Carviolin - Compound Card

Carviolin

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Carviolin

Structure
Zoomed Structure
  • Family: Trichocomaceae
  • Kingdom: Fungi
  • Class: Quinone
    • Subclass: Anthraquinone
Canonical Smiles OCc1cc(OC)c2c(c1)C(=O)c1c(C2=O)c(O)cc(c1)O
InChI InChI=1S/C16H12O6/c1-22-12-3-7(6-17)2-9-14(12)16(21)13-10(15(9)20)4-8(18)5-11(13)19/h2-5,17-19H,6H2,1H3
InChIKey XNMZBRJAWRIJII-UHFFFAOYSA-N
Formula C16H12O6
HBA 6
HBD 3
MW 300.27
Rotatable Bonds 2
TPSA 104.06
LogP 1.37
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 22
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 300.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Penicillium species Trichocomaceae Fungi 5073

Showing of synonyms

  • Aly AH, Debbab A, et al. (2011). NF kappa B inhibitors and antitrypanosomal metabolites from endophytic fungus Penicillium sp. isolated from Limonium tubiflorum. Bioorganic and Medicinal Chemistry,2011,19(1),414-421. [View] [PubMed]
Pubchem: 10040432
Nmrshiftdb2: 70010887

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)C(=O)c3c(C2=O)cccc3

Level: 0

Mol. Weight: 208.22 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.98
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.8
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.26

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.79
Plasma Protein Binding
58.33
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.83
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.13
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.86
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.42
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.78
Rat (Acute)
2.35
Rat (Chronic Oral)
3.37
Fathead Minnow
4.19
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
452.61
Hydration Free Energy
-10.9
Log(D) at pH=7.4
1.42
Log(P)
2.29
Log S
-5.46
Log(Vapor Pressure)
-7.4
Melting Point
213.15
pKa Acid
7.09
pKa Basic
3.95
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9410
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9410
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9367
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9367
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9060
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9060
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8977
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8977
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.8968
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.8968
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8863
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8863
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.8854
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.8854
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8826
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8826
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.8766
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.8766
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8637
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8637
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8603
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8603
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8588
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8588
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 4 0.8558
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 4 0.8558
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8548
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8548
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8497
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8497
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8494
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8494
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8462
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8462
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8426
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8426
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8404
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8404
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8400
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8400
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8378
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8378
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8373
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8373
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8256
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8256
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.8233
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.8233
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 4 0.8232
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 4 0.8232
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8191
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8191
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8134
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8134
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8125
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8125
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8108
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8108
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8084
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8084
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7998
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7998
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.7974
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.7974
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7967
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7967
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7959
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7959
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7949
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7949
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7947
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7947
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7916
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7916
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7875
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7875
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7865
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7865
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.7744
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.7744
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7743
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7743
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7689
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7689
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7687
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7687
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7662
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7662
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7648
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7648
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7643
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7643
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7626
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7626
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7566
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7566
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7550
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7550
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7539
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7539
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7506
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7506
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7485
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7485
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7481
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7481
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7477
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7477
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 5 0.7441
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 5 0.7441
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.7430
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.7430
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7419
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7419
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7414
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7414
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7412
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7412
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7401
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7401
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7374
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7374
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7358
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7358
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7339
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7339
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7327
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7327
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7320
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7320
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7318
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7318
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7312
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7312
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.7260
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.7260
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7229
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7229
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.7203
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.7203
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7199
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7199
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7182
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7182
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7162
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7162
Orotidine 5'-phosphate decarboxylase O58462 PYRF_PYRHO Pyrococcus horikoshii 3 0.7152
Orotidine 5'-phosphate decarboxylase O58462 PYRF_PYRHO Pyrococcus horikoshii 3 0.7152
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7145
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7145
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7139
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7139
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7130
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7130
D-mycarose 3-C-methyltransferase Q194Q4 Q194Q4_STRAA Streptomyces argillaceus 4 0.7129
D-mycarose 3-C-methyltransferase Q194Q4 Q194Q4_STRAA Streptomyces argillaceus 4 0.7129
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7123
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7123
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7117
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7117
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7113
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7113
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7112
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7112
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7108
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7108
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7106
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7106
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7104
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7104
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7068
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7068
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7067
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7067
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7056
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7056
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7039
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7039
Aklanonic acid methyl ester cyclase AcmA O52646 DNRD_STRGJ Streptomyces galilaeus 3 0.7038
Aklanonic acid methyl ester cyclase AcmA O52646 DNRD_STRGJ Streptomyces galilaeus 3 0.7038
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 4 0.7031
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 4 0.7031
Tubulin alpha chain A0A0R4I993 A0A0R4I993_SUSBA Sus barbatus 3 0.7022
Tubulin alpha chain A0A0R4I993 A0A0R4I993_SUSBA Sus barbatus 3 0.7022
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7020
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7020
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 4 0.7017
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 4 0.7017

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