5-chloro-omega-hydroxy-1-O-methylemodin - Compound Card

5-chloro-omega-hydroxy-1-O-methylemodin

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5-chloro-omega-hydroxy-1-O-methylemodin

Structure
Zoomed Structure
  • Family: Fungi - Trichocomaceae
  • Kingdom: Fungi
  • Class: Quinone
    • Subclass: Anthraquinone
Canonical Smiles OCc1cc(OC)c2c(c1)C(=O)c1c(C2=O)c(O)cc(c1Cl)O
InChI InChI=1S/C16H11ClO6/c1-23-10-3-6(5-18)2-7-11(10)16(22)12-8(19)4-9(20)14(17)13(12)15(7)21/h2-4,18-20H,5H2,1H3
InChIKey GFNBQXKNWQSVTJ-UHFFFAOYSA-N
Formula C16H11ClO6
HBA 6
HBD 3
MW 334.71
Rotatable Bonds 2
TPSA 104.06
LogP 2.03
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 334.02
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Penicillium species Trichocomaceae Fungi 5073

Showing of synonyms

  • Aly AH, Debbab A, et al. (2011). NF kappa B inhibitors and antitrypanosomal metabolites from endophytic fungus Penicillium sp. isolated from Limonium tubiflorum. Bioorganic and Medicinal Chemistry,2011,19(1),414-421. [View] [PubMed]
Pubchem: 53319344
Nmrshiftdb2: 60076799

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)C(=O)c3c(C2=O)cccc3

Level: 0

Mol. Weight: 334.71 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.79
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.8
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.0

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.0
Plasma Protein Binding
62.73
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.23
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.13
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.91
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.72
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.94
Rat (Acute)
2.31
Rat (Chronic Oral)
3.21
Fathead Minnow
4.42
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
458.6
Hydration Free Energy
-10.82
Log(D) at pH=7.4
1.16
Log(P)
2.9
Log S
-5.58
Log(Vapor Pressure)
-7.69
Melting Point
196.76
pKa Acid
6.31
pKa Basic
3.8
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9416
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9416
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9158
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9158
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 3 0.9085
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 3 0.9085
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 3 0.9048
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 3 0.9048
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9006
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9006
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8859
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8859
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8840
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8840
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8834
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8834
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8730
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8730
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8699
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8699
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8662
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8662
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8620
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8620
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8593
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8593
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8529
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8529
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8472
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8472
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8461
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8461
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8414
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8414
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8388
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8388
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8378
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8378
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8300
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8300
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8295
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8295
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8169
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8169
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8142
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8142
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8141
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8141
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8074
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8074
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8055
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8055
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8050
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8050
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8033
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8033
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8024
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8024
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8019
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8019
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8016
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8016
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7926
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7926
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.7879
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.7879
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.7876
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.7876
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7872
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7872
Dimethylsulfonioproprionate demethylase DmdA Q4FP21 DMDA_PELUB Pelagibacter ubique 4 0.7868
Dimethylsulfonioproprionate demethylase DmdA Q4FP21 DMDA_PELUB Pelagibacter ubique 4 0.7868
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7860
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7860
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7840
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7840
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7829
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7829
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.7809
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.7809
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.7759
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.7759
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7743
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7743
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7678
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7678
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.7669
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.7669
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7666
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7666
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7660
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7660
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7649
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7649
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7644
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7644
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7632
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7632
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7628
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7628
Decapping and exoribonuclease protein O70348 DXO_MOUSE Mus musculus 3 0.7617
Decapping and exoribonuclease protein O70348 DXO_MOUSE Mus musculus 3 0.7617
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7577
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7577
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7569
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7569
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7555
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7555
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7499
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7499
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7496
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7496
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.7481
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.7481
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7455
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7455
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7453
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7453
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7447
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7447
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7435
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7435
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7417
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7417
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7412
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7412
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7396
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7396
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7371
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7371
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7357
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7357
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7347
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7347
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7337
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7337
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7332
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7332
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7308
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7308
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7302
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7302
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7286
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7286
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7284
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7284
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7281
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7281
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7280
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7280
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7278
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7278
Orotidine 5'-phosphate decarboxylase O58462 PYRF_PYRHO Pyrococcus horikoshii 3 0.7273
Orotidine 5'-phosphate decarboxylase O58462 PYRF_PYRHO Pyrococcus horikoshii 3 0.7273
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7255
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7255
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7247
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7247
D-mycarose 3-C-methyltransferase Q194Q4 Q194Q4_STRAA Streptomyces argillaceus 4 0.7246
D-mycarose 3-C-methyltransferase Q194Q4 Q194Q4_STRAA Streptomyces argillaceus 4 0.7246
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7245
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7245
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7240
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7240
dTDP-4-dehydro-6-deoxyglucose 3-epimerase Q5SFD1 CHMJ_STRBI Streptomyces bikiniensis 3 0.7236
dTDP-4-dehydro-6-deoxyglucose 3-epimerase Q5SFD1 CHMJ_STRBI Streptomyces bikiniensis 3 0.7236
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7218
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7218
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7214
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7214
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7208
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7208
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7185
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7185
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7176
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7176
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.7171
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.7171
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7150
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7150
Thymidylate synthase Q9Y052 Q9Y052_CAEEL Caenorhabditis elegans 4 0.7149
Thymidylate synthase Q9Y052 Q9Y052_CAEEL Caenorhabditis elegans 4 0.7149
Death-associated protein kinase 3 O43293 DAPK3_HUMAN Homo sapiens 4 0.7147
Death-associated protein kinase 3 O43293 DAPK3_HUMAN Homo sapiens 4 0.7147
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7146
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7146
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7144
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7144
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7139
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7139
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7121
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7121
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7119
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7119
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 3 0.7109
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 3 0.7109
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7097
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7097
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7087
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7087
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 3 0.7085
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 3 0.7085
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7076
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7076
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7067
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7067
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7051
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7051
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7045
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7045
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7044
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7044
Cysteine synthase P45040 CYSK_HAEIN Haemophilus influenzae 3 0.7040
Cysteine synthase P45040 CYSK_HAEIN Haemophilus influenzae 3 0.7040
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7035
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7035
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7025
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7025
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7011
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7011
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7006
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7006
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7002
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7002

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