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Penicinoline

Family: Fungi - Trichocomaceae
Kingdom: Fungi
Class: Alkaloid

Canonical Smiles	OC(=O)c1c([nH]c2c(c1=O)cccc2)c1ccc[nH]1
InChI	InChI=1S/C14H10N2O3/c17-13-8-4-1-2-5-9(8)16-12(11(13)14(18)19)10-6-3-7-15-10/h1-7,15H,(H,16,17)(H,18,19)
InChIKey	DWKAQISLZUQZNU-UHFFFAOYSA-N
Formula	C₁₄H₁₀N₂O₃
HBA	2
HBD	3
MW	254.25
Rotatable Bonds	2
TPSA	85.95
LogP	2.22
Number Rings	3
Number Aromatic Rings	3
Heavy Atom Count	19
Formal Charge	0
Fraction CSP3	0.0
Exact Mass	254.07
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Penicillium citrinum	Trichocomaceae	Fungi	5077

Showing of synonyms

El-Neketi M, Ebrahim W, et al. (2013). Alkaloids and polyketides from Penicillium citrinum, an endophyte isolated from the Moroccan plant Ceratonia siliqua. Journal of Natural Products,2013,76(6),1099-1104. [View] [PubMed]

Pubchem: 46890175

Zinc: ZINC000101992276

Nmrshiftdb2: 70023950

Chembl: CHEMBL1084651

No compound-protein relationship available.

SMILES: [nH]1cccc1-c(cc2=O)[nH]c(c23)cccc3

Level: 1

Mol. Weight: 254.25 g/mol

SMILES: c1cccc(c12)[nH]ccc2=O

Level: 0

Mol. Weight: 254.25 g/mol

SMILES: c1cc[nH]c1

Level: 0

Mol. Weight: 254.25 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -5.11
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.73
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -0.54

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.3
Plasma Protein Binding: 43.17
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 4.44
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: -0.5
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.06
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 3.55
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 1.62
Rat (Acute): 2.27
Rat (Chronic Oral): 2.75
Fathead Minnow: 4.05
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 451.15
Hydration Free Energy: -14.82
Log(D) at pH=7.4: -0.77
Log(P): 1.63
Log S: -4.29
Log(Vapor Pressure): -9.36
Melting Point: 316.21
pKa Acid: 7.99
pKa Basic: 4.86

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9658
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9658
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.9610
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.9610
Flavin reductase (NADPH)	P30043	BLVRB_HUMAN	Homo sapiens	3	0.9353
Flavin reductase (NADPH)	P30043	BLVRB_HUMAN	Homo sapiens	3	0.9353
Streptogramin A acetyltransferase	P50870	VATD_ENTFC	Enterococcus faecium	3	0.9280
Streptogramin A acetyltransferase	P50870	VATD_ENTFC	Enterococcus faecium	3	0.9280
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9110
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9110
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.9037
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.9037
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	3	0.9018
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	3	0.9018
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8999
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8999
E3 ubiquitin-protein ligase Mdm2	Q00987	MDM2_HUMAN	Homo sapiens	3	0.8983
E3 ubiquitin-protein ligase Mdm2	Q00987	MDM2_HUMAN	Homo sapiens	3	0.8983
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8980
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8980
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	4	0.8853
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	4	0.8853
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	4	0.8850
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	4	0.8850
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8829
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8829
E3 ubiquitin-protein ligase Mdm2	P56273	MDM2_XENLA	Xenopus laevis	3	0.8789
E3 ubiquitin-protein ligase Mdm2	P56273	MDM2_XENLA	Xenopus laevis	3	0.8789
Beta-ketoacyl-[acyl-carrier-protein] synthase III	Q820T1	FABH_ENTFA	Enterococcus faecalis	3	0.8750
Beta-ketoacyl-[acyl-carrier-protein] synthase III	Q820T1	FABH_ENTFA	Enterococcus faecalis	3	0.8750
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.8694
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.8694
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.8671
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.8671
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	3	0.8641
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	3	0.8641
Casein kinase I isoform delta	P48730	KC1D_HUMAN	Homo sapiens	3	0.8625
Casein kinase I isoform delta	P48730	KC1D_HUMAN	Homo sapiens	3	0.8625
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	4	0.8610
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	4	0.8610
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.8596
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.8596
Casein kinase I isoform delta	P48730	KC1D_HUMAN	Homo sapiens	3	0.8589
Casein kinase I isoform delta	P48730	KC1D_HUMAN	Homo sapiens	3	0.8589
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.8578
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.8578
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.8524
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.8524
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.8486
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.8486
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.8486
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.8486
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.8445
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.8445
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8433
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8433
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	3	0.8432
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	3	0.8432
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.8397
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.8397
Glutathione S-transferase A1	P08263	GSTA1_HUMAN	Homo sapiens	3	0.8383
Glutathione S-transferase A1	P08263	GSTA1_HUMAN	Homo sapiens	3	0.8383
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	3	0.8357
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	3	0.8357
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	3	0.8346
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	3	0.8346
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.8340
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.8340
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.8325
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.8325
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8297
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8297
Biphenyl dioxygenase subunit alpha	P37333	BPHA_PARXL	Paraburkholderia xenovorans	4	0.8271
Biphenyl dioxygenase subunit alpha	P37333	BPHA_PARXL	Paraburkholderia xenovorans	4	0.8271
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	3	0.8259
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	3	0.8259
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.8214
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.8214
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8201
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8201
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8197
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8197
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	3	0.8170
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	3	0.8170
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	P33038	MURA_ENTCC	Enterobacter cloacae subsp. cloacae	3	0.8158
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	P33038	MURA_ENTCC	Enterobacter cloacae subsp. cloacae	3	0.8158
Prostaglandin E synthase 2	Q9N0A4	PGES2_MACFA	Macaca fascicularis	3	0.8136
Prostaglandin E synthase 2	Q9N0A4	PGES2_MACFA	Macaca fascicularis	3	0.8136
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8134
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8134
Stimulator of interferon genes protein	Q86WV6	STING_HUMAN	Homo sapiens	3	0.8130
Stimulator of interferon genes protein	Q86WV6	STING_HUMAN	Homo sapiens	3	0.8130
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8127
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8127
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.8112
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.8112
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	P60472	UPPS_ECOLI	Escherichia coli	3	0.8076
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	P60472	UPPS_ECOLI	Escherichia coli	3	0.8076
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8032
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8032
Prostaglandin reductase 3	Q8N4Q0	PTGR3_HUMAN	Homo sapiens	3	0.8008
Prostaglandin reductase 3	Q8N4Q0	PTGR3_HUMAN	Homo sapiens	3	0.8008
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7993
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7993
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7988
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7988
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7985
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7985
NmrA-like family domain-containing protein 1	Q9HBL8	NMRL1_HUMAN	Homo sapiens	3	0.7977
NmrA-like family domain-containing protein 1	Q9HBL8	NMRL1_HUMAN	Homo sapiens	3	0.7977
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	3	0.7971
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	3	0.7971
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7966
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7966
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7962
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7962
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7960
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7960
Beta-glucuronidase	P05804	BGLR_ECOLI	Escherichia coli	3	0.7926
Beta-glucuronidase	P05804	BGLR_ECOLI	Escherichia coli	3	0.7926
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7920
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7920
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.7905
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.7905
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7900
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7900
E3 ubiquitin-protein ligase Mdm2	Q00987	MDM2_HUMAN	Homo sapiens	3	0.7891
E3 ubiquitin-protein ligase Mdm2	Q00987	MDM2_HUMAN	Homo sapiens	3	0.7891
Cytochrome P450 119	Q55080	CP119_SULAC	Sulfolobus acidocaldarius	4	0.7890
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.7890
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.7890
Cytochrome P450 119	Q55080	CP119_SULAC	Sulfolobus acidocaldarius	4	0.7890
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7884
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7884
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7859
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7859
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7826
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7826
Protein S100-A4	P26447	S10A4_HUMAN	Homo sapiens	3	0.7824
Protein S100-A4	P26447	S10A4_HUMAN	Homo sapiens	3	0.7824
Albumin	P14639	ALBU_SHEEP	Ovis aries	3	0.7823
Albumin	P14639	ALBU_SHEEP	Ovis aries	3	0.7823
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7819
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7819
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.7815
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.7815
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.7803
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.7803
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7796
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7796
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.7792
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.7792
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7777
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7777
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7773
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7773
Cytochrome P450 2B4	P00178	CP2B4_RABIT	Oryctolagus cuniculus	4	0.7766
Cytochrome P450 2B4	P00178	CP2B4_RABIT	Oryctolagus cuniculus	4	0.7766
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7743
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7743
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7723
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7723
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7710
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7710
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7703
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7703
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7686
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7686
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7680
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7680
Metallo-beta-lactamase type 2	P52699	BLAB_SERMA	Serratia marcescens	3	0.7674
Metallo-beta-lactamase type 2	P52699	BLAB_SERMA	Serratia marcescens	3	0.7674
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7658
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	2	0.7658
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7658
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	2	0.7658
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7655
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7655
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	2	0.7653
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	2	0.7653
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7643
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7643
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7638
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7638
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7636
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7636
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	2	0.7633
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	2	0.7633
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7605
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7605
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	4	0.7601
Nucleoprotein	P33469	NCAP_CVHOC	Human coronavirus OC43	3	0.7601
Nucleoprotein	P33469	NCAP_CVHOC	Human coronavirus OC43	3	0.7601
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	4	0.7601
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7584
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7584
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	2	0.7574
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7574
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7574
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	2	0.7574
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	3	0.7572
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	3	0.7572
Abscisic acid receptor PYL1	Q8VZS8	PYL1_ARATH	Arabidopsis thaliana	3	0.7569
Abscisic acid receptor PYL1	Q8VZS8	PYL1_ARATH	Arabidopsis thaliana	3	0.7569
Stimulator of interferon genes protein	Q3TBT3	STING_MOUSE	Mus musculus	3	0.7562
Stimulator of interferon genes protein	Q3TBT3	STING_MOUSE	Mus musculus	3	0.7562
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7552
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7552
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7546
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7546
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7538
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7538
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7527
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7527
Beta-secretase 2	Q9Y5Z0	BACE2_HUMAN	Homo sapiens	2	0.7511
Beta-secretase 2	Q9Y5Z0	BACE2_HUMAN	Homo sapiens	2	0.7511
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7507
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7507
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7505
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7505
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7503
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7503
Cytochrome P450 2B6	P20813	CP2B6_HUMAN	Homo sapiens	4	0.7500
Cytochrome P450 2B6	P20813	CP2B6_HUMAN	Homo sapiens	4	0.7500
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7497
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7497
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7492
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7492
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	2	0.7480
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	2	0.7480
histone deacetylase	A5H660	A5H660_SCHMA	Schistosoma mansoni	3	0.7476
histone deacetylase	A5H660	A5H660_SCHMA	Schistosoma mansoni	3	0.7476
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7475
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7475
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7450
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7450
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	2	0.7445
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	2	0.7445
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7445
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7445
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.7439
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.7439
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.7426
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.7426
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7423
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7423
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	2	0.7411
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	2	0.7411
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.7404
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.7404
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7397
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7397
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7389
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7389
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7388
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7388
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7387
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7387
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7386
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7386
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.7381
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.7381
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7376
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7376
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.7373
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.7373
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.7372
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.7372
Catalase-peroxidase 2	O59651	KATG2_HALMA	Haloarcula marismortui	2	0.7370
Catalase-peroxidase 2	O59651	KATG2_HALMA	Haloarcula marismortui	2	0.7370
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7368
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7368
Cholinesterase	P06276	CHLE_HUMAN	Homo sapiens	2	0.7367
Cholinesterase	P06276	CHLE_HUMAN	Homo sapiens	2	0.7367
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7364
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7364
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.7355
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.7355
Gag-Pol polyprotein	O12158	POL_HV192	Human immunodeficiency virus type 1 group M subtype C	2	0.7352
Gag-Pol polyprotein	O12158	POL_HV192	Human immunodeficiency virus type 1 group M subtype C	2	0.7352
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	2	0.7345
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	2	0.7345
Cytosol aminopeptidase	P00727	AMPL_BOVIN	Bos taurus	2	0.7342
Cytosol aminopeptidase	P00727	AMPL_BOVIN	Bos taurus	2	0.7342
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7337
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7337
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.7334
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.7334
Prostatic acid phosphatase	P15309	PPAP_HUMAN	Homo sapiens	3	0.7331
Prostatic acid phosphatase	P15309	PPAP_HUMAN	Homo sapiens	3	0.7331
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7321
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7321
Flavonoid 3-O-glucosyltransferase	A6XNC6	UGFGT_MEDTR	Medicago truncatula	2	0.7313
Flavonoid 3-O-glucosyltransferase	A6XNC6	UGFGT_MEDTR	Medicago truncatula	2	0.7313
Fatty acid-binding protein, adipocyte	P04117	FABP4_MOUSE	Mus musculus	2	0.7312
Fatty acid-binding protein, adipocyte	P04117	FABP4_MOUSE	Mus musculus	2	0.7312
Calmodulin	P62157	CALM_BOVIN	Bos taurus	3	0.7302
Calmodulin	P62157	CALM_BOVIN	Bos taurus	3	0.7302
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7300
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7300
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7297
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7297
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7290
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7290
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7286
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7286
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	4	0.7284
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	4	0.7284
Histamine N-methyltransferase	P50135	HNMT_HUMAN	Homo sapiens	3	0.7280
Histamine N-methyltransferase	P50135	HNMT_HUMAN	Homo sapiens	3	0.7280
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7271
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7271
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	2	0.7271
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	2	0.7271
Troponin C, slow skeletal and cardiac muscles	P09860	TNNC1_CHICK	Gallus gallus	2	0.7268
Troponin C, slow skeletal and cardiac muscles	P09860	TNNC1_CHICK	Gallus gallus	2	0.7268
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7266
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7266
Biphenyl dioxygenase subunit alpha	P37333	BPHA_PARXL	Paraburkholderia xenovorans	3	0.7264
Biphenyl dioxygenase subunit alpha	P37333	BPHA_PARXL	Paraburkholderia xenovorans	3	0.7264
L-lactate dehydrogenase	Q27743	LDH_PLAFD	Plasmodium falciparum	2	0.7258
L-lactate dehydrogenase	Q27743	LDH_PLAFD	Plasmodium falciparum	2	0.7258
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7255
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7255
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7252
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7252
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	2	0.7250
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	2	0.7250
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.7249
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.7249
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	4	0.7242
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	4	0.7242
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7237
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7237
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	3	0.7236
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	3	0.7236
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	3	0.7234
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	3	0.7234
Pyruvate kinase PKM	P14618	KPYM_HUMAN	Homo sapiens	3	0.7230
Pyruvate kinase PKM	P14618	KPYM_HUMAN	Homo sapiens	3	0.7230
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7226
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7226
Achbp	I6L8L2	I6L8L2_CAPTE	Capitella teleta	3	0.7221
Achbp	I6L8L2	I6L8L2_CAPTE	Capitella teleta	3	0.7221
Cytochrome P450 130	P9WPN5	CP130_MYCTU	Mycobacterium tuberculosis	3	0.7212
Cytochrome P450 130	P9WPN5	CP130_MYCTU	Mycobacterium tuberculosis	3	0.7212
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7210
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7210
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7201
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7201
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7195
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7195
LysR-type regulatory protein	Q7WT50	Q7WT50_9BURK	Burkholderia sp. DNT	3	0.7185
LysR-type regulatory protein	Q7WT50	Q7WT50_9BURK	Burkholderia sp. DNT	3	0.7185
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7184
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7184
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7176
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7176
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7173
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7173
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7171
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7171
Histone-lysine N-methyltransferase SETD7	Q8WTS6	SETD7_HUMAN	Homo sapiens	3	0.7167
Histone-lysine N-methyltransferase SETD7	Q8WTS6	SETD7_HUMAN	Homo sapiens	3	0.7167
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	2	0.7165
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	2	0.7165
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	3	0.7164
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	3	0.7164
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7157
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	3	0.7157
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7157
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	3	0.7157
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7156
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7156
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	2	0.7148
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	2	0.7148
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7143
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7143
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7137
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7137
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7128
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7128
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7126
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7126
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7123
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7123
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7123
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7123
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7123
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7123
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7122
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7122
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	2	0.7120
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	2	0.7120
Orf1a polyprotein	Q692E5	Q692E5_CVHSA	SARS coronavirus TJF	2	0.7117
Orf1a polyprotein	Q692E5	Q692E5_CVHSA	SARS coronavirus TJF	2	0.7117
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7116
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7116
Interstitial collagenase	P03956	MMP1_HUMAN	Homo sapiens	3	0.7114
Interstitial collagenase	P03956	MMP1_HUMAN	Homo sapiens	3	0.7114
Tau-tubulin kinase 1	Q5TCY1	TTBK1_HUMAN	Homo sapiens	3	0.7110
Tau-tubulin kinase 1	Q5TCY1	TTBK1_HUMAN	Homo sapiens	3	0.7110
5-formyltetrahydrofolate cyclo-ligase	P75430	MTHFS_MYCPN	Mycoplasma pneumoniae	2	0.7106
5-formyltetrahydrofolate cyclo-ligase	P75430	MTHFS_MYCPN	Mycoplasma pneumoniae	2	0.7106
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7099
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7099
1-deoxy-D-xylulose 5-phosphate reductoisomerase	P45568	DXR_ECOLI	Escherichia coli	2	0.7096
1-deoxy-D-xylulose 5-phosphate reductoisomerase	P45568	DXR_ECOLI	Escherichia coli	2	0.7096
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	2	0.7091
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	2	0.7091
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7090
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7090
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7089
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7089
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7088
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7088
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7087
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7087
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7080
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7080
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7074
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7074
Cytosolic IMP-GMP specific 5'-nucleotidase	Q5ZZB6	Q5ZZB6_LEGPH	Legionella pneumophila subsp. pneumophila	3	0.7072
Cytosolic IMP-GMP specific 5'-nucleotidase	Q5ZZB6	Q5ZZB6_LEGPH	Legionella pneumophila subsp. pneumophila	3	0.7072
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Q13526	PIN1_HUMAN	Homo sapiens	3	0.7070
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Q13526	PIN1_HUMAN	Homo sapiens	3	0.7070
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7065
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7065
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7065
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7065
11-beta-hydroxysteroid dehydrogenase 1	Q6QLL4	DHI1_CAVPO	Cavia porcellus	3	0.7062
11-beta-hydroxysteroid dehydrogenase 1	Q6QLL4	DHI1_CAVPO	Cavia porcellus	3	0.7062
Polymerase basic protein 2	P31345	PB2_I75A3	Influenza A virus	3	0.7061
Polymerase basic protein 2	P31345	PB2_I75A3	Influenza A virus	3	0.7061
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7058
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7058
3',5'-cyclic-AMP phosphodiesterase 4B	Q07343	PDE4B_HUMAN	Homo sapiens	3	0.7045
3',5'-cyclic-AMP phosphodiesterase 4B	Q07343	PDE4B_HUMAN	Homo sapiens	3	0.7045
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7041
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7041
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7035
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7035
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7023
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7023
Oxysterols receptor LXR-beta	P55055	NR1H2_HUMAN	Homo sapiens	3	0.7022
Oxysterols receptor LXR-beta	P55055	NR1H2_HUMAN	Homo sapiens	3	0.7022
DNA-directed DNA polymerase	Q38087	DPOL_BPR69	Escherichia phage RB69	3	0.7020
DNA-directed DNA polymerase	Q38087	DPOL_BPR69	Escherichia phage RB69	3	0.7020
Anthranilate phosphoribosyltransferase	P9WFX5	TRPD_MYCTU	Mycobacterium tuberculosis	3	0.7015
Anthranilate phosphoribosyltransferase	P9WFX5	TRPD_MYCTU	Mycobacterium tuberculosis	3	0.7015
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7006
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7006
Sterol 14-alpha demethylase	Q7Z1V1	CP51_TRYCC	Trypanosoma cruzi	3	0.7005
Sterol 14-alpha demethylase	Q7Z1V1	CP51_TRYCC	Trypanosoma cruzi	3	0.7005

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