3 0.8012
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 3 0.8012
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8005
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8005
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7987
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7987
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7956
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7956
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7929
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7929
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7929
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7929
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7921
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7921
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7900
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7900
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7888
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7888
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7859
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7859
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.7854
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.7854
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7851
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7851
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7851
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7851
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7820
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7820
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7768
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7768
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7767
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7767
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7728
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7728
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 4 0.7696
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 4 0.7696
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7686
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7686
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7679
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7679
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7667
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7667
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7655
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7655
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7631
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7631
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7630
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7630
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7627
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7627
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7624
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7624
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7620
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7620
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7602
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7602
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7599
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7599
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7564
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7564
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7532
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7532
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7509
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7509
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7492
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7492
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7482
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7482
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7480
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7480
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7470
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7470
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7450
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7450
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 4 0.7424
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 4 0.7424
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7421
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7421
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7412
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7412
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7403
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7403
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7395
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7395
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7390
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7390
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7389
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7389
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7375
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7375
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7371
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7371
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7367
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7367
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 3 0.7324
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 3 0.7324
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7321
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7321
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7314
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7314
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7288
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7288
Orotidine 5'-phosphate decarboxylase Q5L0U0 PYRF_GEOKA Geobacillus kaustophilus 3 0.7250
Orotidine 5'-phosphate decarboxylase Q5L0U0 PYRF_GEOKA Geobacillus kaustophilus 3 0.7250
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7242
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7242
Bromodomain testis-specific protein Q58F21 BRDT_HUMAN Homo sapiens 3 0.7241
Bromodomain testis-specific protein Q58F21 BRDT_HUMAN Homo sapiens 3 0.7241
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7241
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7241
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7224
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7224
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 3 0.7219
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 3 0.7219
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7210
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7210
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7194
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7194
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7191
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7191
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7167
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7167
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7139
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7139
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7121
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7121
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7113
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7113
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7106
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7106
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7104
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7104
Putative secreted protein C9Z6T8 C9Z6T8_STRSW Streptomyces scabiei 4 0.7096
Putative secreted protein C9Z6T8 C9Z6T8_STRSW Streptomyces scabiei 4 0.7096
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7092
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7092
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7084
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7084
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7084
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7084
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7072
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7072
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 3 0.7070
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 3 0.7070
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7063
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7063
Phospholipase A2, membrane associated P14555 PA2GA_HUMAN Homo sapiens 3 0.7042
Phospholipase A2, membrane associated P14555 PA2GA_HUMAN Homo sapiens 3 0.7042
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7039
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7039
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7030
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7030
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7026
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7026
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7022
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7022
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7000
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7000

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