Ammirol - Compound Card

Ammirol

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Ammirol

Structure
Zoomed Structure
  • Family: Plantae - Apiaceae
  • Kingdom: Plantae
  • Class: Coumarin
Canonical Smiles COc1c2oc(CO)cc(=O)c2c(c2c1occ2)OC
InChI InChI=1S/C14H12O6/c1-17-11-8-3-4-19-12(8)14(18-2)13-10(11)9(16)5-7(6-15)20-13/h3-5,15H,6H2,1-2H3
InChIKey XSKZZVYURGCOGM-UHFFFAOYSA-N
Formula C14H12O6
HBA 6
HBD 1
MW 276.24
Rotatable Bonds 3
TPSA 82.04
LogP 2.05
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.21
Exact Mass 276.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Ammi majus Apiaceae Plantae 48026

Showing of synonyms

  • Elgamal MHA, Shalaby NMM, et al. (1993). Coumarins and coumarin glucosides from the fruits of Ammi majus. Phytochemistry,1993,34(3),819-823. [View]
Pubchem: 621572
Nmrshiftdb2: 60058744

No compound-protein relationship available.

Structure

SMILES: c1coc(c12)cc3c(c2)c(=O)cco3

Level: 0

Mol. Weight: 276.24 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.53
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.230
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.75

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.110
Plasma Protein Binding
76.17
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
12.240
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.510
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-0.240
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.130
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.870
Rat (Acute)
2.730
Rat (Chronic Oral)
2.680
Fathead Minnow
4.530
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
424.890
Hydration Free Energy
-11.090
Log(D) at pH=7.4
1.440
Log(P)
0.93
Log S
-2.96
Log(Vapor Pressure)
-7.22
Melting Point
153.19
pKa Acid
8.29
pKa Basic
5.54
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9576
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9576
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9524
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9524
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9468
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9468
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9399
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9399
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9380
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9380
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.9136
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.9136
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8805
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8805
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8766
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8766
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8725
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8725
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8717
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8717
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8717
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8717
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8676
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8676
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8668
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8668
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.8658
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.8658
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8648
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8648
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8642
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8642
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8620
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8620
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8599
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8599
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.8483
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.8483
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8483
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8483
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8482
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8482
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8470
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8470
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8456
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8456
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.8445
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.8445
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8423
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8423
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8391
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8391
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8388
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8388
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8375
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8375
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8374
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8374
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8362
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8362
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8343
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8343
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8341
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8341
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8300
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8300
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8256
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8256
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8247
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8247
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8241
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8241
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8216
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8216
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8169
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8169
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8142
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8142
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7992
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7992
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7987
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7987
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7943
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7943
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7943
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7943
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7895
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7895
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7862
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7862
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7856
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7856
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7821
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7821
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7820
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7820
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7795
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7795
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7795
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7795
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 4 0.7793
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 4 0.7793
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7781
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7781
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7757
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7757
Envelope glycoprotein gp160 Q0ED31 Q0ED31_9HIV1 Human immunodeficiency virus 1 3 0.7750
Envelope glycoprotein gp160 Q0ED31 Q0ED31_9HIV1 Human immunodeficiency virus 1 3 0.7750
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7742
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7742
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7740
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7740
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7740
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7740
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7700
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7700
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7698
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7698
Acetylcholine-binding protein P58154 ACHP_LYMST Lymnaea stagnalis 3 0.7682
Acetylcholine-binding protein P58154 ACHP_LYMST Lymnaea stagnalis 3 0.7682
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7673
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7673
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 3 0.7668
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 3 0.7668
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7656
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7656
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7652
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7652
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7647
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7647
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7644
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7644
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7626
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7626
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.7622
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.7622
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7620
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7620
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7614
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7614
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7604
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7604
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7593
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7593
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7590
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7590
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7589
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7589
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7568
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7568
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7546
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7546
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7535
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7535
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7533
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7533
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7527
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7527
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7521
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7521
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.7510
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.7510
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7509
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7509
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7499
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7499
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7498
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7498
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7495
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7495
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7490
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7490
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7484
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7484
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7480
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7480
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7480
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7480
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7468
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7468
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7460
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7460
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7448
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7448
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7446
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7446
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.7437
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.7437
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7429
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7429
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7425
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7425
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7425
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7425
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7424
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7424
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7408
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7408
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7408
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7408
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.7400
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.7400
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7396
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7396
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7393
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7393
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7389
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7389
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.7387
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.7387
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7382
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7382
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.7377
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.7377
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7376
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7376
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7369
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7369
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7368
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7368
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7366
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7366
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7362
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7362
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7362
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7362
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7347
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7347
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7346
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7346
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7338
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7338
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7335
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7335
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7328
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7328
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7324
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7324
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7320
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 2 0.7320
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7320
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 2 0.7320
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7291
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7291
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7282
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7282
Aklanonic acid methyl ester cyclase AcmA O52646 DNRD_STRGJ Streptomyces galilaeus 3 0.7263
Aklanonic acid methyl ester cyclase AcmA O52646 DNRD_STRGJ Streptomyces galilaeus 3 0.7263
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7261
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7261
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7261
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7261
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7260
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7260
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7244
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7244
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7234
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7234
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7226
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7226
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7225
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7225
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7224
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7224
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7224
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7224
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7223
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7223
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 3 0.7222
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 3 0.7222
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7213
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7213
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7211
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7211
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7202
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7202
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7201
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7201
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7190
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7190
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7187
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7187
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7179
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7179
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7173
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7173
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7164
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7164
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7157
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7157
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7144
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7144
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7138
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7138
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7136
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7136
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7134
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7134
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7134
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7134
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7129
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7129
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7129
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7129
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7128
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7128
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7126
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7126
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7125
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7125
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 3 0.7117
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7117
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7117
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 3 0.7117
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7116
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7116
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7116
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7116
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7114
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7114
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7111
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7111
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7107
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7107
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7091
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7091
Riboflavin synthase Q58584 RISC_METJA Methanocaldococcus jannaschii 4 0.7090
Riboflavin synthase Q58584 RISC_METJA Methanocaldococcus jannaschii 4 0.7090
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7074
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7074
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7069
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7069
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7067
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7067
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 2 0.7062
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 2 0.7062
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 2 0.7062
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 2 0.7062
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7059
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7059
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7054
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7054
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7047
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7047
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7039
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7039
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7038
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7038
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7035
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7035
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7034
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7034
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.7032
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.7032
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7030
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7030
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7022
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 2 0.7022
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 2 0.7022
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7022
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7016
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7016
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.7004
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.7004

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