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Decarboxy dehydrodigallic acid

Family: Tamaricaceae
Kingdom: Plantae
Class: Tannin
- Subclass: Ellagitannin

Canonical Smiles	Oc1cc(cc(c1O)Oc1ccc(c(c1O)O)O)C(=O)O
InChI	InChI=1S/C13H10O8/c14-6-1-2-8(12(18)11(6)17)21-9-4-5(13(19)20)3-7(15)10(9)16/h1-4,14-18H,(H,19,20)
InChIKey	RCFLHUOOZRSCPO-UHFFFAOYSA-N
Formula	C₁₃H₁₀O₈
HBA	7
HBD	6
MW	294.22
Rotatable Bonds	3
TPSA	147.68
LogP	1.71
Number Rings	2
Number Aromatic Rings	2
Heavy Atom Count	21
Formal Charge	0
Fraction CSP3	0.0
Exact Mass	294.04
Number of Lipinski Rule Violations	1

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Tamarix aphylla	Tamaricaceae	Plantae	189786
2	Reaumuria vermiculata	Tamaricaceae	Plantae	1518163

Showing of synonyms

Nawwar MA, Ayoub NA, et al. (2012). Cytotoxic ellagitannins from Reaumuria vermiculata. Fitoterapia,2012,83(7),1256-1266. [View] [PubMed]
Souliman A, Barakat H, et al. (1991). Phenolics From The Bark Of Tamarix Aphylla. Phytochemistry, 1991, 30(11), 3763-3766. [View]

Pubchem: 15714543

Zinc: ZINC000196559695

Nmrshiftdb2: 60033266

No compound-protein relationship available.

SMILES: c1ccccc1Oc2ccccc2

Level: 1

Mol. Weight: 170.21 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -6.71
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.690
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -0.44

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.780
Plasma Protein Binding: 74.03
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 11.430
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: -1.120
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.020
Liver Injury II: Safe
hERG Blockers: Safe
Daphnia Maga: 4.000
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 3.210
Rat (Acute): 2.290
Rat (Chronic Oral): 4.130
Fathead Minnow: 3.650
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 498.930
Hydration Free Energy: -9.230
Log(D) at pH=7.4: -1.510
Log(P): 1.22
Log S: -1.96
Log(Vapor Pressure): -7.53
Melting Point: 238.57
pKa Acid: 6.52
pKa Basic: 5.47

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	3	0.9534
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	3	0.9534
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	3	0.9468
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	3	0.9468
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	3	0.9422
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	3	0.9422
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9295
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9295
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9278
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9278
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9115
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9115
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	3	0.9086
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	3	0.9086
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.9033
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.9033
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.9030
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.9030
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	3	0.8881
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	3	0.8881
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8861
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8861
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.8752
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.8752
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	4	0.8746
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	4	0.8746
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8732
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8732
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8688
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8688
Hypoxanthine-guanine phosphoribosyltransferase	P00492	HPRT_HUMAN	Homo sapiens	4	0.8583
Hypoxanthine-guanine phosphoribosyltransferase	P00492	HPRT_HUMAN	Homo sapiens	4	0.8583
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8582
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8582
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	3	0.8542
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	3	0.8542
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	3	0.8478
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	3	0.8478
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8467
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8467
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8419
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8419
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8416
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8416
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.8411
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.8411
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8377
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8377
Purine nucleoside phosphorylase	P55859	PNPH_BOVIN	Bos taurus	4	0.8334
Purine nucleoside phosphorylase	P55859	PNPH_BOVIN	Bos taurus	4	0.8334
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8290
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8290
dTDP-4-dehydrorhamnose 3,5-epimerase	A0A6L7H6N0	A0A1S0QLH9_BACAN	Bacillus anthracis	4	0.8273
dTDP-4-dehydrorhamnose 3,5-epimerase	A0A6L7H6N0	A0A1S0QLH9_BACAN	Bacillus anthracis	4	0.8273
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8266
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8266
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	4	0.8255
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	4	0.8255
Polymerase acidic protein	Q5EP34	Q5EP34_9INFA	Influenza A virus	3	0.8233
Polymerase acidic protein	Q5EP34	Q5EP34_9INFA	Influenza A virus	3	0.8233
Purine nucleoside phosphorylase	P55859	PNPH_BOVIN	Bos taurus	4	0.8230
Purine nucleoside phosphorylase	P55859	PNPH_BOVIN	Bos taurus	4	0.8230
Thiazole tautomerase	P25053	TENI_BACSU	Bacillus subtilis	3	0.8221
Thiazole tautomerase	P25053	TENI_BACSU	Bacillus subtilis	3	0.8221
Casein kinase I isoform gamma-3	Q9Y6M4	KC1G3_HUMAN	Homo sapiens	4	0.8197
Casein kinase I isoform gamma-3	Q9Y6M4	KC1G3_HUMAN	Homo sapiens	4	0.8197
Purine nucleoside phosphorylase	P55859	PNPH_BOVIN	Bos taurus	4	0.8160
Purine nucleoside phosphorylase	P55859	PNPH_BOVIN	Bos taurus	4	0.8160
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8149
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8149
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.8106
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.8106
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8099
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8099
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8070
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8070
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.8068
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.8068
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.8027
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.8027
S-methyl-5'-thioinosine phosphorylase	Q9HZK1	MTIP_PSEAE	Pseudomonas aeruginosa	4	0.8024
S-methyl-5'-thioinosine phosphorylase	Q9HZK1	MTIP_PSEAE	Pseudomonas aeruginosa	4	0.8024
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7986
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7986
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7970
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7970
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7936
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7936
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	4	0.7932
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	4	0.7932
Albumin	P35747	ALBU_HORSE	Equus caballus	3	0.7929
Albumin	P35747	ALBU_HORSE	Equus caballus	3	0.7929
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7912
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7912
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7897
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7897
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7892
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7892
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.7891
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.7891
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.7889
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.7889
Avidin	P02701	AVID_CHICK	Gallus gallus	3	0.7853
Avidin	P02701	AVID_CHICK	Gallus gallus	3	0.7853
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7831
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7831
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7814
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7814
Purine nucleoside phosphorylase	B9JYS2	B9JYS2_AGRVS	Agrobacterium vitis	4	0.7785
Purine nucleoside phosphorylase	B9JYS2	B9JYS2_AGRVS	Agrobacterium vitis	4	0.7785
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7771
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7771
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.7734
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.7734
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7733
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7733
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7727
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7727
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.7709
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.7709
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.7697
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.7697
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7644
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7644
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7627
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7627
Shikimate dehydrogenase (NADP(+))	P56119	AROE_HELPY	Helicobacter pylori	3	0.7624
Shikimate dehydrogenase (NADP(+))	P56119	AROE_HELPY	Helicobacter pylori	3	0.7624
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	3	0.7616
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	3	0.7616
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7594
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7594
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7573
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7573
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7572
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7572
Cytochrome P450 2C5	P00179	CP2C5_RABIT	Oryctolagus cuniculus	3	0.7568
Cytochrome P450 2C5	P00179	CP2C5_RABIT	Oryctolagus cuniculus	3	0.7568
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	4	0.7556
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	4	0.7556
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	4	0.7556
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	4	0.7556
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7547
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7547
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.7546
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.7546
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7531
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7531
Purine nucleoside phosphorylase	Q9BMI9	Q9BMI9_SCHMA	Schistosoma mansoni	4	0.7521
Purine nucleoside phosphorylase	Q9BMI9	Q9BMI9_SCHMA	Schistosoma mansoni	4	0.7521
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7519
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7519
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	4	0.7504
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	4	0.7504
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7495
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7495
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	3	0.7492
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	3	0.7492
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7476
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7476
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7467
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7467
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	4	0.7462
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	4	0.7462
Decapping and exoribonuclease protein	O70348	DXO_MOUSE	Mus musculus	3	0.7455
Decapping and exoribonuclease protein	O70348	DXO_MOUSE	Mus musculus	3	0.7455
Hypoxanthine-guanine phosphoribosyltransferase	P00492	HPRT_HUMAN	Homo sapiens	4	0.7453
Hypoxanthine-guanine phosphoribosyltransferase	P00492	HPRT_HUMAN	Homo sapiens	4	0.7453
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7420
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7420
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7396
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7396
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.7381
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7381
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7381
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.7381
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	3	0.7380
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	3	0.7380
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7368
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7368
Glutamate receptor 3	P19492	GRIA3_RAT	Rattus norvegicus	3	0.7367
Glutamate receptor 3	P19492	GRIA3_RAT	Rattus norvegicus	3	0.7367
Purine nucleoside phosphorylase	Q8DTU4	Q8DTU4_STRMU	Streptococcus mutans serotype c	4	0.7364
Purine nucleoside phosphorylase	Q8DTU4	Q8DTU4_STRMU	Streptococcus mutans serotype c	4	0.7364
DNA-directed DNA polymerase	Q38087	DPOL_BPR69	Escherichia phage RB69	3	0.7346
DNA-directed DNA polymerase	Q38087	DPOL_BPR69	Escherichia phage RB69	3	0.7346
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	3	0.7341
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	3	0.7341
Vascular endothelial growth factor receptor 2	P35968	VGFR2_HUMAN	Homo sapiens	3	0.7333
Vascular endothelial growth factor receptor 2	P35968	VGFR2_HUMAN	Homo sapiens	3	0.7333
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.7331
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.7331
NTPase P4	Q94M05	Q94M05_9VIRU	Pseudomonas phage phi12	3	0.7320
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7320
YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein	Q5SHN1	Q5SHN1_THET8	Thermus thermophilus	3	0.7320
NTPase P4	Q94M05	Q94M05_9VIRU	Pseudomonas phage phi12	3	0.7320
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7320
YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein	Q5SHN1	Q5SHN1_THET8	Thermus thermophilus	3	0.7320
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7315
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7315
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	3	0.7307
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	3	0.7307
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.7305
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.7305
Ribonuclease 4	P15468	RNAS4_PIG	Sus scrofa	3	0.7298
Ribonuclease 4	P15468	RNAS4_PIG	Sus scrofa	3	0.7298
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.7294
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.7294
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7292
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7292
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7262
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7262
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7251
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7251
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7233
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7233
3-hydroxybenzoate 4-monooxygenase	Q6SSJ6	MOBA_COMTE	Comamonas testosteroni	3	0.7228
3-hydroxybenzoate 4-monooxygenase	Q6SSJ6	MOBA_COMTE	Comamonas testosteroni	3	0.7228
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7221
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7221
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	4	0.7207
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	4	0.7207
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	4	0.7206
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	4	0.7206
Beta-lactamase	P00811	AMPC_ECOLI	Escherichia coli	4	0.7203
Beta-lactamase	P00811	AMPC_ECOLI	Escherichia coli	4	0.7203
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	3	0.7194
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	3	0.7194
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7193
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7193
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	3	0.7191
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	3	0.7191
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7184
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7184
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	3	0.7177
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	3	0.7177
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7175
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7175
Hygromycin-B 4-O-kinase	P00557	KHYB_ECOLX	Escherichia coli	3	0.7174
Hygromycin-B 4-O-kinase	P00557	KHYB_ECOLX	Escherichia coli	3	0.7174
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.7172
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.7172
Purine nucleoside phosphorylase DeoD-type	B1JL34	DEOD_YERPY	Yersinia pseudotuberculosis serotype O:3	3	0.7165
Purine nucleoside phosphorylase DeoD-type	B1JL34	DEOD_YERPY	Yersinia pseudotuberculosis serotype O:3	3	0.7165
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7165
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7165
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	4	0.7164
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	4	0.7164
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7153
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7153
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7147
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7147
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7143
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7143
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	4	0.7133
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	4	0.7133
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7119
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7119
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7113
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7113
Phospholipase A2, membrane associated	P14555	PA2GA_HUMAN	Homo sapiens	3	0.7103
Phospholipase A2, membrane associated	P14555	PA2GA_HUMAN	Homo sapiens	3	0.7103
DNA-directed DNA polymerase	Q38087	DPOL_BPR69	Escherichia phage RB69	3	0.7089
DNA-directed DNA polymerase	Q38087	DPOL_BPR69	Escherichia phage RB69	3	0.7089
DNA-directed DNA polymerase	Q38087	DPOL_BPR69	Escherichia phage RB69	3	0.7078
DNA-directed DNA polymerase	Q38087	DPOL_BPR69	Escherichia phage RB69	3	0.7078
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7074
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7074
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	4	0.7071
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	4	0.7071
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7066
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7066
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7066
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7066
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	4	0.7058
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	4	0.7058
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.7053
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.7053
Histone-lysine N-methyltransferase SETD7	Q8WTS6	SETD7_HUMAN	Homo sapiens	3	0.7051
Histone-lysine N-methyltransferase SETD7	Q8WTS6	SETD7_HUMAN	Homo sapiens	3	0.7051
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7046
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7046
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	B1MKD5	B1MKD5_MYCA9	Mycobacteroides abscessus	3	0.7032
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	B1MKD5	B1MKD5_MYCA9	Mycobacteroides abscessus	3	0.7032
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	5	0.7031
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	5	0.7031
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7014
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7014

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