ANPDB

Select a section from the left sidebar

Hyrtioerectine A

Family: Animalia - Thorectidae
Kingdom: Animalia
Class: Alkaloid

Canonical Smiles	Oc1ccc2c(c1)[nH]cc2c1ncc2c(c1C(=O)C(=O)O)c1cc(O)ccc1[nH]2
InChI	InChI=1S/C21H13N3O5/c25-9-2-4-14-12(5-9)17-16(24-14)8-23-19(18(17)20(27)21(28)29)13-7-22-15-6-10(26)1-3-11(13)15/h1-8,22,24-26H,(H,28,29)
InChIKey	AYFYGTZIXVBNOU-UHFFFAOYSA-N
Formula	C₂₁H₁₃N₃O₅
HBA	5
HBD	5
MW	387.35
Rotatable Bonds	3
TPSA	139.3
LogP	3.54
Number Rings	5
Number Aromatic Rings	5
Heavy Atom Count	29
Formal Charge	0
Fraction CSP3	0.0
Exact Mass	387.09
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Hyrtios erectus	Thorectidae	Animalia	—

Showing of synonyms

Youssef DT (2005). Hyrtioerectines A-C, cytotoxic alkaloids from the red sea sponge Hyrtios erectus. Journal of Natural Products,2005,68(9),1416-1419. [View] [PubMed]

Pubchem: 11589139

Cas: 866402-94-0

Zinc: ZINC000014514705

Nmrshiftdb2: 70066828

Chembl: CHEMBL517192

No compound-protein relationship available.

SMILES: c1cccc(c1c23)[nH]c2cnc(c3)-c4c[nH]c(c45)cccc5

Level: 1

Mol. Weight: 387.35 g/mol

SMILES: c1cncc(c1c23)[nH]c2cccc3

Level: 0

Mol. Weight: 387.35 g/mol

SMILES: c1c[nH]c(c12)cccc2

Level: 0

Mol. Weight: 387.35 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp): -5.8
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.150
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: 1.5

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 1.690
Plasma Protein Binding: 83.09
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 3.330
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: -1.160
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -0.360
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 4.630
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: -33.800
Rat (Acute): 2.230
Rat (Chronic Oral): 2.850
Fathead Minnow: 4.610
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Toxic

General Properties

Boiling Point: 605.780
Hydration Free Energy: -6.850
Log(D) at pH=7.4: 0.720
Log(P): 2.76
Log S: -4.48
Log(Vapor Pressure): -11.37
Melting Point: 428.67
pKa Acid: 13.44
pKa Basic: 5.16

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.9156
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.9156
Multidrug-efflux transporter 1 regulator	P39075	BMRR_BACSU	Bacillus subtilis	3	0.9130
Multidrug-efflux transporter 1 regulator	P39075	BMRR_BACSU	Bacillus subtilis	3	0.9130
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9059
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9059
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9029
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9029
Polymerase acidic protein	P03433	PA_I34A1	Influenza A virus	3	0.8997
Polymerase acidic protein	P03433	PA_I34A1	Influenza A virus	3	0.8997
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8930
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8930
Polymerase basic protein 2	P31345	PB2_I75A3	Influenza A virus	3	0.8891
Polymerase basic protein 2	P31345	PB2_I75A3	Influenza A virus	3	0.8891
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8813
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8813
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8745
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8745
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8706
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8706
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8667
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8667
Cyclin-dependent kinase 6	Q00534	CDK6_HUMAN	Homo sapiens	3	0.8552
Cyclin-dependent kinase 6	Q00534	CDK6_HUMAN	Homo sapiens	3	0.8552
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	3	0.8544
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	3	0.8544
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8427
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8427
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8407
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8407
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.8389
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.8389
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	4	0.8293
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	4	0.8293
Three-prime repair exonuclease 1	Q91XB0	TREX1_MOUSE	Mus musculus	3	0.8271
Three-prime repair exonuclease 1	Q91XB0	TREX1_MOUSE	Mus musculus	3	0.8271
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.8268
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.8268
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8267
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8267
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8257
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8257
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	4	0.8223
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	4	0.8223
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	4	0.8215
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	4	0.8215
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8198
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8198
Streptogramin A acetyltransferase	P50870	VATD_ENTFC	Enterococcus faecium	3	0.8197
Streptogramin A acetyltransferase	P50870	VATD_ENTFC	Enterococcus faecium	3	0.8197
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8194
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8194
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8191
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8191
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8184
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8184
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.8173
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.8173
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	3	0.8111
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	3	0.8111
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.8108
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.8108
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8107
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8107
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.8096
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.8096
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8089
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8089
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	4	0.8082
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	4	0.8082
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8080
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8080
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	4	0.8034
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	4	0.8034
DNA ligase	P43813	DNLJ_HAEIN	Haemophilus influenzae	3	0.8031
DNA ligase	P43813	DNLJ_HAEIN	Haemophilus influenzae	3	0.8031
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8021
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8021
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7995
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7995
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.7959
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.7959
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.7901
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.7901
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.7866
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.7866
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7842
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7842
HLA class I histocompatibility antigen, B alpha chain	P01889	HLAB_HUMAN	Homo sapiens	3	0.7833
HLA class I histocompatibility antigen, B alpha chain	P01889	HLAB_HUMAN	Homo sapiens	3	0.7833
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7829
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7829
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7799
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7799
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7773
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7773
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.7759
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.7759
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7750
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7750
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7747
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7747
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7737
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7737
Enoyl-[acyl-carrier-protein] reductase [NADH]	P9WGR1	INHA_MYCTU	Mycobacterium tuberculosis	3	0.7737
Enoyl-[acyl-carrier-protein] reductase [NADH]	P9WGR1	INHA_MYCTU	Mycobacterium tuberculosis	3	0.7737
Caspase-6	P55212	CASP6_HUMAN	Homo sapiens	3	0.7706
Caspase-6	P55212	CASP6_HUMAN	Homo sapiens	3	0.7706
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7699
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7699
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7681
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7681
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.7667
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.7667
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7652
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7652
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7626
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7626
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7597
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7597
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7596
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7596
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7588
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7588
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.7580
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.7580
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.7577
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.7577
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7576
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7576
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7568
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7568
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	3	0.7550
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	3	0.7550
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7543
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7543
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7527
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7527
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7526
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7526
Renin	P00797	RENI_HUMAN	Homo sapiens	4	0.7523
Renin	P00797	RENI_HUMAN	Homo sapiens	4	0.7523
Bifunctional dihydrofolate reductase-thymidylate synthase	Q27793	DRTS_TRYCR	Trypanosoma cruzi	5	0.7517
Bifunctional dihydrofolate reductase-thymidylate synthase	Q27793	DRTS_TRYCR	Trypanosoma cruzi	5	0.7517
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7513
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7513
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7466
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7466
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	3	0.7451
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	3	0.7451
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7448
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7448
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7388
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7388
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7387
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7387
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7386
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7386
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7350
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7350
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7323
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7323
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7323
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7323
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7316
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7316
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	4	0.7307
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	4	0.7307
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	4	0.7306
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	4	0.7306
Orf1a polyprotein	Q692E5	Q692E5_CVHSA	SARS coronavirus TJF	3	0.7304
Orf1a polyprotein	Q692E5	Q692E5_CVHSA	SARS coronavirus TJF	3	0.7304
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	4	0.7294
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	4	0.7294
Matrilysin	P09237	MMP7_HUMAN	Homo sapiens	3	0.7282
Matrilysin	P09237	MMP7_HUMAN	Homo sapiens	3	0.7282
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7269
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7269
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.7255
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.7255
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7250
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7250
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.7193
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.7193
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7193
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7193
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7192
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7192
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7191
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7191
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7182
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7182
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7179
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7179
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7173
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7173
Reductase homolog	Q9ZGC1	Q9ZGC1_STRCY	Streptomyces cyanogenus	4	0.7170
Reductase homolog	Q9ZGC1	Q9ZGC1_STRCY	Streptomyces cyanogenus	4	0.7170
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7159
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7159
Cholinesterase	P06276	CHLE_HUMAN	Homo sapiens	3	0.7146
Cholinesterase	P06276	CHLE_HUMAN	Homo sapiens	3	0.7146
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7131
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7131
Casein kinase I isoform gamma-3	Q9Y6M4	KC1G3_HUMAN	Homo sapiens	4	0.7123
Casein kinase I isoform gamma-3	Q9Y6M4	KC1G3_HUMAN	Homo sapiens	4	0.7123
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7109
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7109
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7108
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7108
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7085
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7085
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7076
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7076
Glycogen phosphorylase, liver form	P06737	PYGL_HUMAN	Homo sapiens	3	0.7071
Glycogen phosphorylase, liver form	P06737	PYGL_HUMAN	Homo sapiens	3	0.7071
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7070
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7070
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	3	0.7069
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	3	0.7069
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	4	0.7068
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	4	0.7068
Aminopeptidase N	P04825	AMPN_ECOLI	Escherichia coli	3	0.7066
Aminopeptidase N	P04825	AMPN_ECOLI	Escherichia coli	3	0.7066
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7055
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7055
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7054
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7054
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7051
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7051
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7040
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7040
Renin	P00797	RENI_HUMAN	Homo sapiens	3	0.7039
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7039
Renin	P00797	RENI_HUMAN	Homo sapiens	3	0.7039
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7039
Bifunctional protein GlmU	P43889	GLMU_HAEIN	Haemophilus influenzae	4	0.7023
Bifunctional protein GlmU	P43889	GLMU_HAEIN	Haemophilus influenzae	4	0.7023
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7021
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7021
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	3	0.7012
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	3	0.7012

Download SDF