4-hydroxyquinolin-2(1H)-one - Compound Card

4-hydroxyquinolin-2(1H)-one

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4-hydroxyquinolin-2(1H)-one

Structure
Zoomed Structure
  • Family: Fungi - Trichocomaceae
  • Kingdom: Fungi
  • Class: Alkaloid
Canonical Smiles COC(=O)Cc1cc2c([nH]1)cccc2
InChI InChI=1S/C11H11NO2/c1-14-11(13)7-9-6-8-4-2-3-5-10(8)12-9/h2-6,12H,7H2,1H3
InChIKey ZXAOWDBYBUEVKE-UHFFFAOYSA-N
Formula C11H11NO2
HBA 2
HBD 1
MW 189.21
Rotatable Bonds 2
TPSA 42.09
LogP 1.88
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 14
Formal Charge 0
Fraction CSP3 0.18
Exact Mass 189.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Penicillium citrinum Trichocomaceae Fungi 5077

Showing of synonyms

  • El-Neketi M, Ebrahim W, et al. (2013). Alkaloids and polyketides from Penicillium citrinum, an endophyte isolated from the Moroccan plant Ceratonia siliqua. Journal of Natural Products,2013,76(6),1099-1104. [View] [PubMed]
Pubchem: 10932216
Nmrshiftdb2: 70023949
CPRiL: 152228
Structure

SMILES: c1c[nH]c(c12)cccc2

Level: 0

Mol. Weight: 189.21 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.53
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.090
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.37

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.600
Plasma Protein Binding
22.96
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.320
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.090
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.180
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.050
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.860
Rat (Acute)
1.960
Rat (Chronic Oral)
2.400
Fathead Minnow
4.000
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
317.260
Hydration Free Energy
-10.640
Log(D) at pH=7.4
2.210
Log(P)
2.01
Log S
-2.67
Log(Vapor Pressure)
-4.02
Melting Point
119.86
pKa Acid
11.16
pKa Basic
7.68
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9663
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9663
Matrix metalloproteinase-20 O60882 MMP20_HUMAN Homo sapiens 3 0.9416
Matrix metalloproteinase-20 O60882 MMP20_HUMAN Homo sapiens 3 0.9416
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9246
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9246
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9190
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9190
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.9119
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.9119
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8940
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8940
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8857
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8857
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8658
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8658
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.8635
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.8635
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.8558
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.8558
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8554
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8554
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.8504
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.8504
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.8479
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.8479
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.8455
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.8455
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 3 0.8450
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 3 0.8450
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8345
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8345
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8277
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8277
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.8081
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.8081
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8036
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8036
Cytochrome P450 2A6 P11509 CP2A6_HUMAN Homo sapiens 3 0.7927
Cytochrome P450 2A6 P11509 CP2A6_HUMAN Homo sapiens 3 0.7927
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7835
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7835
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7815
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7815
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7756
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7756
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7686
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7686
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7577
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7577
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7562
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7562
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7560
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7560
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7551
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7551
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7542
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7542
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7512
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7512
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7494
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7494
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7483
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7483
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 2 0.7480
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 2 0.7480
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7467
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7467
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7445
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7445
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7442
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7442
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 2 0.7432
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 2 0.7432
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7431
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7431
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 2 0.7399
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 2 0.7399
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7385
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7385
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7360
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7360
glutaryl-CoA dehydrogenase (ETF) Q3JP94 Q3JP94_BURP1 Burkholderia pseudomallei 2 0.7349
glutaryl-CoA dehydrogenase (ETF) Q3JP94 Q3JP94_BURP1 Burkholderia pseudomallei 2 0.7349
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7342
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7342
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7340
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7340
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7329
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7329
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7321
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7321
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 3 0.7285
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 3 0.7285
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7281
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7281
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 2 0.7265
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 2 0.7265
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7264
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7264
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7253
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7253
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7245
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7245
Dihydroorotate dehydrogenase (quinone), mitochondrial Q02127 PYRD_HUMAN Homo sapiens 3 0.7237
Dihydroorotate dehydrogenase (quinone), mitochondrial Q02127 PYRD_HUMAN Homo sapiens 3 0.7237
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.7228
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.7228
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7199
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7199
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7195
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7195
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7195
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7195
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7194
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7194
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7172
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7172
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7170
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7170
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7165
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7165
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7164
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7164
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7156
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7156
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7139
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7139
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7136
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7136
Albumin P14639 ALBU_SHEEP Ovis aries 2 0.7127
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7127
Albumin P14639 ALBU_SHEEP Ovis aries 2 0.7127
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7127
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7127
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7127
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7126
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7126
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7125
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7125
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 2 0.7119
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 2 0.7119
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7113
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7113
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.7108
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.7108
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7106
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7106
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7096
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7096
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7093
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7093
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7089
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7089
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7089
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7089
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7088
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7088
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7088
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7088
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7087
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7087
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7079
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7079
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7065
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7065
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7060
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7060
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7059
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7059
Dicamba O-demethylase, oxygenase component Q5S3I3 DDMC_STEMA Stenotrophomonas maltophilia 2 0.7049
Dicamba O-demethylase, oxygenase component Q5S3I3 DDMC_STEMA Stenotrophomonas maltophilia 2 0.7049
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7038
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7038
Purine phosphoribosyltransferase (GpT-1) Q97W95 Q97W95_SACS2 Saccharolobus solfataricus 3 0.7028
Purine phosphoribosyltransferase (GpT-1) Q97W95 Q97W95_SACS2 Saccharolobus solfataricus 3 0.7028
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7024
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7024
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 2 0.7023
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 2 0.7023
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 2 0.7014
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 2 0.7014
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 2 0.7001
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 2 0.7001

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