Hyrtioerectine C - Compound Card

Hyrtioerectine C

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Hyrtioerectine C

Structure
Zoomed Structure
  • Family: Animalia - Thorectidae
  • Kingdom: Animalia
  • Class: Alkaloid
Canonical Smiles OC(=O)[C@@H](Cc1c[nH]c2c1cc(O)cc2)O
InChI InChI=1S/C11H11NO4/c13-7-1-2-9-8(4-7)6(5-12-9)3-10(14)11(15)16/h1-2,4-5,10,12-14H,3H2,(H,15,16)/t10-/m1/s1
InChIKey UFDRBNQJYZJRJV-SNVBAGLBSA-N
Formula C11H11NO4
HBA 3
HBD 4
MW 221.21
Rotatable Bonds 3
TPSA 93.55
LogP 0.86
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 16
Formal Charge 0
Fraction CSP3 0.18
Exact Mass 221.07
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Hyrtios erectus Thorectidae Animalia —

Showing of synonyms

  • Youssef DT (2005). Hyrtioerectines A-C, cytotoxic alkaloids from the red sea sponge Hyrtios erectus. Journal of Natural Products,2005,68(9),1416-1419. [View] [PubMed]
Pubchem: 101772684

No compound-protein relationship available.

Structure

SMILES: c1c[nH]c(c12)cccc2

Level: 0

Mol. Weight: 221.21 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp)
-5.44
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.030
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.44

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.550
Plasma Protein Binding
40.8
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.360
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
-0.960
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.330
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
3.750
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-0.240
Rat (Acute)
1.830
Rat (Chronic Oral)
3.320
Fathead Minnow
3.960
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
390.160
Hydration Free Energy
-12.410
Log(D) at pH=7.4
-1.770
Log(P)
0.08
Log S
-2.06
Log(Vapor Pressure)
-7.87
Melting Point
199.94
pKa Acid
7.54
pKa Basic
5.46
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9620
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9620
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9377
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9377
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9310
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9310
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9284
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9284
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 3 0.9270
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 3 0.9270
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.9253
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.9253
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.9162
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.9162
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.9066
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.9066
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9024
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9024
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.8874
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.8874
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8868
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8868
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8863
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8863
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8849
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8849
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 3 0.8831
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 3 0.8831
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.8810
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.8810
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.8802
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.8802
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 3 0.8667
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 3 0.8667
Branched-chain-amino-acid aminotransferase, mitochondrial O15382 BCAT2_HUMAN Homo sapiens 3 0.8664
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8664
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8664
Branched-chain-amino-acid aminotransferase, mitochondrial O15382 BCAT2_HUMAN Homo sapiens 3 0.8664
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 3 0.8551
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 3 0.8551
L-methionine gamma-lyase Q84AR1 Q84AR1_CITFR Citrobacter freundii 4 0.8542
L-methionine gamma-lyase Q84AR1 Q84AR1_CITFR Citrobacter freundii 4 0.8542
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8541
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8541
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8398
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8398
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.8373
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.8373
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.8318
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.8318
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8317
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8317
glutaryl-CoA dehydrogenase (ETF) Q3JP94 Q3JP94_BURP1 Burkholderia pseudomallei 3 0.8287
glutaryl-CoA dehydrogenase (ETF) Q3JP94 Q3JP94_BURP1 Burkholderia pseudomallei 3 0.8287
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8280
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8280
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.8279
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.8279
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic P49235 HGGL1_MAIZE Zea mays 3 0.8271
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic P49235 HGGL1_MAIZE Zea mays 3 0.8271
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8249
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8249
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 3 0.8229
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 3 0.8229
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8221
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8221
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8173
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8173
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8163
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8163
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8144
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8144
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8143
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8143
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8119
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8119
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8082
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8082
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 3 0.8053
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 3 0.8053
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 3 0.8027
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 3 0.8027
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8008
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8008
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7998
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7998
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7968
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7968
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7834
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7834
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.7824
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.7824
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7785
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7785
Acetylornithine/succinyldiaminopimelate aminotransferase P40732 ARGD_SALTY Salmonella typhimurium 3 0.7765
Acetylornithine/succinyldiaminopimelate aminotransferase P40732 ARGD_SALTY Salmonella typhimurium 3 0.7765
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.7723
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.7723
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7691
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7691
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7660
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7660
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7636
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7636
Glutamate receptor 2 P42262 GRIA2_HUMAN Homo sapiens 3 0.7617
Glutamate receptor 2 P42262 GRIA2_HUMAN Homo sapiens 3 0.7617
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7616
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7616
Deoxycytidylate deaminase H6WFU3 H6WFU3_9CAUD Cyanophage S-TIM5 4 0.7598
Deoxycytidylate deaminase H6WFU3 H6WFU3_9CAUD Cyanophage S-TIM5 4 0.7598
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7554
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7554
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7532
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7532
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7522
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7522
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7521
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7521
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7513
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7513
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7504
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7504
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 3 0.7502
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 3 0.7502
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 3 0.7489
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 3 0.7489
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7455
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7455
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7422
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7422
Three-prime repair exonuclease 1 Q91XB0 TREX1_MOUSE Mus musculus 3 0.7420
Three-prime repair exonuclease 1 Q91XB0 TREX1_MOUSE Mus musculus 3 0.7420
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7407
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7407
4-hydroxyphenylacetate 3-monooxygenase, reductase component Q5SJP7 HPAC_THET8 Thermus thermophilus 3 0.7395
4-hydroxyphenylacetate 3-monooxygenase, reductase component Q5SJP7 HPAC_THET8 Thermus thermophilus 3 0.7395
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7392
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7392
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7368
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7368
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7359
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7359
Guanylate kinase P15454 KGUA_YEAST Saccharomyces cerevisiae 3 0.7356
Guanylate kinase P15454 KGUA_YEAST Saccharomyces cerevisiae 3 0.7356
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7346
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7346
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7343
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7343
Aspartate aminotransferase P00509 AAT_ECOLI Escherichia coli 3 0.7336
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7336
Aspartate aminotransferase P00509 AAT_ECOLI Escherichia coli 3 0.7336
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7336
Peptide deformylase 1B, chloroplastic/mitochondrial Q9FUZ2 DEF1B_ARATH Arabidopsis thaliana 3 0.7328
Peptide deformylase 1B, chloroplastic/mitochondrial Q9FUZ2 DEF1B_ARATH Arabidopsis thaliana 3 0.7328
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7318
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7318
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7315
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7315
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7310
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7310
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7308
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7308
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7304
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7304
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7299
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7299
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 3 0.7296
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 3 0.7296
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7294
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7294
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7290
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7290
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7277
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7277
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 3 0.7275
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 3 0.7275
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7272
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7272
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7266
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7266
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7261
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7261
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7257
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7257
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7255
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7255
Copper-transporting ATPase 1 Q04656 ATP7A_HUMAN Homo sapiens 3 0.7250
Copper-transporting ATPase 1 Q04656 ATP7A_HUMAN Homo sapiens 3 0.7250
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7247
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7247
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 4 0.7246
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 4 0.7246
L-malyl-CoA/beta-methylmalyl-CoA lyase Q3J5L6 MCAL_RHOS4 Cereibacter sphaeroides 3 0.7235
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7235
L-malyl-CoA/beta-methylmalyl-CoA lyase Q3J5L6 MCAL_RHOS4 Cereibacter sphaeroides 3 0.7235
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7235
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7223
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7223
Methionine--tRNA ligase P00959 SYM_ECOLI Escherichia coli 3 0.7222
Methionine--tRNA ligase P00959 SYM_ECOLI Escherichia coli 3 0.7222
23S rRNA (guanine(745)-N(1))-methyltransferase P36999 RLMA_ECOLI Escherichia coli 3 0.7211
23S rRNA (guanine(745)-N(1))-methyltransferase P36999 RLMA_ECOLI Escherichia coli 3 0.7211
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7202
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7202
Gamma-aminobutyric acid type B receptor subunit 1 Q9UBS5 GABR1_HUMAN Homo sapiens 2 0.7195
Gamma-aminobutyric acid type B receptor subunit 1 Q9UBS5 GABR1_HUMAN Homo sapiens 2 0.7195
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7191
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7191
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7191
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7191
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7187
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7187
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7186
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7186
Cytosol aminopeptidase P00727 AMPL_BOVIN Bos taurus 2 0.7185
Cytosol aminopeptidase P00727 AMPL_BOVIN Bos taurus 2 0.7185
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7184
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7184
Malate synthase G P9WK17 MASZ_MYCTU Mycobacterium tuberculosis 3 0.7174
Malate synthase G P9WK17 MASZ_MYCTU Mycobacterium tuberculosis 3 0.7174
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7158
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7158
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7158
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7158
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7156
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7156
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7144
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7144
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7139
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7139
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7133
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7133
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7125
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7125
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7121
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7121
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7110
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7110
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.7099
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.7099
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7098
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7098
Polyamine aminopropyltransferase Q5SK28 SPEE_THET8 Thermus thermophilus 3 0.7083
Polyamine aminopropyltransferase Q5SK28 SPEE_THET8 Thermus thermophilus 3 0.7083
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7081
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7081
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 3 0.7080
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 3 0.7080
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7073
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7073
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7066
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7066
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7046
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7046
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7045
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7045
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7039
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7039
Archaeal actin homolog Q9HKL4 ACTH_THEAC Thermoplasma acidophilum 2 0.7033
Archaeal actin homolog Q9HKL4 ACTH_THEAC Thermoplasma acidophilum 2 0.7033
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7029
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7029
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7027
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7027
Malate dehydrogenase P10584 MDH_THETH Thermus thermophilus 3 0.7010
Malate dehydrogenase P10584 MDH_THETH Thermus thermophilus 3 0.7010
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.7003
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.7003

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