Cystomexicone A - Compound Card

Cystomexicone A

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Cystomexicone A

Structure
Zoomed Structure
  • Family: Chromista - Sargassaceae-Fucaceae
  • Kingdom: Chromista
  • Class: Terpenoid
    • Subclass: Meroditerpenoid
Canonical Smiles COc1c(C/C=C(/CC(=O)/C=C(\CCCC(=O)C)/C)\C)cc(cc1C)O
InChI InChI=1S/C22H30O4/c1-15(7-6-8-18(4)23)11-20(24)12-16(2)9-10-19-14-21(25)13-17(3)22(19)26-5/h9,11,13-14,25H,6-8,10,12H2,1-5H3/b15-11-,16-9+
InChIKey YHLPKYKKWOFVQL-DHHDRDHJSA-N
Formula C22H30O4
HBA 4
HBD 1
MW 358.48
Rotatable Bonds 10
TPSA 63.6
LogP 4.86
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 26
Formal Charge 0
Fraction CSP3 0.45
Exact Mass 358.21
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Cystoseira usneoides Sargassaceae-Fucaceae Chromista 590723

Showing of synonyms

  • de Los Reyes C, Zbakh H, et al. (2013). Antioxidant and anti-inflammatory meroterpenoids from the brown alga Cystoseira usneoides. Journal of Natural Products,2013,76(4),621-629. [View] [PubMed]
Pubchem: 21575348
Nmrshiftdb2: 70030210

No compound-protein relationship available.

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 358.48 g/mol

Antiinflammatory property
Antioxidant

Absorption

Caco-2 (logPapp)
-4.81
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.630
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.59

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.860
Plasma Protein Binding
57.02
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.400
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.530
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.550
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.390
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.180
Rat (Acute)
2.080
Rat (Chronic Oral)
2.190
Fathead Minnow
5.150
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
413.000
Hydration Free Energy
-7.910
Log(D) at pH=7.4
3.160
Log(P)
3.75
Log S
-5.54
Log(Vapor Pressure)
-6.75
Melting Point
72.95
pKa Acid
10.66
pKa Basic
4.67
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.9779
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.9779
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.9653
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.9653
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 3 0.9193
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 3 0.9193
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.9176
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.9176
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9121
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9121
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9117
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9117
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.9084
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.9084
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.9072
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.9072
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9022
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9022
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9013
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9013
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8981
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8981
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8952
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8952
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8934
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8934
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8903
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8903
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8865
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8865
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8719
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8719
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.8698
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.8698
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8648
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8648
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.8636
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.8636
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8617
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8617
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8594
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8594
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8571
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8571
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8546
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8546
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8546
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8546
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8537
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8537
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8523
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8523
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8511
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8511
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8500
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8500
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8493
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8493
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.8466
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.8466
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8462
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8462
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.8453
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.8453
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.8448
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.8448
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8431
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8431
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8426
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8426
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8408
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8408
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8395
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8395
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8383
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8383
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 3 0.8367
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 3 0.8367
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8332
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8332
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8306
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8306
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8303
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8303
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8302
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8302
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8272
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8272
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.8257
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.8257
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8252
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8252
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8243
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8243
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8206
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8206
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8185
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8185
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8182
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8182
Vitamin D(3) 25-hydroxylase C4B644 CPVDH_PSEAH Pseudonocardia autotrophica 3 0.8144
Vitamin D(3) 25-hydroxylase C4B644 CPVDH_PSEAH Pseudonocardia autotrophica 3 0.8144
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8128
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8128
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8096
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8096
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8076
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8076
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.8071
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.8071
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8055
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8055
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8039
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8039
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8036
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8036
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8020
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8020
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8015
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8015
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8003
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8003
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7969
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7969
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7966
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7966
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7910
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7910
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.7909
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.7909
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 3 0.7882
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 3 0.7882
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7858
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7858
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7855
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7855
Albumin P02769 ALBU_BOVIN Bos taurus 3 0.7826
Albumin P02769 ALBU_BOVIN Bos taurus 3 0.7826
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7800
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7800
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7799
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7799
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7786
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7786
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7778
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7778
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7762
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7762
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7759
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7759
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7743
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7743
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7740
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7740
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7734
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7734
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7720
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7720
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7718
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7718
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7714
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7714
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7709
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7709
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7707
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7707
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7701
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7701
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7692
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7692
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7687
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7687
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 3 0.7686
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 3 0.7686
Lanosterol 14-alpha-demethylase Q385E8 Q385E8_TRYB2 Trypanosoma brucei brucei 3 0.7681
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7681
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7681
Lanosterol 14-alpha-demethylase Q385E8 Q385E8_TRYB2 Trypanosoma brucei brucei 3 0.7681
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7667
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7667
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7663
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7663
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7662
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7662
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.7651
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.7651
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7642
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7642
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7622
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7622
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7613
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7613
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7604
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7604
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7595
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7595
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7591
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7591
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7588
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7588
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7579
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7579
Virginiamycin A acetyltransferase P26839 VATA_STAAU Staphylococcus aureus 4 0.7575
Virginiamycin A acetyltransferase P26839 VATA_STAAU Staphylococcus aureus 4 0.7575
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7569
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7569
Kynurenine 3-monooxygenase P38169 KMO_YEAST Saccharomyces cerevisiae 2 0.7564
Kynurenine 3-monooxygenase P38169 KMO_YEAST Saccharomyces cerevisiae 2 0.7564
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7562
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7562
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7559
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7559
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7543
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7543
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7540
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7540
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7530
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7530
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7529
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7529
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7522
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7522
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7511
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7511
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 4 0.7492
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 4 0.7492
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7480
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7480
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.7475
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.7475
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7470
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7470
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7469
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7469
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7459
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7459
Type IV pilus retractation ATPase PilT P24559 PILT_PSEAE Pseudomonas aeruginosa 3 0.7456
Type IV pilus retractation ATPase PilT P24559 PILT_PSEAE Pseudomonas aeruginosa 3 0.7456
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7451
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7451
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7450
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7450
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7438
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7438
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7437
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7437
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7431
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7431
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7427
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7427
Beta-elicitin cryptogein P15570 ELIB_PHYCR Phytophthora cryptogea 3 0.7420
Beta-elicitin cryptogein P15570 ELIB_PHYCR Phytophthora cryptogea 3 0.7420
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7416
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7416
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.7415
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.7415
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 4 0.7411
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 4 0.7411
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7407
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.7407
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7407
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.7407
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7403
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7403
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7401
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7401
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7397
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7397
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7395
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7395
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7395
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7395
Regulatory protein SdiA P07026 SDIA_ECOLI Escherichia coli 3 0.7394
Regulatory protein SdiA P07026 SDIA_ECOLI Escherichia coli 3 0.7394
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7390
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7390
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7388
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7388
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.7370
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.7370
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 2 0.7369
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 2 0.7369
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7355
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7355
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7353
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7353
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7353
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7353
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7352
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7352
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7350
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7350
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7348
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7348
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7346
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7346
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.7335
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.7335
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 2 0.7327
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 2 0.7327
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7326
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7326
Caspase-7 P55210 CASP7_HUMAN Homo sapiens 3 0.7319
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7319
Caspase-7 P55210 CASP7_HUMAN Homo sapiens 3 0.7319
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7319
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7316
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7316
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7315
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7315
Fructose-1,6-bisphosphatase 1 P00636 F16P1_PIG Sus scrofa 3 0.7314
Fructose-1,6-bisphosphatase 1 P00636 F16P1_PIG Sus scrofa 3 0.7314
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7314
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7314
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7309
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7309
Putative cytochrome P450 120 Q59990 CP120_SYNY3 Synechocystis sp 3 0.7304
Putative cytochrome P450 120 Q59990 CP120_SYNY3 Synechocystis sp 3 0.7304
Petrobactin biosynthesis protein AsbB Q81RQ8 Q81RQ8_BACAN Bacillus anthracis 3 0.7303
Petrobactin biosynthesis protein AsbB Q81RQ8 Q81RQ8_BACAN Bacillus anthracis 3 0.7303
Orotidine 5'-phosphate decarboxylase Q5L0U0 PYRF_GEOKA Geobacillus kaustophilus 3 0.7289
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7289
Orotidine 5'-phosphate decarboxylase Q5L0U0 PYRF_GEOKA Geobacillus kaustophilus 3 0.7289
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7289
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7279
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7279
Cellular retinol-binding protein type II Q8UVG6 Q8UVG6_DANRE Danio rerio 3 0.7277
Cellular retinol-binding protein type II Q8UVG6 Q8UVG6_DANRE Danio rerio 3 0.7277
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7274
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7274
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7271
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7271
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7270
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7270
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7270
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7270
Retinol-binding protein 2 P06768 RET2_RAT Rattus norvegicus 3 0.7269
Retinol-binding protein 2 P06768 RET2_RAT Rattus norvegicus 3 0.7269
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7268
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7268
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7265
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7265
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7252
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7252
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 2 0.7246
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 2 0.7246
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7238
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7238
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7228
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7228
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7213
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7213
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7210
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7210
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7204
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7204
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7203
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7203
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7203
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7203
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7201
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7201
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7200
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7200
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7198
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7198
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7198
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7198
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7196
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 2 0.7196
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7196
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 2 0.7196
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7190
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7190
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7183
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7183
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7179
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7179
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7172
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7172
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7171
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7171
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.7169
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.7169
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7168
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7168
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7159
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7159
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 2 0.7158
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7158
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 2 0.7158
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7158
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7147
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7147
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7144
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7144
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7144
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7144
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7143
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7143
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7141
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7141
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7141
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7141
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7140
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7140
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7138
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7138
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7125
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7125
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.7121
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7121
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7121
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7121
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7121
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.7121
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7116
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7116
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7107
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7107
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7106
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7106
Retinoic acid receptor gamma P13631 RARG_HUMAN Homo sapiens 3 0.7105
Retinoic acid receptor gamma P13631 RARG_HUMAN Homo sapiens 3 0.7105
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7104
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7104
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7102
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7102
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 2 0.7095
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 2 0.7095
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7092
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7092
Protein RecA Q59560 RECA_MYCS2 Mycolicibacterium smegmatis155) 3 0.7091
Protein RecA Q59560 RECA_MYCS2 Mycolicibacterium smegmatis155) 3 0.7091
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7090
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7090
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7090
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7090
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7087
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7087
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7085
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7085
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7084
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7084
Lactoylglutathione lyase Q04760 LGUL_HUMAN Homo sapiens 2 0.7083
Lactoylglutathione lyase Q04760 LGUL_HUMAN Homo sapiens 2 0.7083
Androgen receptor P19091 ANDR_MOUSE Mus musculus 3 0.7081
Androgen receptor P19091 ANDR_MOUSE Mus musculus 3 0.7081
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7080
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7080
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7076
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 2 0.7076
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7076
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 2 0.7076
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7074
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7074
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7063
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7063
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7060
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7060
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7059
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7059
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7057
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7057
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7056
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7056
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7053
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7053
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7050
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7050
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7038
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7038
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7037
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7037
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7036
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7036
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7034
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7034
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7032
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7032
Holliday junction branch migration complex subunit RuvB Q9PMT7 RUVB_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 2 0.7025
Holliday junction branch migration complex subunit RuvB Q9PMT7 RUVB_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 2 0.7025
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7024
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7024
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7021
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7021
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7018
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7018
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7016
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7016
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7015
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7015
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7012
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7012
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7008
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7008

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