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Moloka'iakitamide

Family: Animalia - Pseudoceratinidae
Kingdom: Animalia
Class: Brominated Compound
- Subclass: Bromotyramine Derivative

Canonical Smiles	NCCc1cc(Br)c(c(c1)Br)OCCCNC(=O)C(=O)N
InChI	InChI=1S/C13H17Br2N3O3/c14-9-6-8(2-3-16)7-10(15)11(9)21-5-1-4-18-13(20)12(17)19/h6-7H,1-5,16H2,(H2,17,19)(H,18,20)
InChIKey	NMOWVTVURUKLSV-UHFFFAOYSA-N
Formula	C₁₃H₁₇Br₂N₃O₃
HBA	4
HBD	3
MW	423.11
Rotatable Bonds	7
TPSA	107.44
LogP	1.08
Number Rings	1
Number Aromatic Rings	1
Heavy Atom Count	21
Formal Charge	0
Fraction CSP3	0.38
Exact Mass	420.96
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Pseudoceratina arabica	Pseudoceratinidae	Animalia	375148

Showing of synonyms

Badr JM, Shaala LA, et al. (2008). Bioactive brominated metabolites from the Red Sea sponge Pseudoceratina arabica. Journal of Natural Products,2008,71(8),1472-1474. [View] [PubMed]

Pubchem: 25016409

Zinc: ZINC000040916766

Nmrshiftdb2: 60044293

Chembl: CHEMBL478006

No compound-protein relationship available.

SMILES: c1ccccc1

Level: 0

Mol. Weight: 423.11 g/mol

Antimicrobial

Parasympatholytic

Absorption

Caco-2 (logPapp): -5.57
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.710
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -3.12

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.610
Plasma Protein Binding: 20.84
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 4.110
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 0.140
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 1.110
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 4.100
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 3.430
Rat (Acute): 2.670
Rat (Chronic Oral): 1.280
Fathead Minnow: 4.110
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 429.500
Hydration Free Energy: -17.120
Log(D) at pH=7.4: 1.290
Log(P): 1.37
Log S: -2.33
Log(Vapor Pressure): -10.11
Melting Point: 166.79
pKa Acid: 8.12
pKa Basic: 9.3

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	3	0.9799
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	3	0.9799
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.9737
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.9737
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	3	0.9736
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	3	0.9736
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.9712
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.9712
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.9710
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.9710
5-methylthioadenosine/S-adenosylhomocysteine deaminase	Q7NZ90	Q7NZ90_CHRVO	Chromobacterium violaceum	3	0.9626
5-methylthioadenosine/S-adenosylhomocysteine deaminase	Q7NZ90	Q7NZ90_CHRVO	Chromobacterium violaceum	3	0.9626
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.9590
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.9590
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.9564
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.9564
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.9502
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.9502
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.9495
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.9495
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.9493
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.9493
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.9416
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.9416
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.9356
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.9356
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.9302
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.9302
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.9285
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.9285
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.9279
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.9279
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.9237
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.9237
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.9120
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.9120
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.9084
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.9084
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	3	0.9064
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	3	0.9064
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.8891
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.8891
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.8834
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.8834
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8804
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8804
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8599
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8599
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.8514
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.8514
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Q9NTG7	SIR3_HUMAN	Homo sapiens	3	0.8492
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Q9NTG7	SIR3_HUMAN	Homo sapiens	3	0.8492
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.8480
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.8480
Purine nucleoside phosphorylase	Q8I3X4	Q8I3X4_PLAF7	Plasmodium falciparum	3	0.8428
Purine nucleoside phosphorylase	Q8I3X4	Q8I3X4_PLAF7	Plasmodium falciparum	3	0.8428
Purine nucleoside phosphorylase	P55859	PNPH_BOVIN	Bos taurus	3	0.8418
Purine nucleoside phosphorylase	P55859	PNPH_BOVIN	Bos taurus	3	0.8418
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8394
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8394
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.8334
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.8334
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.8296
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.8296
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.8219
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.8219
Putative FAD-dependent oxygenase EncM	Q9KHK2	Q9KHK2_9ACTN	Streptomyces maritimus	3	0.8189
Putative FAD-dependent oxygenase EncM	Q9KHK2	Q9KHK2_9ACTN	Streptomyces maritimus	3	0.8189
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	3	0.8188
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	3	0.8188
BMP-2-inducible protein kinase	Q9NSY1	BMP2K_HUMAN	Homo sapiens	3	0.8169
BMP-2-inducible protein kinase	Q9NSY1	BMP2K_HUMAN	Homo sapiens	3	0.8169
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	2	0.8146
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	2	0.8146
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8145
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8145
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.8080
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.8080
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8023
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8023
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7984
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7984
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7977
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7977
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	P11310	ACADM_HUMAN	Homo sapiens	3	0.7976
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	P11310	ACADM_HUMAN	Homo sapiens	3	0.7976
Oleandomycin glycosyltransferase	Q53685	OLED_STRAT	Streptomyces antibioticus	2	0.7969
Oleandomycin glycosyltransferase	Q53685	OLED_STRAT	Streptomyces antibioticus	2	0.7969
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7938
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7938
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7879
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7879
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7876
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7876
tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase	O58523	TYW2_PYRHO	Pyrococcus horikoshii	3	0.7837
tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase	O58523	TYW2_PYRHO	Pyrococcus horikoshii	3	0.7837
Lysozyme C II	P11941	LYSC2_ONCMY	Oncorhynchus mykiss	3	0.7827
Lysozyme C II	P11941	LYSC2_ONCMY	Oncorhynchus mykiss	3	0.7827
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7816
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7816
7,8-dihydroneopterin aldolase	J7VEZ6	J7VEZ6_BACCE	Bacillus cereus BAG3X2-1	3	0.7783
7,8-dihydroneopterin aldolase	J7VEZ6	J7VEZ6_BACCE	Bacillus cereus BAG3X2-1	3	0.7783
Histamine N-methyltransferase	P50135	HNMT_HUMAN	Homo sapiens	3	0.7768
Histamine N-methyltransferase	P50135	HNMT_HUMAN	Homo sapiens	3	0.7768
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	3	0.7732
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	3	0.7732
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	3	0.7732
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	3	0.7732
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7712
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7712
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7702
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7702
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7690
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7690
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	3	0.7683
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	3	0.7683
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7679
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7679
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	3	0.7678
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	3	0.7678
Type IV pilus retractation ATPase PilT	P24559	PILT_PSEAE	Pseudomonas aeruginosa	3	0.7662
Type IV pilus retractation ATPase PilT	P24559	PILT_PSEAE	Pseudomonas aeruginosa	3	0.7662
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	3	0.7635
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	3	0.7635
Adenosine 5'-monophosphoramidase HINT1	P80912	HINT1_RABIT	Oryctolagus cuniculus	3	0.7629
Adenosine 5'-monophosphoramidase HINT1	P80912	HINT1_RABIT	Oryctolagus cuniculus	3	0.7629
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7626
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7626
Raucaffricine-O-beta-D-glucosidase	Q9SPP9	RG1_RAUSE	Rauvolfia serpentina	3	0.7625
Raucaffricine-O-beta-D-glucosidase	Q9SPP9	RG1_RAUSE	Rauvolfia serpentina	3	0.7625
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7623
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7623
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7601
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7601
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7600
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7600
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7582
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7582
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7565
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7565
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7547
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7547
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7544
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7544
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7525
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7525
Disks large homolog 1	Q12959	DLG1_HUMAN	Homo sapiens	3	0.7521
Disks large homolog 1	Q12959	DLG1_HUMAN	Homo sapiens	3	0.7521
IAG-nucleoside hydrolase	Q9GPQ4	Q9GPQ4_TRYVI	Trypanosoma vivax	3	0.7506
IAG-nucleoside hydrolase	Q9GPQ4	Q9GPQ4_TRYVI	Trypanosoma vivax	3	0.7506
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic	P49235	HGGL1_MAIZE	Zea mays	2	0.7499
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic	P49235	HGGL1_MAIZE	Zea mays	2	0.7499
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase	Q9WY79	MURE_THEMA	Thermotoga maritima	3	0.7492
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.7492
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.7492
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase	Q9WY79	MURE_THEMA	Thermotoga maritima	3	0.7492
Cyclin-dependent kinase 8	P49336	CDK8_HUMAN	Homo sapiens	3	0.7487
Cyclin-dependent kinase 8	P49336	CDK8_HUMAN	Homo sapiens	3	0.7487
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7482
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7482
Uridine phosphorylase	P0A1F6	UDP_SALTY	Salmonella typhimurium	3	0.7476
Uridine phosphorylase	P0A1F6	UDP_SALTY	Salmonella typhimurium	3	0.7476
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7468
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7468
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7467
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7467
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	3	0.7451
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	3	0.7451
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7439
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7439
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	3	0.7423
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	3	0.7423
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7422
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7422
Cytosine-specific methyltransferase	Q8EVR5	Q8EVR5_MYCPE	Mycoplasma penetrans	3	0.7422
Cytosine-specific methyltransferase	Q8EVR5	Q8EVR5_MYCPE	Mycoplasma penetrans	3	0.7422
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7421
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7421
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7405
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7405
DNA-directed DNA polymerase	Q38087	DPOL_BPR69	Escherichia phage RB69	3	0.7386
Integrin beta-1-binding protein 1	O14713	ITBP1_HUMAN	Homo sapiens	3	0.7386
Integrin beta-1-binding protein 1	O14713	ITBP1_HUMAN	Homo sapiens	3	0.7386
Collagenase 3	P45452	MMP13_HUMAN	Homo sapiens	3	0.7386
DNA-directed DNA polymerase	Q38087	DPOL_BPR69	Escherichia phage RB69	3	0.7386
Collagenase 3	P45452	MMP13_HUMAN	Homo sapiens	3	0.7386
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	2	0.7381
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	2	0.7381
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7373
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7373
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7369
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7369
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	2	0.7357
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	2	0.7357
S-norcoclaurine synthase	Q67A25	NCS_THLFG	Thalictrum flavum subsp. glaucum	3	0.7345
S-norcoclaurine synthase	Q67A25	NCS_THLFG	Thalictrum flavum subsp. glaucum	3	0.7345
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7344
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7344
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7342
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7342
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	2	0.7341
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	2	0.7341
Pantothenate synthetase	P9WIL4	PANC_MYCTO	Mycobacterium tuberculosis	2	0.7337
Pantothenate synthetase	P9WIL4	PANC_MYCTO	Mycobacterium tuberculosis	2	0.7337
Short form salivary protein D7R4	Q7PNF2	Q9BIH3_ANOGA	Anopheles gambiae	2	0.7329
Short form salivary protein D7R4	Q7PNF2	Q9BIH3_ANOGA	Anopheles gambiae	2	0.7329
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	2	0.7319
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	2	0.7319
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.7317
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.7317
Beta-glucosidase A	Q08638	BGLA_THEMA	Thermotoga maritima	3	0.7316
Beta-glucosidase A	Q08638	BGLA_THEMA	Thermotoga maritima	3	0.7316
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7315
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7315
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7314
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7314
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7314
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7314
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7314
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7314
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7312
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7312
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7304
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7304
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7302
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7302
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7299
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7299
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	3	0.7297
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	3	0.7297
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7296
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7296
Proline iminopeptidase	O32449	PIP_SERMA	Serratia marcescens	2	0.7274
Proline iminopeptidase	O32449	PIP_SERMA	Serratia marcescens	2	0.7274
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7269
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7269
Alpha-L-fucosidase, putative	Q9WYE2	Q9WYE2_THEMA	Thermotoga maritima	3	0.7266
Alpha-L-fucosidase, putative	Q9WYE2	Q9WYE2_THEMA	Thermotoga maritima	3	0.7266
Cobalt-precorrin-4 C(11)-methyltransferase	O87696	CBIF_BACME	Priestia megaterium	3	0.7264
Cobalt-precorrin-4 C(11)-methyltransferase	O87696	CBIF_BACME	Priestia megaterium	3	0.7264
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7264
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7264
Leucine--tRNA ligase	P07813	SYL_ECOLI	Escherichia coli	3	0.7259
Leucine--tRNA ligase	P07813	SYL_ECOLI	Escherichia coli	3	0.7259
Archaeal actin homolog	Q9HKL4	ACTH_THEAC	Thermoplasma acidophilum	2	0.7256
Archaeal actin homolog	Q9HKL4	ACTH_THEAC	Thermoplasma acidophilum	2	0.7256
O-GlcNAcase NagJ	Q0TR53	OGA_CLOP1	Clostridium perfringens	3	0.7254
O-GlcNAcase NagJ	Q0TR53	OGA_CLOP1	Clostridium perfringens	3	0.7254
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7247
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7247
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7242
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7242
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7239
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7239
Glutamate receptor ionotropic, kainate 1	P22756	GRIK1_RAT	Rattus norvegicus	2	0.7237
Glutamate receptor ionotropic, kainate 1	P22756	GRIK1_RAT	Rattus norvegicus	2	0.7237
3'-5' exoribonuclease Rv2179c	P9WJ73	EXRBN_MYCTU	Mycobacterium tuberculosis	3	0.7227
3'-5' exoribonuclease Rv2179c	P9WJ73	EXRBN_MYCTU	Mycobacterium tuberculosis	3	0.7227
Proline iminopeptidase	O32449	PIP_SERMA	Serratia marcescens	2	0.7226
Proline iminopeptidase	O32449	PIP_SERMA	Serratia marcescens	2	0.7226
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7221
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7221
Putative cysteine ligase BshC	P55342	BSHC_BACSU	Bacillus subtilis	3	0.7213
Putative cysteine ligase BshC	P55342	BSHC_BACSU	Bacillus subtilis	3	0.7213
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	2	0.7203
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	2	0.7203
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7200
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7200
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7197
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7197
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7197
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7197
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7195
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7195
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7191
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7191
Dihydrofolate reductase	P00378	DYR_CHICK	Gallus gallus	3	0.7189
Dihydrofolate reductase	P00378	DYR_CHICK	Gallus gallus	3	0.7189
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	2	0.7187
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	2	0.7187
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7181
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7181
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7181
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7181
Aminopeptidase N	P15145	AMPN_PIG	Sus scrofa	2	0.7175
Aminopeptidase N	P15145	AMPN_PIG	Sus scrofa	2	0.7175
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7174
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7174
Aminoglycoside N(3)-acetyltransferase	A0A3P1UCA6	Q81P86_BACAN	Bacillus anthracis	2	0.7172
Aminoglycoside N(3)-acetyltransferase	A0A3P1UCA6	Q81P86_BACAN	Bacillus anthracis	2	0.7172
Small heat shock protein StHsp14.0	Q970D9	Q970D9_SULTO	Sulfurisphaera tokodaii	3	0.7162
Small heat shock protein StHsp14.0	Q970D9	Q970D9_SULTO	Sulfurisphaera tokodaii	3	0.7162
Ribosome-inactivating protein alpha-trichosanthin	P09989	RIPT_TRIKI	Trichosanthes kirilowii	3	0.7160
Ribosome-inactivating protein alpha-trichosanthin	P09989	RIPT_TRIKI	Trichosanthes kirilowii	3	0.7160
Glycoside Hydrolase Family 13	Q65MI2	Q65MI2_BACLD	Bacillus licheniformis	2	0.7159
Glycoside Hydrolase Family 13	Q65MI2	Q65MI2_BACLD	Bacillus licheniformis	2	0.7159
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7157
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7157
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7155
Adenosine 5'-monophosphoramidase HINT1	P49773	HINT1_HUMAN	Homo sapiens	3	0.7155
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7155
Adenosine 5'-monophosphoramidase HINT1	P49773	HINT1_HUMAN	Homo sapiens	3	0.7155
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	3	0.7153
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	3	0.7153
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	2	0.7150
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	2	0.7150
NAD-dependent protein deacetylase	Q9WYW0	NPD_THEMA	Thermotoga maritima	2	0.7147
NAD-dependent protein deacetylase	Q9WYW0	NPD_THEMA	Thermotoga maritima	2	0.7147
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	3	0.7146
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	3	0.7146
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7139
Kallikrein-4	Q9Y5K2	KLK4_HUMAN	Homo sapiens	2	0.7139
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7139
Kallikrein-4	Q9Y5K2	KLK4_HUMAN	Homo sapiens	2	0.7139
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	2	0.7136
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	2	0.7136
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7133
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7133
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7132
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7132
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7131
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7131
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7131
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7131
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.7126
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.7126
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7124
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	2	0.7124
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7124
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	2	0.7124
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7119
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7119
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7105
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7105
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	2	0.7100
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	2	0.7100
Tissue factor	P13726	TF_HUMAN	Homo sapiens	3	0.7099
Tissue factor	P13726	TF_HUMAN	Homo sapiens	3	0.7099
Bifunctional dihydrofolate reductase-thymidylate synthase	A7UD81	A7UD81_PLAFA	Plasmodium falciparum	2	0.7095
Bifunctional dihydrofolate reductase-thymidylate synthase	A7UD81	A7UD81_PLAFA	Plasmodium falciparum	2	0.7095
NADPH-dependent 7-cyano-7-deazaguanine reductase	Q9KTK0	QUEF_VIBCH	Vibrio cholerae serotype O1	3	0.7095
NADPH-dependent 7-cyano-7-deazaguanine reductase	Q9KTK0	QUEF_VIBCH	Vibrio cholerae serotype O1	3	0.7095
Proline iminopeptidase	O32449	PIP_SERMA	Serratia marcescens	2	0.7093
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7093
Proline iminopeptidase	O32449	PIP_SERMA	Serratia marcescens	2	0.7093
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7093
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.7086
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.7086
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7082
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7082
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	3	0.7073
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	3	0.7073
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	2	0.7071
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	2	0.7071
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7069
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7069
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7067
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7067
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7063
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7063
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7056
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7056
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7050
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7050
Phosphotriesterase	Q5KZU5	Q5KZU5_GEOKA	Geobacillus kaustophilus	2	0.7049
Phosphotriesterase	Q5KZU5	Q5KZU5_GEOKA	Geobacillus kaustophilus	2	0.7049
5-formyltetrahydrofolate cyclo-ligase	P75430	MTHFS_MYCPN	Mycoplasma pneumoniae	2	0.7047
5-formyltetrahydrofolate cyclo-ligase	P75430	MTHFS_MYCPN	Mycoplasma pneumoniae	2	0.7047
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7043
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7043
Beta-galactosidase	P00722	BGAL_ECOLI	Escherichia coli	2	0.7036
Beta-galactosidase	P00722	BGAL_ECOLI	Escherichia coli	2	0.7036
Rho-associated protein kinase 1	Q13464	ROCK1_HUMAN	Homo sapiens	3	0.7033
Rho-associated protein kinase 1	Q13464	ROCK1_HUMAN	Homo sapiens	3	0.7033
Purine nucleoside phosphorylase	P50389	PNPH_SACS2	Saccharolobus solfataricus	4	0.7029
Purine nucleoside phosphorylase	P50389	PNPH_SACS2	Saccharolobus solfataricus	4	0.7029
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7029
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7029
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7026
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7026
Matrix metalloproteinase-9	P14780	MMP9_HUMAN	Homo sapiens	4	0.7026
Matrix metalloproteinase-9	P14780	MMP9_HUMAN	Homo sapiens	4	0.7026
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	2	0.7022
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	2	0.7022
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7019
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7019
Proto-oncogene tyrosine-protein kinase receptor Ret	P07949	RET_HUMAN	Homo sapiens	3	0.7015
Proto-oncogene tyrosine-protein kinase receptor Ret	P07949	RET_HUMAN	Homo sapiens	3	0.7015
Orotidine 5'-phosphate decarboxylase	Q5L0U0	PYRF_GEOKA	Geobacillus kaustophilus	3	0.7013
Orotidine 5'-phosphate decarboxylase	Q5L0U0	PYRF_GEOKA	Geobacillus kaustophilus	3	0.7013
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7009
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7009
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7009
Ribonuclease 4	P15468	RNAS4_PIG	Sus scrofa	2	0.7009
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	3	0.7009
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	3	0.7009
Ribonuclease 4	P15468	RNAS4_PIG	Sus scrofa	2	0.7009
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7009
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7005
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7005

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