Evolitrine - Compound Card

Evolitrine

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Evolitrine

Structure
Zoomed Structure
  • Family: Plantae - Rutaceae
  • Kingdom: Plantae
  • Class: Alkaloid
    • Subclass: Quinoline Alkaloid
Canonical Smiles COc1ccc2c(c1)nc1c(c2OC)cco1
InChI InChI=1S/C13H11NO3/c1-15-8-3-4-9-11(7-8)14-13-10(5-6-17-13)12(9)16-2/h3-7H,1-2H3
InChIKey TWGHMXOYRUTQOL-UHFFFAOYSA-N
Formula C13H11NO3
HBA 4
HBD 0
MW 229.23
Rotatable Bonds 2
TPSA 44.49
LogP 3.0
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 17
Formal Charge 0
Fraction CSP3 0.15
Exact Mass 229.07
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Ruta montana Rutaceae Plantae 266085

Showing of synonyms

  • Touati D, Atta-ur-Rahman, et al. (2000). Alkaloids from Ruta montana. Phytochemistry,2000,53(2),277-279. [View] [PubMed]
Pubchem: 196980
Nmrshiftdb2: 60028682

No compound-protein relationship available.

Structure

SMILES: c1coc(c12)nc3c(c2)cccc3

Level: 0

Mol. Weight: 229.23 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.57
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.160
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.49

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.100
Plasma Protein Binding
74.23
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
11.450
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.690
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-0.280
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.960
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.420
Rat (Acute)
2.490
Rat (Chronic Oral)
2.500
Fathead Minnow
4.700
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
376.360
Hydration Free Energy
-10.790
Log(D) at pH=7.4
3.030
Log(P)
2.86
Log S
-3.22
Log(Vapor Pressure)
-5.6
Melting Point
131.04
pKa Acid
9.23
pKa Basic
6.29
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9873
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9873
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9626
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9626
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9592
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9592
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9514
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9514
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9504
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9504
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9464
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9464
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9437
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9437
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.9343
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.9343
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9134
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9134
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9095
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9095
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8990
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8990
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8869
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8869
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8863
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8863
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8862
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8862
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8850
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8850
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8813
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8813
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8807
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8807
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8769
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8769
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8734
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8734
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8640
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8640
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8632
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8632
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8606
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8606
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8525
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8525
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8469
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8469
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8402
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8402
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8363
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8363
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.8341
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.8341
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8315
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8315
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8268
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8268
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 2 0.8229
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 2 0.8229
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.8228
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.8228
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8210
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8210
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.8200
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.8200
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8163
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8163
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8156
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8156
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.8135
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.8135
Renin P00797 RENI_HUMAN Homo sapiens 3 0.8131
Renin P00797 RENI_HUMAN Homo sapiens 3 0.8131
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.8126
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.8126
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8123
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8123
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8052
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8052
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.8050
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.8050
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.8011
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.8011
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7965
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7965
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7945
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7945
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7907
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7907
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7889
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7889
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7877
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7877
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7864
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7864
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7860
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7860
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7828
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7828
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7809
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7809
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 2 0.7795
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 2 0.7795
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7794
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7794
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7789
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7789
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7784
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7784
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7769
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7769
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7759
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7759
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7752
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7752
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7706
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7706
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7698
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7698
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7690
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7690
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7690
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7690
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7681
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7681
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7681
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7681
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7663
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7663
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7644
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7644
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7642
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7642
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7632
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7632
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7604
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7604
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7573
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7573
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7571
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7571
Interleukin-2 P60568 IL2_HUMAN Homo sapiens 2 0.7568
Interleukin-2 P60568 IL2_HUMAN Homo sapiens 2 0.7568
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.7565
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.7565
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7552
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7552
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7541
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7541
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7541
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7541
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7538
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7538
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7527
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7527
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7512
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7512
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7506
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7506
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 3 0.7502
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 3 0.7502
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7501
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7501
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7501
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7501
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7496
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7496
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7488
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7488
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7478
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7478
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7468
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7468
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7468
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7468
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7461
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7461
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7458
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7458
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7455
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7455
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7453
Pentalenic acid synthase Q825I8 CYP28_STRAW Streptomyces avermitilis 2 0.7453
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7453
Pentalenic acid synthase Q825I8 CYP28_STRAW Streptomyces avermitilis 2 0.7453
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7449
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7449
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7437
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7437
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7433
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7433
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7424
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7424
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7418
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7418
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7399
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7399
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7390
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7390
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7387
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7387
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7377
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7377
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7375
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7375
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 2 0.7374
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 2 0.7374
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7370
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7370
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7367
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7367
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7360
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7360
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7348
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7348
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7348
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7348
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7342
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7342
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 3 0.7341
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 3 0.7341
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7332
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7332
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7322
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7322
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7312
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7312
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7304
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7304
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7304
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7304
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7294
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7294
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7287
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7287
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7285
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7285
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7284
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7284
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7283
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7283
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7274
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7274
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.7272
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.7272
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7266
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7266
Agglutinin alpha chain P18674 LECA_MACPO Maclura pomifera 3 0.7264
Agglutinin alpha chain P18674 LECA_MACPO Maclura pomifera 3 0.7264
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7249
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7249
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7248
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7248
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7240
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7240
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7238
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7238
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7231
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7231
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7228
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7228
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7221
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7221
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7219
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7219
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7218
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7218
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7199
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7199
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7188
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7188
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7184
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7184
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7180
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7180
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7176
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7176
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 2 0.7175
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 2 0.7175
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7173
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7173
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7172
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7172
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7169
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7169
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7164
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7164
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 2 0.7157
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 2 0.7157
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7157
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7157
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7157
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7157
Fatty acid-binding protein, adipocyte P04117 FABP4_MOUSE Mus musculus 2 0.7148
Fatty acid-binding protein, adipocyte P04117 FABP4_MOUSE Mus musculus 2 0.7148
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7148
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7148
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.7146
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.7146
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7140
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7140
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7120
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7120
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7118
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7118
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7116
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7116
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7116
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7116
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7113
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7113
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7104
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7104
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7101
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7101
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7094
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7094
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7092
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7092
Farnesyl pyrophosphate synthase P14324 FPPS_HUMAN Homo sapiens 2 0.7089
Farnesyl pyrophosphate synthase P14324 FPPS_HUMAN Homo sapiens 2 0.7089
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7089
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7089
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7083
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7083
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 2 0.7081
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 2 0.7081
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7079
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7079
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7073
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7073
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7070
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7070
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7067
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7067
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 2 0.7060
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 2 0.7060
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 2 0.7058
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 2 0.7058
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 2 0.7054
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 2 0.7054
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7051
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7051
Thymidylate synthase P45352 TYSY_RAT Rattus norvegicus 2 0.7045
Thymidylate synthase P45352 TYSY_RAT Rattus norvegicus 2 0.7045
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7043
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7043
Neutrophil collagenase P22894 MMP8_HUMAN Homo sapiens 2 0.7030
Neutrophil collagenase P22894 MMP8_HUMAN Homo sapiens 2 0.7030
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 2 0.7026
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 2 0.7026
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7020
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7020
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 2 0.7018
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 2 0.7018
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7010
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7010

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