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Farnesiferol A

Family: Plantae - Apiaceae
Kingdom: Plantae
Class: Terpenoid
- Subclass: Sesquiterpenoid

Canonical Smiles	C=C1CC[C@H]2[C@@]([C@H]1COc1ccc3c(c1)oc(=O)cc3)(C)CC[C@H](C2(C)C)O
InChI	InChI=1S/C24H30O4/c1-15-5-9-20-23(2,3)21(25)11-12-24(20,4)18(15)14-27-17-8-6-16-7-10-22(26)28-19(16)13-17/h6-8,10,13,18,20-21,25H,1,5,9,11-12,14H2,2-4H3/t18-,20+,21+,24-/m0/s1
InChIKey	FCWYNTDTQPCVPG-WTMJVXIESA-N
Formula	C₂₄H₃₀O₄
HBA	4
HBD	1
MW	382.5
Rotatable Bonds	3
TPSA	59.67
LogP	4.94
Number Rings	4
Number Aromatic Rings	2
Heavy Atom Count	28
Formal Charge	0
Fraction CSP3	0.54
Exact Mass	382.21
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Ferula vesceritensis	Apiaceae	Plantae	1514058

Showing of synonyms

Oughlissi-Dehak K, Lawton P, et al. (2008). Sesquiterpenes from aerial parts of Ferula vesceritensis. Phytochemistry,2008,69(9),1933-1938. [View] [PubMed]

Pubchem: 7067262

Cas: 511-33-1

Gnps: CCMSLIB00000848946

Zinc: ZINC000004081322

Nmrshiftdb2: 60079874

Chembl: CHEMBL1078138

Comptox: DTXSID00199105

CPRiL: 221677

SMILES: C1CCCC(C12)CCC(=C)C2COc(cc3)cc(c34)oc(=O)cc4

Level: 1

Mol. Weight: 382.5 g/mol

SMILES: C=C(C1)CCC(C12)CCCC2

Level: 0

Mol. Weight: 382.5 g/mol

SMILES: c1cccc(c12)oc(=O)cc2

Level: 0

Mol. Weight: 382.5 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -5.07
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.32
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.34

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.31
Plasma Protein Binding: 92.62
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 6.4
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.6
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -0.14
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 6.17
Micronucleos: Safe
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: -10.16
Rat (Acute): 3.08
Rat (Chronic Oral): 1.61
Fathead Minnow: 3.93
Respiratory Disease: Safe
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Toxic

General Properties

Boiling Point: 457.82
Hydration Free Energy: -5.15
Log(D) at pH=7.4: 4.24
Log(P): 4.77
Log S: -5.7
Log(Vapor Pressure): -8.38
Melting Point: 152.2
pKa Acid: 7.62
pKa Basic: 7.19

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.9631
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.9631
Achbp	I6L8L2	I6L8L2_CAPTE	Capitella teleta	3	0.9628
Achbp	I6L8L2	I6L8L2_CAPTE	Capitella teleta	3	0.9628
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.9541
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.9541
NADH:flavin oxidoreductase Sye1	Q8EEC8	Q8EEC8_SHEON	Shewanella oneidensis	3	0.9482
NADH:flavin oxidoreductase Sye1	Q8EEC8	Q8EEC8_SHEON	Shewanella oneidensis	3	0.9482
Metapyrocatechase	Q7WYF5	Q7WYF5_9PSED	Pseudomonas alkylphenolica	3	0.9424
Metapyrocatechase	Q7WYF5	Q7WYF5_9PSED	Pseudomonas alkylphenolica	3	0.9424
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9288
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9288
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.9158
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.9158
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8806
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8806
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8517
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8517
Retinol-binding protein 1	P02696	RET1_RAT	Rattus norvegicus	3	0.8456
Retinol-binding protein 1	P02696	RET1_RAT	Rattus norvegicus	3	0.8456
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8439
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8439
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.8415
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.8415
Retinol-binding protein 2	P50120	RET2_HUMAN	Homo sapiens	3	0.8334
Retinol-binding protein 2	P50120	RET2_HUMAN	Homo sapiens	3	0.8334
glutaryl-CoA dehydrogenase (ETF)	Q3JP94	Q3JP94_BURP1	Burkholderia pseudomallei	2	0.8325
glutaryl-CoA dehydrogenase (ETF)	Q3JP94	Q3JP94_BURP1	Burkholderia pseudomallei	2	0.8325
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8261
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8261
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.8254
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.8254
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.8161
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.8161
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.8128
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.8128
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8038
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8038
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.8030
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.8030
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8017
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8017
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.8006
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.8006
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.7973
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.7973
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7928
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7928
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7903
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7903
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7811
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7811
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	3	0.7786
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	3	0.7786
cGMP-dependent protein kinase 1	P00516	KGP1_BOVIN	Bos taurus	3	0.7738
cGMP-dependent protein kinase 1	P00516	KGP1_BOVIN	Bos taurus	3	0.7738
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	2	0.7705
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	2	0.7705
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7692
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7692
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7568
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7568
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7567
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7567
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	2	0.7552
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	2	0.7552
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	2	0.7548
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	2	0.7548
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7537
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7537
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7530
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7530
Bifunctional dihydrofolate reductase-thymidylate synthase	P13922	DRTS_PLAFK	Plasmodium falciparum	2	0.7514
Bifunctional dihydrofolate reductase-thymidylate synthase	P13922	DRTS_PLAFK	Plasmodium falciparum	2	0.7514
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7499
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7499
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7497
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7497
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7496
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7496
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7458
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7458
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7453
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7453
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7451
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7451
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7450
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7450
Elongation factor Tu 1	P0CE47	EFTU1_ECOLI	Escherichia coli	3	0.7429
Elongation factor Tu 1	P0CE47	EFTU1_ECOLI	Escherichia coli	3	0.7429
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7428
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7428
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7395
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7395
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7384
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7384
N-alpha-acetyltransferase 50	Q9GZZ1	NAA50_HUMAN	Homo sapiens	3	0.7377
N-alpha-acetyltransferase 50	Q9GZZ1	NAA50_HUMAN	Homo sapiens	3	0.7377
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7365
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7365
Eugenol synthase 1	Q15GI4	EGS1_OCIBA	Ocimum basilicum	3	0.7364
Eugenol synthase 1	Q15GI4	EGS1_OCIBA	Ocimum basilicum	3	0.7364
AGAP003309-PA	A0A1U7F4W2	A0A1U7F4W2_ANOGA	Anopheles gambiae	2	0.7351
AGAP003309-PA	A0A1U7F4W2	A0A1U7F4W2_ANOGA	Anopheles gambiae	2	0.7351
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7340
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7340
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7340
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7340
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7336
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7336
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7328
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7328
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7328
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7328
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7301
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7301
DNA topoisomerase 1	P06612	TOP1_ECOLI	Escherichia coli	3	0.7290
DNA topoisomerase 1	P06612	TOP1_ECOLI	Escherichia coli	3	0.7290
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	2	0.7281
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	2	0.7281
Dicamba O-demethylase, oxygenase component	Q5S3I3	DDMC_STEMA	Stenotrophomonas maltophilia	2	0.7281
Dicamba O-demethylase, oxygenase component	Q5S3I3	DDMC_STEMA	Stenotrophomonas maltophilia	2	0.7281
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	2	0.7278
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	2	0.7278
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7276
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7276
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	2	0.7273
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	2	0.7273
Aromatic-amino-acid aminotransferase	P95468	TYRB_PARDE	Paracoccus denitrificans	2	0.7271
Aromatic-amino-acid aminotransferase	P95468	TYRB_PARDE	Paracoccus denitrificans	2	0.7271
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7262
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7262
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7238
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7238
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7232
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7232
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7222
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7222
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	2	0.7221
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	2	0.7221
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7213
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7213
Gastrotropin	Q6IMW5	Q6IMW5_DANRE	Danio rerio	2	0.7208
Gastrotropin	Q6IMW5	Q6IMW5_DANRE	Danio rerio	2	0.7208
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7205
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7205
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	4	0.7194
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	4	0.7194
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.7181
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.7181
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7177
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7177
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.7165
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.7165
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	3	0.7157
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	3	0.7157
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7155
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7155
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7151
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7151
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7129
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7129
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7113
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7113
Aldo-keto reductase family 1 member A1	P50578	AK1A1_PIG	Sus scrofa	3	0.7094
Aldo-keto reductase family 1 member A1	P50578	AK1A1_PIG	Sus scrofa	3	0.7094
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	2	0.7087
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	2	0.7087
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7043
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7043
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	2	0.7040
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	2	0.7040
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7023
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7023
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.7016
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.7016

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