Sargassaceae meroditerpenoid 8a - Compound Card

Sargassaceae meroditerpenoid 8a

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Sargassaceae meroditerpenoid 8a

Structure
Zoomed Structure
  • Family: Sargassaceae-Fucaceae
  • Kingdom: Chromista
  • Class: Terpenoid
    • Subclass: Meroditerpenoid Derivative
Canonical Smiles COc1cc(C/C=C(/CC2=C(CC(O)(C)C)C(=O)[C@]3([C@](C2)(C)CCC3)C)\C)c(c(c1)C)O
InChI InChI=1S/C28H40O4/c1-18(9-10-20-15-22(32-7)14-19(2)24(20)29)13-21-16-27(5)11-8-12-28(27,6)25(30)23(21)17-26(3,4)31/h9,14-15,29,31H,8,10-13,16-17H2,1-7H3/b18-9+/t27-,28+/m1/s1
InChIKey FFNCYUFWSPYUFV-TUTAVQRMSA-N
Formula C28H40O4
HBA 4
HBD 2
MW 440.62
Rotatable Bonds 7
TPSA 66.76
LogP 6.22
Number Rings 3
Number Aromatic Rings 1
Heavy Atom Count 32
Formal Charge 0
Fraction CSP3 0.61
Exact Mass 440.29
Number of Lipinski Rule Violations 1
# Species Family Kingdom NCBI Taxonomy ID
1 Cystoseira baccata Sargassaceae-Fucaceae Chromista 2823494

Showing of synonyms

  • Mokrini R, Mesaoud MB, et al. (2008). Meroditerpenoids and derivatives from the brown alga Cystoseira baccata and their antifouling properties. Journal of Natural Products,2008,71(11),1806-1181. [View] [PubMed]
Pubchem: 14035355
Nmrshiftdb2: 60043623

No compound-protein relationship available.

Structure

SMILES: c1ccccc1CC=CCC(=CC2=O)CC(C23)CCC3

Level: 1

Mol. Weight: 266.38 g/mol

Structure

SMILES: C1CCC(C12)CC=CC2=O

Level: 0

Mol. Weight: 136.19 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.68
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.660
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.38

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.200
Plasma Protein Binding
94.86
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.070
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.810
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-0.640
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
7.220
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-36.010
Rat (Acute)
2.680
Rat (Chronic Oral)
2.170
Fathead Minnow
4.940
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
448.210
Hydration Free Energy
-3.740
Log(D) at pH=7.4
4.750
Log(P)
5.85
Log S
-6.0
Log(Vapor Pressure)
-7.58
Melting Point
152.28
pKa Acid
9.91
pKa Basic
5.17
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9811
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9811
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9494
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9494
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9140
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9140
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.9134
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.9134
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.9062
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.9062
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9042
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9042
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.9024
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.9024
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9012
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9012
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8993
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8993
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.8953
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.8953
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.8949
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.8949
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8870
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8870
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8823
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8823
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8798
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8798
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8788
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8788
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8715
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8715
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8714
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8714
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8707
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8707
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8684
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8684
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8681
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8681
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 3 0.8642
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 3 0.8642
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.8477
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.8477
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8456
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8456
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8450
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8450
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.8448
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.8448
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.8317
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.8317
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8248
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8248
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8171
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8171
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8169
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8169
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8088
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8088
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8083
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8083
glutaryl-CoA dehydrogenase (ETF) Q3JP94 Q3JP94_BURP1 Burkholderia pseudomallei 2 0.8082
glutaryl-CoA dehydrogenase (ETF) Q3JP94 Q3JP94_BURP1 Burkholderia pseudomallei 2 0.8082
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.8034
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.8034
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7988
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7988
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7968
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7968
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.7933
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.7933
Methionine aminotransferase P77806 YBDL_ECOLI Escherichia coli 3 0.7921
Methionine aminotransferase P77806 YBDL_ECOLI Escherichia coli 3 0.7921
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 4 0.7916
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 4 0.7916
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.7900
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.7900
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7876
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7876
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7871
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7871
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7864
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7864
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7858
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7858
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7848
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7848
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7841
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7841
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7839
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7839
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7836
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7836
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7831
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7831
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7810
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7810
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7809
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7809
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7809
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7809
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 2 0.7789
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 2 0.7789
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7779
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7779
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7767
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7767
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.7760
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.7760
Kynurenine 3-monooxygenase P38169 KMO_YEAST Saccharomyces cerevisiae 2 0.7757
Kynurenine 3-monooxygenase P38169 KMO_YEAST Saccharomyces cerevisiae 2 0.7757
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7749
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7749
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7749
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7749
Cyclic nucleotide-binding protein B8FW11 B8FW11_DESHD Desulfitobacterium hafniense 3 0.7744
Cyclic nucleotide-binding protein B8FW11 B8FW11_DESHD Desulfitobacterium hafniense 3 0.7744
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7743
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7743
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7727
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7727
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7710
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7710
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7709
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7709
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7704
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7704
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7704
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7704
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7701
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7701
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7693
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7693
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7691
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7691
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 2 0.7690
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 2 0.7690
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7673
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7673
Aromatic/aminoadipate aminotransferase 1 P53090 ARO8_YEAST Saccharomyces cerevisiae 3 0.7624
Aromatic/aminoadipate aminotransferase 1 P53090 ARO8_YEAST Saccharomyces cerevisiae 3 0.7624
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7609
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7609
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7603
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7603
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7600
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7600
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7595
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7595
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7587
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7587
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7576
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7576
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7575
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7575
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7572
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7572
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7566
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7566
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7540
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7540
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7532
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7532
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7530
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7530
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7525
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7525
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.7524
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.7524
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7521
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7521
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7517
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7517
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7516
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7516
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7516
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7516
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7510
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7510
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 2 0.7510
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 2 0.7510
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7493
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7493
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7492
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7492
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7491
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7491
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7491
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7491
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7490
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7490
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7485
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7485
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7478
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7478
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7468
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7468
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7465
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7465
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7456
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7456
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7454
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7454
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.7453
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.7453
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7452
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7452
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 2 0.7447
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 2 0.7447
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7438
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7438
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7434
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7434
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7421
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7421
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7412
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7412
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7410
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7410
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7408
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7408
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7406
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7406
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7399
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7399
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7391
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7391
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7389
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7389
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7389
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7389
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7387
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7387
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7387
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7387
Cellular retinoic acid-binding protein 2 P29373 RABP2_HUMAN Homo sapiens 2 0.7386
Cellular retinoic acid-binding protein 2 P29373 RABP2_HUMAN Homo sapiens 2 0.7386
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7377
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7377
Trichosurin Q29147 TRIC_TRIVU Trichosurus vulpecula 2 0.7376
Trichosurin Q29147 TRIC_TRIVU Trichosurus vulpecula 2 0.7376
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7372
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7372
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 2 0.7368
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 2 0.7368
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 2 0.7366
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7366
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7366
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 2 0.7366
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7363
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7363
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7356
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7356
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7356
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7356
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7356
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7356
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7355
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7355
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7355
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7355
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7351
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7351
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7336
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7336
Albumin P02769 ALBU_BOVIN Bos taurus 3 0.7326
Albumin P02769 ALBU_BOVIN Bos taurus 3 0.7326
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7319
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7319
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7319
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7319
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7315
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7315
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7311
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7311
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7303
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7303
Death-associated protein kinase 3 O43293 DAPK3_HUMAN Homo sapiens 2 0.7301
Death-associated protein kinase 3 O43293 DAPK3_HUMAN Homo sapiens 2 0.7301
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7300
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7300
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7299
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7299
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7295
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7295
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7294
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7294
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7293
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7293
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7289
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7289
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7278
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7278
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7277
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7277
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7275
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7275
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7271
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7271
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 2 0.7270
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 2 0.7270
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7266
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7266
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7260
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7260
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7259
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7259
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7253
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7253
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7250
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7250
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7235
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7235
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7232
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7232
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 2 0.7231
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7231
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 2 0.7231
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7231
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7229
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7229
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7228
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7228
Dicamba O-demethylase, oxygenase component Q5S3I3 DDMC_STEMA Stenotrophomonas maltophilia 2 0.7216
Dicamba O-demethylase, oxygenase component Q5S3I3 DDMC_STEMA Stenotrophomonas maltophilia 2 0.7216
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7214
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7214
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 2 0.7214
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7214
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7214
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7214
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 2 0.7214
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7214
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 2 0.7211
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7211
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7211
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 2 0.7211
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7209
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7209
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7206
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7206
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 2 0.7204
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 2 0.7204
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7202
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7202
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7201
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7201
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7198
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7198
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7197
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7197
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 2 0.7192
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 2 0.7192
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7191
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7191
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7191
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7191
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 2 0.7190
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 2 0.7190
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7185
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7185
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7184
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7184
D-alanine--D-alanine ligase Q5HEB7 DDL_STAAC Staphylococcus aureus 2 0.7183
D-alanine--D-alanine ligase Q5HEB7 DDL_STAAC Staphylococcus aureus 2 0.7183
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7180
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7180
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7177
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7177
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 2 0.7173
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 2 0.7173
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7171
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7171
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 2 0.7170
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 2 0.7170
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 2 0.7166
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 2 0.7166
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7164
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7164
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.7162
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.7162
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7154
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7154
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7152
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7152
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7151
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7151
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7150
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7150
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7146
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7146
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7141
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7141
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7140
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7140
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7137
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7137
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7135
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7135
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7134
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7134
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7132
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7132
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 2 0.7126
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 2 0.7126
Beta-hexosaminidase Q9KU37 NAGZ_VIBCH Vibrio cholerae serotype O1 3 0.7112
Beta-hexosaminidase Q9KU37 NAGZ_VIBCH Vibrio cholerae serotype O1 3 0.7112
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7109
Toluene-4-monooxygenase system, hydroxylase component subunit alpha Q00456 TMOA_PSEME Pseudomonas mendocina 2 0.7109
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7109
Toluene-4-monooxygenase system, hydroxylase component subunit alpha Q00456 TMOA_PSEME Pseudomonas mendocina 2 0.7109
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7106
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7106
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7106
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7106
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7105
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7105
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7104
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7104
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7103
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7103
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7098
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7098
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7094
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7094
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7089
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7089
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7088
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7088
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7087
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7087
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7085
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7085
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7083
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7083
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7082
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7082
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7082
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7082
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7080
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7080
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7077
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7077
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7067
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7067
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7065
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7065
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 4 0.7059
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 4 0.7059
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7058
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7058
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7058
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7058
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7053
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7053
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7049
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7049
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7048
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7048
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7046
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 2 0.7046
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 2 0.7046
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7046
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7038
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7038
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7038
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7038
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7037
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7037
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7036
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7036
cysteine-S-conjugate beta-lyase Q8DST5 Q8DST5_STRMU Streptococcus mutans serotype c 3 0.7034
cysteine-S-conjugate beta-lyase Q8DST5 Q8DST5_STRMU Streptococcus mutans serotype c 3 0.7034
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7030
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7030
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 2 0.7026
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 2 0.7026
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7025
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 2 0.7025
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 2 0.7025
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7025
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7021
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7021
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 2 0.7020
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 2 0.7020
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7020
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7020
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7018
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7018
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7017
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7017
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7012
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7012
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7011
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7011
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7009
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7009
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7005
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7005
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7002
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7002

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