Hyrtioerectine B - Compound Card

Hyrtioerectine B

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Hyrtioerectine B

Structure
Zoomed Structure
  • Family: Animalia - Thorectidae
  • Kingdom: Animalia
  • Class: Alkaloid
Canonical Smiles OC(=O)[C@@H]1N[C@H](C)c2c(C1)c1cc(O)ccc1[nH]2
InChI InChI=1S/C13H14N2O3/c1-6-12-9(5-11(14-6)13(17)18)8-4-7(16)2-3-10(8)15-12/h2-4,6,11,14-16H,5H2,1H3,(H,17,18)/t6-,11-/m1/s1
InChIKey WYQWRMWMBQUYSD-KSBSHMNSSA-N
Formula C13H14N2O3
HBA 3
HBD 4
MW 246.27
Rotatable Bonds 1
TPSA 85.35
LogP 1.53
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 18
Formal Charge 0
Fraction CSP3 0.31
Exact Mass 246.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Hyrtios erectus Thorectidae Animalia —

Showing of synonyms

  • Youssef DT (2005). Hyrtioerectines A-C, cytotoxic alkaloids from the red sea sponge Hyrtios erectus. Journal of Natural Products,2005,68(9),1416-1419. [View] [PubMed]
Pubchem: 11665960
Nmrshiftdb2: 80000067

No compound-protein relationship available.

Structure

SMILES: C1CNCc(c1c23)[nH]c2cccc3

Level: 0

Mol. Weight: 246.27 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp)
-5.3
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.77
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.98

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.72
Plasma Protein Binding
46.6
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.86
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
-0.61
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-0.05
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.28
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-0.19
Rat (Acute)
2.05
Rat (Chronic Oral)
2.7
Fathead Minnow
4.04
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
405.8
Hydration Free Energy
-9.07
Log(D) at pH=7.4
-0.8
Log(P)
-0.43
Log S
-2.11
Log(Vapor Pressure)
-8.68
Melting Point
261.04
pKa Acid
6.39
pKa Basic
9.21
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9600
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9600
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9527
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9527
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9198
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9198
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.8956
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.8956
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 3 0.8942
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 3 0.8942
Gamma-aminobutyric acid type B receptor subunit 1 Q9UBS5 GABR1_HUMAN Homo sapiens 3 0.8819
Gamma-aminobutyric acid type B receptor subunit 1 Q9UBS5 GABR1_HUMAN Homo sapiens 3 0.8819
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.8746
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.8746
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8717
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8717
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8709
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8709
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8706
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8706
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8619
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8619
M17 leucyl aminopeptidase Q8IL11 Q8IL11_PLAF7 Plasmodium falciparum 3 0.8610
M17 leucyl aminopeptidase Q8IL11 Q8IL11_PLAF7 Plasmodium falciparum 3 0.8610
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8529
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8529
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8491
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8491
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8418
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8418
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8378
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8378
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8377
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8377
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 3 0.8364
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 3 0.8364
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8349
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8349
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8335
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8335
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8244
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8244
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8238
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8238
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8170
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8170
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.8117
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.8117
Mannosylglycerate synthase D0MI02 D0MI02_RHOM4 Rhodothermus marinus 4 0.8006
Mannosylglycerate synthase D0MI02 D0MI02_RHOM4 Rhodothermus marinus 4 0.8006
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.7937
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.7937
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7881
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7881
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 3 0.7863
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 3 0.7863
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.7826
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.7826
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7734
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7734
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7694
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7694
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7670
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7670
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7662
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7662
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7662
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7662
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7657
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7657
Probable nicotinate-nucleotide adenylyltransferase Q9HX21 NADD_PSEAE Pseudomonas aeruginosa 3 0.7624
Probable nicotinate-nucleotide adenylyltransferase Q9HX21 NADD_PSEAE Pseudomonas aeruginosa 3 0.7624
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.7592
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.7592
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7549
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7549
Adenosine deaminase P56658 ADA_BOVIN Bos taurus 3 0.7525
Adenosine deaminase P56658 ADA_BOVIN Bos taurus 3 0.7525
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7498
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7498
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7477
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7477
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 3 0.7471
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 3 0.7471
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7449
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7449
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7431
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7431
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7419
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7419
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7402
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7402
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7391
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7391
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7386
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7386
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7385
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7385
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7381
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7381
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7378
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7378
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7366
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7366
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7362
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7362
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7344
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7344
L-malyl-CoA/beta-methylmalyl-CoA lyase Q3J5L6 MCAL_RHOS4 Cereibacter sphaeroides 3 0.7325
L-malyl-CoA/beta-methylmalyl-CoA lyase Q3J5L6 MCAL_RHOS4 Cereibacter sphaeroides 3 0.7325
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7323
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7323
RNA 2',3'-cyclic phosphodiesterase P37025 THPR_ECOLI Escherichia coli 3 0.7315
RNA 2',3'-cyclic phosphodiesterase P37025 THPR_ECOLI Escherichia coli 3 0.7315
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 3 0.7309
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 3 0.7309
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7307
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7307
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase Q9WY79 MURE_THEMA Thermotoga maritima 3 0.7304
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase Q9WY79 MURE_THEMA Thermotoga maritima 3 0.7304
cAMP-activated global transcriptional regulator Vfr P55222 VFR_PSEAE Pseudomonas aeruginosa 3 0.7257
cAMP-activated global transcriptional regulator Vfr P55222 VFR_PSEAE Pseudomonas aeruginosa 3 0.7257
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.7250
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.7250
Orotidine 5'-phosphate decarboxylase O58462 PYRF_PYRHO Pyrococcus horikoshii 3 0.7249
Orotidine 5'-phosphate decarboxylase O58462 PYRF_PYRHO Pyrococcus horikoshii 3 0.7249
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7243
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7243
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7232
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7232
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7220
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7220
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7195
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7195
Glycoside Hydrolase Family 13 Q65MI2 Q65MI2_BACLD Bacillus licheniformis 2 0.7192
Glycoside Hydrolase Family 13 Q65MI2 Q65MI2_BACLD Bacillus licheniformis 2 0.7192
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7191
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7191
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7185
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7185
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7172
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7172
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7172
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7172
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7167
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7167
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7163
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7163
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7153
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7153
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7146
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7146
DNA translocase FtsK Q9I0M3 FTSK_PSEAE Pseudomonas aeruginosa 3 0.7138
DNA translocase FtsK Q9I0M3 FTSK_PSEAE Pseudomonas aeruginosa 3 0.7138
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7109
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7109
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7108
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7108
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7107
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7107
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 3 0.7103
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 3 0.7103
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7097
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7097
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 3 0.7090
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 3 0.7090
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7089
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7089
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7089
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7089
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7084
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7084
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7075
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7075
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7070
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7070
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7068
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7068
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7058
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7058
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7056
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7056
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7055
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7055
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7052
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7052
Rho-associated protein kinase 1 Q13464 ROCK1_HUMAN Homo sapiens 3 0.7050
Rho-associated protein kinase 1 Q13464 ROCK1_HUMAN Homo sapiens 3 0.7050
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 3 0.7048
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 3 0.7048
Glutathione S-transferase Q8ILQ7 GST_PLAFA Plasmodium falciparum 3 0.7030
Glutathione S-transferase Q8ILQ7 GST_PLAFA Plasmodium falciparum 3 0.7030
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7030
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7030
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7027
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7027

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