Pinostrobin chalcone - Compound Card

Pinostrobin chalcone

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Pinostrobin chalcone

Structure
Zoomed Structure
  • Family: Plantae - Polygonaceae
  • Kingdom: Plantae, Animalia
  • Class: Flavonoid
Canonical Smiles COc1cc(O)c(c(c1)O)C(=O)/C=C/c1ccccc1
InChI InChI=1S/C16H14O4/c1-20-12-9-14(18)16(15(19)10-12)13(17)8-7-11-5-3-2-4-6-11/h2-10,18-19H,1H3/b8-7+
InChIKey CUGDOWNTXKLQMD-BQYQJAHWSA-N
Formula C16H14O4
HBA 4
HBD 2
MW 270.28
Rotatable Bonds 4
TPSA 66.76
LogP 3.0
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.06
Exact Mass 270.09
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Apis species Apidae Animalia 7459
2 Polygonum senegalense Polygonaceae Plantae 471708

Showing of synonyms

  • Midiwo JO, Matasi JJ, et al. (1992). Anti-feedant effects of surface accumulated flavonoids of Polygonum senegalense.. Bulletin of the Chemical Society of Ethiopia,1992,6(2),119-122. [View] [PubMed]
  • Boutabet K, Kebsa W, et al. (2011). Polyphenolic fraction of Algerian propolis protects rat kidney against acute oxidative stress induced by doxorubicin. Indian Journal of Nephrology,2011,21(2),101-106. [View] [PubMed]
CPRiL: 130111
Structure

SMILES: c1ccccc1C(=O)C=Cc2ccccc2

Level: 1

Mol. Weight: 270.28 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 270.28 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.46
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.460
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.98

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.000
Plasma Protein Binding
61.95
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.740
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.630
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.280
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.610
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.480
Rat (Acute)
2.310
Rat (Chronic Oral)
3.020
Fathead Minnow
4.660
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
380.910
Hydration Free Energy
-10.990
Log(D) at pH=7.4
3.450
Log(P)
3.53
Log S
-5.77
Log(Vapor Pressure)
-6.58
Melting Point
128.24
pKa Acid
7.3
pKa Basic
5.13
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9605
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9605
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9532
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9532
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 3 0.9441
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 3 0.9441
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9412
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9412
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9387
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9387
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9382
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9382
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9307
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9307
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9303
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9303
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.9288
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.9288
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.9285
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.9285
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.9205
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.9205
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.9144
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.9144
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9077
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9077
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.9062
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.9062
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.9040
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.9040
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8987
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8987
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8978
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8978
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8940
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8940
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8899
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8899
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8887
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8887
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8874
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8874
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 3 0.8863
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 3 0.8863
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8811
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8811
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8799
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8799
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.8792
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.8792
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8738
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8738
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8735
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8735
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.8699
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.8699
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8698
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 3 0.8698
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 3 0.8698
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8698
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8694
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8694
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8676
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8676
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8668
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8668
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8661
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8661
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8632
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8632
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8623
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8623
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8612
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8612
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.8601
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.8601
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8570
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8570
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.8566
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.8566
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8538
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8538
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8535
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8535
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 3 0.8528
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 3 0.8528
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8526
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8526
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8510
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8510
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8493
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8493
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8481
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8481
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8425
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8425
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8364
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8364
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8361
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8361
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.8358
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.8358
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 3 0.8355
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 3 0.8355
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8344
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8344
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.8327
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.8327
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8321
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8321
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8319
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8319
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8297
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8297
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8295
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8295
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8282
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8282
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8271
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8271
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.8240
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8240
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.8240
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8240
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.8209
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.8209
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.8206
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.8206
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8205
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8205
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.8197
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.8197
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8191
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8191
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 3 0.8190
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 3 0.8190
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.8111
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.8111
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8105
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8105
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.8103
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.8103
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8101
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8101
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8082
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8082
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8064
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8064
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.8063
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.8063
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8021
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8021
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.8018
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.8018
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 3 0.7946
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 3 0.7946
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7884
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7884
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7882
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7882
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7874
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7874
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7862
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7862
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7854
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7854
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7809
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7809
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7805
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7805
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7801
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7801
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7799
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7799
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7792
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7792
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7764
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7764
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7762
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7762
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7761
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7761
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7751
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7751
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7740
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7740
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7729
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7729
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 4 0.7719
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 4 0.7719
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7714
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7714
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7708
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7708
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7701
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7701
cytokinin dehydrogenase E3T1W8 E3T1W8_MAIZE Zea mays 3 0.7699
cytokinin dehydrogenase E3T1W8 E3T1W8_MAIZE Zea mays 3 0.7699
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7691
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 4 0.7691
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7691
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 4 0.7691
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7682
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7682
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7679
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7679
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 4 0.7671
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 4 0.7671
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7667
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7667
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7660
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7660
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7647
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7647
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7643
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7643
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7638
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7638
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7589
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7589
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7589
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7589
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7587
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7587
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7573
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7573
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7572
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7572
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7567
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7567
Shikimate dehydrogenase (NADP(+)) O67049 AROE_AQUAE Aquifex aeolicus 3 0.7565
Shikimate dehydrogenase (NADP(+)) O67049 AROE_AQUAE Aquifex aeolicus 3 0.7565
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7564
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7564
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7562
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7562
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7551
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7551
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7549
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7549
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7546
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7546
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7532
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7532
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7527
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7527
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7520
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7520
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7518
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7518
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7507
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7507
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7498
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7498
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7495
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7495
Hydroxymethylglutaryl-CoA synthase Q9FD71 HMGCS_ENTFL Enterococcus faecalis 2 0.7493
Hydroxymethylglutaryl-CoA synthase Q9FD71 HMGCS_ENTFL Enterococcus faecalis 2 0.7493
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7485
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7485
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7478
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7478
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 3 0.7466
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 3 0.7466
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7462
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7462
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7460
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7460
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7459
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7459
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7456
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7456
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7452
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7452
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7435
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7435
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7433
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7433
Botulinum neurotoxin type B P10844 BXB_CLOBO Clostridium botulinum 3 0.7420
Botulinum neurotoxin type B P10844 BXB_CLOBO Clostridium botulinum 3 0.7420
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7417
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7417
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7416
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7416
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7412
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7412
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7412
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7412
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7412
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7412
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7397
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7397
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7395
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7395
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7390
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7390
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7389
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7389
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7376
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7376
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7375
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7375
Serine endoprotease DegS P0AEE3 DEGS_ECOLI Escherichia coli 4 0.7373
Serine endoprotease DegS P0AEE3 DEGS_ECOLI Escherichia coli 4 0.7373
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7372
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7372
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7371
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7371
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7370
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7370
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7358
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7358
Uricase Q00511 URIC_ASPFL Aspergillus flavus 3 0.7355
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7355
Uricase Q00511 URIC_ASPFL Aspergillus flavus 3 0.7355
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7355
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7347
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7347
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7346
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7346
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7345
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7345
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7343
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7343
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7341
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7341
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7337
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7337
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7337
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7337
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7335
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7335
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7327
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7327
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7326
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7326
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7326
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7326
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7325
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7325
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7317
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7317
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7313
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7313
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7309
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7309
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7291
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7291
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7291
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7291
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7291
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7291
Peroxisome proliferator-activated receptor alpha Q07869 PPARA_HUMAN Homo sapiens 2 0.7288
Peroxisome proliferator-activated receptor alpha Q07869 PPARA_HUMAN Homo sapiens 2 0.7288
5-formyltetrahydrofolate cyclo-ligase P75430 MTHFS_MYCPN Mycoplasma pneumoniae 2 0.7287
5-formyltetrahydrofolate cyclo-ligase P75430 MTHFS_MYCPN Mycoplasma pneumoniae 2 0.7287
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7278
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7278
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7274
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7274
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7271
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7271
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7271
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7271
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7267
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7267
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7265
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7265
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7259
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7259
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7256
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7256
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7254
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7254
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7254
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7254
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 2 0.7253
UDP-N-acetylglucosamine 1-carboxyvinyltransferase P33038 MURA_ENTCC Enterobacter cloacae subsp. cloacae 3 0.7253
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 2 0.7253
UDP-N-acetylglucosamine 1-carboxyvinyltransferase P33038 MURA_ENTCC Enterobacter cloacae subsp. cloacae 3 0.7253
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7248
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7248
Formate--tetrahydrofolate ligase Q2RM91 FTHS_MOOTA Moorella thermoacetica 2 0.7247
Formate--tetrahydrofolate ligase Q2RM91 FTHS_MOOTA Moorella thermoacetica 2 0.7247
Trimethylamine monooxygenase Q83XK4 Q83XK4_9GAMM Methylophaga aminisulfidivorans 3 0.7242
Trimethylamine monooxygenase Q83XK4 Q83XK4_9GAMM Methylophaga aminisulfidivorans 3 0.7242
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7240
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7240
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7240
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7240
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7238
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7238
EhpF Q8GPH0 Q8GPH0_ENTAG Enterobacter agglomerans 3 0.7235
EhpF Q8GPH0 Q8GPH0_ENTAG Enterobacter agglomerans 3 0.7235
Type 4 fimbrial biogenesis protein PilM G3XD28 G3XD28_PSEAE Pseudomonas aeruginosa 3 0.7232
Type 4 fimbrial biogenesis protein PilM G3XD28 G3XD28_PSEAE Pseudomonas aeruginosa 3 0.7232
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7226
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7226
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7221
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7221
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 3 0.7221
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 3 0.7221
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7216
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7216
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7214
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7214
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7209
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7209
chitinase B0Y2Y2 B0Y2Y2_ASPFC Aspergillus fumigatus 3 0.7204
chitinase B0Y2Y2 B0Y2Y2_ASPFC Aspergillus fumigatus 3 0.7204
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7203
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7203
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7201
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7201
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7201
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7201
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7200
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7200
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7195
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7195
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7195
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7195
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7192
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7192
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7191
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7191
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7191
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7191
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7190
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7190
GTPase IMAP family member 2 Q9UG22 GIMA2_HUMAN Homo sapiens 3 0.7187
GTPase IMAP family member 2 Q9UG22 GIMA2_HUMAN Homo sapiens 3 0.7187
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7184
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7184
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7184
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7184
4'-phosphopantetheinyl transferase Sfp P39135 SFP_BACSU Bacillus subtilis 3 0.7182
4'-phosphopantetheinyl transferase Sfp P39135 SFP_BACSU Bacillus subtilis 3 0.7182
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7180
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7180
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7161
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7161
Cyclic GMP-AMP synthase Q8C6L5 CGAS_MOUSE Mus musculus 3 0.7160
Cyclic GMP-AMP synthase Q8C6L5 CGAS_MOUSE Mus musculus 3 0.7160
2'-5'-oligoadenylate synthase 1 P00973 OAS1_HUMAN Homo sapiens 2 0.7158
2'-5'-oligoadenylate synthase 1 P00973 OAS1_HUMAN Homo sapiens 2 0.7158
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7147
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7147
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7145
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7145
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7143
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7143
Glutamate decarboxylase 1 Q99259 DCE1_HUMAN Homo sapiens 3 0.7142
Glutamate decarboxylase 1 Q99259 DCE1_HUMAN Homo sapiens 3 0.7142
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7139
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7139
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7138
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7138
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7138
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7138
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7125
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7125
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7122
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7122
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7120
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7120
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7114
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7114
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 2 0.7113
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 2 0.7113
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7112
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7112
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.7106
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.7106
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7105
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7105
Nitrogen regulatory protein P-II O66513 GLNB_AQUAE Aquifex aeolicus 2 0.7102
Nitrogen regulatory protein P-II O66513 GLNB_AQUAE Aquifex aeolicus 2 0.7102
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7101
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7101
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7095
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7095
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7094
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7094
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 2 0.7092
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 2 0.7092
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7091
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7091
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7086
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7086
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7078
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7078
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7077
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7077
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7076
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7076
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7075
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7075
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7074
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7074
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7072
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7072
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7072
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7072
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7071
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7071
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7071
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7071
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7055
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7055
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7052
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7052
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7050
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7050
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7050
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7050
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7048
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7048
Cytosolic IMP-GMP specific 5'-nucleotidase Q5ZZB6 Q5ZZB6_LEGPH Legionella pneumophila subsp. pneumophila 3 0.7047
Cytosolic IMP-GMP specific 5'-nucleotidase Q5ZZB6 Q5ZZB6_LEGPH Legionella pneumophila subsp. pneumophila 3 0.7047
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7046
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7046
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7042
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7042
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7036
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7036
ATP synthase subunit alpha, mitochondrial P07251 ATPA_YEAST Saccharomyces cerevisiae 2 0.7035
ATP synthase subunit alpha, mitochondrial P07251 ATPA_YEAST Saccharomyces cerevisiae 2 0.7035
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7033
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7033
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7028
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7028
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 2 0.7026
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 2 0.7026
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7025
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7025
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.7016
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.7016
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7012
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7012
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7011
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7011
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7009
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7009
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7007
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7007
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7006
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7006
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7004
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7004
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7004
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7004

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