5,6-dimethoxy-2-(2',5',6'-trimethoxyphenyl)-1H-quinolin-4-one - Compound Card

5,6-dimethoxy-2-(2',5',6'-trimethoxyphenyl)-1H-quinolin-4-one

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5,6-dimethoxy-2-(2',5',6'-trimethoxyphenyl)-1H-quinolin-4-one

Structure
Zoomed Structure
  • Family: Plantae - Rutaceae
  • Kingdom: Plantae
  • Class: Alkaloid
    • Subclass: Quinolinone Alkaloid
Canonical Smiles COc1ccc(c(c1c1cc(=O)c2c([nH]1)ccc(c2OC)OC)OC)OC
InChI InChI=1S/C20H21NO6/c1-23-14-8-9-16(25-3)20(27-5)18(14)12-10-13(22)17-11(21-12)6-7-15(24-2)19(17)26-4/h6-10H,1-5H3,(H,21,22)
InChIKey DRMUWMGSSNYPKK-UHFFFAOYSA-N
Formula C20H21NO6
HBA 6
HBD 1
MW 371.39
Rotatable Bonds 6
TPSA 79.01
LogP 3.24
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 27
Formal Charge 0
Fraction CSP3 0.25
Exact Mass 371.14
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Casimiroa edulis Rutaceae Plantae 68535

Showing of synonyms

  • Awaad AS, Maitland DJ, et al. (2007). New alkaloids from Casimiroa edulis fruits and their pharmacological activity. Chemistry of Natural Compounds,2007,43(5),576-580. [View]
Pubchem: 11132423
Nmrshiftdb2: 70071981

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)[nH]c(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 371.39 g/mol

Structure

SMILES: c1cccc(c12)[nH]ccc2=O

Level: 0

Mol. Weight: 371.39 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 371.39 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.51
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.890
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.69

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.440
Plasma Protein Binding
74.85
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.390
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
2.480
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.530
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.310
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-3.670
Rat (Acute)
2.360
Rat (Chronic Oral)
2.370
Fathead Minnow
5.090
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
458.710
Hydration Free Energy
-8.020
Log(D) at pH=7.4
2.510
Log(P)
2.21
Log S
-4.86
Log(Vapor Pressure)
-7.08
Melting Point
218.33
pKa Acid
8.71
pKa Basic
5.03
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9687
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9687
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9571
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9571
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9308
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9308
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9232
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9232
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.9184
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.9184
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9168
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9168
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9080
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9080
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9079
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9079
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9071
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9071
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8949
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8949
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8866
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8866
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8826
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8826
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8812
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8812
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8789
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8789
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8782
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8782
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 4 0.8756
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 4 0.8756
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8729
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8729
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8630
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8630
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8529
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8529
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8463
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8463
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8347
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8347
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8344
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8344
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8273
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8273
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.8189
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.8189
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8168
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8168
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8153
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8153
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8129
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8129
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8063
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8063
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.8027
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.8027
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8016
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8016
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8014
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8014
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 4 0.7983
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 4 0.7983
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7969
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7969
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7962
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7962
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7935
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7935
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7928
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7928
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7921
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7921
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7912
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7912
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7905
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7905
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7904
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7904
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7864
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7864
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7862
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7862
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7829
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7829
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7805
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7805
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7802
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7802
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7800
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7800
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7794
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7794
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7790
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7790
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7787
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7787
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7786
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7786
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7759
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7759
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7749
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7749
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7739
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7739
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7726
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7726
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7717
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7717
Uridine phosphorylase P12758 UDP_ECOLI Escherichia coli 3 0.7676
Uridine phosphorylase P12758 UDP_ECOLI Escherichia coli 3 0.7676
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7668
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7668
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7662
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7662
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7650
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7650
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7646
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7646
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7644
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7644
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.7642
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.7642
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7629
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7629
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7622
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7622
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7601
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7601
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7600
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7600
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7597
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7597
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7576
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7576
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7567
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7567
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7561
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7561
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7550
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7550
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7544
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7544
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7538
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7538
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7536
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7536
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.7531
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.7531
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7529
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7529
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7528
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7528
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7525
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7525
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7494
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7494
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7490
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7490
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7468
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7468
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7466
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7466
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 3 0.7455
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 3 0.7455
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7454
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7454
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7434
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7434
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7418
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7418
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7386
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7386
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7383
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7383
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7380
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7380
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7375
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7375
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7365
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7365
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7354
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7354
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7339
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7339
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7336
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7336
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7314
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7314
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7306
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7306
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 3 0.7302
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 3 0.7302
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7299
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7299
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7289
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7289
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7288
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7288
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7276
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7276
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7268
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7268
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7259
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7259
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7252
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7252
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7246
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7246
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7243
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7243
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7241
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7241
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 3 0.7238
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 3 0.7238
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7228
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7228
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7227
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7227
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7213
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7213
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7205
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7205
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7204
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7204
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7204
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7204
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7197
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7197
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7191
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7191
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7191
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 2 0.7191
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7191
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 2 0.7191
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7190
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7190
TamL D3Y1I2 D3Y1I2_9ACTN Streptomyces sp. 307-9 2 0.7185
TamL D3Y1I2 D3Y1I2_9ACTN Streptomyces sp. 307-9 2 0.7185
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7177
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7177
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 2 0.7177
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 2 0.7177
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7174
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7174
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7160
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7160
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7157
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7157
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7148
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7148
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7143
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7143
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7143
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7143
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7139
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7139
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7137
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7137
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7137
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7137
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7137
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7137
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7136
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7136
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7134
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7134
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7132
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7132
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 3 0.7115
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 3 0.7115
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7108
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7108
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7102
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7102
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7101
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7101
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7092
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7092
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7084
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7084
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7075
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7075
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 3 0.7050
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 3 0.7050
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7041
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7041
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7035
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7035
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7031
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7031
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7030
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7030
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7021
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7021
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7019
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7019
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7018
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7018
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7017
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7017
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 2 0.7010
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 2 0.7010
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7009
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7009

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