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Alterlactone

Family: Fungi - Pleosporaceae
Kingdom: Fungi
Class: Coumarin
- Subclass: Coumestan

Canonical Smiles	COc1cc(O)c2c(c1)c1cc(O)c(cc1COC2=O)O
InChI	InChI=1S/C15H12O6/c1-20-8-3-10-9-5-12(17)11(16)2-7(9)6-21-15(19)14(10)13(18)4-8/h2-5,16-18H,6H2,1H3
InChIKey	JAAWVSLYMPCCOD-UHFFFAOYSA-N
Formula	C₁₅H₁₂O₆
HBA	6
HBD	3
MW	288.25
Rotatable Bonds	1
TPSA	96.22
LogP	2.15
Number Rings	3
Number Aromatic Rings	2
Heavy Atom Count	21
Formal Charge	0
Fraction CSP3	0.13
Exact Mass	288.06
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Alternaria species	Pleosporaceae	Fungi	5598
2	Alternaria species	Pleosporineae	Fungi	5598

Showing of synonyms

Aly AH, Edrada-Ebel R, et al. (2008). Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense. Journal of Natural Products,2008,71(6),972-980. [View] [PubMed]

Pubchem: 24899917

Cas: 1030376-89-6

Zinc: ZINC000040979343

Nmrshiftdb2: 80005816

Chembl: CHEMBL507058

Bindingdb: 50479262

No compound-protein relationship available.

SMILES: c1cccc(c1c23)COC(=O)c2cccc3

Level: 0

Mol. Weight: 288.25 g/mol

Cytotoxic

Kinase inhibitory

Absorption

Caco-2 (logPapp): -4.91
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.920
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.7

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.940
Plasma Protein Binding: 59.67
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 11.170
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 0.980
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 0.620
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 4.930
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 4.470
Rat (Acute): 2.280
Rat (Chronic Oral): 2.710
Fathead Minnow: 4.380
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Toxic

General Properties

Boiling Point: 447.710
Hydration Free Energy: -10.160
Log(D) at pH=7.4: 2.280
Log(P): 1.74
Log S: -3.52
Log(Vapor Pressure): -7.3
Melting Point: 254.49
pKa Acid: 7.84
pKa Basic: 4.79

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	4	0.9452
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	4	0.9452
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9422
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9422
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.9280
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.9280
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	4	0.9266
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	4	0.9266
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.9260
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.9260
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.9165
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.9165
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9156
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9156
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8971
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8971
Cytochrome P450	Q93H81	Q93H81_STRAX	Streptomyces avermitilis	3	0.8911
Cytochrome P450	Q93H81	Q93H81_STRAX	Streptomyces avermitilis	3	0.8911
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.8871
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.8871
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8850
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8850
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.8820
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.8820
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8776
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8776
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8764
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8764
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.8713
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.8713
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8702
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8702
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8646
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8646
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.8590
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.8590
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.8535
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.8535
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8492
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8492
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.8481
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.8481
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.8463
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.8463
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8444
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8444
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8434
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8434
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8410
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8410
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8336
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8336
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.8321
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.8321
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	3	0.8315
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	3	0.8315
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.8242
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.8242
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.8222
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.8222
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8182
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8182
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8180
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8180
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.8170
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.8170
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8169
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8169
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.8162
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.8162
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.8142
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.8142
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.8140
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.8140
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8134
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8134
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.8125
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.8125
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8107
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8107
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.8103
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.8103
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8098
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8098
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8080
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8080
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	4	0.8070
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	4	0.8070
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.8035
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8035
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8035
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.8035
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8024
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8024
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.8005
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.8005
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8004
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8004
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.7998
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.7998
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	3	0.7982
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	3	0.7982
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7981
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7981
5-methylthioadenosine/S-adenosylhomocysteine deaminase	Q7NZ90	Q7NZ90_CHRVO	Chromobacterium violaceum	3	0.7972
5-methylthioadenosine/S-adenosylhomocysteine deaminase	Q7NZ90	Q7NZ90_CHRVO	Chromobacterium violaceum	3	0.7972
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.7962
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.7962
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	4	0.7902
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	4	0.7902
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7890
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7890
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	4	0.7873
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7873
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7873
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	4	0.7873
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.7810
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.7810
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	3	0.7792
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	3	0.7792
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	3	0.7778
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	3	0.7778
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7757
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7757
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	4	0.7732
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	4	0.7732
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7729
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7729
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7666
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7666
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	3	0.7659
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	3	0.7659
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	5	0.7622
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	5	0.7622
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7593
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7593
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7572
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7572
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7549
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7549
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7535
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7535
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7488
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7488
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7478
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7478
EbrA repressor	Q79SH7	Q79SH7_STRLI	Streptomyces lividans	3	0.7458
EbrA repressor	Q79SH7	Q79SH7_STRLI	Streptomyces lividans	3	0.7458
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7453
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7453
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7434
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7434
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	4	0.7431
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	4	0.7431
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7428
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7428
TetR family transcriptional regulator	Q58L87	Q58L87_MYCSM	Mycolicibacterium smegmatis	3	0.7425
TetR family transcriptional regulator	Q58L87	Q58L87_MYCSM	Mycolicibacterium smegmatis	3	0.7425
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7421
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7421
Ephrin type-B receptor 4	P54760	EPHB4_HUMAN	Homo sapiens	3	0.7407
Ephrin type-B receptor 4	P54760	EPHB4_HUMAN	Homo sapiens	3	0.7407
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.7405
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.7405
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	2	0.7401
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	2	0.7401
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7391
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7391
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7388
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7388
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7388
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7388
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7374
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7374
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.7370
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.7370
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7368
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7368
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7366
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7366
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.7357
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.7357
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7355
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7355
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.7318
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.7318
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7301
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.7301
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7301
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.7301
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7293
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7293
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7289
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7289
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.7269
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.7269
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7256
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7256
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A	Q13946	PDE7A_HUMAN	Homo sapiens	3	0.7225
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A	Q13946	PDE7A_HUMAN	Homo sapiens	3	0.7225
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7224
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7224
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7223
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7223
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7217
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7217
Acetylcholine-binding protein	P58154	ACHP_LYMST	Lymnaea stagnalis	3	0.7215
Acetylcholine-binding protein	P58154	ACHP_LYMST	Lymnaea stagnalis	3	0.7215
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7205
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7205
Lysozyme C II	P11941	LYSC2_ONCMY	Oncorhynchus mykiss	3	0.7204
Lysozyme C II	P11941	LYSC2_ONCMY	Oncorhynchus mykiss	3	0.7204
16S rRNA (guanine(1405)-N(7))-methyltransferase	Q763K9	Q763K9_ECOLX	Escherichia coli	3	0.7202
16S rRNA (guanine(1405)-N(7))-methyltransferase	Q763K9	Q763K9_ECOLX	Escherichia coli	3	0.7202
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7198
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7198
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7195
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7195
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7187
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7187
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7139
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7139
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7137
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7137
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7127
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7127
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7125
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7125
Catalase-peroxidase 2	O59651	KATG2_HALMA	Haloarcula marismortui	3	0.7115
Catalase-peroxidase 2	O59651	KATG2_HALMA	Haloarcula marismortui	3	0.7115
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7107
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7107
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7073
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7073
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7072
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7072
orotidine-5'-phosphate decarboxylase	Q8T6J6	Q8T6J6_PLAFA	Plasmodium falciparum	4	0.7056
orotidine-5'-phosphate decarboxylase	Q8T6J6	Q8T6J6_PLAFA	Plasmodium falciparum	4	0.7056
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7039
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7039
Tyrosine 3-monooxygenase	P04177	TY3H_RAT	Rattus norvegicus	3	0.7032
Tyrosine 3-monooxygenase	P04177	TY3H_RAT	Rattus norvegicus	3	0.7032
GTPase IMAP family member 2	Q9UG22	GIMA2_HUMAN	Homo sapiens	3	0.7030
GTPase IMAP family member 2	Q9UG22	GIMA2_HUMAN	Homo sapiens	3	0.7030
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7027
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7027
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7024
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7024
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7016
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7016
Deoxycytidine kinase	P27707	DCK_HUMAN	Homo sapiens	4	0.7003
Deoxycytidine kinase	P27707	DCK_HUMAN	Homo sapiens	4	0.7003
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.7002
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.7002

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