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Aspergillus diketopiperazine 8

Family: Fungi - Trichocomaceae
Kingdom: Fungi
Class: Alkaloid
- Subclass: Diketopiperazine

Canonical Smiles	O=C1N[C@@H](Cc2ccc(cc2)O)C(=O)N2[C@H]1CCC2
InChI	InChI=1S/C14H16N2O3/c17-10-5-3-9(4-6-10)8-11-14(19)16-7-1-2-12(16)13(18)15-11/h3-6,11-12,17H,1-2,7-8H2,(H,15,18)/t11-,12-/m0/s1
InChIKey	LSGOTAXPWMCUCK-RYUDHWBXSA-N
Formula	C₁₄H₁₆N₂O₃
HBA	3
HBD	2
MW	260.29
Rotatable Bonds	2
TPSA	69.64
LogP	0.42
Number Rings	3
Number Aromatic Rings	1
Heavy Atom Count	19
Formal Charge	0
Fraction CSP3	0.43
Exact Mass	260.12
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Aspergillus fumigatus	Trichocomaceae	Fungi	746128

Showing of synonyms

El-Gendy BEDM, Rateb ME (2015). Antibacterial activity of diketopiperazines isolated from a marine fungus using t-butoxycarbonyl group as a simple tool for purification. Bioorganic and Medicinal Chemistry Letters,2015,25(16),3125-3128. [View] [PubMed]

Pubchem: 119404

Cas: 4549-02-4

Gnps: CCMSLIB00000007140

Zinc: ZINC000001629943

Kegg Ligand: C10605

Chebi: 6631

Nmrshiftdb2: 60023680

Metabolights: MTBLC6631

Chembl: CHEMBL359788

Comptox: DTXSID30196526

Drugbank: DB04520

Pdb Ligand: TYP

CPRiL: 449080

SMILES: c1ccccc1CC(NC2=O)C(=O)N(C23)CCC3

Level: 1

Mol. Weight: 260.29 g/mol

SMILES: C1CCN(C12)C(=O)CNC2=O

Level: 0

Mol. Weight: 260.29 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 260.29 g/mol

Antibacterial

Absorption

Caco-2 (logPapp): -5.11
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.63
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.5

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.32
Plasma Protein Binding: 46.08
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 7.0
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: -1.22
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.08
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 4.13
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 0.61
Rat (Acute): 1.98
Rat (Chronic Oral): 2.27
Fathead Minnow: 3.92
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 411.4
Hydration Free Energy: -15.31
Log(D) at pH=7.4: 0.28
Log(P): 0.32
Log S: -1.76
Log(Vapor Pressure): -8.04
Melting Point: 230.77
pKa Acid: 8.72
pKa Basic: 6.05

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.9492
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.9492
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.9224
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9224
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.9224
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9224
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	3	0.8999
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	3	0.8999
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8798
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8798
Type II methyltransferase M.RsrI	P14751	MTR1_RHOSH	Cereibacter sphaeroides	4	0.8689
Type II methyltransferase M.RsrI	P14751	MTR1_RHOSH	Cereibacter sphaeroides	4	0.8689
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8677
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8677
Reaction center protein L chain	P0C0Y7	RCEH_RHOSH	Rhodobacter sphaeroides	3	0.8591
Reaction center protein L chain	P0C0Y7	RCEH_RHOSH	Rhodobacter sphaeroides	3	0.8591
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8570
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8570
Type II methyltransferase M.RsrI	P14751	MTR1_RHOSH	Cereibacter sphaeroides	4	0.8542
Type II methyltransferase M.RsrI	P14751	MTR1_RHOSH	Cereibacter sphaeroides	4	0.8542
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8539
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8539
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8390
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8390
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8363
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8363
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.8309
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.8309
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.8303
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.8303
Ras-related protein Ral-B	P11234	RALB_HUMAN	Homo sapiens	3	0.8232
Ras-related protein Ral-B	P11234	RALB_HUMAN	Homo sapiens	3	0.8232
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8176
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8176
Mycinamicin VI 2''-O-methyltransferase	Q83WF2	MYCE_MICGR	Micromonospora griseorubida	4	0.8159
Mycinamicin VI 2''-O-methyltransferase	Q83WF2	MYCE_MICGR	Micromonospora griseorubida	4	0.8159
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8061
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8061
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7969
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7969
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.7951
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.7951
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7944
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7944
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7875
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7875
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	3	0.7869
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	3	0.7869
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7860
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7860
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7855
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7855
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7822
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7822
cGMP-dependent protein kinase 1	P00516	KGP1_BOVIN	Bos taurus	3	0.7810
cGMP-dependent protein kinase 1	P00516	KGP1_BOVIN	Bos taurus	3	0.7810
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7791
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7791
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.7754
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.7754
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	3	0.7750
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	3	0.7750
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7746
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7746
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7745
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7745
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7703
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7703
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7691
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7691
Prenyltransferase	Q4R2T2	Q4R2T2_STRC1	Streptomyces sp	3	0.7682
Prenyltransferase	Q4R2T2	Q4R2T2_STRC1	Streptomyces sp	3	0.7682
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7635
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7635
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7627
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7627
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7605
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7605
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7549
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7549
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7514
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7514
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7512
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7512
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.7456
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.7456
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	3	0.7438
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	3	0.7438
Type II methyltransferase M.RsrI	P14751	MTR1_RHOSH	Cereibacter sphaeroides	4	0.7414
Type II methyltransferase M.RsrI	P14751	MTR1_RHOSH	Cereibacter sphaeroides	4	0.7414
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7382
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7382
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7372
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7372
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7371
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7371
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.7341
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.7341
Flavin reductase like domain-containing protein	Q4UKE8	Q4UKE8_RICFE	Rickettsia felis	3	0.7332
Flavin reductase like domain-containing protein	Q4UKE8	Q4UKE8_RICFE	Rickettsia felis	3	0.7332
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7331
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7331
Ethylene receptor 1	P49333	ETR1_ARATH	Arabidopsis thaliana	3	0.7326
Ethylene receptor 1	P49333	ETR1_ARATH	Arabidopsis thaliana	3	0.7326
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7325
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7325
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7316
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7316
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	2	0.7314
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	2	0.7314
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7314
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7314
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7302
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7302
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7301
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7301
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7280
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7280
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	3	0.7266
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	3	0.7266
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	2	0.7263
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	2	0.7263
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7262
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7262
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	2	0.7245
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	2	0.7245
S-methyl-5'-thioadenosine phosphorylase	Q97W94	MTAP_SACS2	Saccharolobus solfataricus	3	0.7223
S-methyl-5'-thioadenosine phosphorylase	Q97W94	MTAP_SACS2	Saccharolobus solfataricus	3	0.7223
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7219
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7219
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7211
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7211
Myosin heavy chain, striated muscle	P24733	MYS_ARGIR	Argopecten irradians	3	0.7209
Myosin heavy chain, striated muscle	P24733	MYS_ARGIR	Argopecten irradians	3	0.7209
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7208
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7208
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7192
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7192
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7181
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7181
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7171
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7171
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7150
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7150
DNA adenine methylase	P0AEE8	DMA_ECOLI	Escherichia coli	4	0.7146
DNA adenine methylase	P0AEE8	DMA_ECOLI	Escherichia coli	4	0.7146
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7141
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7141
Mannosylglycerate synthase	D0MI02	D0MI02_RHOM4	Rhodothermus marinus	3	0.7140
Mannosylglycerate synthase	D0MI02	D0MI02_RHOM4	Rhodothermus marinus	3	0.7140
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7130
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7130
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7121
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7121
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7119
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7119
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7086
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7086
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7076
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7076
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	2	0.7072
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	2	0.7072
SibL	C0LTM6	C0LTM6_9ACTN	Streptosporangium sibiricum	4	0.7071
SibL	C0LTM6	C0LTM6_9ACTN	Streptosporangium sibiricum	4	0.7071
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7046
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7046
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7044
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7044
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7042
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7042
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	2	0.7041
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	2	0.7041
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7040
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7040
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7040
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7040
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7040
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7040
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	4	0.7029
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	4	0.7029
Serine/threonine-protein kinase toxin HipA	P23874	HIPA_ECOLI	Escherichia coli	2	0.7025
Serine/threonine-protein kinase toxin HipA	P23874	HIPA_ECOLI	Escherichia coli	2	0.7025
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7024
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7024
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7012
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7012

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