Ceratinamine - Compound Card

Ceratinamine

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Ceratinamine

Structure
Zoomed Structure
  • Family: Pseudoceratinidae
  • Kingdom: Animalia
  • Class: Brominated Compound
    • Subclass: Bromotyramine Derivative
Canonical Smiles NCCc1cc(Br)c(c(c1)Br)OCCCNC(=O)C#N
InChI InChI=1S/C13H15Br2N3O2/c14-10-6-9(2-3-16)7-11(15)13(10)20-5-1-4-18-12(19)8-17/h6-7H,1-5,16H2,(H,18,19)
InChIKey VLXGYEMZRIGDRH-UHFFFAOYSA-N
Formula C13H15Br2N3O2
HBA 4
HBD 2
MW 405.09
Rotatable Bonds 7
TPSA 88.14
LogP 2.12
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.38
Exact Mass 402.95
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Pseudoceratina arabica Pseudoceratinidae Animalia 375148

Showing of synonyms

  • Badr JM, Shaala LA, et al. (2008). Bioactive brominated metabolites from the Red Sea sponge Pseudoceratina arabica. Journal of Natural Products,2008,71(8),1472-1474. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

Antimicrobial

Absorption

Caco-2 (logPapp)
-4.8
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.440
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.81

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.440
Plasma Protein Binding
30.74
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.260
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.710
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.190
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
7.650
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.650
Rat (Acute)
2.680
Rat (Chronic Oral)
1.100
Fathead Minnow
4.360
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
389.230
Hydration Free Energy
-15.230
Log(D) at pH=7.4
1.720
Log(P)
2.0
Log S
-2.69
Log(Vapor Pressure)
-7.92
Melting Point
138.45
pKa Acid
6.41
pKa Basic
8.24
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.9834
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.9834
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.9776
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.9776
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9495
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9495
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9325
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9325
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.9293
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.9293
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.9245
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.9245
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.9202
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.9202
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.9196
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.9196
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8948
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8948
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8893
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8893
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8884
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8884
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.8854
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.8854
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8849
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8849
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 3 0.8842
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 3 0.8842
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8840
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8840
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8827
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8827
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.8752
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.8752
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8668
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8668
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8657
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8657
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8601
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8601
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8581
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8581
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.8565
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.8565
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8427
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8427
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.8412
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.8412
NAD-dependent protein deacetylase sirtuin-3, mitochondrial Q9NTG7 SIR3_HUMAN Homo sapiens 3 0.8394
NAD-dependent protein deacetylase sirtuin-3, mitochondrial Q9NTG7 SIR3_HUMAN Homo sapiens 3 0.8394
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8359
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8359
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.8354
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.8354
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8324
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8324
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8307
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8307
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.8194
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.8194
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.8173
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.8173
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8136
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8136
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8068
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8068
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8063
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8063
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7980
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7980
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7979
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7979
7,8-dihydroneopterin aldolase J7VEZ6 J7VEZ6_BACCE Bacillus cereus BAG3X2-1 3 0.7956
7,8-dihydroneopterin aldolase J7VEZ6 J7VEZ6_BACCE Bacillus cereus BAG3X2-1 3 0.7956
Type IV pilus retractation ATPase PilT P24559 PILT_PSEAE Pseudomonas aeruginosa 3 0.7844
Type IV pilus retractation ATPase PilT P24559 PILT_PSEAE Pseudomonas aeruginosa 3 0.7844
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7843
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7843
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7807
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7807
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7784
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7784
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7761
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7761
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7747
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7747
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7747
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7747
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7720
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7720
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7715
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7715
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase Q9WY79 MURE_THEMA Thermotoga maritima 3 0.7707
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase Q9WY79 MURE_THEMA Thermotoga maritima 3 0.7707
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.7705
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.7705
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.7697
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.7697
Indole-3-glycerol phosphate synthase P9WFX7 TRPC_MYCTU Mycobacterium tuberculosis 3 0.7694
Indole-3-glycerol phosphate synthase P9WFX7 TRPC_MYCTU Mycobacterium tuberculosis 3 0.7694
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7679
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7679
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7656
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7656
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7637
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7637
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7605
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7605
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7581
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7581
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7579
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7579
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7559
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7559
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7553
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7553
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7542
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7542
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7541
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7541
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7535
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7535
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7534
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7534
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7534
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7534
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7520
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7520
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7518
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7518
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7512
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7512
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7508
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7508
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7499
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7499
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic P49235 HGGL1_MAIZE Zea mays 2 0.7498
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic P49235 HGGL1_MAIZE Zea mays 2 0.7498
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7497
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7497
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7487
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7487
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7484
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7484
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7476
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7476
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7469
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7469
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7465
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7465
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7443
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7443
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7437
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7437
tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase O58523 TYW2_PYRHO Pyrococcus horikoshii 3 0.7434
tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase O58523 TYW2_PYRHO Pyrococcus horikoshii 3 0.7434
Integrin beta-1-binding protein 1 O14713 ITBP1_HUMAN Homo sapiens 3 0.7425
Integrin beta-1-binding protein 1 O14713 ITBP1_HUMAN Homo sapiens 3 0.7425
Glycoside Hydrolase Family 13 Q65MI2 Q65MI2_BACLD Bacillus licheniformis 2 0.7411
Glycoside Hydrolase Family 13 Q65MI2 Q65MI2_BACLD Bacillus licheniformis 2 0.7411
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7406
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7406
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7403
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7403
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7386
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7386
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7385
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7385
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7374
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7374
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7367
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7367
Short form salivary protein D7R4 Q7PNF2 Q9BIH3_ANOGA Anopheles gambiae 2 0.7354
Short form salivary protein D7R4 Q7PNF2 Q9BIH3_ANOGA Anopheles gambiae 2 0.7354
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.7349
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.7349
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7336
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7336
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7335
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7335
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7332
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7332
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7328
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7328
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7326
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7326
Orotidine 5'-phosphate decarboxylase Q5L0U0 PYRF_GEOKA Geobacillus kaustophilus 3 0.7315
Orotidine 5'-phosphate decarboxylase Q5L0U0 PYRF_GEOKA Geobacillus kaustophilus 3 0.7315
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7304
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7304
Glutamate receptor ionotropic, kainate 1 P22756 GRIK1_RAT Rattus norvegicus 2 0.7300
Glutamate receptor ionotropic, kainate 1 P22756 GRIK1_RAT Rattus norvegicus 2 0.7300
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7293
Cobalt-precorrin-4 C(11)-methyltransferase O87696 CBIF_BACME Priestia megaterium 3 0.7293
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7293
Cobalt-precorrin-4 C(11)-methyltransferase O87696 CBIF_BACME Priestia megaterium 3 0.7293
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7291
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7291
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7290
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7290
NTPase P4 Q94M05 Q94M05_9VIRU Pseudomonas phage phi12 2 0.7288
NTPase P4 Q94M05 Q94M05_9VIRU Pseudomonas phage phi12 2 0.7288
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7285
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7285
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7283
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7283
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 3 0.7274
Beta-glucosidase Q8T0W7 Q8T0W7_9NEOP Neotermes koshunensis 3 0.7274
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 3 0.7274
Beta-glucosidase Q8T0W7 Q8T0W7_9NEOP Neotermes koshunensis 3 0.7274
Archaeal actin homolog Q9HKL4 ACTH_THEAC Thermoplasma acidophilum 2 0.7271
Archaeal actin homolog Q9HKL4 ACTH_THEAC Thermoplasma acidophilum 2 0.7271
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7268
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7268
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7262
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7262
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7261
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7261
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7260
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7260
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7257
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7257
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 3 0.7254
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 3 0.7254
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7247
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7247
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7245
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7245
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7243
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7243
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7242
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7242
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7234
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7234
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7231
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7231
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7228
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7228
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7228
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7228
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7221
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7221
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7215
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7215
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.7212
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.7212
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7206
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7206
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7203
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7203
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7200
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7200
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 2 0.7192
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 2 0.7192
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7192
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7192
Kallikrein-4 Q9Y5K2 KLK4_HUMAN Homo sapiens 2 0.7190
Kallikrein-4 Q9Y5K2 KLK4_HUMAN Homo sapiens 2 0.7190
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.7188
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.7188
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7185
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7185
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7182
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7182
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7175
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7175
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7173
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7173
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7172
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7172
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7171
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7171
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7158
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7158
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7157
Capsid protein VP1 O56137 O56137_9VIRU Adeno-associated virus - 6 3 0.7157
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7157
Capsid protein VP1 O56137 O56137_9VIRU Adeno-associated virus - 6 3 0.7157
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7155
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7155
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7154
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7154
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7151
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7151
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7151
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7151
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 2 0.7148
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 2 0.7148
Ribosome-inactivating protein alpha-trichosanthin P09989 RIPT_TRIKI Trichosanthes kirilowii 3 0.7147
Ribosome-inactivating protein alpha-trichosanthin P09989 RIPT_TRIKI Trichosanthes kirilowii 3 0.7147
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7134
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7134
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7132
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7132
Leukotriene A(4) hydrolase Q6IP81 Q6IP81_XENLA Xenopus laevis 3 0.7129
Leukotriene A(4) hydrolase Q6IP81 Q6IP81_XENLA Xenopus laevis 3 0.7129
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7122
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7122
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7117
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7117
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7107
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7107
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 2 0.7104
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 2 0.7104
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7102
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7102
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7101
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7101
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7100
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7100
Angiotensin-converting enzyme Q10714 ACE_DROME Drosophila melanogaster 3 0.7097
Angiotensin-converting enzyme Q10714 ACE_DROME Drosophila melanogaster 3 0.7097
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7096
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7096
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7096
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7096
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.7095
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.7095
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 2 0.7087
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 2 0.7087
Phosphotriesterase Q5KZU5 Q5KZU5_GEOKA Geobacillus kaustophilus 2 0.7086
Phosphotriesterase Q5KZU5 Q5KZU5_GEOKA Geobacillus kaustophilus 2 0.7086
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7086
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7086
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7085
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7085
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7084
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7084
Protein claret segregational P20480 NCD_DROME Drosophila melanogaster 2 0.7078
Protein claret segregational P20480 NCD_DROME Drosophila melanogaster 2 0.7078
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7076
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7076
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7075
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7075
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7072
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7072
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7071
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7071
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7065
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7065
Nucleoside diphosphate kinase Q5HFV4 NDK_STAAC Staphylococcus aureus 2 0.7064
Nucleoside diphosphate kinase Q5HFV4 NDK_STAAC Staphylococcus aureus 2 0.7064
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 2 0.7063
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 2 0.7063
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 2 0.7056
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 2 0.7056
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7054
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7054
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7054
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7054
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7053
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7053
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.7051
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.7051
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7049
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7049
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7048
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7048
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7046
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7046
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7045
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7045
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7044
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7044
GMP reductase Q81JJ9 GUAC_BACAN Bacillus anthracis 2 0.7043
GMP reductase Q81JJ9 GUAC_BACAN Bacillus anthracis 2 0.7043
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7039
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7039
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7036
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7036
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7020
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7020
Kallikrein-4 Q9Y5K2 KLK4_HUMAN Homo sapiens 2 0.7019
Kallikrein-4 Q9Y5K2 KLK4_HUMAN Homo sapiens 2 0.7019
Alpha/beta hydrolase fold protein D2J2T6 D2J2T6_9RHIZ Ochrobactrum sp. T63 2 0.7018
Alpha/beta hydrolase fold protein D2J2T6 D2J2T6_9RHIZ Ochrobactrum sp. T63 2 0.7018
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase P47229 BPHD_PARXL Paraburkholderia xenovorans 3 0.7018
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase P47229 BPHD_PARXL Paraburkholderia xenovorans 3 0.7018
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 3 0.7016
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 3 0.7016
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7015
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7015
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7012
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7012
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7010
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7010

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