1-O-methylemodin - Compound Card

1-O-methylemodin

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1-O-methylemodin

Structure
Zoomed Structure
  • Family: Fungi - Trichocomaceae
  • Kingdom: Fungi
  • Class: Quinone
    • Subclass: Anthraquinone
Canonical Smiles COc1cc(C)cc2c1C(=O)c1c(C2=O)cc(cc1O)O
InChI InChI=1S/C16H12O5/c1-7-3-9-14(12(4-7)21-2)16(20)13-10(15(9)19)5-8(17)6-11(13)18/h3-6,17-18H,1-2H3
InChIKey IKIAXVIGUJMLHC-UHFFFAOYSA-N
Formula C16H12O5
HBA 5
HBD 2
MW 284.27
Rotatable Bonds 1
TPSA 83.83
LogP 2.19
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 284.07
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Penicillium species Trichocomaceae Fungi 5073

Showing of synonyms

  • Aly AH, Debbab A, et al. (2011). NF kappa B inhibitors and antitrypanosomal metabolites from endophytic fungus Penicillium sp. isolated from Limonium tubiflorum. Bioorganic and Medicinal Chemistry,2011,19(1),414-421. [View] [PubMed]
Pubchem: 10469084
Nmrshiftdb2: 60063664

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)C(=O)c3c(C2=O)cccc3

Level: 0

Mol. Weight: 284.27 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.47
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.650
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.12

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.970
Plasma Protein Binding
64.2
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.820
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.420
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.120
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.500
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.660
Rat (Acute)
2.360
Rat (Chronic Oral)
3.020
Fathead Minnow
4.420
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
429.400
Hydration Free Energy
-10.600
Log(D) at pH=7.4
2.350
Log(P)
3.33
Log S
-6.66
Log(Vapor Pressure)
-7.11
Melting Point
231.7
pKa Acid
6.79
pKa Basic
4.28
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.9636
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.9636
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9380
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9380
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9154
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9154
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8965
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8965
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8933
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8933
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8925
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8925
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8857
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8857
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8845
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8845
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8839
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8839
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8786
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8786
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.8770
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.8770
E3 ubiquitin-protein ligase Mdm2 P56273 MDM2_XENLA Xenopus laevis 3 0.8642
E3 ubiquitin-protein ligase Mdm2 P56273 MDM2_XENLA Xenopus laevis 3 0.8642
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8589
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8589
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8519
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8519
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 4 0.8518
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 4 0.8518
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8505
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8505
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8464
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8464
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8444
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8444
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8438
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8438
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8433
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8433
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8430
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8430
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8427
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8427
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8417
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8417
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.8417
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.8417
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.8388
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.8388
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8378
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8378
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8361
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8361
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8262
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8262
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.8200
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.8200
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8185
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8185
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8167
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8167
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8164
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8164
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 4 0.8162
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 4 0.8162
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.8145
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.8145
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8051
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8051
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8050
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8050
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.8048
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.8048
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8043
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8043
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.8024
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.8024
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8019
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8019
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8012
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8012
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7996
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7996
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7989
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7989
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.7979
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.7979
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7953
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7953
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7950
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7950
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7874
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7874
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7820
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7820
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7817
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7817
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7815
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7815
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7811
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7811
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7797
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7797
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7755
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7755
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7748
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7748
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7737
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7737
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7735
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7735
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7730
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7730
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.7722
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.7722
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7698
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7698
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7683
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7683
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7668
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7668
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7648
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7648
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7637
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7637
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 4 0.7632
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 4 0.7632
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7621
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7621
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7620
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7620
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7612
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7612
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7610
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7610
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7600
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7600
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7598
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7598
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7539
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7539
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7495
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7495
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7488
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7488
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7473
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7473
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7473
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7473
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7435
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7435
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7417
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7417
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7387
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7387
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Q9R1E6 ENPP2_MOUSE Mus musculus 4 0.7374
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Q9R1E6 ENPP2_MOUSE Mus musculus 4 0.7374
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7300
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7300
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7286
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7286
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7264
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7264
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7262
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7262
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7256
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7256
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7253
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7253
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7242
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7242
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.7233
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.7233
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7185
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7185
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7184
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7184
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7181
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7181
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7162
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7162
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7159
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7159
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7150
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7150
D-mycarose 3-C-methyltransferase Q194Q4 Q194Q4_STRAA Streptomyces argillaceus 4 0.7135
D-mycarose 3-C-methyltransferase Q194Q4 Q194Q4_STRAA Streptomyces argillaceus 4 0.7135
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7129
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7129
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7121
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7121
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7104
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7104
Orotidine 5'-phosphate decarboxylase O58462 PYRF_PYRHO Pyrococcus horikoshii 3 0.7103
Orotidine 5'-phosphate decarboxylase O58462 PYRF_PYRHO Pyrococcus horikoshii 3 0.7103
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7087
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7087
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7076
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7076
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7076
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7076
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7075
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7075
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7072
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7072
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7066
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7066
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7056
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7056
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7054
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7054
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7053
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7053
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7048
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7048
Bifunctional F420 biosynthesis protein FbiB P9WP79 FBIB_MYCTU Mycobacterium tuberculosis 5 0.7030
Bifunctional F420 biosynthesis protein FbiB P9WP79 FBIB_MYCTU Mycobacterium tuberculosis 5 0.7030
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7030
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7030
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7029
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7029
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7023
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7023
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7000
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7000

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