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Meranzin hydrate

Family: Rutaceae
Kingdom: Plantae
Class: Coumarin

Canonical Smiles	CCCCCCCCCCCCCCCC(=O)OC(C(O)(C)C)CCOc1c(OC)ccc2c1oc(=O)cc2
InChI	InChI=1S/C32H50O7/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-28(33)38-27(32(2,3)35)23-24-37-31-26(36-4)21-19-25-20-22-29(34)39-30(25)31/h19-22,27,35H,5-18,23-24H2,1-4H3
InChIKey	XBUJZRCBRIKDDK-UHFFFAOYSA-N
Formula	C₃₂H₅₀O₇
HBA	7
HBD	1
MW	546.75
Rotatable Bonds	21
TPSA	95.2
LogP	7.73
Number Rings	2
Number Aromatic Rings	2
Heavy Atom Count	39
Formal Charge	0
Fraction CSP3	0.69
Exact Mass	546.36
Number of Lipinski Rule Violations	2

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Murraya exotica	Rutaceae	Plantae	2901850

Showing of synonyms

Negi N, Ochi A, et al. (2005). Two new dimeric coumarins isolated from Murraya exotica. Chemical and Pharmaceutical Bulletin,2005,53(9),1180-1182. [View] [PubMed]

Pubchem: 101245396

Nmrshiftdb2: 70086169

CPRiL: 115128

SMILES: c1cccc(c12)oc(=O)cc2

Level: 0

Mol. Weight: 146.15 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.68
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.44
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: -2.09

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.49
Plasma Protein Binding: 53.86
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 3.1
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.63
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 1.06
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 6.51
Micronucleos: Safe
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -1400.55
Rat (Acute): 2.3
Rat (Chronic Oral): 2.34
Fathead Minnow: 9.98
Respiratory Disease: Safe
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 481.41
Hydration Free Energy: -2.83
Log(D) at pH=7.4: 4.55
Log(P): 8.39
Log S: -5.71
Log(Vapor Pressure): -8.98
Melting Point: 54.03
pKa Acid: 9.14
pKa Basic: 6.15

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.9357
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.9357
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.9262
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.9262
NADH:flavin oxidoreductase Sye1	Q8EEC8	Q8EEC8_SHEON	Shewanella oneidensis	3	0.9184
NADH:flavin oxidoreductase Sye1	Q8EEC8	Q8EEC8_SHEON	Shewanella oneidensis	3	0.9184
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.9175
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.9175
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	4	0.9034
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	4	0.9034
Enoyl-[acyl-carrier-protein] reductase [NADH]	P9WGR1	INHA_MYCTU	Mycobacterium tuberculosis	3	0.8994
Enoyl-[acyl-carrier-protein] reductase [NADH]	P9WGR1	INHA_MYCTU	Mycobacterium tuberculosis	3	0.8994
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8928
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8928
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8846
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8846
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.8708
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.8708
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	3	0.8587
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	3	0.8587
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8487
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8487
Bifunctional dihydrofolate reductase-thymidylate synthase	P13922	DRTS_PLAFK	Plasmodium falciparum	3	0.8486
Bifunctional dihydrofolate reductase-thymidylate synthase	P13922	DRTS_PLAFK	Plasmodium falciparum	3	0.8486
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	3	0.8428
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	3	0.8428
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.8352
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.8352
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.8298
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.8298
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8289
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8289
Protein LlR18A	P52778	L18A_LUPLU	Lupinus luteus	3	0.8228
Protein LlR18A	P52778	L18A_LUPLU	Lupinus luteus	3	0.8228
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.8212
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.8212
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8211
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8211
Achbp	I6L8L2	I6L8L2_CAPTE	Capitella teleta	3	0.8177
Achbp	I6L8L2	I6L8L2_CAPTE	Capitella teleta	3	0.8177
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.8118
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.8118
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.8112
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.8112
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.8045
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.8045
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8017
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8017
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7952
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7952
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	3	0.7931
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	3	0.7931
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.7898
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.7898
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7882
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7882
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7856
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7856
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7840
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7840
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7832
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7832
glutaryl-CoA dehydrogenase (ETF)	Q3JP94	Q3JP94_BURP1	Burkholderia pseudomallei	2	0.7829
glutaryl-CoA dehydrogenase (ETF)	Q3JP94	Q3JP94_BURP1	Burkholderia pseudomallei	2	0.7829
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7828
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7828
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7806
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7806
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	3	0.7795
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	3	0.7795
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7776
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.7776
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.7776
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7776
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7759
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7759
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	2	0.7754
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	2	0.7754
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7741
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7741
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.7737
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.7737
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.7733
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.7733
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7719
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7719
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7709
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7709
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7694
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7694
DNA polymerase theta	O75417	DPOLQ_HUMAN	Homo sapiens	4	0.7669
DNA polymerase theta	O75417	DPOLQ_HUMAN	Homo sapiens	4	0.7669
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7667
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7667
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7651
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7651
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7636
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7636
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7635
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7635
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7630
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7630
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	3	0.7619
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	3	0.7619
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	2	0.7605
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	2	0.7605
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	3	0.7598
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	3	0.7598
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7589
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7589
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7586
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7586
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7574
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7574
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7561
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7561
cAMP-dependent protein kinase catalytic subunit alpha	P17612	KAPCA_HUMAN	Homo sapiens	2	0.7529
cAMP-dependent protein kinase catalytic subunit alpha	P17612	KAPCA_HUMAN	Homo sapiens	2	0.7529
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7517
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7517
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7515
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7515
[LysW]-aminoadipate kinase	O50147	LYSZ_THET2	Thermus thermophilus	3	0.7512
[LysW]-aminoadipate kinase	O50147	LYSZ_THET2	Thermus thermophilus	3	0.7512
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7492
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7492
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7491
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7491
Rifampin ADP-ribosyl transferase	A0QRS5	A0QRS5_MYCS2	Mycolicibacterium smegmatis155)	3	0.7473
Rifampin ADP-ribosyl transferase	A0QRS5	A0QRS5_MYCS2	Mycolicibacterium smegmatis155)	3	0.7473
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7461
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7461
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7455
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7455
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7449
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7449
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7447
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7447
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7445
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7445
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7438
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7438
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	2	0.7435
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	2	0.7435
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7415
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7415
Aromatic-amino-acid aminotransferase	P95468	TYRB_PARDE	Paracoccus denitrificans	2	0.7409
Aromatic-amino-acid aminotransferase	P95468	TYRB_PARDE	Paracoccus denitrificans	2	0.7409
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7402
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7402
Acyl-homoserine-lactone synthase	Q4VSJ8	Q4VSJ8_BURGL	Burkholderia glumae	4	0.7400
Acyl-homoserine-lactone synthase	Q4VSJ8	Q4VSJ8_BURGL	Burkholderia glumae	4	0.7400
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7383
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7383
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	2	0.7371
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	2	0.7371
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7368
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7368
Enoyl-[acyl-carrier-protein] reductase [NADH]	P9WGR0	INHA_MYCTO	Mycobacterium tuberculosis	3	0.7360
Enoyl-[acyl-carrier-protein] reductase [NADH]	P9WGR0	INHA_MYCTO	Mycobacterium tuberculosis	3	0.7360
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7339
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7339
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7332
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7332
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	3	0.7328
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	3	0.7328
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.7327
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.7327
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	2	0.7324
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	2	0.7324
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.7320
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.7320
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7318
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7318
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7317
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7317
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7314
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7314
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7308
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7308
cGMP-dependent protein kinase 1	P00516	KGP1_BOVIN	Bos taurus	3	0.7301
cGMP-dependent protein kinase 1	P00516	KGP1_BOVIN	Bos taurus	3	0.7301
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	2	0.7299
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	2	0.7299
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7297
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7297
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7292
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7292
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7286
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7286
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7274
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7274
Trichothecene 15-O-acetyltransferase TRI3	Q9C1B7	TRI3_FUSSP	Fusarium sporotrichioides	3	0.7273
Trichothecene 15-O-acetyltransferase TRI3	Q9C1B7	TRI3_FUSSP	Fusarium sporotrichioides	3	0.7273
Gastrotropin	P51161	FABP6_HUMAN	Homo sapiens	3	0.7272
Gastrotropin	P51161	FABP6_HUMAN	Homo sapiens	3	0.7272
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7271
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7271
Cytochrome P450	Q93H81	Q93H81_STRAX	Streptomyces avermitilis	3	0.7254
Cytochrome P450	Q93H81	Q93H81_STRAX	Streptomyces avermitilis	3	0.7254
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7246
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7246
Aromatic-amino-acid aminotransferase	P95468	TYRB_PARDE	Paracoccus denitrificans	2	0.7241
Aromatic-amino-acid aminotransferase	P95468	TYRB_PARDE	Paracoccus denitrificans	2	0.7241
GCN5-related N-acetyltransferase	Q3M362	Q3M362_TRIV2	Trichormus variabilis	2	0.7237
GCN5-related N-acetyltransferase	Q3M362	Q3M362_TRIV2	Trichormus variabilis	2	0.7237
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7232
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7232
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7228
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	2	0.7228
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7228
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	2	0.7228
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	2	0.7226
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	2	0.7226
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7208
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7208
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7204
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7204
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.7201
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.7201
Pantothenate kinase	P9WPA7	COAA_MYCTU	Mycobacterium tuberculosis	3	0.7195
Pantothenate kinase	P9WPA7	COAA_MYCTU	Mycobacterium tuberculosis	3	0.7195
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7194
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7194
Uncharacterized protein	Q3F0V8	Q3F0V8_BACTI	Bacillus thuringiensis serovar israelensis ATCC 35646	3	0.7189
Uncharacterized protein	Q3F0V8	Q3F0V8_BACTI	Bacillus thuringiensis serovar israelensis ATCC 35646	3	0.7189
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	3	0.7183
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	3	0.7183
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.7180
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.7180
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7179
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7179
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7163
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7163
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7160
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7160
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7141
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7141
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7141
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7141
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7140
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7140
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7139
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7139
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7135
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7135
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7126
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7126
AcsD	Q93AT8	Q93AT8_DICCH	Dickeya chrysanthemi	3	0.7122
AcsD	Q93AT8	Q93AT8_DICCH	Dickeya chrysanthemi	3	0.7122
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7121
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7121
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7121
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7121
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7116
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7116
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.7105
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.7105
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7103
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7103
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.7101
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.7101
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7090
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7090
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7087
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7087
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase	Q9WY79	MURE_THEMA	Thermotoga maritima	3	0.7079
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase	Q9WY79	MURE_THEMA	Thermotoga maritima	3	0.7079
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7078
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7078
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7072
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7072
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7067
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7067
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7065
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7065
dTDP-fucosamine acetyltransferase	Q8FBQ3	WECD_ECOL6	Escherichia coli O6:H1	3	0.7064
dTDP-fucosamine acetyltransferase	Q8FBQ3	WECD_ECOL6	Escherichia coli O6:H1	3	0.7064
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7052
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7052
Capsid protein VP1	O56137	O56137_9VIRU	Adeno-associated virus - 6	3	0.7048
Capsid protein VP1	O56137	O56137_9VIRU	Adeno-associated virus - 6	3	0.7048
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7043
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7043
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7023
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7023
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7023
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7023
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7023
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7023

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