Moloka'iamine - Compound Card

Moloka'iamine

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Moloka'iamine

Structure
Zoomed Structure
  • Family: Animalia - Pseudoceratinidae
  • Kingdom: Animalia
  • Class: Alkaloid
    • Subclass: Brominated Alkaloid
Canonical Smiles NCCCOc1c(Br)cc(cc1Br)CCN
InChI InChI=1S/C11H16Br2N2O/c12-9-6-8(2-4-15)7-10(13)11(9)16-5-1-3-14/h6-7H,1-5,14-15H2
InChIKey GEEVJNJYEZHGHA-UHFFFAOYSA-N
Formula C11H16Br2N2O
HBA 3
HBD 2
MW 352.07
Rotatable Bonds 6
TPSA 61.27
LogP 2.44
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 16
Formal Charge 0
Fraction CSP3 0.45
Exact Mass 349.96
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Pseudoceratina arabica Pseudoceratinidae Animalia 375148
2 Pseudoceratina arabica Pseudoceratinidae Animalia 375148

Showing of synonyms

  • Shaala L, Youssef D, et al. (2015). Bioactive alkaloids from the Red Sea marine Verongid sponge Pseudoceratina arabica. Tetrahedron, 2015, 71(41), 7837-7841. [View]
  • Badr JM, Shaala LA, et al. (2008). Bioactive brominated metabolites from the Red Sea sponge Pseudoceratina arabica. Journal of Natural Products,2008,71(8),1472-1474. [View] [PubMed]
Pubchem: 10712937
Nmrshiftdb2: 20180225

No compound-protein relationship available.

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 352.07 g/mol

Antimicrobial
Parasympatholytic

Absorption

Caco-2 (logPapp)
-4.93
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.830
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-3.59

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.570
Plasma Protein Binding
11.88
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.530
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.480
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Toxic
Eye Irritation
Safe
Maximum Tolerated Dose
0.540
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
8.220
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.590
Rat (Acute)
2.430
Rat (Chronic Oral)
1.120
Fathead Minnow
4.260
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
333.980
Hydration Free Energy
-10.210
Log(D) at pH=7.4
1.580
Log(P)
2.11
Log S
-1.53
Log(Vapor Pressure)
-6.07
Melting Point
130.37
pKa Acid
9.08
pKa Basic
11.22
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.9767
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.9767
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.9600
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.9600
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9336
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9336
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9205
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9205
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.9199
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.9199
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.9156
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.9156
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.9069
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.9069
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.9068
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.9068
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.9019
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.9019
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8968
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8968
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8910
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8910
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.8806
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.8806
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8790
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8790
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 3 0.8775
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 3 0.8775
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8682
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8682
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8678
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8678
7,8-dihydroneopterin aldolase J7VEZ6 J7VEZ6_BACCE Bacillus cereus BAG3X2-1 3 0.8637
7,8-dihydroneopterin aldolase J7VEZ6 J7VEZ6_BACCE Bacillus cereus BAG3X2-1 3 0.8637
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.8633
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.8633
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8629
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8629
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8578
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8578
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.8572
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.8572
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.8572
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.8572
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8553
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8553
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.8520
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.8520
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 3 0.8510
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 3 0.8510
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 3 0.8492
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 3 0.8492
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8425
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8425
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.8408
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.8408
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8382
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8382
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.8377
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.8377
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.8342
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.8342
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.8271
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.8271
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.8128
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.8128
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.8054
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.8054
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8010
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8010
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 3 0.7995
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 3 0.7995
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 3 0.7953
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 3 0.7953
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7913
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7913
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.7780
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.7780
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7756
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7756
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7722
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7722
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7715
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7715
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7683
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7683
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7676
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7676
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7646
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7646
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7638
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7638
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7626
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7626
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7622
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7622
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7569
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7569
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7563
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7563
Indole-3-glycerol phosphate synthase P9WFX7 TRPC_MYCTU Mycobacterium tuberculosis 2 0.7541
Indole-3-glycerol phosphate synthase P9WFX7 TRPC_MYCTU Mycobacterium tuberculosis 2 0.7541
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7530
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7530
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7517
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7517
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7517
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7517
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7515
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7515
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic P49235 HGGL1_MAIZE Zea mays 2 0.7502
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic P49235 HGGL1_MAIZE Zea mays 2 0.7502
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7497
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7497
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7483
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7483
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7478
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7478
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7466
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7466
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7457
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7457
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7451
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7451
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7441
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7441
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7441
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7441
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7432
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7432
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7423
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7423
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7410
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7410
Cobalt-precorrin-4 C(11)-methyltransferase O87696 CBIF_BACME Priestia megaterium 3 0.7408
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.7408
Cobalt-precorrin-4 C(11)-methyltransferase O87696 CBIF_BACME Priestia megaterium 3 0.7408
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.7408
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7403
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7403
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7399
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7399
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7392
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7392
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7388
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7388
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7384
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7384
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7382
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7382
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7381
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7381
Endoglycoceramidase II O33853 O33853_RHOSO Rhodococcus sp 3 0.7378
Endoglycoceramidase II O33853 O33853_RHOSO Rhodococcus sp 3 0.7378
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 2 0.7367
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 2 0.7367
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7365
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7365
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7365
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7365
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7351
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7351
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7348
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7348
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7344
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7344
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7341
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7341
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7328
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7328
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.7309
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.7309
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7304
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7304
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7293
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7293
Angiotensin-converting enzyme P12821 ACE_HUMAN Homo sapiens 2 0.7292
Angiotensin-converting enzyme P12821 ACE_HUMAN Homo sapiens 2 0.7292
Glutamate receptor ionotropic, kainate 1 P22756 GRIK1_RAT Rattus norvegicus 2 0.7282
Glutamate receptor ionotropic, kainate 1 P22756 GRIK1_RAT Rattus norvegicus 2 0.7282
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7281
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7281
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7277
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7277
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 2 0.7275
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 2 0.7275
Archaeal actin homolog Q9HKL4 ACTH_THEAC Thermoplasma acidophilum 2 0.7271
Archaeal actin homolog Q9HKL4 ACTH_THEAC Thermoplasma acidophilum 2 0.7271
Polyamine oxidase FMS1 P50264 FMS1_YEAST Saccharomyces cerevisiae 2 0.7267
Polyamine oxidase FMS1 P50264 FMS1_YEAST Saccharomyces cerevisiae 2 0.7267
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7263
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7263
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7249
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7249
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7248
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7248
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7245
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7245
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7238
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7238
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7225
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7225
Glucanase Q7LHI2 Q7LHI2_PHACH Phanerodontia chrysosporium 2 0.7219
Glucanase Q7LHI2 Q7LHI2_PHACH Phanerodontia chrysosporium 2 0.7219
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7218
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7218
DNA (cytosine-5)-methyltransferase 3A O88508 DNM3A_MOUSE Mus musculus 3 0.7215
DNA (cytosine-5)-methyltransferase 3A O88508 DNM3A_MOUSE Mus musculus 3 0.7215
Angiotensin-converting enzyme P12821 ACE_HUMAN Homo sapiens 2 0.7213
Angiotensin-converting enzyme P12821 ACE_HUMAN Homo sapiens 2 0.7213
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7210
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7210
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7209
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7209
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7207
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7207
Deacetoxycephalosporin C synthase P18548 CEFE_STRCL Streptomyces clavuligerus 2 0.7204
Deacetoxycephalosporin C synthase P18548 CEFE_STRCL Streptomyces clavuligerus 2 0.7204
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 3 0.7200
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 3 0.7200
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7197
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7197
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7189
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7189
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7189
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7189
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7187
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7187
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7184
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7184
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.7183
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.7183
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7175
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7175
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7175
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7175
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7173
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7173
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.7164
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.7164
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7161
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7161
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7157
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7157
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7153
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7153
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 2 0.7152
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 2 0.7152
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7146
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7146
Short form salivary protein D7R4 Q7PNF2 Q9BIH3_ANOGA Anopheles gambiae 2 0.7135
Short form salivary protein D7R4 Q7PNF2 Q9BIH3_ANOGA Anopheles gambiae 2 0.7135
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7131
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7131
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7130
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7130
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7129
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7129
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7129
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7129
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7128
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7128
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7117
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7117
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7106
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7106
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7106
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7106
Beta-galactoside alpha-2,6-sialyltransferase 1 P15907 SIAT1_HUMAN Homo sapiens 3 0.7101
Beta-galactoside alpha-2,6-sialyltransferase 1 P15907 SIAT1_HUMAN Homo sapiens 3 0.7101
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7099
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7099
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7090
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7090
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7087
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7087
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.7083
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.7083
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7079
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7079
Ribonucleoside-diphosphate reductase large chain 1 P21524 RIR1_YEAST Saccharomyces cerevisiae 3 0.7074
Ribonucleoside-diphosphate reductase large chain 1 P21524 RIR1_YEAST Saccharomyces cerevisiae 3 0.7074
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7072
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 3 0.7072
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 3 0.7072
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7072
Rho-associated protein kinase 1 Q13464 ROCK1_HUMAN Homo sapiens 3 0.7064
Rho-associated protein kinase 1 Q13464 ROCK1_HUMAN Homo sapiens 3 0.7064
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7064
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7064
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7059
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7059
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 2 0.7058
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 2 0.7058
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7049
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7049
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7048
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7048
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7047
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7047
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7040
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7040
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7040
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7040
Geranyl diphosphate 2-C-methyltransferase D3KYU3 GPPMT_STRLS Streptomyces lasalocidi 3 0.7039
Geranyl diphosphate 2-C-methyltransferase D3KYU3 GPPMT_STRLS Streptomyces lasalocidi 3 0.7039
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7035
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7035
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7033
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7033
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7018
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7018
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7015
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7015
Kallikrein-4 Q9Y5K2 KLK4_HUMAN Homo sapiens 2 0.7009
Kallikrein-4 Q9Y5K2 KLK4_HUMAN Homo sapiens 2 0.7009
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7008
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7008
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7007
Kallikrein-4 Q9Y5K2 KLK4_HUMAN Homo sapiens 2 0.7007
Kallikrein-4 Q9Y5K2 KLK4_HUMAN Homo sapiens 2 0.7007
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7007
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7003
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7003
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7000
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7000

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