Cystodione D - Compound Card

Cystodione D

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Cystodione D

Structure
Zoomed Structure
  • Family: Chromista - Sargassaceae-Fucaceae
  • Kingdom: Chromista
  • Class: Terpenoid
    • Subclass: Meroditerpenoid
Canonical Smiles COc1c(/C=C/C(CC(=O)/C=C(/CCCC(=O)C)\C)(O)C)cc(cc1C)O
InChI InChI=1S/C22H30O5/c1-15(7-6-8-17(3)23)11-20(25)14-22(4,26)10-9-18-13-19(24)12-16(2)21(18)27-5/h9-13,24,26H,6-8,14H2,1-5H3/b10-9+,15-11+
InChIKey DMSQHIJLAFYSCV-LVICEBGESA-N
Formula C22H30O5
HBA 5
HBD 2
MW 374.48
Rotatable Bonds 10
TPSA 83.83
LogP 4.14
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 27
Formal Charge 0
Fraction CSP3 0.45
Exact Mass 374.21
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Cystoseira usneoides Sargassaceae-Fucaceae Chromista 590723

Showing of synonyms

  • de Los Reyes C, Zbakh H, et al. (2013). Antioxidant and anti-inflammatory meroterpenoids from the brown alga Cystoseira usneoides. Journal of Natural Products,2013,76(4),621-629. [View] [PubMed]
Pubchem: 71665624
Nmrshiftdb2: 70030211

No compound-protein relationship available.

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 374.48 g/mol

Antiinflammatory property
Antioxidant

Absorption

Caco-2 (logPapp)
-4.69
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.680
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.19

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.750
Plasma Protein Binding
47.92
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.550
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.390
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.470
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.090
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.060
Rat (Acute)
2.320
Rat (Chronic Oral)
2.300
Fathead Minnow
4.910
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
417.780
Hydration Free Energy
-8.480
Log(D) at pH=7.4
2.790
Log(P)
3.5
Log S
-4.76
Log(Vapor Pressure)
-7.07
Melting Point
115.25
pKa Acid
9.91
pKa Basic
4.54
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.9389
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.9389
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.9302
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.9302
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9286
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9286
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.9257
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.9257
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.9252
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.9252
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9055
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9055
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.9043
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.9043
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8973
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8973
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.8952
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.8952
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8914
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8914
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8818
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8818
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8805
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8805
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.8747
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.8747
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8706
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8706
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8681
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8681
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.8629
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.8629
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8571
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8571
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8564
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8564
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8511
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8511
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8488
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8488
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8372
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8372
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8301
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8301
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8281
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8281
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8230
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8230
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8224
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8224
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8208
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8208
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8139
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8139
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 3 0.8124
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 3 0.8124
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8119
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8119
1,4-alpha-glucan branching enzyme GlgB A7ZSW5 GLGB_ECO24 Escherichia coli O139:H28 3 0.8119
1,4-alpha-glucan branching enzyme GlgB A7ZSW5 GLGB_ECO24 Escherichia coli O139:H28 3 0.8119
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8112
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8112
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8100
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8100
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.8083
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.8083
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.8058
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.8058
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8023
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8023
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8015
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8015
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR0 INHA_MYCTO Mycobacterium tuberculosis 3 0.7982
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR0 INHA_MYCTO Mycobacterium tuberculosis 3 0.7982
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7968
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7968
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7941
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7941
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.7915
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.7915
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7902
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7902
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7900
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7900
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7875
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7875
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7864
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7864
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7853
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7853
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 3 0.7833
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 3 0.7833
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7826
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7826
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7790
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7790
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.7781
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.7781
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.7768
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.7768
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7761
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7761
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7755
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7755
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7747
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7747
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7736
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7736
Jasmonoyl--L-amino acid synthetase JAR1 Q9SKE2 JAR1_ARATH Arabidopsis thaliana 3 0.7721
Jasmonoyl--L-amino acid synthetase JAR1 Q9SKE2 JAR1_ARATH Arabidopsis thaliana 3 0.7721
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7702
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7702
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7702
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7702
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.7689
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.7689
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.7679
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.7679
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7646
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7646
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7641
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7641
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7628
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7628
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7624
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7624
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7619
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7619
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7615
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7615
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 4 0.7610
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 4 0.7610
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7606
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7606
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.7592
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.7592
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7585
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7585
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7583
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7583
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7582
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7582
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7562
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7562
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 3 0.7554
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 3 0.7554
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7523
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7523
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7516
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7516
Methyl-branched lipid omega-hydroxylase P9WPP3 CP124_MYCTU Mycobacterium tuberculosis 3 0.7511
Methyl-branched lipid omega-hydroxylase P9WPP3 CP124_MYCTU Mycobacterium tuberculosis 3 0.7511
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7509
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7509
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7501
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7501
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 3 0.7475
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 3 0.7475
Fructose-1,6-bisphosphatase 1 P00636 F16P1_PIG Sus scrofa 3 0.7465
Fructose-1,6-bisphosphatase 1 P00636 F16P1_PIG Sus scrofa 3 0.7465
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7463
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7463
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7452
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7452
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7448
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7448
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7444
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7444
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7437
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7437
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7429
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7429
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7428
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7428
Cholesterol side-chain cleavage enzyme, mitochondrial P00189 CP11A_BOVIN Bos taurus 4 0.7428
Cholesterol side-chain cleavage enzyme, mitochondrial P00189 CP11A_BOVIN Bos taurus 4 0.7428
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7415
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7415
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7412
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7412
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7411
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7411
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.7398
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.7398
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7395
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7395
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 2 0.7375
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 2 0.7375
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7373
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7373
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7368
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7368
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7363
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7363
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7363
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7363
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7355
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7355
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7355
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7355
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7335
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7335
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7333
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7333
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7305
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7305
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7297
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7297
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7294
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7294
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7291
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7291
N-acetylhexosamine 1-kinase E8MF12 NAHK_BIFL2 Bifidobacterium longum subsp. longum 3 0.7264
N-acetylhexosamine 1-kinase E8MF12 NAHK_BIFL2 Bifidobacterium longum subsp. longum 3 0.7264
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7262
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7262
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7261
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7261
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7259
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7259
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.7259
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.7259
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7256
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7256
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 3 0.7242
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 3 0.7242
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7238
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7238
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7231
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7231
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7222
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7222
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7217
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7217
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7207
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7207
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7199
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7199
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7196
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7196
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7184
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7184
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7181
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7181
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7178
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7178
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 2 0.7173
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 2 0.7173
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7171
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7171
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7170
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7170
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7164
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7164
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7156
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7156
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7153
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7153
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7132
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7132
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.7130
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.7130
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 2 0.7122
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 2 0.7122
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7120
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7120
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7114
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7114
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 2 0.7109
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 2 0.7109
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7093
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7093
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7083
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7083
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.7079
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.7079
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7079
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7079
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7077
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7077
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7071
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7071
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7057
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7057
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7047
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7047
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7044
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7044
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7044
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7044
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7041
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7041
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 3 0.7039
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 3 0.7039
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7038
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7038
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 2 0.7036
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 2 0.7036
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7029
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7029
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7029
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7029
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7019
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7019
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7018
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7018
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7017
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7017
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7012
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7012
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7008
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7008
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7005
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7005

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