Ferulsinaic acid - Compound Card

Ferulsinaic acid

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Ferulsinaic acid

Structure
Zoomed Structure
  • Family: Apiaceae
  • Kingdom: Plantae
  • Class: Coumarin
    • Subclass: Sesquiterpene Coumarin
Canonical Smiles OC(=O)CC[C@]1(C)[C@H](C=C(C)C)C[C@@H]([C@H]1COc1ccc2c(c1)oc(=O)cc2)C
InChI InChI=1S/C24H30O5/c1-15(2)11-18-12-16(3)20(24(18,4)10-9-22(25)26)14-28-19-7-5-17-6-8-23(27)29-21(17)13-19/h5-8,11,13,16,18,20H,9-10,12,14H2,1-4H3,(H,25,26)/t16-,18+,20+,24+/m0/s1
InChIKey OFSGQKZUVVKFEX-XXDRUXBBSA-N
Formula C24H30O5
HBA 4
HBD 1
MW 398.5
Rotatable Bonds 7
TPSA 76.74
LogP 5.28
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 29
Formal Charge 0
Fraction CSP3 0.5
Exact Mass 398.21
Number of Lipinski Rule Violations 1
# Species Family Kingdom NCBI Taxonomy ID
1 Ferula sinaica Apiaceae Plantae 1514050

Showing of synonyms

  • Ahmed AA, Hegazy MEF, et al. (2007). Ferulsinaic acid, a sesquiterpene coumarin with a rare carbon skeleton from Ferula species. Phytochemistry,2007,68(5),680-686. [View]
Pubchem: 102469382
Chebi: 180832
Nmrshiftdb2: 70028009
Metabolights: MTBLC180832

No compound-protein relationship available.

Structure

SMILES: C1CCCC1COc(cc2)cc(c23)oc(=O)cc3

Level: 1

Mol. Weight: 244.29 g/mol

Structure

SMILES: c1cccc(c12)oc(=O)cc2

Level: 0

Mol. Weight: 146.15 g/mol

Structure

SMILES: C1CCCC1

Level: 0

Mol. Weight: 70.14 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.01
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.95
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.21

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
2.08
Plasma Protein Binding
107.69
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
2.8
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.37
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-0.24
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.52
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Toxic
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-10.53
Rat (Acute)
2.13
Rat (Chronic Oral)
1.94
Fathead Minnow
4.04
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
454.83
Hydration Free Energy
-3.68
Log(D) at pH=7.4
2.04
Log(P)
5.33
Log S
-5.52
Log(Vapor Pressure)
-8.93
Melting Point
160.16
pKa Acid
5.87
pKa Basic
5.89
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.9560
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.9560
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.9551
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.9551
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9501
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9501
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.9427
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.9427
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.9179
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.9179
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.9100
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.9100
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.9078
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.9078
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9026
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9026
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8998
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8998
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8986
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8986
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8949
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8949
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.8947
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.8947
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 3 0.8930
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 3 0.8930
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8912
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8912
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8851
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8851
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8830
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8830
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 3 0.8748
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 3 0.8748
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.8688
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.8688
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8542
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8542
Avidin P02701 AVID_CHICK Gallus gallus 3 0.8475
Avidin P02701 AVID_CHICK Gallus gallus 3 0.8475
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8457
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8457
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.8423
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.8423
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.8409
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.8409
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8318
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8318
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8251
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8251
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8235
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8235
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.8197
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.8197
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8184
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8184
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8126
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8126
glutaryl-CoA dehydrogenase (ETF) Q3JP94 Q3JP94_BURP1 Burkholderia pseudomallei 2 0.8115
glutaryl-CoA dehydrogenase (ETF) Q3JP94 Q3JP94_BURP1 Burkholderia pseudomallei 2 0.8115
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8104
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8104
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.8019
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.8019
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.8012
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.8012
UTP-monosaccharide-1-phosphate uridylyltransferase D3G6S4 D3G6S4_LEIMA Leishmania major 3 0.7973
UTP-monosaccharide-1-phosphate uridylyltransferase D3G6S4 D3G6S4_LEIMA Leishmania major 3 0.7973
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7904
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7904
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7860
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7860
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7848
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7848
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7829
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7829
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7823
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7823
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 3 0.7810
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 3 0.7810
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7761
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7761
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7750
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7750
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7744
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7744
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7740
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7740
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7735
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7735
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7734
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7734
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7724
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7724
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 2 0.7706
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 2 0.7706
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7673
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7673
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7663
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7663
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7660
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7660
Nucleoside diphosphate kinase Q5SLV5 NDK_THET8 Thermus thermophilus 2 0.7629
Nucleoside diphosphate kinase Q5SLV5 NDK_THET8 Thermus thermophilus 2 0.7629
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 3 0.7619
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 3 0.7619
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7607
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7607
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7596
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7596
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7579
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7579
mRNA-capping enzyme subunit alpha P78587 MCE1_CANAX Candida albicans 3 0.7573
mRNA-capping enzyme subunit alpha P78587 MCE1_CANAX Candida albicans 3 0.7573
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7567
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7567
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7552
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7552
GTPase HRas P01112 RASH_HUMAN Homo sapiens 3 0.7542
GTPase HRas P01112 RASH_HUMAN Homo sapiens 3 0.7542
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 2 0.7518
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 2 0.7518
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 3 0.7516
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 3 0.7516
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7501
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7501
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7495
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.7495
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.7495
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7495
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7488
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7488
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7483
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7483
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7461
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7461
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7457
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7457
Hydroxymethylglutaryl-CoA synthase Q9FD71 HMGCS_ENTFL Enterococcus faecalis 2 0.7456
Hydroxymethylglutaryl-CoA synthase Q9FD71 HMGCS_ENTFL Enterococcus faecalis 2 0.7456
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.7450
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.7450
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7442
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7442
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7434
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7434
[LysW]-aminoadipate kinase O50147 LYSZ_THET2 Thermus thermophilus 3 0.7416
[LysW]-aminoadipate kinase O50147 LYSZ_THET2 Thermus thermophilus 3 0.7416
Beta-1,4-galactosyltransferase 1 P08037 B4GT1_BOVIN Bos taurus 3 0.7409
Beta-1,4-galactosyltransferase 1 P08037 B4GT1_BOVIN Bos taurus 3 0.7409
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.7395
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.7395
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7388
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7388
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7361
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7361
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7344
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7344
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7337
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7337
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7328
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 2 0.7328
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7328
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 2 0.7328
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7296
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7296
2'-5'-oligoadenylate synthase 1 P00973 OAS1_HUMAN Homo sapiens 2 0.7282
2'-5'-oligoadenylate synthase 1 P00973 OAS1_HUMAN Homo sapiens 2 0.7282
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.7276
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.7276
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7274
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7274
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7273
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7273
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7273
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7273
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7261
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7261
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 2 0.7254
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 2 0.7254
Ferrichrome outer membrane transporter/phage receptor P06971 FHUA_ECOLI Escherichia coli 3 0.7241
Ferrichrome outer membrane transporter/phage receptor P06971 FHUA_ECOLI Escherichia coli 3 0.7241
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7237
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7237
Jasmonoyl--L-amino acid synthetase JAR1 Q9SKE2 JAR1_ARATH Arabidopsis thaliana 3 0.7234
Jasmonoyl--L-amino acid synthetase JAR1 Q9SKE2 JAR1_ARATH Arabidopsis thaliana 3 0.7234
Tryptophan synthase beta chain 2 Q97TX6 TRPB2_SACS2 Saccharolobus solfataricus 3 0.7215
Tryptophan synthase beta chain 2 Q97TX6 TRPB2_SACS2 Saccharolobus solfataricus 3 0.7215
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7207
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7207
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7203
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7203
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7201
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7201
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7201
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7201
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7201
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7201
Trichosurin Q29147 TRIC_TRIVU Trichosurus vulpecula 2 0.7200
Trichosurin Q29147 TRIC_TRIVU Trichosurus vulpecula 2 0.7200
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7199
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7199
Glutamate receptor ionotropic, kainate 1 P22756 GRIK1_RAT Rattus norvegicus 2 0.7182
Glutamate receptor ionotropic, kainate 1 P22756 GRIK1_RAT Rattus norvegicus 2 0.7182
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 2 0.7181
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 2 0.7181
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7174
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7174
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7174
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7174
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7167
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7167
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7158
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7158
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7155
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7155
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7153
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7153
DNA topoisomerase 1 P06612 TOP1_ECOLI Escherichia coli 3 0.7140
DNA topoisomerase 1 P06612 TOP1_ECOLI Escherichia coli 3 0.7140
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7135
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7135
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7121
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7121
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7120
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7120
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7116
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7116
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7115
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7115
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7113
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7113
Aldo-keto reductase family 1 member A1 P50578 AK1A1_PIG Sus scrofa 3 0.7110
Aldo-keto reductase family 1 member A1 P50578 AK1A1_PIG Sus scrofa 3 0.7110
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7095
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7095
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7071
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7071
Dicamba O-demethylase, oxygenase component Q5S3I3 DDMC_STEMA Stenotrophomonas maltophilia 2 0.7059
Dicamba O-demethylase, oxygenase component Q5S3I3 DDMC_STEMA Stenotrophomonas maltophilia 2 0.7059
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7049
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7049
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7044
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 2 0.7044
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7044
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7044
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 2 0.7044
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7044
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7043
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7043
Probable enoyl-CoA hydratase EchA8 P9WNN9 ECHA8_MYCTU Mycobacterium tuberculosis 3 0.7041
Probable enoyl-CoA hydratase EchA8 P9WNN9 ECHA8_MYCTU Mycobacterium tuberculosis 3 0.7041
L-lactate dehydrogenase Q5SJA1 LDH_THET8 Thermus thermophilus 3 0.7036
L-lactate dehydrogenase Q5SJA1 LDH_THET8 Thermus thermophilus 3 0.7036
Aspartate-semialdehyde dehydrogenase Q51344 DHAS_PSEAE Pseudomonas aeruginosa 3 0.7032
Aspartate-semialdehyde dehydrogenase Q51344 DHAS_PSEAE Pseudomonas aeruginosa 3 0.7032
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7030
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7030
5-formyltetrahydrofolate cyclo-ligase P75430 MTHFS_MYCPN Mycoplasma pneumoniae 2 0.7028
5-formyltetrahydrofolate cyclo-ligase P75430 MTHFS_MYCPN Mycoplasma pneumoniae 2 0.7028
Mitogen-activated protein kinase kinase kinase 21 Q5TCX8 M3K21_HUMAN Homo sapiens 3 0.7014
Mitogen-activated protein kinase kinase kinase 21 Q5TCX8 M3K21_HUMAN Homo sapiens 3 0.7014
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 2 0.7011
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 2 0.7011
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 2 0.7008
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 2 0.7008
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7003
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7003

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