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6-phenyl-n-hexanol

Family: Animalia - Apidae
Kingdom: Animalia
Class: Alcohol

Canonical Smiles	OCCCCCCc1ccccc1
InChI	InChI=1S/C12H18O/c13-11-7-2-1-4-8-12-9-5-3-6-10-12/h3,5-6,9-10,13H,1-2,4,7-8,11H2
InChIKey	FDXBUMXUJRZANT-UHFFFAOYSA-N
Formula	C₁₂H₁₈O
HBA	1
HBD	1
MW	178.28
Rotatable Bonds	6
TPSA	20.23
LogP	2.78
Number Rings	1
Number Aromatic Rings	1
Heavy Atom Count	13
Formal Charge	0
Fraction CSP3	0.5
Exact Mass	178.14
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Apis species	Apidae	Animalia	7459

Showing of synonyms

Boutabet K, Kebsa W, et al. (2011). Polyphenolic fraction of Algerian propolis protects rat kidney against acute oxidative stress induced by doxorubicin. Indian Journal of Nephrology,2011,21(2),101-106. [View] [PubMed]

Pubchem: 520110

Cas: 2430-16-2

Zinc: ZINC000002560471

Nmrshiftdb2: 80005023

Chembl: CHEMBL3730920

Comptox: DTXSID50179033

No compound-protein relationship available.

SMILES: c1ccccc1

Level: 0

Mol. Weight: 178.28 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.6
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -3.62
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -3.47

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.13
Plasma Protein Binding: 47.69
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 6.9
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 1.92
Biodegradation: Toxic
Carcinogenesis: Toxic
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Toxic
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.3
Liver Injury II: Safe
hERG Blockers: Safe
Daphnia Maga: 4.25
Micronucleos: Safe
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 3.98
Rat (Acute): 1.75
Rat (Chronic Oral): 1.99
Fathead Minnow: 3.84
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 283.92
Hydration Free Energy: -6.18
Log(D) at pH=7.4: 2.83
Log(P): 3.48
Log S: -2.64
Log(Vapor Pressure): -2.98
Melting Point: 14.27
pKa Acid: 11.66
pKa Basic: 4.62

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.8671
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.8671
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.8457
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.8457
rRNA methylase	Q8DSS3	Q8DSS3_STRMU	Streptococcus mutans serotype c	2	0.8441
rRNA methylase	Q8DSS3	Q8DSS3_STRMU	Streptococcus mutans serotype c	2	0.8441
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.8163
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.8163
Indole-3-glycerol phosphate synthase	P9WFX7	TRPC_MYCTU	Mycobacterium tuberculosis	2	0.7963
Indole-3-glycerol phosphate synthase	P9WFX7	TRPC_MYCTU	Mycobacterium tuberculosis	2	0.7963
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	2	0.7924
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	2	0.7924
Prenyltransferase	Q4R2T2	Q4R2T2_STRC1	Streptomyces sp	2	0.7899
Prenyltransferase	Q4R2T2	Q4R2T2_STRC1	Streptomyces sp	2	0.7899
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.7896
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.7896
Cyclic nucleotide-binding domain-containing protein	E0RR11	E0RR11_SPITD	Spirochaeta thermophila	2	0.7711
Cyclic nucleotide-binding domain-containing protein	E0RR11	E0RR11_SPITD	Spirochaeta thermophila	2	0.7711
Class 10 plant pathogenesis-related protein 2B	Q9LLQ2	P102B_LUPLU	Lupinus luteus	2	0.7641
Class 10 plant pathogenesis-related protein 2B	Q9LLQ2	P102B_LUPLU	Lupinus luteus	2	0.7641
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic	P49235	HGGL1_MAIZE	Zea mays	2	0.7621
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic	P49235	HGGL1_MAIZE	Zea mays	2	0.7621
Toluene-4-monooxygenase system, hydroxylase component subunit alpha	Q00456	TMOA_PSEME	Pseudomonas mendocina	2	0.7613
Toluene-4-monooxygenase system, hydroxylase component subunit alpha	Q00456	TMOA_PSEME	Pseudomonas mendocina	2	0.7613
Cyclic nucleotide-gated potassium channel mll3241	Q98GN8	CNGK1_RHILO	Mesorhizobium japonicum)	2	0.7608
Cyclic nucleotide-gated potassium channel mll3241	Q98GN8	CNGK1_RHILO	Mesorhizobium japonicum)	2	0.7608
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7542
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7542
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	Q0QF01	SDHA_PIG	Sus scrofa	2	0.7541
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	Q0QF01	SDHA_PIG	Sus scrofa	2	0.7541
Peroxidase C1A	P00433	PER1A_ARMRU	Armoracia rusticana	2	0.7517
Peroxidase C1A	P00433	PER1A_ARMRU	Armoracia rusticana	2	0.7517
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7508
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	2	0.7508
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7508
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	2	0.7508
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	2	0.7495
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	2	0.7495
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7485
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7485
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase	O33877	FABA_PSEAE	Pseudomonas aeruginosa	2	0.7484
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase	O33877	FABA_PSEAE	Pseudomonas aeruginosa	2	0.7484
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7481
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7481
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	2	0.7480
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	2	0.7480
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7476
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7476
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7474
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7474
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7459
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7459
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7456
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7456
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	2	0.7453
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	2	0.7453
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7443
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7443
Cytochrome P450 2A6	P11509	CP2A6_HUMAN	Homo sapiens	2	0.7438
Cytochrome P450 2A6	P11509	CP2A6_HUMAN	Homo sapiens	2	0.7438
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7435
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7435
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7426
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7426
Dihydrofolate reductase	P00378	DYR_CHICK	Gallus gallus	2	0.7423
Dihydrofolate reductase	P00378	DYR_CHICK	Gallus gallus	2	0.7423
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	2	0.7421
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	2	0.7421
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7420
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7420
Beta-glucosidase 12	B8AVF0	BGL12_ORYSI	Oryza sativa subsp. indica	2	0.7410
Beta-glucosidase 12	B8AVF0	BGL12_ORYSI	Oryza sativa subsp. indica	2	0.7410
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	2	0.7402
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	2	0.7402
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	2	0.7400
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	2	0.7400
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7397
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7397
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	2	0.7391
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	2	0.7391
Protein mono-ADP-ribosyltransferase PARP10	Q53GL7	PAR10_HUMAN	Homo sapiens	2	0.7374
Protein mono-ADP-ribosyltransferase PARP10	Q53GL7	PAR10_HUMAN	Homo sapiens	2	0.7374
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7367
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7367
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	2	0.7364
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	2	0.7364
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	2	0.7361
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	2	0.7361
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	2	0.7356
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	2	0.7356
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7354
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7354
cAMP-dependent protein kinase type II-beta regulatory subunit	P12369	KAP3_RAT	Rattus norvegicus	2	0.7353
cAMP-dependent protein kinase type II-beta regulatory subunit	P12369	KAP3_RAT	Rattus norvegicus	2	0.7353
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	2	0.7352
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	2	0.7352
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	2	0.7351
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	2	0.7351
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7349
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7349
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7349
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7349
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	2	0.7342
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	2	0.7342
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7337
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7337
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	2	0.7337
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	2	0.7337
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	2	0.7333
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	2	0.7333
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	2	0.7329
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	2	0.7329
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7323
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	2	0.7323
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7323
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	2	0.7323
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7320
Protein UshA	P07024	USHA_ECOLI	Escherichia coli	2	0.7320
Protein UshA	P07024	USHA_ECOLI	Escherichia coli	2	0.7320
Epothilone C/D epoxidase	Q9KIZ4	C167_SORCE	Sorangium cellulosum	2	0.7320
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7320
Epothilone C/D epoxidase	Q9KIZ4	C167_SORCE	Sorangium cellulosum	2	0.7320
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	2	0.7316
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	2	0.7316
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7312
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	2	0.7312
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7312
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	2	0.7312
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7308
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7308
Methionine aminopeptidase 1	P53582	MAP11_HUMAN	Homo sapiens	2	0.7304
Methionine aminopeptidase 1	P53582	MAP11_HUMAN	Homo sapiens	2	0.7304
NAD-dependent protein deacetylase	Q9WYW0	NPD_THEMA	Thermotoga maritima	2	0.7303
Archaeal actin homolog	Q9HKL4	ACTH_THEAC	Thermoplasma acidophilum	2	0.7303
Archaeal actin homolog	Q9HKL4	ACTH_THEAC	Thermoplasma acidophilum	2	0.7303
NAD-dependent protein deacetylase	Q9WYW0	NPD_THEMA	Thermotoga maritima	2	0.7303
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	2	0.7299
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	2	0.7299
Bifunctional dihydrofolate reductase-thymidylate synthase	A7UD81	A7UD81_PLAFA	Plasmodium falciparum	2	0.7295
Bifunctional dihydrofolate reductase-thymidylate synthase	A7UD81	A7UD81_PLAFA	Plasmodium falciparum	2	0.7295
Prostaglandin F2a synthase	Q8I6L9	Q8I6L9_TRYCR	Trypanosoma cruzi	2	0.7294
Prostaglandin F2a synthase	Q8I6L9	Q8I6L9_TRYCR	Trypanosoma cruzi	2	0.7294
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	2	0.7287
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	2	0.7287
Protein claret segregational	P20480	NCD_DROME	Drosophila melanogaster	2	0.7286
Protein claret segregational	P20480	NCD_DROME	Drosophila melanogaster	2	0.7286
Transcriptional activator, LuxR/UhpA family of regulators	Q7NQP7	Q7NQP7_CHRVO	Chromobacterium violaceum	2	0.7286
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7286
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7286
Transcriptional activator, LuxR/UhpA family of regulators	Q7NQP7	Q7NQP7_CHRVO	Chromobacterium violaceum	2	0.7286
NTPase P4	Q94M05	Q94M05_9VIRU	Pseudomonas phage phi12	2	0.7285
NTPase P4	Q94M05	Q94M05_9VIRU	Pseudomonas phage phi12	2	0.7285
Epothilone C/D epoxidase	Q9KIZ4	C167_SORCE	Sorangium cellulosum	2	0.7284
Epothilone C/D epoxidase	Q9KIZ4	C167_SORCE	Sorangium cellulosum	2	0.7284
Metallo-beta-lactamase type 2	P26918	BLAB_AERHY	Aeromonas hydrophila	2	0.7279
Metallo-beta-lactamase type 2	P26918	BLAB_AERHY	Aeromonas hydrophila	2	0.7279
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	2	0.7278
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	2	0.7278
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	2	0.7277
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	2	0.7277
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	2	0.7277
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	2	0.7277
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	2	0.7275
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	2	0.7275
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	2	0.7273
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	2	0.7273
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	2	0.7271
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	2	0.7271
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	2	0.7265
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	2	0.7265
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	2	0.7265
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	2	0.7265
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	2	0.7263
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	2	0.7263
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7262
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7262
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7261
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7261
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7260
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7260
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	2	0.7260
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	2	0.7260
Pyridoxal kinase	O00764	PDXK_HUMAN	Homo sapiens	2	0.7259
Alpha/beta hydrolase fold protein	D2J2T6	D2J2T6_9RHIZ	Ochrobactrum sp. T63	2	0.7259
Pyridoxal kinase	O00764	PDXK_HUMAN	Homo sapiens	2	0.7259
Alpha/beta hydrolase fold protein	D2J2T6	D2J2T6_9RHIZ	Ochrobactrum sp. T63	2	0.7259
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7257
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7257
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	2	0.7255
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	2	0.7255
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	2	0.7254
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7254
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	2	0.7254
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7254
Purine nucleoside phosphorylase	P55859	PNPH_BOVIN	Bos taurus	2	0.7252
Purine nucleoside phosphorylase	P55859	PNPH_BOVIN	Bos taurus	2	0.7252
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7248
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	2	0.7248
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7248
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	2	0.7248
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	2	0.7248
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7248
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	2	0.7248
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7248
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7247
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7247
Quorum-sensing transcriptional activator	Q8XBD0	Q8XBD0_ECO57	Escherichia coli O157:H7	2	0.7246
Quorum-sensing transcriptional activator	Q8XBD0	Q8XBD0_ECO57	Escherichia coli O157:H7	2	0.7246
Muconolactone Delta-isomerase	Q8G9L0	Q8G9L0_RHOOP	Rhodococcus opacus	2	0.7245
Muconolactone Delta-isomerase	Q8G9L0	Q8G9L0_RHOOP	Rhodococcus opacus	2	0.7245
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7244
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7244
Chorismate mutase AroH	P19080	AROH_BACSU	Bacillus subtilis	2	0.7241
Chorismate mutase AroH	P19080	AROH_BACSU	Bacillus subtilis	2	0.7241
Beta-galactosidase	P00722	BGAL_ECOLI	Escherichia coli	2	0.7239
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7239
Beta-galactosidase	P00722	BGAL_ECOLI	Escherichia coli	2	0.7239
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7239
Succinyl-CoA:acetate CoA-transferase	B3EY95	SCACT_ACEAC	Acetobacter aceti	2	0.7237
Succinyl-CoA:acetate CoA-transferase	B3EY95	SCACT_ACEAC	Acetobacter aceti	2	0.7237
1-deoxy-D-xylulose 5-phosphate reductoisomerase	P45568	DXR_ECOLI	Escherichia coli	2	0.7236
1-deoxy-D-xylulose 5-phosphate reductoisomerase	P45568	DXR_ECOLI	Escherichia coli	2	0.7236
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7233
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7233
Bifunctional dihydrofolate reductase-thymidylate synthase	A7UD81	A7UD81_PLAFA	Plasmodium falciparum	2	0.7232
Bifunctional dihydrofolate reductase-thymidylate synthase	A7UD81	A7UD81_PLAFA	Plasmodium falciparum	2	0.7232
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7231
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7231
Ceramide transfer protein	Q9Y5P4	CERT_HUMAN	Homo sapiens	2	0.7229
Ceramide transfer protein	Q9Y5P4	CERT_HUMAN	Homo sapiens	2	0.7229
Nitric oxide synthase, inducible	P35228	NOS2_HUMAN	Homo sapiens	2	0.7228
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	2	0.7228
Nitric oxide synthase, inducible	P35228	NOS2_HUMAN	Homo sapiens	2	0.7228
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	2	0.7228
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7225
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7225
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	2	0.7224
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	2	0.7224
Transcriptional activator, LuxR/UhpA family of regulators	Q7NQP7	Q7NQP7_CHRVO	Chromobacterium violaceum	2	0.7222
Transcriptional activator, LuxR/UhpA family of regulators	Q7NQP7	Q7NQP7_CHRVO	Chromobacterium violaceum	2	0.7222
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7220
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7220
Adenosine 5'-monophosphoramidase HINT1	P80912	HINT1_RABIT	Oryctolagus cuniculus	2	0.7220
Adenosine 5'-monophosphoramidase HINT1	P80912	HINT1_RABIT	Oryctolagus cuniculus	2	0.7220
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	2	0.7215
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	2	0.7215
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7212
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7212
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	2	0.7210
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	2	0.7210
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	2	0.7209
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	2	0.7209
Carboxypeptidase A1	P00730	CBPA1_BOVIN	Bos taurus	2	0.7206
Carboxypeptidase A1	P00730	CBPA1_BOVIN	Bos taurus	2	0.7206
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	2	0.7206
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	2	0.7206
Prolyl tripeptidyl peptidase	Q7MUW6	PTP_PORGI	Porphyromonas gingivalis	2	0.7200
Prolyl tripeptidyl peptidase	Q7MUW6	PTP_PORGI	Porphyromonas gingivalis	2	0.7200
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7199
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7199
Pantothenate kinase	P9WPA7	COAA_MYCTU	Mycobacterium tuberculosis	2	0.7198
Pantothenate kinase	P9WPA7	COAA_MYCTU	Mycobacterium tuberculosis	2	0.7198
BMP-2-inducible protein kinase	Q9NSY1	BMP2K_HUMAN	Homo sapiens	2	0.7196
BMP-2-inducible protein kinase	Q9NSY1	BMP2K_HUMAN	Homo sapiens	2	0.7196
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	2	0.7194
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	2	0.7194
Purine nucleoside phosphorylase	Q8I3X4	Q8I3X4_PLAF7	Plasmodium falciparum	2	0.7193
Amino-acid acetyltransferase	Q5FAK7	Q5FAK7_NEIG1	Neisseria gonorrhoeae	2	0.7193
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7193
Purine nucleoside phosphorylase	Q8I3X4	Q8I3X4_PLAF7	Plasmodium falciparum	2	0.7193
Amino-acid acetyltransferase	Q5FAK7	Q5FAK7_NEIG1	Neisseria gonorrhoeae	2	0.7193
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7193
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7192
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7192
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7190
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7190
Phosphotriesterase	Q5KZU5	Q5KZU5_GEOKA	Geobacillus kaustophilus	2	0.7189
Phosphotriesterase	Q5KZU5	Q5KZU5_GEOKA	Geobacillus kaustophilus	2	0.7189
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	2	0.7188
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	2	0.7188
cAMP-dependent protein kinase catalytic subunit alpha	P05132	KAPCA_MOUSE	Mus musculus	2	0.7188
cAMP-dependent protein kinase catalytic subunit alpha	P05132	KAPCA_MOUSE	Mus musculus	2	0.7188
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	2	0.7187
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	2	0.7187
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	2	0.7184
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7184
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	2	0.7184
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7184
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	2	0.7183
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	2	0.7183
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	2	0.7183
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	2	0.7183
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	2	0.7182
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	2	0.7182
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7176
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7176
D-cysteine desulfhydrase	Q8ZNT7	DCYD_SALTY	Salmonella typhimurium	2	0.7174
D-cysteine desulfhydrase	Q8ZNT7	DCYD_SALTY	Salmonella typhimurium	2	0.7174
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7173
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7173
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7168
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7168
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	2	0.7167
Ribonuclease J	Q72JJ7	RNJ_THET2	Thermus thermophilus	2	0.7167
Ribonuclease J	Q72JJ7	RNJ_THET2	Thermus thermophilus	2	0.7167
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	2	0.7167
Mitogen-activated protein kinase kinase kinase 5	Q99683	M3K5_HUMAN	Homo sapiens	2	0.7166
Mitogen-activated protein kinase kinase kinase 5	Q99683	M3K5_HUMAN	Homo sapiens	2	0.7166
Thiazole tautomerase	P25053	TENI_BACSU	Bacillus subtilis	2	0.7163
Thiazole tautomerase	P25053	TENI_BACSU	Bacillus subtilis	2	0.7163
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7163
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7163
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	P19992	HSD_STREX	Streptomyces exfoliatus	2	0.7162
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	P19992	HSD_STREX	Streptomyces exfoliatus	2	0.7162
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7160
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	2	0.7160
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7160
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	2	0.7160
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7158
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7158
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7156
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7156
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	2	0.7155
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	2	0.7155
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	2	0.7154
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	2	0.7154
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	2	0.7149
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	2	0.7149
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16875	F263_HUMAN	Homo sapiens	2	0.7148
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16875	F263_HUMAN	Homo sapiens	2	0.7148
Cyclic AMP receptor protein	Q5SID7	CRP_THET8	Thermus thermophilus	2	0.7147
Cyclic AMP receptor protein	Q5SID7	CRP_THET8	Thermus thermophilus	2	0.7147
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	2	0.7146
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	2	0.7146
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7144
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7144
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7144
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7144
Diphtheria toxin	P00588	DTX_CORBE	Corynephage beta	2	0.7143
Diphtheria toxin	P00588	DTX_CORBE	Corynephage beta	2	0.7143
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	2	0.7142
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	2	0.7142
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	2	0.7138
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	2	0.7138
Glycoside Hydrolase Family 13	Q65MI2	Q65MI2_BACLD	Bacillus licheniformis	2	0.7136
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	2	0.7136
Glycoside Hydrolase Family 13	Q65MI2	Q65MI2_BACLD	Bacillus licheniformis	2	0.7136
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	2	0.7136
Bifunctional dihydrofolate reductase-thymidylate synthase	Q27793	DRTS_TRYCR	Trypanosoma cruzi	2	0.7135
Bifunctional dihydrofolate reductase-thymidylate synthase	Q27793	DRTS_TRYCR	Trypanosoma cruzi	2	0.7135
Diamine acetyltransferase 1	P21673	SAT1_HUMAN	Homo sapiens	2	0.7134
Diamine acetyltransferase 1	P21673	SAT1_HUMAN	Homo sapiens	2	0.7134
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7131
Carnitine O-acetyltransferase	P47934	CACP_MOUSE	Mus musculus	2	0.7131
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7131
Carnitine O-acetyltransferase	P47934	CACP_MOUSE	Mus musculus	2	0.7131
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7130
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7130
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7129
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7129
Metallophosphoesterase	A3DJ38	A3DJ38_HUNT2	Clostridium thermocellum	2	0.7126
Metallophosphoesterase	A3DJ38	A3DJ38_HUNT2	Clostridium thermocellum	2	0.7126
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7125
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7125
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7124
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7124
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	2	0.7122
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	2	0.7122
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	2	0.7120
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	2	0.7120
Tryptophan synthase alpha chain	P00929	TRPA_SALTY	Salmonella typhimurium	2	0.7119
Tryptophan synthase alpha chain	P00929	TRPA_SALTY	Salmonella typhimurium	2	0.7119
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	2	0.7117
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	2	0.7117
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	2	0.7116
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	2	0.7116
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7115
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7115
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7115
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7115
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	2	0.7113
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	2	0.7113
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7113
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7113
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7112
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	2	0.7112
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7112
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7112
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	2	0.7112
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7112
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7110
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7110
Class B acid phosphatase	P0AE22	APHA_ECOLI	Escherichia coli	2	0.7105
Class B acid phosphatase	P0AE22	APHA_ECOLI	Escherichia coli	2	0.7105
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	2	0.7104
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	2	0.7104
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7103
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7103
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7102
Threonine synthase 1, chloroplastic	Q9S7B5	THRC1_ARATH	Arabidopsis thaliana	2	0.7102
Threonine synthase 1, chloroplastic	Q9S7B5	THRC1_ARATH	Arabidopsis thaliana	2	0.7102
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7102
Adenosine kinase	Q9TVW2	ADK_TOXGO	Toxoplasma gondii	2	0.7099
Formate--tetrahydrofolate ligase	P21164	FTHS_MOOTH	Moorella thermoacetica	2	0.7099
Adenosine kinase	Q9TVW2	ADK_TOXGO	Toxoplasma gondii	2	0.7099
Formate--tetrahydrofolate ligase	P21164	FTHS_MOOTH	Moorella thermoacetica	2	0.7099
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7098
Purine nucleoside phosphorylase DeoD-type	B1JL34	DEOD_YERPY	Yersinia pseudotuberculosis serotype O:3	2	0.7098
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7098
Purine nucleoside phosphorylase DeoD-type	B1JL34	DEOD_YERPY	Yersinia pseudotuberculosis serotype O:3	2	0.7098
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1	O50008	METE1_ARATH	Arabidopsis thaliana	2	0.7092
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	2	0.7092
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1	O50008	METE1_ARATH	Arabidopsis thaliana	2	0.7092
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	2	0.7092
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	2	0.7091
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	2	0.7091
Karilysin	D0EM77	KLY_TANFA	Tannerella forsythia	2	0.7084
Karilysin	D0EM77	KLY_TANFA	Tannerella forsythia	2	0.7084
Inosine-5'-monophosphate dehydrogenase	P50097	IMDH_TRIFO	Tritrichomonas foetus	2	0.7082
Inosine-5'-monophosphate dehydrogenase	P50097	IMDH_TRIFO	Tritrichomonas foetus	2	0.7082
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7081
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7081
5-methylthioadenosine/S-adenosylhomocysteine deaminase	Q7NZ90	Q7NZ90_CHRVO	Chromobacterium violaceum	2	0.7078
5-methylthioadenosine/S-adenosylhomocysteine deaminase	Q7NZ90	Q7NZ90_CHRVO	Chromobacterium violaceum	2	0.7078
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	2	0.7078
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	2	0.7078
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	2	0.7078
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	2	0.7078
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7077
adenine phosphoribosyltransferase	Q967M2	Q967M2_GIAIN	Giardia intestinalis	2	0.7077
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7077
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	2	0.7077
adenine phosphoribosyltransferase	Q967M2	Q967M2_GIAIN	Giardia intestinalis	2	0.7077
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	2	0.7077
Phenylpyruvate C(3)-methyltransferase	Q643C8	MPPJ_STRHY	Streptomyces hygroscopicus	2	0.7074
Phenylpyruvate C(3)-methyltransferase	Q643C8	MPPJ_STRHY	Streptomyces hygroscopicus	2	0.7074
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7070
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7070
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7069
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2	O95340	PAPS2_HUMAN	Homo sapiens	2	0.7069
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7069
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2	O95340	PAPS2_HUMAN	Homo sapiens	2	0.7069
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7068
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7068
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	2	0.7067
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	2	0.7067
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7064
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7064
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	2	0.7063
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	2	0.7063
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	2	0.7061
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	2	0.7061
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	2	0.7061
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	2	0.7061
SKP1-like protein 1A	Q39255	SKP1A_ARATH	Arabidopsis thaliana	2	0.7060
SKP1-like protein 1A	Q39255	SKP1A_ARATH	Arabidopsis thaliana	2	0.7060
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	2	0.7059
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	2	0.7059
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	2	0.7059
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	2	0.7059
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	2	0.7058
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	2	0.7058
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	2	0.7056
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	2	0.7056
7,8-dihydroneopterin aldolase	J7VEZ6	J7VEZ6_BACCE	Bacillus cereus BAG3X2-1	2	0.7054
DNA-directed DNA polymerase	Q38087	DPOL_BPR69	Escherichia phage RB69	2	0.7054
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	2	0.7054
DNA-directed DNA polymerase	Q38087	DPOL_BPR69	Escherichia phage RB69	2	0.7054
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	2	0.7054
7,8-dihydroneopterin aldolase	J7VEZ6	J7VEZ6_BACCE	Bacillus cereus BAG3X2-1	2	0.7054
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	2	0.7053
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	2	0.7053
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	2	0.7052
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	2	0.7052
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7050
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7050
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7048
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7048
Protein mono-ADP-ribosyltransferase PARP14	Q460N5	PAR14_HUMAN	Homo sapiens	2	0.7048
Protein mono-ADP-ribosyltransferase PARP14	Q460N5	PAR14_HUMAN	Homo sapiens	2	0.7048
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7047
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7047
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase	P9WNH5	HSAD_MYCTU	Mycobacterium tuberculosis	2	0.7046
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase	P9WNH5	HSAD_MYCTU	Mycobacterium tuberculosis	2	0.7046
Alpha/beta hydrolase fold	A5VAT9	A5VAT9_SPHWW	Sphingomonas wittichii	2	0.7045
Alpha/beta hydrolase fold	A5VAT9	A5VAT9_SPHWW	Sphingomonas wittichii	2	0.7045
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16875	F263_HUMAN	Homo sapiens	2	0.7042
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16875	F263_HUMAN	Homo sapiens	2	0.7042
Cytokinin dehydrogenase 1	Q9T0N8	CKX1_MAIZE	Zea mays	2	0.7039
Cytokinin dehydrogenase 1	Q9T0N8	CKX1_MAIZE	Zea mays	2	0.7039
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7036
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7036
cAMP-dependent protein kinase type II-beta regulatory subunit	P12369	KAP3_RAT	Rattus norvegicus	2	0.7034
cAMP-dependent protein kinase type II-beta regulatory subunit	P12369	KAP3_RAT	Rattus norvegicus	2	0.7034
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7033
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7033
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	2	0.7032
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	2	0.7032
Mandelate racemase	P11444	MANR_PSEPU	Pseudomonas putida	2	0.7030
Mandelate racemase	P11444	MANR_PSEPU	Pseudomonas putida	2	0.7030
3'-5' exoribonuclease Rv2179c	P9WJ73	EXRBN_MYCTU	Mycobacterium tuberculosis	2	0.7029
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	2	0.7029
Adenylate cyclase 2	A0A2U2H3Y1	A0A384LKY8_YERPE	Yersinia pestis	2	0.7029
3'-5' exoribonuclease Rv2179c	P9WJ73	EXRBN_MYCTU	Mycobacterium tuberculosis	2	0.7029
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	2	0.7029
Adenylate cyclase 2	A0A2U2H3Y1	A0A384LKY8_YERPE	Yersinia pestis	2	0.7029
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7023
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7023
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7023
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7023
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	2	0.7019
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	2	0.7019
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7018
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7018
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic	O96693	DXR_PLAFX	Plasmodium falciparum	2	0.7016
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic	O96693	DXR_PLAFX	Plasmodium falciparum	2	0.7016
SKP1-like protein 1A	Q39255	SKP1A_ARATH	Arabidopsis thaliana	2	0.7014
SKP1-like protein 1A	Q39255	SKP1A_ARATH	Arabidopsis thaliana	2	0.7014
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	2	0.7012
RIO-type serine/threonine-protein kinase Rio1	O28471	RIO1_ARCFU	Archaeoglobus fulgidus	2	0.7012
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	2	0.7012
RIO-type serine/threonine-protein kinase Rio1	O28471	RIO1_ARCFU	Archaeoglobus fulgidus	2	0.7012
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	2	0.7011
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	2	0.7011
Putative FAD-dependent oxygenase EncM	Q9KHK2	Q9KHK2_9ACTN	Streptomyces maritimus	2	0.7009
Putative FAD-dependent oxygenase EncM	Q9KHK2	Q9KHK2_9ACTN	Streptomyces maritimus	2	0.7009
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7007
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7007
Ribonuclease 4	P15468	RNAS4_PIG	Sus scrofa	2	0.7007
Ribonuclease 4	P15468	RNAS4_PIG	Sus scrofa	2	0.7007
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7004
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7004
Purine nucleoside phosphorylase, putative	A2E7Y6	A2E7Y6_TRIVA	Trichomonas vaginalis	2	0.7003
Purine nucleoside phosphorylase, putative	A2E7Y6	A2E7Y6_TRIVA	Trichomonas vaginalis	2	0.7003
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7003
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7003
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7002
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7002
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7001
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7001

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