6-hydroxy-7-methoxy-4 methyl coumarin - Compound Card

6-hydroxy-7-methoxy-4 methyl coumarin

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6-hydroxy-7-methoxy-4 methyl coumarin

Structure
Zoomed Structure
  • Family: Plantae - Apiaceae
  • Kingdom: Plantae
  • Class: Coumarin
Canonical Smiles COc1cc2oc(=O)cc(c2cc1O)C
InChI InChI=1S/C11H10O4/c1-6-3-11(13)15-9-5-10(14-2)8(12)4-7(6)9/h3-5,12H,1-2H3
InChIKey XICLZVQOVIQOBV-UHFFFAOYSA-N
Formula C11H10O4
HBA 4
HBD 1
MW 206.2
Rotatable Bonds 1
TPSA 59.67
LogP 1.82
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 15
Formal Charge 0
Fraction CSP3 0.18
Exact Mass 206.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Ammi majus Apiaceae Plantae 48026

Showing of synonyms

  • Selim YA, Ouf NH. (2012). Anti-inflammatory new coumarin from the Ammi majus L.. Organic and Medicinal Chemistry Letters,2012,2,1. [View] [PubMed]
Pubchem: 238946
Nmrshiftdb2: 60064709

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(=O)cc2

Level: 0

Mol. Weight: 206.2 g/mol

Anti-inflammatory
Antiviral

Absorption

Caco-2 (logPapp)
-4.51
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.190
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.14

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.070
Plasma Protein Binding
59.86
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.250
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.380
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.530
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.630
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.680
Rat (Acute)
1.940
Rat (Chronic Oral)
2.160
Fathead Minnow
4.140
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Toxic

General Properties

Boiling Point
345.990
Hydration Free Energy
-9.030
Log(D) at pH=7.4
2.220
Log(P)
1.34
Log S
-3.02
Log(Vapor Pressure)
-4.94
Melting Point
189.73
pKa Acid
7.76
pKa Basic
4.82
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.9851
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.9851
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.9764
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.9764
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.9635
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.9635
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.9570
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.9570
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9450
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9450
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9423
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9423
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.9408
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.9408
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9267
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9267
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9226
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9226
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.9106
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.9106
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9073
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9073
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9008
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9008
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9005
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9005
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 3 0.8972
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 3 0.8972
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8937
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8937
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.8912
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.8912
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8798
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8798
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.8765
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.8765
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8740
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8740
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8735
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8735
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8668
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8668
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8643
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8643
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8602
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8602
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.8538
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.8538
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8522
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8522
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8522
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8522
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8483
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8483
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8436
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8436
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8317
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8317
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8275
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8275
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8272
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8272
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8248
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8248
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8222
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8222
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8221
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8221
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8208
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8208
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8200
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8200
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 3 0.8188
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 3 0.8188
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8183
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8183
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8180
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8180
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8147
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8147
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8093
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8093
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7996
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7996
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7982
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7982
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7957
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7957
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7932
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7932
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7932
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7932
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7912
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7912
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.7848
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.7848
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7828
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7828
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7773
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7773
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7731
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7731
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7716
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7716
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 3 0.7709
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 3 0.7709
Calmodulin-1 P0DP29 CALM1_RAT Rattus norvegicus 3 0.7703
Calmodulin-1 P0DP29 CALM1_RAT Rattus norvegicus 3 0.7703
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7669
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7669
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7664
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7664
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.7644
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.7644
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.7624
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.7624
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7622
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7622
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.7511
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.7511
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7423
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7423
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7417
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7417
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7415
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7415
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7408
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7408
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7400
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7400
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7394
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7394
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.7367
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.7367
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7346
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7346
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7336
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7336
Acetylcholine-binding protein P58154 ACHP_LYMST Lymnaea stagnalis 3 0.7331
Acetylcholine-binding protein P58154 ACHP_LYMST Lymnaea stagnalis 3 0.7331
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7317
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7317
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7316
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7316
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7300
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7300
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7254
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7254
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7232
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7232
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7224
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7224
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7207
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 3 0.7207
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 3 0.7207
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7207
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7204
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7204
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 3 0.7195
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 3 0.7195
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7178
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7178
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7173
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7173
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7169
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7169
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7169
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7169
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7131
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7131
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7123
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7123
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7120
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7120
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7106
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7106
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7093
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7093
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7090
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7090
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7085
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7085
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7079
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7079
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7074
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7074
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7072
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7072
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.7067
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.7067
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7065
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7065
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7062
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7062
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7060
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7060
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7042
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7042
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7030
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7030
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7027
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7027
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7017
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7017
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7002
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7002
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7002
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7002
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7000
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7000

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