3-methyl-3-butenyl (E)-caffeate - Compound Card

3-methyl-3-butenyl (E)-caffeate

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3-methyl-3-butenyl (E)-caffeate

Structure
Zoomed Structure
  • Family: Animalia - Apidae
  • Kingdom: Animalia
  • Class: Phenolic
    • Subclass: Caffeic Acid Derivative
Canonical Smiles CC(=C)CCOC(=O)/C=C/c1ccc(c(c1)O)O
InChI InChI=1S/C14H16O4/c1-10(2)7-8-18-14(17)6-4-11-3-5-12(15)13(16)9-11/h3-6,9,15-16H,1,7-8H2,2H3/b6-4+
InChIKey APFXJJMDUXKKAG-GQCTYLIASA-N
Formula C14H16O4
HBA 4
HBD 2
MW 248.28
Rotatable Bonds 5
TPSA 66.76
LogP 2.62
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 18
Formal Charge 0
Fraction CSP3 0.21
Exact Mass 248.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Apis species Apidae Animalia 7459

Showing of synonyms

  • Piccinelli AL, Mencherini T, et al. (2013). Chemical composition and antioxidant activity of Algerian propolis. Journal of Agricultural and Food Chemistry,2013,61(21),5080-5088. [View] [PubMed]
Pubchem: 14237599
Nmrshiftdb2: 80004901

No compound-protein relationship available.

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 248.28 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.52
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.42
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.34

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.64
Plasma Protein Binding
31.56
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
12.52
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.36
Biodegradation
Toxic
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.46
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
4.69
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
5.17
Rat (Acute)
2.0
Rat (Chronic Oral)
2.49
Fathead Minnow
4.3
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
353.94
Hydration Free Energy
-10.84
Log(D) at pH=7.4
2.25
Log(P)
3.28
Log S
-3.31
Log(Vapor Pressure)
-5.26
Melting Point
105.01
pKa Acid
8.99
pKa Basic
4.76
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9359
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9359
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.9211
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.9211
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.9175
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.9175
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.9159
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.9159
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.9150
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.9150
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9149
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9149
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9122
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9122
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.9121
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.9121
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9070
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9070
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.9030
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.9030
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9009
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9009
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8999
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8999
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8998
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8998
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8992
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8992
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8922
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8922
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 4 0.8812
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 4 0.8812
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8764
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8764
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.8687
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.8687
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8680
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8680
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8676
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8676
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.8623
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.8623
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.8507
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.8507
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8458
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8458
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8451
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8451
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8439
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8439
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8365
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8365
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8352
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8352
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8315
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8315
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8290
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8290
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8267
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8267
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8256
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8256
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8244
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8244
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8188
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8188
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8097
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8097
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8093
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8093
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8084
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8084
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8074
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8074
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8059
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8059
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7989
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7989
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7927
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7927
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7886
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7886
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7881
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7881
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.7868
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.7868
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7836
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7836
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7801
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7801
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7798
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7798
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7785
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7785
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7777
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7777
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7765
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7765
Cytochrome P450 3A4 P08684 CP3A4_HUMAN Homo sapiens 3 0.7754
Cytochrome P450 3A4 P08684 CP3A4_HUMAN Homo sapiens 3 0.7754
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7726
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7726
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7705
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7705
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7698
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7698
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7685
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7685
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7671
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7671
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7668
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7668
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.7664
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.7664
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7654
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7654
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7641
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7641
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7637
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7637
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7633
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7633
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7626
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7626
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7621
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7621
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7617
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7617
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7613
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7613
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 3 0.7610
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 3 0.7610
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7602
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7602
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7582
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7582
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7579
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7579
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7566
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7566
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7546
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7546
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7511
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7511
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7506
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7506
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7503
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7503
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7501
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7501
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7483
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7483
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7481
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7481
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7472
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7472
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7460
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7460
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7454
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7454
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7431
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7431
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7416
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7416
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7410
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7410
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7408
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7408
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7393
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7393
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7390
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7390
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7372
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7372
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7370
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7370
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7361
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7361
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.7342
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.7342
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7333
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7333
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7328
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7328
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7324
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7324
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7314
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7314
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7303
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7303
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7285
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7285
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7284
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7284
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7275
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7275
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7265
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7265
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7258
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7258
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7248
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7248
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7246
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7246
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7229
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7229
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7208
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7208
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7206
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7206
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7202
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7202
Tryptophan--tRNA ligase Q9PIB4 SYW_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 4 0.7193
Tryptophan--tRNA ligase Q9PIB4 SYW_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 4 0.7193
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7174
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7174
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7163
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7163
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7161
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7161
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 3 0.7158
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 3 0.7158
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7156
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7156
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7149
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7149
Ribosomal RNA small subunit methyltransferase Nep1 Q57977 NEP1_METJA Methanocaldococcus jannaschii 3 0.7146
Ribosomal RNA small subunit methyltransferase Nep1 Q57977 NEP1_METJA Methanocaldococcus jannaschii 3 0.7146
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7144
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7144
Thymidylate synthase Q4JQW2 TYSY_VZVO Varicella-zoster virus 3 0.7142
Thymidylate synthase Q4JQW2 TYSY_VZVO Varicella-zoster virus 3 0.7142
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7134
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7134
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7131
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7131
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7130
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7130
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7129
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7129
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7128
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7128
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7127
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7127
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7121
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7121
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7120
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7120
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7115
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7115
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7113
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7113
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7111
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7111
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7111
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7111
Guanylate kinase P15454 KGUA_YEAST Saccharomyces cerevisiae 3 0.7107
Guanylate kinase P15454 KGUA_YEAST Saccharomyces cerevisiae 3 0.7107
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7103
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7103
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7093
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7093
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 Q8GZB6 SUVH4_ARATH Arabidopsis thaliana 3 0.7088
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7088
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7088
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 Q8GZB6 SUVH4_ARATH Arabidopsis thaliana 3 0.7088
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7085
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7085
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7072
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7072
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7069
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7069
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7067
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7067
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7062
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7062
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7060
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7060
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7057
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7057
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7057
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7057
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7053
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7053
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 3 0.7052
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 3 0.7052
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7046
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7046
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7036
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 3 0.7036
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 3 0.7036
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7036
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7029
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7029
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7023
LD-carboxypeptidase A0A6L8PVW7 A0A1Q4LWC0_BACAN Bacillus anthracis 3 0.7023
LD-carboxypeptidase A0A6L8PVW7 A0A1Q4LWC0_BACAN Bacillus anthracis 3 0.7023
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7023
Kynurenine--oxoglutarate transaminase 1 Q16773 KAT1_HUMAN Homo sapiens 2 0.7020
Kynurenine--oxoglutarate transaminase 1 Q16773 KAT1_HUMAN Homo sapiens 2 0.7020
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7017
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7017
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7005
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7005
SKP1-like protein 1A Q39255 SKP1A_ARATH Arabidopsis thaliana 3 0.7003
SKP1-like protein 1A Q39255 SKP1A_ARATH Arabidopsis thaliana 3 0.7003
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7002
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7002

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