Pinobanksin 3-(E)-caffeate - Compound Card

Pinobanksin 3-(E)-caffeate

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Pinobanksin 3-(E)-caffeate

Structure
Zoomed Structure
  • Family: Animalia - Apidae
  • Kingdom: Animalia
  • Class: Flavonoid
    • Subclass: Flavanonol
Canonical Smiles O=C(O[C@@H]1[C@H](Oc2c(C1=O)c(O)cc(c2)O)c1ccccc1)/C=C/c1ccc(c(c1)O)O
InChI InChI=1S/C24H18O8/c25-15-11-18(28)21-19(12-15)31-23(14-4-2-1-3-5-14)24(22(21)30)32-20(29)9-7-13-6-8-16(26)17(27)10-13/h1-12,23-28H/b9-7+/t23-,24+/m1/s1
InChIKey ONJCIGFCUCTTGU-RQYSCLCCSA-N
Formula C24H18O8
HBA 8
HBD 4
MW 434.4
Rotatable Bonds 4
TPSA 133.52
LogP 3.45
Number Rings 4
Number Aromatic Rings 3
Heavy Atom Count 32
Formal Charge 0
Fraction CSP3 0.08
Exact Mass 434.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Apis species Apidae Animalia 7459

Showing of synonyms

  • Piccinelli AL, Mencherini T, et al. (2013). Chemical composition and antioxidant activity of Algerian propolis. Journal of Agricultural and Food Chemistry,2013,61(21),5080-5088. [View] [PubMed]
Pubchem: 163036752
Nmrshiftdb2: 80004898

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C=CC(=O)OC(C2=O)C(c3ccccc3)Oc(c24)cccc4

Level: 2

Mol. Weight: 434.4 g/mol

Structure

SMILES: c1ccccc1C=CC(=O)OC(C2=O)COc(c23)cccc3

Level: 1

Mol. Weight: 434.4 g/mol

Structure

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 434.4 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 434.4 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 434.4 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.81
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.79
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.51

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.34
Plasma Protein Binding
99.75
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.96
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.05
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.11
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.69
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
-81.3
Rat (Acute)
2.4
Rat (Chronic Oral)
3.31
Fathead Minnow
5.24
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
532.0
Hydration Free Energy
-3.29
Log(D) at pH=7.4
2.93
Log(P)
4.38
Log S
-5.62
Log(Vapor Pressure)
-11.35
Melting Point
244.44
pKa Acid
7.21
pKa Basic
4.43
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9359
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9359
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9235
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9235
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9215
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9215
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9122
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9122
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.9035
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.9035
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8982
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8982
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8970
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8970
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8958
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8958
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8956
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8956
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8912
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8912
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8868
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8868
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8833
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8833
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8816
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8816
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8814
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8814
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8807
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8807
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8798
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8798
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8755
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8755
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8740
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8740
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8682
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8682
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8600
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8600
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8545
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8545
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8532
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8532
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8500
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8500
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.8495
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.8495
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8492
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8492
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8474
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8474
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8454
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8454
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8430
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8430
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8414
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8414
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8404
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8404
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8393
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8393
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8377
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8377
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8365
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8365
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8365
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8365
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8350
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8350
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8340
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8340
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8339
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8339
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8336
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8336
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8334
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8334
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8315
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8315
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8288
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8288
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8270
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8270
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8254
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8254
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8164
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8164
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8155
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8155
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8103
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8103
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8097
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8097
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8089
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8089
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8070
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8070
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8050
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8050
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8045
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8045
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8016
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8016
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.8012
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.8012
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8009
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8009
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8007
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8007
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7971
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7971
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7962
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7962
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7957
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7957
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7951
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7951
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7945
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7945
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7935
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7935
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7929
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7929
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7928
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7928
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7924
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7924
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7908
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7908
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7880
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7880
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7865
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7865
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7832
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7832
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7827
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7827
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.7814
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.7814
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7789
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7789
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.7787
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.7787
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7778
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7778
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7778
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7778
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7771
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7771
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7768
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7768
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7766
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7766
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7765
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7765
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7760
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7760
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7753
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7753
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7752
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7752
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7749
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7749
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7742
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7742
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7741
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7741
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7686
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7686
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7683
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7683
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7668
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7668
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7658
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7658
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7627
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7627
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7594
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7594
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7574
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7574
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7526
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7526
Annexin A5 P08758 ANXA5_HUMAN Homo sapiens 2 0.7514
Annexin A5 P08758 ANXA5_HUMAN Homo sapiens 2 0.7514
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7510
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7510
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7499
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7499
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7489
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7489
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7487
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7487
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7461
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7461
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7456
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7456
Beta-glucuronidase P05804 BGLR_ECOLI Escherichia coli 3 0.7442
Beta-glucuronidase P05804 BGLR_ECOLI Escherichia coli 3 0.7442
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7440
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7440
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 3 0.7425
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 3 0.7425
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7411
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7411
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7408
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7408
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7398
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7398
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7397
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7397
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7355
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7355
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7354
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7354
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7349
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7349
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7345
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7345
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7338
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7338
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7336
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7336
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7332
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7332
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7330
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7330
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7310
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7310
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7306
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7306
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7304
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7304
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7296
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7296
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7286
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7286
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7283
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7283
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7282
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7282
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7273
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7273
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7264
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7264
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7261
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7261
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7261
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7261
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7257
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7257
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.7253
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.7253
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7241
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7241
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7234
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7234
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7230
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7230
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7230
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7230
Antitumor antibiotic C-1027 apoprotein Q06110 CAGA_STRGL Streptomyces globisporus 3 0.7223
Antitumor antibiotic C-1027 apoprotein Q06110 CAGA_STRGL Streptomyces globisporus 3 0.7223
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7215
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7215
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7213
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7213
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7213
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7213
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7202
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7202
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7200
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7200
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7194
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7194
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7187
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7187
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7186
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7186
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7186
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7186
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7183
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7183
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7182
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7182
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7173
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7173
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7166
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7166
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7164
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7164
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7161
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7161
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 3 0.7158
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 3 0.7158
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7148
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7148
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7134
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7134
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7125
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7125
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7121
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7121
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7119
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7119
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7119
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7119
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7104
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7104
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7100
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7100
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7087
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7087
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7084
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7084
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7071
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7071
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7062
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7062
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7058
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7058
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 4 0.7057
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 4 0.7057
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7056
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7056
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7055
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7055
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7051
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7051
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7044
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 3 0.7044
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7044
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7044
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 3 0.7044
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7044
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7035
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7035
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 3 0.7034
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 3 0.7034
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7032
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7032
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7030
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7030
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7022
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7022
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7021
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7021
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7017
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7017
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7014
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7014
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7008
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7008

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