3- hydroxy-5-(4-hydroxybenzyl)-4-(4-hydroxyphenyl)furan-2(5H)-one - Compound Card

3- hydroxy-5-(4-hydroxybenzyl)-4-(4-hydroxyphenyl)furan-2(5H)-one

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3- hydroxy-5-(4-hydroxybenzyl)-4-(4-hydroxyphenyl)furan-2(5H)-one

Structure
Zoomed Structure
  • Family: Trichocomaceae
  • Kingdom: Fungi
  • Class: Lactone
    • Subclass: Butyrolactone Derivative
Canonical Smiles Oc1ccc(cc1)C[C@H]1OC(=O)C(=C1c1ccc(cc1)O)O
InChI InChI=1S/C17H14O5/c18-12-5-1-10(2-6-12)9-14-15(16(20)17(21)22-14)11-3-7-13(19)8-4-11/h1-8,14,18-20H,9H2/t14-/m1/s1
InChIKey YFDAFIBRAHBXFL-CQSZACIVSA-N
Formula C17H14O5
HBA 5
HBD 3
MW 298.29
Rotatable Bonds 3
TPSA 86.99
LogP 2.54
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 22
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 298.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Aspergillus terreus Trichocomaceae Fungi 33178

Showing of synonyms

  • Chen H, Daletos G, et al. (2015). Inducing secondary metabolite production by the soil-dwelling fungus Aspergillus terreus through bacterial co-culture. Phytochemistry Letters,2015,12,35-41. [View]
Pubchem: 145960141
Nmrshiftdb2: 70007037

No compound-protein relationship available.

Structure

SMILES: c1ccccc1CC2OC(=O)C=C2c3ccccc3

Level: 2

Mol. Weight: 250.3 g/mol

Structure

SMILES: O=C1C=CC(O1)Cc2ccccc2

Level: 1

Mol. Weight: 174.2 g/mol

Structure

SMILES: C1OC(=O)C=C1c2ccccc2

Level: 1

Mol. Weight: 160.17 g/mol

Structure

SMILES: O=C1C=CCO1

Level: 0

Mol. Weight: 84.07 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

Antibacterial

Absorption

Caco-2 (logPapp)
-4.69
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.850
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.02

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.880
Plasma Protein Binding
72.45
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.260
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.680
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.850
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.630
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.540
Rat (Acute)
2.020
Rat (Chronic Oral)
2.380
Fathead Minnow
4.360
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
439.440
Hydration Free Energy
-12.050
Log(D) at pH=7.4
2.200
Log(P)
1.3
Log S
-2.67
Log(Vapor Pressure)
-8.39
Melting Point
238.72
pKa Acid
7.07
pKa Basic
3.97
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9597
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9597
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9257
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9257
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9184
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9184
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9112
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9112
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9055
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9055
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9043
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9043
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8958
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8958
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 3 0.8848
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 3 0.8848
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8837
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8837
Polymerase acidic protein Q5EP34 Q5EP34_9INFA Influenza A virus 3 0.8763
Polymerase acidic protein Q5EP34 Q5EP34_9INFA Influenza A virus 3 0.8763
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8753
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8753
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8743
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8743
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 3 0.8547
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 3 0.8547
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8496
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8496
Vanillate porin OpdK Q9HUR5 Q9HUR5_PSEAE Pseudomonas aeruginosa 3 0.8476
Vanillate porin OpdK Q9HUR5 Q9HUR5_PSEAE Pseudomonas aeruginosa 3 0.8476
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8430
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8430
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8382
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8382
Vanillate porin OpdK Q9HUR5 Q9HUR5_PSEAE Pseudomonas aeruginosa 3 0.8287
Vanillate porin OpdK Q9HUR5 Q9HUR5_PSEAE Pseudomonas aeruginosa 3 0.8287
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8270
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8270
Prostaglandin reductase 3 Q8N4Q0 PTGR3_HUMAN Homo sapiens 3 0.8252
Prostaglandin reductase 3 Q8N4Q0 PTGR3_HUMAN Homo sapiens 3 0.8252
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.8233
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.8233
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.8216
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.8216
Carboxypeptidase A1 P00730 CBPA1_BOVIN Bos taurus 3 0.8192
Carboxypeptidase A1 P00730 CBPA1_BOVIN Bos taurus 3 0.8192
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8175
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8175
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8164
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8164
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8137
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8137
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8134
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8134
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8121
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8121
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8107
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8107
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 3 0.8060
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 3 0.8060
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 3 0.7981
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 3 0.7981
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7977
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7977
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7976
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7976
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7920
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7920
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 4 0.7870
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 4 0.7870
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7865
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7865
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7813
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7813
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7722
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7722
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7711
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7711
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7688
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7688
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7683
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7683
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7678
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7678
GCN5-related N-acetyltransferase Q3M362 Q3M362_TRIV2 Trichormus variabilis 3 0.7674
GCN5-related N-acetyltransferase Q3M362 Q3M362_TRIV2 Trichormus variabilis 3 0.7674
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.7668
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.7668
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7667
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7667
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7667
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7667
Ribosomal RNA large subunit methyltransferase H P0C1V0 RLMH_STAAU Staphylococcus aureus 3 0.7650
Ribosomal RNA large subunit methyltransferase H P0C1V0 RLMH_STAAU Staphylococcus aureus 3 0.7650
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 3 0.7646
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 3 0.7646
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7622
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7622
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7574
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7574
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7541
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7541
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7537
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7537
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7535
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7535
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7516
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7516
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7514
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7514
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7504
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7504
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 3 0.7486
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 3 0.7486
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7480
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7480
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7476
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7476
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7461
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7461
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7460
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7460
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7452
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7452
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7450
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7450
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7437
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7437
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7424
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7424
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7412
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7412
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7380
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7380
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7380
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7380
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7379
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7379
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7367
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7367
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7355
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7355
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 3 0.7348
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 3 0.7348
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7334
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7334
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.7327
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.7327
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7326
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7326
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7316
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7316
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7281
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7281
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.7260
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.7260
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7254
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7254
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7254
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7254
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7242
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7242
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7236
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7236
Type II methyltransferase M.RsrI P14751 MTR1_RHOSH Cereibacter sphaeroides 3 0.7231
Type II methyltransferase M.RsrI P14751 MTR1_RHOSH Cereibacter sphaeroides 3 0.7231
Protoporphyrinogen oxidase, mitochondrial O24164 PPOM_TOBAC Nicotiana tabacum 3 0.7228
Protoporphyrinogen oxidase, mitochondrial O24164 PPOM_TOBAC Nicotiana tabacum 3 0.7228
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 3 0.7214
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 3 0.7214
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7205
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7205
Hydroxymethylglutaryl-CoA synthase Q9FD71 HMGCS_ENTFL Enterococcus faecalis 2 0.7202
Hydroxymethylglutaryl-CoA synthase Q9FD71 HMGCS_ENTFL Enterococcus faecalis 2 0.7202
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 3 0.7201
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 3 0.7201
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.7199
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.7199
Type II methyltransferase M.RsrI P14751 MTR1_RHOSH Cereibacter sphaeroides 3 0.7199
Type II methyltransferase M.RsrI P14751 MTR1_RHOSH Cereibacter sphaeroides 3 0.7199
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7191
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7191
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7188
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7188
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7176
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7176
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7176
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7176
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7174
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7174
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7170
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7170
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7166
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7166
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7165
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7165
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7160
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7160
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7158
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7158
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7158
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7158
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7157
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7157
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7133
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7133
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7130
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7130
UTP-monosaccharide-1-phosphate uridylyltransferase D3G6S4 D3G6S4_LEIMA Leishmania major 3 0.7124
UTP-monosaccharide-1-phosphate uridylyltransferase D3G6S4 D3G6S4_LEIMA Leishmania major 3 0.7124
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7122
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7122
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7108
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7108
Beta-glucuronidase P05804 BGLR_ECOLI Escherichia coli 3 0.7101
Beta-glucuronidase P05804 BGLR_ECOLI Escherichia coli 3 0.7101
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7085
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7085
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7085
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7085
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7069
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7069
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7063
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7063
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7057
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7057
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.7055
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.7055
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7054
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7054
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7049
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7049
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7045
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7045
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7044
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7044
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 3 0.7042
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 3 0.7042
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7041
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7041
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7041
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7041
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7040
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7040
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 3 0.7039
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 3 0.7039
dTDP-4-dehydro-6-deoxyglucose 3-epimerase Q5SFD1 CHMJ_STRBI Streptomyces bikiniensis 3 0.7035
dTDP-4-dehydro-6-deoxyglucose 3-epimerase Q5SFD1 CHMJ_STRBI Streptomyces bikiniensis 3 0.7035
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7032
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7032
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7029
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7029
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7021
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7021
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 4 0.7010
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 4 0.7010
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7009
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7009
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7005
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7005

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