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Uridine

Family: Fungi - Trichosphaeriaceae
Kingdom: Fungi
Class: Purine Derivative

Canonical Smiles	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1ccc(=O)[nH]c1=O
InChI	InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
InChIKey	DRTQHJPVMGBUCF-XVFCMESISA-N
Formula	C₉H₁₂N₂O₆
HBA	7
HBD	4
MW	244.2
Rotatable Bonds	2
TPSA	124.78
LogP	-2.85
Number Rings	2
Number Aromatic Rings	1
Heavy Atom Count	17
Formal Charge	0
Fraction CSP3	0.56
Exact Mass	244.07
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Nigrospora sphaerica	Trichosphaeriaceae	Fungi	114231

Showing of synonyms

Metwaly AM, Kadry HA, et al. (2014). Nigrosphaerin A a new isochromene derivative from the endophytic fungus Nigrospora sphaerica. Phytochemistry Letters,2014,7,1-5. [View]

Pubchem: 6029

Cas: 58-96-8

Gnps: CCMSLIB00006566453

Zinc: ZINC000002583633

Kegg Ligand: C00299

Chebi: 16704

Nmrshiftdb2: 60021002

Metabolights: MTBLC16704

Chembl: CHEMBL100259

Comptox: DTXSID40891555

Drugbank: DB02745

Pdb Ligand: URI

Bindingdb: 50088517

Selleck: uridine

CPRiL: 1953

SMILES: O1CCCC1n(c(=O)[nH]2)ccc2=O

Level: 1

Mol. Weight: 244.2 g/mol

SMILES: O=c1cc[nH]c(=O)[nH]1

Level: 0

Mol. Weight: 244.2 g/mol

SMILES: C1CCOC1

Level: 0

Mol. Weight: 244.2 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -5.94
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Non-Absorbed
Madin-Darby Canine Kidney: -5.070
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.39

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.360
Plasma Protein Binding: 25.32
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 8.240
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: -0.860
Biodegradation: Toxic
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 1.590
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 3.180
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -1.590
Rat (Acute): 1.920
Rat (Chronic Oral): 2.990
Fathead Minnow: 2.850
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Toxic

General Properties

Boiling Point: 435.190
Hydration Free Energy: -18.660
Log(D) at pH=7.4: -2.340
Log(P): -1.84
Log S: -1.45
Log(Vapor Pressure): -11.48
Melting Point: 178.85
pKa Acid: 7.03
pKa Basic: 7.98

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.9927
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.9927
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.9779
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.9779
Xylose isomerase	P24300	XYLA_STRRU	Streptomyces rubiginosus	3	0.9366
Xylose isomerase	P24300	XYLA_STRRU	Streptomyces rubiginosus	3	0.9366
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	3	0.9262
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	3	0.9262
WxcM-like protein	Q12KT8	Q12KT8_SHEDO	Shewanella denitrificans	4	0.9224
WxcM-like protein	Q12KT8	Q12KT8_SHEDO	Shewanella denitrificans	4	0.9224
Glucose-1-phosphate thymidylyltransferase	Q9AGY4	Q9AGY4_ANETH	Aneurinibacillus thermoaerophilus	4	0.9133
Glucose-1-phosphate thymidylyltransferase	Q9AGY4	Q9AGY4_ANETH	Aneurinibacillus thermoaerophilus	4	0.9133
Uridine phosphorylase	Q9KT71	Q9KT71_VIBCH	Vibrio cholerae serotype O1	4	0.9062
Uridine phosphorylase	Q9KT71	Q9KT71_VIBCH	Vibrio cholerae serotype O1	4	0.9062
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.9028
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.9028
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.9009
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.9009
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8991
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8991
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	5	0.8877
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	5	0.8877
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8445
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8445
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8419
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8419
DNA polymerase III subunit epsilon	P03007	DPO3E_ECOLI	Escherichia coli	3	0.8412
DNA polymerase III subunit epsilon	P03007	DPO3E_ECOLI	Escherichia coli	3	0.8412
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8384
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8384
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.8377
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.8377
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8316
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8316
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8309
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8309
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8302
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8302
Aldos-2-ulose dehydratase	P84193	AUD_PHACH	Phanerodontia chrysosporium	3	0.8299
Aldos-2-ulose dehydratase	P84193	AUD_PHACH	Phanerodontia chrysosporium	3	0.8299
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8193
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8193
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	4	0.8186
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	4	0.8186
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.8148
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.8148
Glycoside Hydrolase Family 13	Q65MI2	Q65MI2_BACLD	Bacillus licheniformis	3	0.8147
Glycoside Hydrolase Family 13	Q65MI2	Q65MI2_BACLD	Bacillus licheniformis	3	0.8147
Gag-Pol polyprotein	P0C6F2	POL_HV1LW	Human immunodeficiency virus type 1 group M subtype B	3	0.8032
Gag-Pol polyprotein	P0C6F2	POL_HV1LW	Human immunodeficiency virus type 1 group M subtype B	3	0.8032
Uridine phosphorylase 2	O95045	UPP2_HUMAN	Homo sapiens	4	0.8024
Uridine phosphorylase 2	O95045	UPP2_HUMAN	Homo sapiens	4	0.8024
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	5	0.7966
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	5	0.7966
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	5	0.7902
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	5	0.7902
Orotidine 5'-phosphate decarboxylase	Q9KQT7	PYRF_VIBCH	Vibrio cholerae serotype O1	4	0.7888
Orotidine 5'-phosphate decarboxylase	Q9KQT7	PYRF_VIBCH	Vibrio cholerae serotype O1	4	0.7888
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.7881
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.7881
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.7880
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.7880
Thymidylate synthase ThyA	P9WFR9	TYSY_MYCTU	Mycobacterium tuberculosis	5	0.7878
Thymidylate synthase ThyA	P9WFR9	TYSY_MYCTU	Mycobacterium tuberculosis	5	0.7878
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	4	0.7854
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	4	0.7854
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7843
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7843
Thymidylate synthase	P67046	TYSY_STAAM	Staphylococcus aureus	5	0.7836
Thymidylate synthase	P67046	TYSY_STAAM	Staphylococcus aureus	5	0.7836
Thymidylate synthase	P07607	TYSY_MOUSE	Mus musculus	5	0.7834
Thymidylate synthase	P07607	TYSY_MOUSE	Mus musculus	5	0.7834
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7785
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7785
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	5	0.7776
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	5	0.7776
Uridine phosphorylase	Q5SID9	Q5SID9_THET8	Thermus thermophilus	3	0.7750
Uridine phosphorylase	Q5SID9	Q5SID9_THET8	Thermus thermophilus	3	0.7750
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.7730
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.7730
Thymidylate synthase	Q8NS38	TYSY_CORGL	Corynebacterium glutamicum	5	0.7727
Thymidylate synthase	Q8NS38	TYSY_CORGL	Corynebacterium glutamicum	5	0.7727
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.7715
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.7715
Thymidylate synthase	P04818	TYSY_HUMAN	Homo sapiens	3	0.7690
Thymidylate synthase	P04818	TYSY_HUMAN	Homo sapiens	3	0.7690
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.7686
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.7686
Bifunctional dihydrofolate reductase-thymidylate synthase	A7UD81	A7UD81_PLAFA	Plasmodium falciparum	5	0.7667
Bifunctional dihydrofolate reductase-thymidylate synthase	A7UD81	A7UD81_PLAFA	Plasmodium falciparum	5	0.7667
Toll-like receptor 8	Q9NR97	TLR8_HUMAN	Homo sapiens	5	0.7662
Toll-like receptor 8	Q9NR97	TLR8_HUMAN	Homo sapiens	5	0.7662
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	4	0.7653
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	4	0.7653
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.7648
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.7648
Cyclin-dependent kinase 8	P49336	CDK8_HUMAN	Homo sapiens	3	0.7638
Cyclin-dependent kinase 8	P49336	CDK8_HUMAN	Homo sapiens	3	0.7638
Glucose-1-phosphate thymidylyltransferase	A4JC15	A4JC15_BURVG	Burkholderia vietnamiensis)	4	0.7632
Glucose-1-phosphate thymidylyltransferase	A4JC15	A4JC15_BURVG	Burkholderia vietnamiensis)	4	0.7632
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7630
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7630
Glucose-1-phosphate thymidylyltransferase	Q9AGY4	Q9AGY4_ANETH	Aneurinibacillus thermoaerophilus	4	0.7622
Glucose-1-phosphate thymidylyltransferase	Q9AGY4	Q9AGY4_ANETH	Aneurinibacillus thermoaerophilus	4	0.7622
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7610
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7610
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.7600
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.7600
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	4	0.7590
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	4	0.7590
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	5	0.7562
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	5	0.7562
Glucose-1-phosphate thymidylyltransferase	Q9AGY4	Q9AGY4_ANETH	Aneurinibacillus thermoaerophilus	4	0.7540
Glucose-1-phosphate thymidylyltransferase	Q9AGY4	Q9AGY4_ANETH	Aneurinibacillus thermoaerophilus	4	0.7540
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.7461
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.7461
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	3	0.7442
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	3	0.7442
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7437
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7437
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	4	0.7435
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	4	0.7435
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.7422
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.7422
Thymidylate synthase	P07607	TYSY_MOUSE	Mus musculus	4	0.7403
Thymidylate synthase	P07607	TYSY_MOUSE	Mus musculus	4	0.7403
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7393
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7393
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7388
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7388
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7384
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7384
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7379
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7379
Uridine phosphorylase	Q9KT71	Q9KT71_VIBCH	Vibrio cholerae serotype O1	4	0.7365
Uridine phosphorylase	Q9KT71	Q9KT71_VIBCH	Vibrio cholerae serotype O1	4	0.7365
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7353
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7353
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	4	0.7348
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	4	0.7348
Thymidylate kinase	P9WKE1	KTHY_MYCTU	Mycobacterium tuberculosis	4	0.7346
Thymidylate kinase	P9WKE1	KTHY_MYCTU	Mycobacterium tuberculosis	4	0.7346
Putative glycosyl transferase	Q9RN61	Q9RN61_STRNO	Streptomyces nogalater	5	0.7343
Putative glycosyl transferase	Q9RN61	Q9RN61_STRNO	Streptomyces nogalater	5	0.7343
cAMP-dependent protein kinase regulatory subunit	P07278	KAPR_YEAST	Saccharomyces cerevisiae	3	0.7336
cAMP-dependent protein kinase regulatory subunit	P07278	KAPR_YEAST	Saccharomyces cerevisiae	3	0.7336
Hypoxanthine-guanine phosphoribosyltransferase	P00492	HPRT_HUMAN	Homo sapiens	3	0.7328
Hypoxanthine-guanine phosphoribosyltransferase	P00492	HPRT_HUMAN	Homo sapiens	3	0.7328
D-mycarose 3-C-methyltransferase	Q194Q4	Q194Q4_STRAA	Streptomyces argillaceus	4	0.7317
D-mycarose 3-C-methyltransferase	Q194Q4	Q194Q4_STRAA	Streptomyces argillaceus	4	0.7317
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7293
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7293
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7275
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7275
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7269
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7269
Avidin	P02701	AVID_CHICK	Gallus gallus	4	0.7258
Avidin	P02701	AVID_CHICK	Gallus gallus	4	0.7258
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7247
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7247
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7238
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7238
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	Q8ZMF7	ISPF_SALTY	Salmonella typhimurium	3	0.7227
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	Q8ZMF7	ISPF_SALTY	Salmonella typhimurium	3	0.7227
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7216
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7216
Nucleoside permease	Q9KPL5	Q9KPL5_VIBCH	Vibrio cholerae serotype O1	3	0.7191
Nucleoside permease	Q9KPL5	Q9KPL5_VIBCH	Vibrio cholerae serotype O1	3	0.7191
Peptide deformylase 1B, chloroplastic/mitochondrial	Q9FUZ2	DEF1B_ARATH	Arabidopsis thaliana	3	0.7156
Peptide deformylase 1B, chloroplastic/mitochondrial	Q9FUZ2	DEF1B_ARATH	Arabidopsis thaliana	3	0.7156
dTDP-4-dehydro-6-deoxyglucose 3-epimerase	Q5SFD1	CHMJ_STRBI	Streptomyces bikiniensis	3	0.7131
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7131
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7131
dTDP-4-dehydro-6-deoxyglucose 3-epimerase	Q5SFD1	CHMJ_STRBI	Streptomyces bikiniensis	3	0.7131
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	4	0.7129
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	4	0.7129
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	4	0.7122
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	4	0.7122
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7120
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7120
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	5	0.7116
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	5	0.7116
Glucosidase II subunit alpha	Q9STC1	Q9STC1_GRALE	Gracilariopsis lemaneiformis	3	0.7115
Glucosidase II subunit alpha	Q9STC1	Q9STC1_GRALE	Gracilariopsis lemaneiformis	3	0.7115
Cytidine deaminase	P19079	CDD_BACSU	Bacillus subtilis	4	0.7107
Cytidine deaminase	P19079	CDD_BACSU	Bacillus subtilis	4	0.7107
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	5	0.7105
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	5	0.7105
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7098
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7098
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7096
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7096
DNA topoisomerase 1	P06612	TOP1_ECOLI	Escherichia coli	3	0.7085
DNA topoisomerase 1	P06612	TOP1_ECOLI	Escherichia coli	3	0.7085
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.7080
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.7080
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7078
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7078
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7073
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7073
Uracil phosphoribosyltransferase	P70881	UPP_BACCL	Bacillus caldolyticus	5	0.7069
Beta-1,4-galactosyltransferase 1	P08037	B4GT1_BOVIN	Bos taurus	3	0.7069
Beta-1,4-galactosyltransferase 1	P08037	B4GT1_BOVIN	Bos taurus	3	0.7069
Uracil phosphoribosyltransferase	P70881	UPP_BACCL	Bacillus caldolyticus	5	0.7069
Uridine phosphorylase	P0A1F6	UDP_SALTY	Salmonella typhimurium	5	0.7047
Uridine phosphorylase	P0A1F6	UDP_SALTY	Salmonella typhimurium	5	0.7047
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7045
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7045
Beta-galactosidase	P00722	BGAL_ECOLI	Escherichia coli	3	0.7038
Beta-galactosidase	P00722	BGAL_ECOLI	Escherichia coli	3	0.7038
Elongation factor Tu 1	P0CE47	EFTU1_ECOLI	Escherichia coli	3	0.7026
Elongation factor Tu 1	P0CE47	EFTU1_ECOLI	Escherichia coli	3	0.7026
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	2	0.7026
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	2	0.7026
AcsD	Q93AT8	Q93AT8_DICCH	Dickeya chrysanthemi	3	0.7020
AcsD	Q93AT8	Q93AT8_DICCH	Dickeya chrysanthemi	3	0.7020
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7017
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7017
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7006
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7006

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