Rutarensin - Compound Card

Rutarensin

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Rutarensin

Structure
Zoomed Structure
  • Family: Plantae - Thymelaeaceae
  • Kingdom: Plantae
  • Class: Coumarin
    • Subclass: Dicoumarin Glycoside
Canonical Smiles COc1cc2cc(Oc3ccc4c(c3)oc(=O)cc4)c(=O)oc2cc1O[C@@H]1O[C@H](COC(=O)CC(CC(=O)O)(O)C)[C@H]([C@@H]([C@H]1O)O)O
InChI InChI=1S/C31H30O16/c1-31(40,11-23(32)33)12-25(35)42-13-22-26(36)27(37)28(38)30(47-22)46-20-10-18-15(7-19(20)41-2)8-21(29(39)45-18)43-16-5-3-14-4-6-24(34)44-17(14)9-16/h3-10,22,26-28,30,36-38,40H,11-13H2,1-2H3,(H,32,33)/t22-,26-,27+,28-,30-,31?/m1/s1
InChIKey ZTLZGWDERZVHNS-AEJCFSGASA-N
Formula C31H30O16
HBA 15
HBD 5
MW 658.57
Rotatable Bonds 11
TPSA 241.86
LogP 1.05
Number Rings 5
Number Aromatic Rings 4
Heavy Atom Count 47
Formal Charge 0
Fraction CSP3 0.35
Exact Mass 658.15
Number of Lipinski Rule Violations 2
# Species Family Kingdom NCBI Taxonomy ID
1 Thymelaea lythroides Thymelaeaceae Plantae 224054

Showing of synonyms

  • Kabbaj FZ, Lai D, et al. (2013). Chemical constituents from aerial parts of Thymelaea lythroides. Biochemical Systematics and Ecology,2013,51,153-155. [View]
Pubchem: 14463052
Nmrshiftdb2: 60145369

No compound-protein relationship available.

Structure

SMILES: O1CCCCC1Oc(cc2)cc(c23)oc(=O)c(c3)Oc(cc4)cc(c45)oc(=O)cc5

Level: 2

Mol. Weight: 658.57 g/mol

Structure

SMILES: c1cccc(c12)oc(=O)c(c2)Oc(cc3)cc(c34)oc(=O)cc4

Level: 1

Mol. Weight: 658.57 g/mol

Structure

SMILES: c1cc(=O)oc(c12)cc(cc2)OC3CCCCO3

Level: 1

Mol. Weight: 658.57 g/mol

Structure

SMILES: c1cccc(c12)oc(=O)cc2

Level: 0

Mol. Weight: 658.57 g/mol

Structure

SMILES: C1CCOCC1

Level: 0

Mol. Weight: 658.57 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-6.61
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Non-Absorbed
Madin-Darby Canine Kidney
-5.000
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
42.81

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.230
Plasma Protein Binding
91.59
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Inhibitor

Excretion

Clearance
0.290
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
-0.360
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.470
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.940
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-80378.890
Rat (Acute)
2.320
Rat (Chronic Oral)
3.690
Fathead Minnow
117.500
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
1891.970
Hydration Free Energy
-2.920
Log(D) at pH=7.4
-0.360
Log(P)
0.3
Log S
-3.81
Log(Vapor Pressure)
-146.37
Melting Point
207.89
pKa Acid
4.02
pKa Basic
4.75
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.9587
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.9587
Branched-chain-amino-acid aminotransferase, mitochondrial O15382 BCAT2_HUMAN Homo sapiens 3 0.9585
Branched-chain-amino-acid aminotransferase, mitochondrial O15382 BCAT2_HUMAN Homo sapiens 3 0.9585
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.9521
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.9521
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.9401
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.9401
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9211
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9211
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.9117
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.9117
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9071
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9071
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 3 0.9060
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 3 0.9060
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.9059
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.9059
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9029
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9029
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 3 0.8940
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 3 0.8940
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8878
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8878
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8843
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8843
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8768
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8768
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8754
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8754
Beta-2-microglobulin P61769 B2MG_HUMAN Homo sapiens 3 0.8719
Beta-2-microglobulin P61769 B2MG_HUMAN Homo sapiens 3 0.8719
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8607
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8607
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8589
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8589
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8586
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8586
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8581
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8581
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8573
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8573
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8559
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8559
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8553
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8553
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.8548
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.8548
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8538
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8538
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.8515
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.8515
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8495
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8495
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8476
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8476
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8444
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8444
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8343
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8343
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8300
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8300
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8289
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8289
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8284
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8284
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8172
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8172
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8156
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8156
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.8040
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.8040
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8033
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8033
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.8019
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.8019
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7981
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7981
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7970
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7970
Predicted acetyltransferase Q97ML2 Q97ML2_CLOAB Clostridium acetobutylicum 3 0.7958
Predicted acetyltransferase Q97ML2 Q97ML2_CLOAB Clostridium acetobutylicum 3 0.7958
11-beta-hydroxysteroid dehydrogenase 1 Q6QLL4 DHI1_CAVPO Cavia porcellus 3 0.7943
11-beta-hydroxysteroid dehydrogenase 1 Q6QLL4 DHI1_CAVPO Cavia porcellus 3 0.7943
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7941
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7941
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7915
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7915
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7896
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7896
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7846
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7846
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7815
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7815
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7762
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7762
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7762
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7762
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7762
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7762
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7757
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 3 0.7757
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7757
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 3 0.7757
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7752
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7752
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7752
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7752
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7751
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7751
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7749
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7749
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7729
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7729
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7721
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7721
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7720
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7720
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 3 0.7695
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 3 0.7695
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7694
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7694
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7691
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7691
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7687
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7687
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7684
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7684
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.7675
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.7675
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7654
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7654
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7653
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7653
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7629
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7629
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7617
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7617
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7604
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7604
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7591
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7591
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7585
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7585
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7566
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7566
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7562
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7562
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7558
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7558
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7556
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7556
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7556
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7556
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7555
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7555
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7529
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7529
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7520
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7520
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7516
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7516
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7508
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7508
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7506
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7506
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7504
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7504
Enoyl-[acyl-carrier-protein] reductase [NADH] Q5NGQ3 Q5NGQ3_FRATT Francisella tularensis subsp. tularensis 3 0.7489
Enoyl-[acyl-carrier-protein] reductase [NADH] Q5NGQ3 Q5NGQ3_FRATT Francisella tularensis subsp. tularensis 3 0.7489
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7481
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7481
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7476
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7476
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7429
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7429
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7427
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7427
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 2 0.7426
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 2 0.7426
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7422
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7422
Polymerase acidic protein P03433 PA_I34A1 Influenza A virus 2 0.7419
Polymerase acidic protein P03433 PA_I34A1 Influenza A virus 2 0.7419
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7414
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7414
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7402
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7402
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7399
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7399
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7398
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7398
Disks large homolog 1 Q12959 DLG1_HUMAN Homo sapiens 3 0.7382
Disks large homolog 1 Q12959 DLG1_HUMAN Homo sapiens 3 0.7382
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7379
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7379
Ferrichrome outer membrane transporter/phage receptor P06971 FHUA_ECOLI Escherichia coli 4 0.7363
Ferrichrome outer membrane transporter/phage receptor P06971 FHUA_ECOLI Escherichia coli 4 0.7363
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7355
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7355
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7348
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7348
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.7347
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.7347
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7345
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7345
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7337
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7337
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7334
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7334
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7320
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7320
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7319
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7319
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 3 0.7315
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 3 0.7315
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7314
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7314
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7309
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7309
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7291
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7291
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7285
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7285
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7284
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7284
Glutamine synthetase P9WN39 GLN1B_MYCTU Mycobacterium tuberculosis 3 0.7284
Glutamine synthetase P9WN39 GLN1B_MYCTU Mycobacterium tuberculosis 3 0.7284
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7281
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7281
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7278
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7278
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7274
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7274
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7269
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7269
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7267
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7267
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7253
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7253
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7252
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7252
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7219
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7219
Aldo-keto reductase family 1 member A1 P50578 AK1A1_PIG Sus scrofa 3 0.7217
Aldo-keto reductase family 1 member A1 P50578 AK1A1_PIG Sus scrofa 3 0.7217
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7212
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7212
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 2 0.7207
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 2 0.7207
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7206
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7206
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7199
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7199
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7190
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7190
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7171
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7171
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7171
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7171
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 2 0.7170
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 2 0.7170
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7167
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7167
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7166
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7166
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7162
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7162
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7155
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7155
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7148
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7148
Oxygenase Q194P4 Q194P4_STRAA Streptomyces argillaceus 3 0.7139
Oxygenase Q194P4 Q194P4_STRAA Streptomyces argillaceus 3 0.7139
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7131
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7131
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 2 0.7115
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 2 0.7115
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7114
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7114
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 2 0.7114
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 2 0.7114
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7112
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7112
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7092
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7092
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7091
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7091
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7086
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7086
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7082
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7082
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7071
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7071
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7065
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7065
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7057
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7057
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7047
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7047
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7033
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7033
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7022
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7022
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7021
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7021
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7019
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7019
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7014
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7014
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7010
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7010
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7001
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7001

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