3-(3'-methoxytropoyloxy)tropane - Compound Card

3-(3'-methoxytropoyloxy)tropane

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3-(3'-methoxytropoyloxy)tropane

Structure
Zoomed Structure
  • Family: Solanaceae
  • Kingdom: Plantae
  • Class: Alkaloid
Canonical Smiles OCC(c1cccc(c1)OC)C(=O)OC1CC2CCC(C1)N2C
InChI InChI=1S/C18H25NO4/c1-19-13-6-7-14(19)10-16(9-13)23-18(21)17(11-20)12-4-3-5-15(8-12)22-2/h3-5,8,13-14,16-17,20H,6-7,9-11H2,1-2H3
InChIKey GTQDIPBCLBLDHT-UHFFFAOYSA-N
Formula C18H25NO4
HBA 5
HBD 1
MW 319.4
Rotatable Bonds 5
TPSA 59.0
LogP 1.94
Number Rings 3
Number Aromatic Rings 1
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.61
Exact Mass 319.18
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Datura stramonium Solanaceae Plantae 4076

Showing of synonyms

  • El Bazaoui A, Bellimam MA, et al. (2011). Nine new tropane alkaloids from Datura stramonium L. identified by GC/MS. Fitoterapia,2011,82(2),193-197. [View] [PubMed]
Pubchem: 123970977
Nmrshiftdb2: 70004762

No compound-protein relationship available.

Structure

SMILES: c1ccccc1CC(=O)OC(C2)CC(N3)CCC23

Level: 1

Mol. Weight: 245.32 g/mol

Structure

SMILES: C12CCC(N2)CCC1

Level: 0

Mol. Weight: 111.19 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.16
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.71
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.01

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.46
Plasma Protein Binding
12.4
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.84
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.29
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-0.47
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
9.35
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
1.93
Rat (Acute)
2.7
Rat (Chronic Oral)
2.01
Fathead Minnow
4.07
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
357.93
Hydration Free Energy
-9.67
Log(D) at pH=7.4
1.01
Log(P)
1.96
Log S
-1.39
Log(Vapor Pressure)
-6.83
Melting Point
123.03
pKa Acid
9.52
pKa Basic
8.66
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9271
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9271
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9195
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9195
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9147
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9147
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.9117
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.9117
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8901
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8901
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.8860
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.8860
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.8856
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.8856
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8800
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8800
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.8691
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.8691
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.8679
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.8679
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8623
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8623
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8593
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8593
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8587
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8587
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8498
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8498
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8480
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8480
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.8313
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.8313
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.8210
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.8210
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8190
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8190
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8156
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8156
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8117
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8117
Indole-3-glycerol phosphate synthase P9WFX7 TRPC_MYCTU Mycobacterium tuberculosis 3 0.8076
Indole-3-glycerol phosphate synthase P9WFX7 TRPC_MYCTU Mycobacterium tuberculosis 3 0.8076
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 3 0.8064
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 3 0.8064
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 3 0.8016
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 3 0.8016
Gag-Pol polyprotein P0C6F2 POL_HV1LW Human immunodeficiency virus type 1 group M subtype B 3 0.7980
Gag-Pol polyprotein P0C6F2 POL_HV1LW Human immunodeficiency virus type 1 group M subtype B 3 0.7980
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7973
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7973
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.7918
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.7918
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7906
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7906
Glycogenin-1 P46976 GLYG_HUMAN Homo sapiens 3 0.7890
Glycogenin-1 P46976 GLYG_HUMAN Homo sapiens 3 0.7890
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7873
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7873
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7860
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7860
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7850
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7850
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7826
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7826
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7811
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7811
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7798
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7798
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7784
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7784
Polyamine oxidase FMS1 P50264 FMS1_YEAST Saccharomyces cerevisiae 3 0.7776
Polyamine oxidase FMS1 P50264 FMS1_YEAST Saccharomyces cerevisiae 3 0.7776
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7731
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7731
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7722
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7722
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 3 0.7712
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 3 0.7712
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7708
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7708
4-alpha-glucanotransferase O87172 MALQ_THETH Thermus thermophilus 3 0.7694
4-alpha-glucanotransferase O87172 MALQ_THETH Thermus thermophilus 3 0.7694
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7660
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7660
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 3 0.7642
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 3 0.7642
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7613
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7613
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7611
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7611
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7600
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7600
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7572
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7572
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7564
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7564
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7561
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7561
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7545
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7545
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 2 0.7536
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 2 0.7536
Capsid protein VP1 O56137 O56137_9VIRU Adeno-associated virus - 6 3 0.7529
Capsid protein VP1 O56137 O56137_9VIRU Adeno-associated virus - 6 3 0.7529
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7508
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7508
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7478
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7478
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7451
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7451
Geranyl diphosphate 2-C-methyltransferase D3KYU3 GPPMT_STRLS Streptomyces lasalocidi 3 0.7443
Geranyl diphosphate 2-C-methyltransferase D3KYU3 GPPMT_STRLS Streptomyces lasalocidi 3 0.7443
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7442
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7442
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7436
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7436
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7429
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7429
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7426
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7426
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7422
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7422
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic P49235 HGGL1_MAIZE Zea mays 2 0.7416
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic P49235 HGGL1_MAIZE Zea mays 2 0.7416
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7412
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7412
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7404
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7404
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7401
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7401
Mitomycin-binding protein O05205 O05205_STRLA Streptomyces lavendulae 2 0.7392
Mitomycin-binding protein O05205 O05205_STRLA Streptomyces lavendulae 2 0.7392
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7385
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7385
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7383
beta-glucosidase Q92AS9 Q92AS9_LISIN Listeria innocua serovar 6a 3 0.7383
beta-glucosidase Q92AS9 Q92AS9_LISIN Listeria innocua serovar 6a 3 0.7383
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7383
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7379
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7379
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7376
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7376
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7364
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7364
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7359
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7359
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.7353
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.7353
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7346
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7346
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7345
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7345
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7335
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7335
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7326
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7326
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7313
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7313
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7307
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 3 0.7307
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 3 0.7307
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7307
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7297
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7297
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7279
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7279
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7277
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7277
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7275
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7275
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7265
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7265
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7265
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7265
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7264
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7264
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7259
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7259
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q8ZMF7 ISPF_SALTY Salmonella typhimurium 3 0.7256
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q8ZMF7 ISPF_SALTY Salmonella typhimurium 3 0.7256
Geranyl diphosphate 2-C-methyltransferase D3KYU3 GPPMT_STRLS Streptomyces lasalocidi 4 0.7255
Geranyl diphosphate 2-C-methyltransferase D3KYU3 GPPMT_STRLS Streptomyces lasalocidi 4 0.7255
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7254
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7254
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7250
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7250
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7245
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7245
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7244
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7244
mRNA cap guanine-N7 methyltransferase O43148 MCES_HUMAN Homo sapiens 3 0.7236
mRNA cap guanine-N7 methyltransferase O43148 MCES_HUMAN Homo sapiens 3 0.7236
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7226
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7226
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 2 0.7220
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7220
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 2 0.7220
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7220
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7213
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7213
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.7192
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.7192
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7191
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7191
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 2 0.7183
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 2 0.7183
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7180
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7180
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7170
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7170
Elongation factor Tu 1 P0CE47 EFTU1_ECOLI Escherichia coli 3 0.7164
Elongation factor Tu 1 P0CE47 EFTU1_ECOLI Escherichia coli 3 0.7164
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7164
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7164
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 2 0.7161
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 2 0.7161
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7160
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7160
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7154
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7154
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7153
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7153
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7140
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7140
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7137
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7137
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7129
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7129
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7117
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7117
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7117
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7117
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7114
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7114
(R)-S-adenosyl-L-methionine hydrolase O58212 O58212_PYRHO Pyrococcus horikoshii OT3 3 0.7113
(R)-S-adenosyl-L-methionine hydrolase O58212 O58212_PYRHO Pyrococcus horikoshii OT3 3 0.7113
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7104
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7104
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7103
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7103
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7097
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7097
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.7095
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.7095
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7088
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7088
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7085
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7085
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7080
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7080
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7070
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7070
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7068
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7068
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7057
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7057
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.7056
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.7056
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7041
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7041
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7039
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7039
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7039
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7039
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7038
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7038
Glycogen synthase P0A6U8 GLGA_ECOLI Escherichia coli 3 0.7036
Glycogen synthase P0A6U8 GLGA_ECOLI Escherichia coli 3 0.7036
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7035
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7035
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 3 0.7034
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 3 0.7034
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7028
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7028
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7022
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7022
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7019
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7019
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7019
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7019
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7019
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7019
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7011
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7011
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7010
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7010
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7010
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7010
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7008
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7008
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7006
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7006
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7001
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7001
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7000
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7000

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